Identification, characterization and molecular analysis of the viable but nonculturable Rhodococcus biphenylivorans

Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, as a vast majority of potent microbial resource can be of great significance in environmental rehabilitation. It is necessa...

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Published inScientific reports Vol. 5; no. 1; p. 18590
Main Authors Su, Xiaomei, Sun, Faqian, Wang, Yalin, Hashmi, Muhammad Zaffar, Guo, Li, Ding, Linxian, Shen, Chaofeng
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 21.12.2015
Nature Publishing Group
Subjects
14/28
38/39
38/91
631/326/171
631/326/41
Air Pollutants - toxicity
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Biodegradation, Environmental
Gene Expression Regulation, Bacterial - drug effects
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
multidisciplinary
Rhodococcus - drug effects
Rhodococcus - genetics
Rhodococcus - growth & development
Science
Temperature
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/srep18590

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Abstract Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, as a vast majority of potent microbial resource can be of great significance in environmental rehabilitation. It is necessary to study the VBNC state of pollutant-degrading bacteria under various stress conditions. The aim of this study was to determine whether Rhodococcus biphenylivorans could enter the VBNC state under oligotrophic and low temperature conditions and to examine the changes of morphology, enzymatic activity and gene expressions that might underline such state. The obtained results indicated that R . biphenylivorans TG9 T could enter into the VBNC state and recover culturability under favorable environmental conditions. Results from Illumina high throughput RNA-sequencing revealed that the up-regulated genes related to ATP accumulation, protein modification, peptidoglycan biosynthesis and RNA polymerase were found in the VBNC cells and the down-regulated genes mainly encoded hypothetical protein, membrane protein and NADH dehydrogenase subunit, which render VBNC cells more tolerant to survive under inhospitable conditions. This study provides new insights into prevention and control of the VBNC state of pollutant-degrading bacteria for their better capabilities in environmental rehabilitation.
AbstractList Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, as a vast majority of potent microbial resource can be of great significance in environmental rehabilitation. It is necessary to study the VBNC state of pollutant-degrading bacteria under various stress conditions. The aim of this study was to determine whether Rhodococcus biphenylivorans could enter the VBNC state under oligotrophic and low temperature conditions, and to examine the changes of morphology, enzymatic activity and gene expressions that might underline such state. The obtained results indicated that R. biphenylivorans TG9(T) could enter into the VBNC state and recover culturability under favorable environmental conditions. Results from Illumina high throughput RNA-sequencing revealed that the up-regulated genes related to ATP accumulation, protein modification, peptidoglycan biosynthesis and RNA polymerase were found in the VBNC cells, and the down-regulated genes mainly encoded hypothetical protein, membrane protein and NADH dehydrogenase subunit, which render VBNC cells more tolerant to survive under inhospitable conditions. This study provides new insights into prevention and control of the VBNC state of pollutant-degrading bacteria for their better capabilities in environmental rehabilitation.
Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, as a vast majority of potent microbial resource can be of great significance in environmental rehabilitation. It is necessary to study the VBNC state of pollutant-degrading bacteria under various stress conditions. The aim of this study was to determine whether Rhodococcus biphenylivorans could enter the VBNC state under oligotrophic and low temperature conditions, and to examine the changes of morphology, enzymatic activity and gene expressions that might underline such state. The obtained results indicated that R. biphenylivorans TG9T could enter into the VBNC state and recover culturability under favorable environmental conditions. Results from Illumina high throughput RNA-sequencing revealed that the up-regulated genes related to ATP accumulation, protein modification, peptidoglycan biosynthesis and RNA polymerase were found in the VBNC cells, and the down-regulated genes mainly encoded hypothetical protein, membrane protein and NADH dehydrogenase subunit, which render VBNC cells more tolerant to survive under inhospitable conditions. This study provides new insights into prevention and control of the VBNC state of pollutant-degrading bacteria for their better capabilities in environmental rehabilitation.
Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, as a vast majority of potent microbial resource can be of great significance in environmental rehabilitation. It is necessary to study the VBNC state of pollutant-degrading bacteria under various stress conditions. The aim of this study was to determine whether Rhodococcus biphenylivorans could enter the VBNC state under oligotrophic and low temperature conditions, and to examine the changes of morphology, enzymatic activity and gene expressions that might underline such state. The obtained results indicated that R. biphenylivorans TG9(T) could enter into the VBNC state and recover culturability under favorable environmental conditions. Results from Illumina high throughput RNA-sequencing revealed that the up-regulated genes related to ATP accumulation, protein modification, peptidoglycan biosynthesis and RNA polymerase were found in the VBNC cells, and the down-regulated genes mainly encoded hypothetical protein, membrane protein and NADH dehydrogenase subunit, which render VBNC cells more tolerant to survive under inhospitable conditions. This study provides new insights into prevention and control of the VBNC state of pollutant-degrading bacteria for their better capabilities in environmental rehabilitation.Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, as a vast majority of potent microbial resource can be of great significance in environmental rehabilitation. It is necessary to study the VBNC state of pollutant-degrading bacteria under various stress conditions. The aim of this study was to determine whether Rhodococcus biphenylivorans could enter the VBNC state under oligotrophic and low temperature conditions, and to examine the changes of morphology, enzymatic activity and gene expressions that might underline such state. The obtained results indicated that R. biphenylivorans TG9(T) could enter into the VBNC state and recover culturability under favorable environmental conditions. Results from Illumina high throughput RNA-sequencing revealed that the up-regulated genes related to ATP accumulation, protein modification, peptidoglycan biosynthesis and RNA polymerase were found in the VBNC cells, and the down-regulated genes mainly encoded hypothetical protein, membrane protein and NADH dehydrogenase subunit, which render VBNC cells more tolerant to survive under inhospitable conditions. This study provides new insights into prevention and control of the VBNC state of pollutant-degrading bacteria for their better capabilities in environmental rehabilitation.
Numerous bacteria, including pollutant-degrading bacteria can enter the viable but nonculturable state (VBNC) when they encounter harsh environmental conditions. VBNC bacteria, as a vast majority of potent microbial resource can be of great significance in environmental rehabilitation. It is necessary to study the VBNC state of pollutant-degrading bacteria under various stress conditions. The aim of this study was to determine whether Rhodococcus biphenylivorans could enter the VBNC state under oligotrophic and low temperature conditions and to examine the changes of morphology, enzymatic activity and gene expressions that might underline such state. The obtained results indicated that R . biphenylivorans TG9 T could enter into the VBNC state and recover culturability under favorable environmental conditions. Results from Illumina high throughput RNA-sequencing revealed that the up-regulated genes related to ATP accumulation, protein modification, peptidoglycan biosynthesis and RNA polymerase were found in the VBNC cells and the down-regulated genes mainly encoded hypothetical protein, membrane protein and NADH dehydrogenase subunit, which render VBNC cells more tolerant to survive under inhospitable conditions. This study provides new insights into prevention and control of the VBNC state of pollutant-degrading bacteria for their better capabilities in environmental rehabilitation.
ArticleNumber 18590
Author Guo, Li
Hashmi, Muhammad Zaffar
Su, Xiaomei
Sun, Faqian
Shen, Chaofeng
Wang, Yalin
Ding, Linxian
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  givenname: Faqian
  surname: Sun
  fullname: Sun, Faqian
  organization: Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Key Laboratory for Water Pollution Control and Environmental Safety
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  givenname: Yalin
  surname: Wang
  fullname: Wang, Yalin
  organization: Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Key Laboratory for Water Pollution Control and Environmental Safety
– sequence: 4
  givenname: Muhammad Zaffar
  surname: Hashmi
  fullname: Hashmi, Muhammad Zaffar
  organization: Department of Meteorology, COMSATS Institute of Information Technology
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  givenname: Li
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  fullname: Guo, Li
  organization: Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Key Laboratory for Water Pollution Control and Environmental Safety
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  givenname: Chaofeng
  surname: Shen
  fullname: Shen, Chaofeng
  organization: Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Key Laboratory for Water Pollution Control and Environmental Safety
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26687808$$D View this record in MEDLINE/PubMed
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SubjectTerms 14/28
38/39
38/91
631/326/171
631/326/41
Air Pollutants - toxicity
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Biodegradation, Environmental
Gene Expression Regulation, Bacterial - drug effects
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
multidisciplinary
Rhodococcus - drug effects
Rhodococcus - genetics
Rhodococcus - growth & development
Science
Temperature
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Title Identification, characterization and molecular analysis of the viable but nonculturable Rhodococcus biphenylivorans
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