DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos
During early embryogenesis of Drosophila melanogaster , mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome functio...
Saved in:
| Published in | Nature cell biology Vol. 2; no. 2; pp. 90 - 95 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.02.2000
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1465-7392 1476-4679 1476-4679 |
| DOI | 10.1038/35000041 |
Cover
| Abstract | During early embryogenesis of
Drosophila melanogaster
, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the γ-tubulin ring complex from a core centrosomal structure. The DNA-replication inhibitor aphidicolin and DNA-damaging agents trigger identical mitotic defects in wild-type embryos, indicating that centrosome inactivation is a checkpoint-independent and mitosis-specific response to damaged or incompletely replicated DNA. We propose that centrosome inactivation is part of a damage-control system that blocks chromosome segregation when replication/damage checkpoint control fails. |
|---|---|
| AbstractList | During early embryogenesis of
Drosophila melanogaster
, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the γ-tubulin ring complex from a core centrosomal structure. The DNA-replication inhibitor aphidicolin and DNA-damaging agents trigger identical mitotic defects in wild-type embryos, indicating that centrosome inactivation is a checkpoint-independent and mitosis-specific response to damaged or incompletely replicated DNA. We propose that centrosome inactivation is part of a damage-control system that blocks chromosome segregation when replication/damage checkpoint control fails. During early embryogenesis of Drosophila melanogaster, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the gamma-tubulin ring complex from a core centrosomal structure. The DNA-replication inhibitor aphidicolin and DNA-damaging agents trigger identical mitotic defects in wild-type embryos, indicating that centrosome inactivation is a checkpoint-independent and mitosis-specific response to damaged or incompletely replicated DNA. We propose that centrosome inactivation is part of a damage-control system that blocks chromosome segregation when replication/damage checkpoint control fails. During early embryogenesis of Drosophila melanogaster, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the gamma-tubulin ring complex from a core centrosomal structure. The DNA-replication inhibitor aphidicolin and DNA-damaging agents trigger identical mitotic defects in wild-type embryos, indicating that centrosome inactivation is a checkpoint-independent and mitosis-specific response to damaged or incompletely replicated DNA. We propose that centrosome inactivation is part of a damage-control system that blocks chromosome segregation when replication/damage checkpoint control fails.During early embryogenesis of Drosophila melanogaster, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the gamma-tubulin ring complex from a core centrosomal structure. The DNA-replication inhibitor aphidicolin and DNA-damaging agents trigger identical mitotic defects in wild-type embryos, indicating that centrosome inactivation is a checkpoint-independent and mitosis-specific response to damaged or incompletely replicated DNA. We propose that centrosome inactivation is part of a damage-control system that blocks chromosome segregation when replication/damage checkpoint control fails. During early embryogenesis of Drosophila melanogaster, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that these segregation failures are associated with the assembly of an anastral microtubule spindle, a mitosis-specific loss of centrosome function, and dissociation of several components of the g-tubulin ring complex from a core centrosomal structure. The DNA-replication inhibitor aphidicolin and DNA-damaging agents trigger identical mitotic defects in wild-type embryos, indicating that centrosome inactivation is a checkpoint-independent and mitosis-specific response to damaged or incompletely replicated DNA. We propose that centrosome inactivation is part of a damage-control system that blocks chromosome segregation when replication/damage checkpoint control fails. |
| Audience | Academic |
| Author | Sibon, Ody C. M. Lemstra, Willy Kelkar, Anju Theurkauf, William E. |
| Author_xml | – sequence: 1 givenname: Ody C. M. surname: Sibon fullname: Sibon, Ody C. M. organization: Department of Radiobiology, Faculty of Medicine, University of Groningen – sequence: 2 givenname: Anju surname: Kelkar fullname: Kelkar, Anju organization: Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center – sequence: 3 givenname: Willy surname: Lemstra fullname: Lemstra, Willy organization: Department of Radiobiology, Faculty of Medicine, University of Groningen – sequence: 4 givenname: William E. surname: Theurkauf fullname: Theurkauf, William E. email: william.theurkauf@umassmed.edu organization: Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10655588$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkttu1DAQhi3Uih5A4gnQigsOF2l9jO3LVVugUlWkAteRY08WV4mT2gmib1-nu6UHEIwl2zP6ZvxbM3toK_QBEHpF8AHBTB0ygbNx8gztEi7LgpdSb833UhSSabqD9lK6xJhwjuVztENwKYRQahddHJ8viwhD660ZfR8OZ9-ZzqygcDBAcBDGhc1b7FPfwcIHY0f_8xbOzuJ4jg8_fGsW0NXxuk8v0HZj2gQvN-c--v7x5NvR5-Lsy6fTo-VZYbPEsag1bgiTVGiCpSKWSc6wVVTWWjkBkmHFtcO0cYw4K7SgzlGjjbK1rDFYto_eresOsb-aII1V55OFtjUB-ilVUmhGNJY0k2__TWJVEo7Zf0EiuSKCzBXfPAEv-ymG_N2KZlOYliJDB2toZVqofGj6MRqbl4PO29zBxuf4kihGFRVsfv7Do4TMjPBrXJkpper068Vj9vVGwVR34Koh-s7E6-qutRl4vwZs7lCK0DxAqnlqqrupuRf6G7V-vO1wFuzbvyVshKZcM6wg3n__D_YGBczLOA |
| CitedBy_id | crossref_primary_10_1038_sj_onc_1205824 crossref_primary_10_1007_s00418_008_0427_6 crossref_primary_10_1007_s10577_015_9503_7 crossref_primary_10_1146_annurev_genet_37_110801_143149 crossref_primary_10_1242_dev_027599 crossref_primary_10_2183_pjab_80_290 crossref_primary_10_1002_em_20533 crossref_primary_10_1007_s00432_008_0472_5 crossref_primary_10_1186_1747_1028_8_7 crossref_primary_10_1096_fj_201901751R crossref_primary_10_1038_35023629 crossref_primary_10_1093_nar_gkv775 crossref_primary_10_1534_genetics_117_300318 crossref_primary_10_1242_dev_02831 crossref_primary_10_1016_j_yexcr_2006_06_008 crossref_primary_10_1016_j_ymeth_2006_08_013 crossref_primary_10_1002_jcb_20848 crossref_primary_10_1371_journal_pgen_1000876 crossref_primary_10_1016_j_devcel_2016_05_004 crossref_primary_10_1016_S1534_5807_04_00096_6 crossref_primary_10_1186_1471_2199_14_1 crossref_primary_10_1016_j_devcel_2006_08_010 crossref_primary_10_1002_cbin_10016 crossref_primary_10_1016_j_ydbio_2009_12_031 crossref_primary_10_1242_jcs_114_19_3445 crossref_primary_10_3390_genes11060642 crossref_primary_10_1007_s00018_012_0961_1 crossref_primary_10_1074_jbc_M111705200 crossref_primary_10_1091_mbc_e08_06_0639 crossref_primary_10_1016_S0167_4781_01_00204_4 crossref_primary_10_1038_ncb1165 crossref_primary_10_1186_1747_1028_7_17 crossref_primary_10_1016_j_dnarep_2004_03_005 crossref_primary_10_1016_j_devcel_2014_05_010 crossref_primary_10_1007_s00412_011_0342_9 crossref_primary_10_1007_s00412_018_0680_y crossref_primary_10_1016_S0955_0674_01_00291_5 crossref_primary_10_1091_mbc_11_12_4173 crossref_primary_10_1073_pnas_0803001105 crossref_primary_10_1016_S0960_9822_02_01226_5 crossref_primary_10_1074_jbc_M505450200 crossref_primary_10_1242_bio_20135801 crossref_primary_10_1038_nrc924 crossref_primary_10_1016_j_cub_2003_12_022 crossref_primary_10_1007_s00441_006_0253_x crossref_primary_10_1016_j_cub_2005_07_031 crossref_primary_10_1016_j_febslet_2011_04_074 crossref_primary_10_1016_j_canlet_2006_01_006 crossref_primary_10_1242_dev_128_9_1697 crossref_primary_10_1007_s10577_015_9512_6 crossref_primary_10_1242_jcs_016626 crossref_primary_10_1074_jbc_M113_535955 crossref_primary_10_1038_emboj_2010_210 crossref_primary_10_1093_genetics_157_4_1623 crossref_primary_10_3390_cells9051300 crossref_primary_10_1101_cshperspect_a025049 crossref_primary_10_1667_RR3211 crossref_primary_10_1016_j_devcel_2014_03_025 crossref_primary_10_1038_sj_onc_1208859 crossref_primary_10_1016_j_cub_2004_06_056 crossref_primary_10_1051_medsci_20143012005 crossref_primary_10_1371_journal_pgen_1002227 crossref_primary_10_1038_sj_onc_1203968 crossref_primary_10_1534_genetics_108_097345 crossref_primary_10_1016_S0300_483X_01_00556_X crossref_primary_10_4161_cc_28419 crossref_primary_10_1096_fj_13_231167 crossref_primary_10_1371_journal_pgen_0030200 crossref_primary_10_1593_neo_04247 crossref_primary_10_1186_1471_2407_8_181 crossref_primary_10_1038_ng0503_6 crossref_primary_10_1103_PhysRevLett_85_4401 crossref_primary_10_1146_annurev_cellbio_21_122303_120418 crossref_primary_10_1158_0008_5472_CAN_10_2684 crossref_primary_10_1016_S0304_419X_00_00025_1 crossref_primary_10_1534_genetics_119_302665 crossref_primary_10_1016_S0027_5107_02_00088_X crossref_primary_10_1091_mbc_e02_08_0510 crossref_primary_10_1098_rstb_2013_0464 crossref_primary_10_1111_j_1600_0854_2009_00905_x crossref_primary_10_1038_35023555 crossref_primary_10_1016_j_cub_2005_02_026 crossref_primary_10_1038_35000099 crossref_primary_10_1242_jcs_107474 crossref_primary_10_1091_mbc_e05_01_0038 crossref_primary_10_1038_onc_2012_310 crossref_primary_10_1242_dev_101196 crossref_primary_10_1007_s10577_015_9506_4 crossref_primary_10_1016_S0092_8674_03_00202_2 crossref_primary_10_1242_bio_019000 crossref_primary_10_1016_j_dnarep_2008_10_007 crossref_primary_10_1002_cm_1016 crossref_primary_10_1126_science_1072802 crossref_primary_10_1016_S1016_8478_23_13152_9 crossref_primary_10_7554_eLife_66668 crossref_primary_10_1016_j_semcancer_2004_09_003 crossref_primary_10_1016_j_ejcb_2014_12_001 crossref_primary_10_4161_15384101_2014_964973 crossref_primary_10_1016_j_ydbio_2008_11_002 crossref_primary_10_1038_35089575 crossref_primary_10_1128_MCB_21_15_5156_5168_2001 crossref_primary_10_1038_ncb2345 crossref_primary_10_1016_j_cub_2009_08_013 crossref_primary_10_1016_j_dnarep_2004_06_011 crossref_primary_10_1534_genetics_106_065219 crossref_primary_10_1016_S0014_5793_03_00536_2 crossref_primary_10_1016_S0960_9822_00_00042_7 crossref_primary_10_1038_35036399 crossref_primary_10_1186_1479_5876_11_77 crossref_primary_10_1016_j_yexcr_2011_01_022 crossref_primary_10_1002_jcb_21195 crossref_primary_10_1111_j_1749_6632_2009_05396_x crossref_primary_10_1016_j_yexcr_2006_09_023 crossref_primary_10_1155_2012_217594 crossref_primary_10_1371_journal_pone_0011760 crossref_primary_10_1242_dev_02028 crossref_primary_10_1091_mbc_E14_07_1238 crossref_primary_10_1016_j_dnarep_2004_10_010 crossref_primary_10_1242_jcs_02454 crossref_primary_10_1016_j_cellsig_2007_03_001 crossref_primary_10_1016_j_ydbio_2005_11_015 crossref_primary_10_1038_423493a |
| Cites_doi | 10.1016/S0960-9822(06)00189-8 10.1083/jcb.109.6.2977 10.1016/0005-2787(80)90060-X 10.1083/jcb.138.3.615 10.1038/2392 10.1083/jcb.144.4.721 10.1083/jcb.103.2.581 10.1083/jcb.140.5.1003 10.1126/science.271.5256.1744 10.1016/S0960-9822(99)80138-9 10.1242/dev.104.3.495 10.1016/S0091-679X(08)61988-3 10.1083/jcb.134.2.455 10.1016/0092-8674(86)90009-7 10.1038/378578a0 10.1083/jcb.107.6.2009 10.1242/dev.126.13.2829 10.1016/S0960-9822(99)80393-5 10.1038/40439 10.1242/jcs.61.1.31 10.1016/0092-8674(91)90389-G 10.1242/dev.104.3.483 10.1038/382420a0 10.1242/dev.103.4.675 10.1016/S0092-8674(00)81258-1 10.1101/gad.8.4.440 10.1242/jcs.108.11.3377 10.1016/0092-8674(86)90771-3 10.1242/dev.120.8.2131 10.1016/0092-8674(95)90478-6 10.1083/jcb.116.5.1167 10.1083/jcb.131.5.1261 10.1016/S0091-679X(08)60928-0 |
| ContentType | Journal Article |
| Copyright | Macmillan Magazines Ltd. 2000 COPYRIGHT 2000 Nature Publishing Group Copyright Nature Publishing Group Feb 2000 |
| Copyright_xml | – notice: Macmillan Magazines Ltd. 2000 – notice: COPYRIGHT 2000 Nature Publishing Group – notice: Copyright Nature Publishing Group Feb 2000 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM ISR 3V. 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7N M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7SS 7X8 |
| DOI | 10.1038/35000041 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Proquest Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database (Proquest) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Entomology Abstracts (Full archive) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest SciTech Collection ProQuest Medical Library Immunology Abstracts ProQuest Central (Alumni) Entomology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic ProQuest Central Student Entomology Abstracts Entomology Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1476-4679 |
| EndPage | 95 |
| ExternalDocumentID | 1025241381 A183282533 10655588 10_1038_35000041 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: R01GM50898 |
| GroupedDBID | --- .55 .GJ 0R~ 123 29M 36B 39C 4.4 53G 5RE 70F 7X7 88E 8AO 8FE 8FH 8FI 8FJ 8R4 8R5 AARCD AAYZH ABAWZ ABCQX ABDBF ABEFU ABFSG ABJNI ABLJU ABNNU ABUWG ACBWK ACGFS ACIWK ACNCT ACPRK ACRPL ACSTC ACUHS ADBBV ADNMO AENEX AEUYN AEZWR AFANA AFBBN AFFNX AFHIU AFKRA AFRAH AFSHS AFWHJ AGAYW AGGDT AGQPQ AHBCP AHMBA AHOSX AHSBF AHWEU AIBTJ AIXLP AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ALPWD ARMCB ASPBG ATHPR AVWKF AXYYD AZFZN B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 D0L DB5 DU5 EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR INH INR ISR ITC J5H L-9 L7B LK8 M1P M7P N9A NFIDA NNMJJ O9- ODYON P2P PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO Q2X QF4 QM4 QN7 QO4 RNS RNT RNTTT SHXYY SIXXV SKT SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP X7M Y6R ZGI ~02 ~8M AAYXX CITATION 3V. 5BI 88A AAEEF AAZLF ADQMX AGHTU CGR CUY CVF ECM EIF M0L NPM AEIIB PMFND 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. M7N P64 PKEHL PQEST PQUKI PRINS PUEGO RC3 7SS 7X8 |
| ID | FETCH-LOGICAL-c476t-b90f13725910781c37430c827b98d5e730849d02fd31dc5952dd2a9a8cb7b0ec3 |
| IEDL.DBID | 7X7 |
| ISSN | 1465-7392 1476-4679 |
| IngestDate | Fri Sep 05 03:28:25 EDT 2025 Fri Sep 05 03:10:43 EDT 2025 Fri Sep 05 08:36:11 EDT 2025 Sat Aug 23 12:46:35 EDT 2025 Tue Jun 10 21:31:16 EDT 2025 Fri Jun 27 05:08:19 EDT 2025 Wed Feb 19 01:21:04 EST 2025 Thu Apr 24 22:57:48 EDT 2025 Tue Jul 01 00:57:09 EDT 2025 Mon Jul 21 06:09:51 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c476t-b90f13725910781c37430c827b98d5e730849d02fd31dc5952dd2a9a8cb7b0ec3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| PMID | 10655588 |
| PQID | 222280265 |
| PQPubID | 23462 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_759319072 proquest_miscellaneous_70861403 proquest_miscellaneous_17481512 proquest_journals_222280265 gale_infotracacademiconefile_A183282533 gale_incontextgauss_ISR_A183282533 pubmed_primary_10655588 crossref_primary_10_1038_35000041 crossref_citationtrail_10_1038_35000041 springer_journals_10_1038_35000041 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2000-02-01 |
| PublicationDateYYYYMMDD | 2000-02-01 |
| PublicationDate_xml | – month: 02 year: 2000 text: 2000-02-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature cell biology |
| PublicationTitleAbbrev | Nat Cell Biol |
| PublicationTitleAlternate | Nat Cell Biol |
| PublicationYear | 2000 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | TL Megraw (BFncb0200_90_CR30) 1999; 126 J Cadet (BFncb0200_90_CR24) 1997; 378 Y Zheng (BFncb0200_90_CR14) 1995; 378 K Li (BFncb0200_90_CR18) 1996; 85 KL Hari (BFncb0200_90_CR9) 1995; 82 DR Kellogg (BFncb0200_90_CR13) 1988; 103 BA Edgar (BFncb0200_90_CR2) 1986; 44 Y Zheng (BFncb0200_90_CR25) 1991; 65 LC Erickson (BFncb0200_90_CR23) 1980; 610 JW Raff (BFncb0200_90_CR22) 1988; 107 K Oegema (BFncb0200_90_CR16) 1995; 131 OC Sibon (BFncb0200_90_CR7) 1999; 9 D Vaizel-Ohayon (BFncb0200_90_CR31) 1999; 9 V Foe (BFncb0200_90_CR1) 1993 WE Theurkauf (BFncb0200_90_CR35) 1994; 44 BA Edgar (BFncb0200_90_CR4) 1986; 44 WE Theurkauf (BFncb0200_90_CR26) 1992; 116 WG Whitfield (BFncb0200_90_CR17) 1995; 108 PT Merrill (BFncb0200_90_CR6) 1988; 104 WE Theurkauf (BFncb0200_90_CR12) 1999; 61 OC Sibon (BFncb0200_90_CR8) 1997; 388 DR Kellogg (BFncb0200_90_CR15) 1989; 109 P Fogarty (BFncb0200_90_CR11) 1994; 120 DP Moore (BFncb0200_90_CR20) 1998; 140 CL Rieder (BFncb0200_90_CR21) 1986; 103 R Heald (BFncb0200_90_CR29) 1996; 382 HJ Matthies (BFncb0200_90_CR27) 1996; 134 K Fukasawa (BFncb0200_90_CR32) 1996; 271 P Fogarty (BFncb0200_90_CR10) 1997; 7 E Wieschaus (BFncb0200_90_CR5) 1988; 104 VE Foe (BFncb0200_90_CR3) 1983; 61 BA Edgar (BFncb0200_90_CR34) 1994; 8 K Oegema (BFncb0200_90_CR19) 1999; 144 R Heald (BFncb0200_90_CR28) 1997; 138 S Doxsey (BFncb0200_90_CR33) 1998; 20 10655600 - Nat Cell Biol. 2000 Feb;2(2):E28-9 |
| References_xml | – volume: 7 start-page: 418 year: 1997 ident: BFncb0200_90_CR10 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(06)00189-8 – volume: 109 start-page: 2977 year: 1989 ident: BFncb0200_90_CR15 publication-title: J. Cell Biol. doi: 10.1083/jcb.109.6.2977 – start-page: 149 volume-title: The Development of Drosophila melanogaster year: 1993 ident: BFncb0200_90_CR1 – volume: 610 start-page: 105 year: 1980 ident: BFncb0200_90_CR23 publication-title: Biochim. Biophys. Acta doi: 10.1016/0005-2787(80)90060-X – volume: 138 start-page: 615 year: 1997 ident: BFncb0200_90_CR28 publication-title: J. Cell Biol. doi: 10.1083/jcb.138.3.615 – volume: 20 start-page: 104 year: 1998 ident: BFncb0200_90_CR33 publication-title: Nature Genet. doi: 10.1038/2392 – volume: 378 start-page: 1275 year: 1997 ident: BFncb0200_90_CR24 publication-title: Biol. Chem. – volume: 144 start-page: 721 year: 1999 ident: BFncb0200_90_CR19 publication-title: J. Cell Biol. doi: 10.1083/jcb.144.4.721 – volume: 103 start-page: 581 year: 1986 ident: BFncb0200_90_CR21 publication-title: J. Cell Biol. doi: 10.1083/jcb.103.2.581 – volume: 140 start-page: 1003 year: 1998 ident: BFncb0200_90_CR20 publication-title: J. Cell Biol. doi: 10.1083/jcb.140.5.1003 – volume: 271 start-page: 1744 year: 1996 ident: BFncb0200_90_CR32 publication-title: Science doi: 10.1126/science.271.5256.1744 – volume: 9 start-page: 302 year: 1999 ident: BFncb0200_90_CR7 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(99)80138-9 – volume: 104 start-page: 495 year: 1988 ident: BFncb0200_90_CR6 publication-title: Development doi: 10.1242/dev.104.3.495 – volume: 61 start-page: 317 year: 1999 ident: BFncb0200_90_CR12 publication-title: Methods Cell Biol. doi: 10.1016/S0091-679X(08)61988-3 – volume: 134 start-page: 455 year: 1996 ident: BFncb0200_90_CR27 publication-title: J. Cell Biol. doi: 10.1083/jcb.134.2.455 – volume: 44 start-page: 871 year: 1986 ident: BFncb0200_90_CR2 publication-title: Cell doi: 10.1016/0092-8674(86)90009-7 – volume: 378 start-page: 578 year: 1995 ident: BFncb0200_90_CR14 publication-title: Nature doi: 10.1038/378578a0 – volume: 107 start-page: 2009 year: 1988 ident: BFncb0200_90_CR22 publication-title: J. Cell Biol. doi: 10.1083/jcb.107.6.2009 – volume: 126 start-page: 2829 year: 1999 ident: BFncb0200_90_CR30 publication-title: Development doi: 10.1242/dev.126.13.2829 – volume: 9 start-page: 889 year: 1999 ident: BFncb0200_90_CR31 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(99)80393-5 – volume: 388 start-page: 93 year: 1997 ident: BFncb0200_90_CR8 publication-title: Nature doi: 10.1038/40439 – volume: 61 start-page: 31 year: 1983 ident: BFncb0200_90_CR3 publication-title: J. Cell Sci. doi: 10.1242/jcs.61.1.31 – volume: 65 start-page: 817 year: 1991 ident: BFncb0200_90_CR25 publication-title: Cell doi: 10.1016/0092-8674(91)90389-G – volume: 104 start-page: 483 year: 1988 ident: BFncb0200_90_CR5 publication-title: Development doi: 10.1242/dev.104.3.483 – volume: 382 start-page: 420 year: 1996 ident: BFncb0200_90_CR29 publication-title: Nature doi: 10.1038/382420a0 – volume: 103 start-page: 675 year: 1988 ident: BFncb0200_90_CR13 publication-title: Development doi: 10.1242/dev.103.4.675 – volume: 85 start-page: 585 year: 1996 ident: BFncb0200_90_CR18 publication-title: Cell doi: 10.1016/S0092-8674(00)81258-1 – volume: 8 start-page: 440 year: 1994 ident: BFncb0200_90_CR34 publication-title: Genes Dev. doi: 10.1101/gad.8.4.440 – volume: 108 start-page: 3377 year: 1995 ident: BFncb0200_90_CR17 publication-title: J. Cell Sci. doi: 10.1242/jcs.108.11.3377 – volume: 44 start-page: 365 year: 1986 ident: BFncb0200_90_CR4 publication-title: Cell doi: 10.1016/0092-8674(86)90771-3 – volume: 120 start-page: 2131 year: 1994 ident: BFncb0200_90_CR11 publication-title: Development doi: 10.1242/dev.120.8.2131 – volume: 82 start-page: 815 year: 1995 ident: BFncb0200_90_CR9 publication-title: Cell doi: 10.1016/0092-8674(95)90478-6 – volume: 116 start-page: 1167 year: 1992 ident: BFncb0200_90_CR26 publication-title: J. Cell Biol. doi: 10.1083/jcb.116.5.1167 – volume: 131 start-page: 1261 year: 1995 ident: BFncb0200_90_CR16 publication-title: J. Cell Biol. doi: 10.1083/jcb.131.5.1261 – volume: 44 start-page: 489 year: 1994 ident: BFncb0200_90_CR35 publication-title: Methods Cell Biol. doi: 10.1016/S0091-679X(08)60928-0 – reference: 10655600 - Nat Cell Biol. 2000 Feb;2(2):E28-9 |
| SSID | ssj0014407 |
| Score | 2.026253 |
| Snippet | During early embryogenesis of
Drosophila melanogaster
, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that... During early embryogenesis of Drosophila melanogaster, mutations in the DNA-replication checkpoint lead to chromosome-segregation failures. Here we show that... |
| SourceID | proquest gale pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 90 |
| SubjectTerms | Animals Aphidicolin - pharmacology Biomedical and Life Sciences Cancer Research Cell Biology Cell cycle Centrosome - physiology Centrosomes Chromosome Aberrations Chromosomes Control systems Deoxyribonucleic acid Developmental Biology DNA DNA Damage DNA Replication Drosophila Drosophila - embryology Drosophila - genetics Drosophila melanogaster Embryonic growth stage Embryos Genetic aspects Inactivation Insects Kinases Life Sciences Localization Mitosis - genetics Mutagens - pharmacology Mutation Physiological aspects Spindle Apparatus - pathology Stem Cells Tubulin |
| Title | DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos |
| URI | https://link.springer.com/article/10.1038/35000041 https://www.ncbi.nlm.nih.gov/pubmed/10655588 https://www.proquest.com/docview/222280265 https://www.proquest.com/docview/17481512 https://www.proquest.com/docview/70861403 https://www.proquest.com/docview/759319072 |
| Volume | 2 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagFRIXxJulUAJC4mRtYsexfUILbVWQWKGFSnuzHNtBlbpJ2ewe-u-ZSZzQrihHKyM7fo2_8Yy_IeS9YqXQygbKdcVonmWWAgrhtLBSO-U0SwW-Rv42L07P8q9LsYyxOW0Mqxx0YqeofePwjnzK8KoCDAbx8fI3xaRR6FyNGTTukv0MgAhmbpDL0d5Ct6XsHxcJKgEHDNyzXE256MBxduM02tXJ1w6lHS9pd_icPCQPImpMZv00PyJ3Qv2Y3OvzSF49IYuj-Yyuw-iKnmLZ2xXoCjpkud0kXRxm0zarkJzX-J6hv42FQnK07tIZnF_YJKzK9VXTPiVnJ8c_P5_SmCyBulwWG1rqtMq4BGsmQ_4exwEapE4xWWrlRYCNrHLtU1Z5nnkntGDeM6utcqUs0-D4M7JXN3V4QZJQsKqAmkJahhwQkHaecS9E8IBHoJEJ-TAMmnGRSRwTWlyYzqPNlRmGd0LejpKXPXvGP2Te4bgbJKOoMdrll922rfnyY2FmqG_AhOXYZBSqGmjK2fh4AH4Y-atuSB4M82fidmzNuHgm5M34FfYROkdsHZpta8AyU4h-bpeQYP0hu-GEJLdJCA0aLZVQyfN-5VzrdYHMagp6Oyylv7-3OyQv_9uHA3K_5wPAmJpXZG-z3obXgIw25WG3_g_J_qfj-ffFHz5yCZA |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1db9Mw0BpDCF4Q33QDFhCIJ6uJHcf2A0IVZWrZ1oexSX0Lju2iSWuyNa1QfxT_kbt8sVWMtz1aOdnx-T59vjtC3iuWCa2Mp1zPGI2jyFCwQjhNjNRWWc1CgdnIR5NkdBp_m4rpFvnd5sLgs8pWJlaC2hUW78j7DK8qwGEQny8uKTaNwuBq20GjpooDv_4FHlv5aTyE4_3A2P7Xky8j2jQVoDaWyZJmOpxFXILVH2GdG8tBhYZWMZlp5YQHglexdiGbOR45K7RgzjGjjbKZzEJvOcx7h9yNMcII7COnnX-HYVJZJzMJKsHuaGvdctXnojLGo2vab1MHXFGCG1HZStntPyIPGys1GNRk9Zhs-fwJuVf3rVw_JcfDyYAufBf67uPYmTnIJtp21V0G1bvPoizmPjjLMX-ivv2FQTBcVO0Tzs5N4OfZYl2Uz8jpreDxOdnOi9y_JIFP2CyBmXyY-RgsLm0d404I78D-gUV65GOLtNQ2lcuxgcZ5WkXQuUpb9PbI2w7yoq7W8Q-Yd4j3FItf5Pi65qdZlWU6_n6cDlC-gcvMcckGaFbAUtY0yQrww1gv6xrkbnt-acP-ZdoRa4_sdV-BbzEYY3JfrMoUPEGF1tbNEBK8Taym2CPBTRBCgwQNJUzyoqacK7tOsJKbgt22pPT39zZRsvPfPeyR-6OTo8P0cDw52CUP6loE-J7nFdleLlb-NVhly-xNxQsB-XHbzPcHZHtDkQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGEIgXxDdlwAIC8WQ1sePYfkCoolQrgwoNJvUtOLaDJq3JaFqh_mn8d9zli61ivO0xysmOL-f78Pl-R8grxTKhlfGU65zROIoMBS-E08RIbZXVLBRYjfx5lhwcxx_nYr5Dfne1MHitstOJtaJ2pcUz8iHDowoIGMQwb29FfBlP3p39pNhAChOtXTeNRkIO_eYXRG_V2-kYfvVrxiYfvr0_oG2DAWpjmaxopsM84hIigAgxbywHcxpaxWSmlRMehF_F2oUsdzxyVmjBnGNGG2UzmYXechj3GrkueRxj1wg572M9TJnKprBJUAk-SId7y9WQi9oxjy5Ywm17cM4gbmVoa8M3uUNutx5rMGpE7C7Z8cU9cqPpYbm5T47GsxFd-j4NPsRnZxagp2jXYXcV1HdAy6pc-OCkwFqK5iQYHoLxsm6lcHJqAr_IlpuyekCOr4SPD8luURb-MQl8wvIERvJh5mPwvrR1jDshvANfCCYZkDcd01LbophjM43TtM6mc5V27B2QFz3lWYPc8Q-al8j3FIEwCpSpH2ZdVen061E6Ql0H4TPHKVuivISprGkLF-CDETvrAuVe9__SVhVUaS-4A7Lfv4U9jIkZU_hyXaUQFSr0vC6nkBB5IrLigASXUQgN2jSUMMijRnLOrTpBVDcFq-1E6e_nbbPkyX_XsE9uwrZLP01nh3vkVgNLgFd7npLd1XLtn4GDtsqe11shIN-veu_9Aa2PR8Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=DNA-replication%2FDNA-damage-dependent+centrosome+inactivation+in+Drosophila+embryos&rft.jtitle=Nature+cell+biology&rft.au=Sibon%2C+Ody+C.+M&rft.au=Kelkar%2C+Anju&rft.au=Lemstra%2C+Willy&rft.au=Theurkauf%2C+William+E&rft.date=2000-02-01&rft.pub=Nature+Publishing+Group&rft.issn=1465-7392&rft.volume=2&rft.issue=2&rft.spage=90&rft_id=info:doi/10.1038%2F35000041&rft.externalDBID=ISR&rft.externalDocID=A183282533 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1465-7392&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1465-7392&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1465-7392&client=summon |