Splicing Factor Transcript Abundance in Saliva as a Diagnostic Tool for Breast Cancer

Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from sa...

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Published inGenes Vol. 11; no. 8; p. 880
Main Authors Bentata, Mercedes, Morgenstern, Guy, Nevo, Yuval, Kay, Gillian, Granit Mizrahi, Avital, Temper, Mark, Maimon, Ofra, Monas, Liza, Basheer, Reham, Ben-Hur, Asa, Peretz, Tamar, Salton, Maayan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 03.08.2020
MDPI
Subjects
Adult
Age
Aged
Alternative splicing
Annotations
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast cancer
breast neoplasms
Breast Neoplasms - diagnosis
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Diagnosis
diagnostic techniques
Female
Gene expression
genes
Genetic aspects
Genetic transcription
Genomes
Health aspects
Humans
Isoforms
Mammography
messenger RNA
Metabolites
MicroRNAs
Middle Aged
neoplasm cells
patients
Proteins
Quality
RNA Splicing Factors - genetics
RNA Splicing Factors - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Saliva
Saliva - metabolism
screening
Splicing factors
Transcription
United States
women
Womens health
Israel
United States > US
Germany
United States
saliva
splicing factors
breast cancer
diagnosis
Online AccessGet full text
ISSN2073-4425
2073-4425
DOI10.3390/genes11080880

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Abstract Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from saliva. To this end, we sequenced RNA from a pool of ten women. The 1254 transcripts identified were enriched for genes with an annotation of alternative pre-mRNA splicing. Pre-mRNA splicing is a tightly regulated process and its misregulation in cancer cells promotes the formation of cancer-driving isoforms. For these reasons, we chose to focus on splicing factors as biomarkers for the early detection of breast cancer. We found that the level of the splicing factors is unique to each woman and consistent in the same woman at different time points. Next, we extracted RNA from 36 healthy subjects and 31 breast cancer patients. Recording the mRNA level of seven splicing factors in these samples demonstrated that the combination of all these factors is different in the two groups (p value = 0.005). Our results demonstrate a differential abundance of splicing factor mRNA in the saliva of breast cancer patients.
AbstractList Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from saliva. To this end, we sequenced RNA from a pool of ten women. The 1254 transcripts identified were enriched for genes with an annotation of alternative pre-mRNA splicing. Pre-mRNA splicing is a tightly regulated process and its misregulation in cancer cells promotes the formation of cancer-driving isoforms. For these reasons, we chose to focus on splicing factors as biomarkers for the early detection of breast cancer. We found that the level of the splicing factors is unique to each woman and consistent in the same woman at different time points. Next, we extracted RNA from 36 healthy subjects and 31 breast cancer patients. Recording the mRNA level of seven splicing factors in these samples demonstrated that the combination of all these factors is different in the two groups ( p value = 0.005). Our results demonstrate a differential abundance of splicing factor mRNA in the saliva of breast cancer patients.
Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from saliva. To this end, we sequenced RNA from a pool of ten women. The 1254 transcripts identified were enriched for genes with an annotation of alternative pre-mRNA splicing. Pre-mRNA splicing is a tightly regulated process and its misregulation in cancer cells promotes the formation of cancer-driving isoforms. For these reasons, we chose to focus on splicing factors as biomarkers for the early detection of breast cancer. We found that the level of the splicing factors is unique to each woman and consistent in the same woman at different time points. Next, we extracted RNA from 36 healthy subjects and 31 breast cancer patients. Recording the mRNA level of seven splicing factors in these samples demonstrated that the combination of all these factors is different in the two groups (p value = 0.005). Our results demonstrate a differential abundance of splicing factor mRNA in the saliva of breast cancer patients.
Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from saliva. To this end, we sequenced RNA from a pool of ten women. The 1254 transcripts identified were enriched for genes with an annotation of alternative pre-mRNA splicing. Pre-mRNA splicing is a tightly regulated process and its misregulation in cancer cells promotes the formation of cancer-driving isoforms. For these reasons, we chose to focus on splicing factors as biomarkers for the early detection of breast cancer. We found that the level of the splicing factors is unique to each woman and consistent in the same woman at different time points. Next, we extracted RNA from 36 healthy subjects and 31 breast cancer patients. Recording the mRNA level of seven splicing factors in these samples demonstrated that the combination of all these factors is different in the two groups (p value = 0.005). Our results demonstrate a differential abundance of splicing factor mRNA in the saliva of breast cancer patients.Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from saliva. To this end, we sequenced RNA from a pool of ten women. The 1254 transcripts identified were enriched for genes with an annotation of alternative pre-mRNA splicing. Pre-mRNA splicing is a tightly regulated process and its misregulation in cancer cells promotes the formation of cancer-driving isoforms. For these reasons, we chose to focus on splicing factors as biomarkers for the early detection of breast cancer. We found that the level of the splicing factors is unique to each woman and consistent in the same woman at different time points. Next, we extracted RNA from 36 healthy subjects and 31 breast cancer patients. Recording the mRNA level of seven splicing factors in these samples demonstrated that the combination of all these factors is different in the two groups (p value = 0.005). Our results demonstrate a differential abundance of splicing factor mRNA in the saliva of breast cancer patients.
Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from saliva. To this end, we sequenced RNA from a pool of ten women. The 1254 transcripts identified were enriched for genes with an annotation of alternative pre-mRNA splicing. Pre-mRNA splicing is a tightly regulated process and its misregulation in cancer cells promotes the formation of cancer-driving isoforms. For these reasons, we chose to focus on splicing factors as biomarkers for the early detection of breast cancer. We found that the level of the splicing factors is unique to each woman and consistent in the same woman at different time points. Next, we extracted RNA from 36 healthy subjects and 31 breast cancer patients. Recording the mRNA level of seven splicing factors in these samples demonstrated that the combination of all these factors is different in the two groups ( value = 0.005). Our results demonstrate a differential abundance of splicing factor mRNA in the saliva of breast cancer patients.
Audience Academic
Author Morgenstern, Guy
Nevo, Yuval
Monas, Liza
Kay, Gillian
Temper, Mark
Basheer, Reham
Maimon, Ofra
Ben-Hur, Asa
Salton, Maayan
Peretz, Tamar
Bentata, Mercedes
Granit Mizrahi, Avital
AuthorAffiliation 3 Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Hebrew University Medical School, Jerusalem 9112102, Israel; granit@hadassah.org.il (A.G.M.); markt@hadassah.org.il (M.T.); ofra406@hadassah.org.il (O.M.); lizam@hadassah.org.il (L.M.); basir@hadassah.org.il (R.B.); tamary@hadassah.org.il (T.P.)
2 Info-CORE, Bioinformatics Unit of the I-CORE at the Hebrew University of Jerusalem and Hadassah Medical Center, Jerusalem 9112102, Israel; yuval.nevo@mail.huji.ac.il
1 Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel–Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel; mercedes.bentata@mail.huji.ac.il (M.B.); morgenstern.guy@gmail.com (G.M.); gilliank@ekmd.huji.ac.il (G.K.)
4 Department of Computer Science, Colorado State University, Fort Collins, CO 80523, USA; asa@cs.colostate.edu
AuthorAffiliation_xml – name: 1 Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel–Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel; mercedes.bentata@mail.huji.ac.il (M.B.); morgenstern.guy@gmail.com (G.M.); gilliank@ekmd.huji.ac.il (G.K.)
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Cites_doi 10.1038/nprot.2008.211
10.7150/ijbs.25018
10.1111/cas.12715
10.4161/23723548.2014.970955
10.1158/0008-5472.CAN-09-1852
10.1016/S0168-9525(00)02176-4
10.1002/jcb.21134
10.1101/gad.241968.114
10.1053/j.seminoncol.2009.03.001
10.1038/embor.2008.189
10.14806/ej.17.1.200
10.1002/ijc.2910640411
10.1002/wrna.1476
10.1016/j.bbrc.2012.06.092
10.1074/jbc.M008514200
10.1038/nrc.2016.51
10.1007/s11306-009-0178-y
10.1177/1010428317694318
10.3109/07357900009038240
10.1038/oncsis.2013.47
10.1016/j.phrs.2019.03.008
10.1002/jcb.24103
10.1038/nsmb1209
10.1261/rna.069856.118
10.1038/ncomms8103
10.4161/cc.9.6.10991
10.1158/0008-5472.CAN-08-1769
10.1016/j.critrevonc.2016.12.009
10.1016/j.celrep.2019.10.110
10.1126/scisignal.2003926
10.1016/j.cell.2009.02.009
10.1002/jcp.26823
10.1093/bioinformatics/btu638
10.1093/nar/gks997
10.1038/nsmb.2207
10.1371/journal.pone.0015573
10.1038/srep01689
10.1016/j.cca.2007.06.001
10.1093/nar/gkn923
10.1093/jnci/djq090
10.1038/nsmb.1608
10.1016/j.molcel.2015.09.005
10.1097/PAS.0000000000000749
10.1158/1538-7445.AM2019-4191
10.1002/path.2751
10.1016/j.cca.2015.05.008
10.1371/journal.pgen.1002218
10.1038/s41598-019-44063-z
10.1186/gb-2013-14-4-r36
10.1371/journal.pone.0110641
10.1001/jama.2015.12783
10.1023/A:1010631915831
10.1016/j.cell.2019.12.011
10.1034/j.1600-0714.2002.00123.x
10.1039/b414194f
10.1158/0008-5472.CAN-04-3294
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Issue 8
Keywords saliva
splicing factors
breast cancer
diagnosis
Language English
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References Luqmani (ref_42) 1995; 64
Yankaskas (ref_60) 2010; 102
Venables (ref_58) 2009; 16
Caracciolo (ref_54) 2010; 9
ref_55
ref_10
Cheng (ref_12) 2015; 447
Sugimoto (ref_11) 2010; 6
Mandal (ref_36) 2001; 276
Huang (ref_20) 2009; 4
ref_16
Pelisch (ref_33) 2012; 113
Anczukow (ref_47) 2012; 19
Watermann (ref_51) 2006; 66
Grzybowska (ref_27) 2012; 424
Shilo (ref_23) 2015; 2
Huang (ref_50) 2007; 384
Yu (ref_15) 2015; 106
Salton (ref_31) 2015; 6
Dvinge (ref_44) 2016; 16
Oeffinger (ref_59) 2015; 314
Zaidi (ref_2) 2019; 79
Kim (ref_18) 2013; 14
Zhou (ref_34) 2001; 66
Anders (ref_4) 2009; 36
Eswaran (ref_46) 2013; 3
Rahman (ref_26) 2020; 180
Assad (ref_6) 2017; 110
He (ref_39) 2014; 3
Huang (ref_21) 2009; 37
Grosso (ref_24) 2008; 9
Park (ref_25) 2019; 29
Buoso (ref_49) 2019; 143
Venables (ref_32) 2008; 68
Bigler (ref_9) 2002; 31
Karni (ref_30) 2007; 14
Duggan (ref_1) 2016; 40
Hu (ref_35) 2017; 39
Song (ref_57) 2010; 222
Martin (ref_17) 2011; 17
Grindlay (ref_52) 2009; 69
Das (ref_40) 2019; 10
Goard (ref_56) 2007; 100
Xu (ref_53) 2014; 28
Wang (ref_38) 2018; 233
Lal (ref_41) 2013; 6
Streckfus (ref_7) 2000; 6
Giulietti (ref_22) 2013; 41
Han (ref_14) 2018; 14
Siam (ref_43) 2019; 25
Wahl (ref_28) 2009; 136
Anczukow (ref_48) 2015; 60
Graveley (ref_29) 2001; 17
Christodoulides (ref_13) 2005; 5
Urbanski (ref_45) 2018; 9
Anders (ref_19) 2015; 31
ref_3
Streckfus (ref_8) 2000; 18
ref_5
Tsai (ref_37) 2019; 9
References_xml – volume: 4
  start-page: 44
  year: 2009
  ident: ref_20
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2008.211
– volume: 14
  start-page: 633
  year: 2018
  ident: ref_14
  article-title: Salivary Exosomes: Emerging Roles in Systemic Disease
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.25018
– volume: 106
  start-page: 959
  year: 2015
  ident: ref_15
  article-title: Exosomes in development, metastasis and drug resistance of breast cancer
  publication-title: Cancer Sci.
  doi: 10.1111/cas.12715
– volume: 2
  start-page: e970955
  year: 2015
  ident: ref_23
  article-title: The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression
  publication-title: Mol. Cell. Oncol.
  doi: 10.4161/23723548.2014.970955
– ident: ref_5
– volume: 69
  start-page: 9219
  year: 2009
  ident: ref_52
  article-title: hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-1852
– volume: 17
  start-page: 100
  year: 2001
  ident: ref_29
  article-title: Alternative splicing: Increasing diversity in the proteomic world
  publication-title: Trends Genet.
  doi: 10.1016/S0168-9525(00)02176-4
– volume: 100
  start-page: 1440
  year: 2007
  ident: ref_56
  article-title: Expression of RBM5-related factors in primary breast tissue
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.21134
– volume: 28
  start-page: 1191
  year: 2014
  ident: ref_53
  article-title: Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing
  publication-title: Genes Dev.
  doi: 10.1101/gad.241968.114
– volume: 36
  start-page: 237
  year: 2009
  ident: ref_4
  article-title: Breast cancer before age 40 years
  publication-title: Semin. Oncol.
  doi: 10.1053/j.seminoncol.2009.03.001
– volume: 9
  start-page: 1087
  year: 2008
  ident: ref_24
  article-title: The emerging role of splicing factors in cancer
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2008.189
– volume: 17
  start-page: 3
  year: 2011
  ident: ref_17
  article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads
  publication-title: EMBnet. J.
  doi: 10.14806/ej.17.1.200
– volume: 64
  start-page: 274
  year: 1995
  ident: ref_42
  article-title: Expression of 2 variant forms of fibroblast growth factor receptor 1 in human breast
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.2910640411
– volume: 9
  start-page: e1476
  year: 2018
  ident: ref_45
  article-title: Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
  publication-title: Wiley Interdiscip. Rev. RNA
  doi: 10.1002/wrna.1476
– volume: 424
  start-page: 1
  year: 2012
  ident: ref_27
  article-title: Human intronless genes: Functional groups, associated diseases, evolution, and mRNA processing in absence of splicing
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2012.06.092
– volume: 276
  start-page: 9699
  year: 2001
  ident: ref_36
  article-title: Growth factors regulate heterogeneous nuclear ribonucleoprotein K expression and function
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M008514200
– volume: 16
  start-page: 413
  year: 2016
  ident: ref_44
  article-title: RNA splicing factors as oncoproteins and tumour suppressors
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.51
– volume: 6
  start-page: 78
  year: 2010
  ident: ref_11
  article-title: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles
  publication-title: Metabolomics
  doi: 10.1007/s11306-009-0178-y
– volume: 39
  start-page: 1010428317694318
  year: 2017
  ident: ref_35
  article-title: Splicing factor hnRNPA2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway
  publication-title: Tumour Biol. J. Int. Soc. Oncodev. Biol. Med.
  doi: 10.1177/1010428317694318
– volume: 18
  start-page: 101
  year: 2000
  ident: ref_8
  article-title: A Preliminary Study of CA15-3, c-erbB-2, Epidermal Growth Factor Receptor, Cathepsin-D, and p53 in Saliva among Women with Breast Carcinoma
  publication-title: Cancer Investig.
  doi: 10.3109/07357900009038240
– volume: 3
  start-page: e84
  year: 2014
  ident: ref_39
  article-title: Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties
  publication-title: Oncogenesis
  doi: 10.1038/oncsis.2013.47
– volume: 143
  start-page: 17
  year: 2019
  ident: ref_49
  article-title: Cortisol-induced SRSF3 expression promotes GR splicing, RACK1 expression and breast cancer cells migration
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2019.03.008
– volume: 113
  start-page: 2319
  year: 2012
  ident: ref_33
  article-title: Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.24103
– volume: 14
  start-page: 185
  year: 2007
  ident: ref_30
  article-title: The gene encoding the splicing factor SF2/ASF is a proto-oncogene
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb1209
– volume: 25
  start-page: 813
  year: 2019
  ident: ref_43
  article-title: Regulation of alternative splicing by p300-mediated acetylation of splicing factors
  publication-title: RNA
  doi: 10.1261/rna.069856.118
– volume: 6
  start-page: 7103
  year: 2015
  ident: ref_31
  article-title: Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8103
– volume: 9
  start-page: 1131
  year: 2010
  ident: ref_54
  article-title: NSP 5a3a’s link to nuclear-cyto proteins B23 and hnRNP-L between normal and aberrant breast cell lines
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.6.10991
– volume: 68
  start-page: 9525
  year: 2008
  ident: ref_32
  article-title: Identification of alternative splicing markers for breast cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-1769
– volume: 110
  start-page: 62
  year: 2017
  ident: ref_6
  article-title: Salivary biomarkers in the diagnosis of breast cancer: A review
  publication-title: Crit. Rev. Oncol. Hematol.
  doi: 10.1016/j.critrevonc.2016.12.009
– volume: 29
  start-page: 2672
  year: 2019
  ident: ref_25
  article-title: Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.10.110
– volume: 6
  start-page: ra53
  year: 2013
  ident: ref_41
  article-title: Estrogen alters the splicing of type 1 corticotropin-releasing hormone receptor in breast cancer cells
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2003926
– volume: 136
  start-page: 701
  year: 2009
  ident: ref_28
  article-title: The spliceosome: Design principles of a dynamic RNP machine
  publication-title: Cell
  doi: 10.1016/j.cell.2009.02.009
– volume: 233
  start-page: 8930
  year: 2018
  ident: ref_38
  article-title: PTBP1 promotes the growth of breast cancer cells through the PTEN/Akt pathway and autophagy
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.26823
– volume: 6
  start-page: 2363
  year: 2000
  ident: ref_7
  article-title: The Presence of Soluble c-erbB-2 in Saliva and Serum among Women with Breast Carcinoma: A Preliminary Study
  publication-title: Clin. Cancer Res.
– ident: ref_3
– volume: 31
  start-page: 166
  year: 2015
  ident: ref_19
  article-title: HTSeq—A Python framework to work with high-throughput sequencing data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu638
– volume: 41
  start-page: D125
  year: 2013
  ident: ref_22
  article-title: SpliceAid-F: A database of human splicing factors and their RNA-binding sites
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks997
– volume: 19
  start-page: 220
  year: 2012
  ident: ref_47
  article-title: The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2207
– ident: ref_10
  doi: 10.1371/journal.pone.0015573
– volume: 3
  start-page: 1689
  year: 2013
  ident: ref_46
  article-title: RNA sequencing of cancer reveals novel splicing alterations
  publication-title: Sci. Rep.
  doi: 10.1038/srep01689
– volume: 384
  start-page: 69
  year: 2007
  ident: ref_50
  article-title: Increased expression of SRp40 affecting CD44 splicing is associated with the clinical outcome of lymph node metastasis in human breast cancer
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2007.06.001
– volume: 37
  start-page: 1
  year: 2009
  ident: ref_21
  article-title: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkn923
– volume: 102
  start-page: 692
  year: 2010
  ident: ref_60
  article-title: Performance of first mammography examination in women younger than 40 years
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/djq090
– volume: 16
  start-page: 670
  year: 2009
  ident: ref_58
  article-title: Cancer-associated regulation of alternative splicing
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1608
– volume: 60
  start-page: 105
  year: 2015
  ident: ref_48
  article-title: SRSF1-Regulated Alternative Splicing in Breast Cancer
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2015.09.005
– volume: 40
  start-page: e94
  year: 2016
  ident: ref_1
  article-title: The Surveillance, Epidemiology, and End Results (SEER) Program and Pathology: Toward Strengthening the Critical Relationship
  publication-title: Am. J. Surg. Pathol.
  doi: 10.1097/PAS.0000000000000749
– volume: 79
  start-page: 4191
  year: 2019
  ident: ref_2
  article-title: Abstract 4191: The worldwide female breast cancer incidence and survival, 2018
  publication-title: Cancer Res.
  doi: 10.1158/1538-7445.AM2019-4191
– volume: 222
  start-page: 227
  year: 2010
  ident: ref_57
  article-title: Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells
  publication-title: J. Pathol.
  doi: 10.1002/path.2751
– volume: 447
  start-page: 23
  year: 2015
  ident: ref_12
  article-title: Investigation of salivary free amino acid profile for early diagnosis of breast cancer with ultra performance liquid chromatography-mass spectrometry
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2015.05.008
– ident: ref_55
  doi: 10.1371/journal.pgen.1002218
– volume: 9
  start-page: 7611
  year: 2019
  ident: ref_37
  article-title: hnRNPK S379 phosphorylation participates in migration regulation of triple negative MDA-MB-231 cells
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-44063-z
– volume: 14
  start-page: R36
  year: 2013
  ident: ref_18
  article-title: TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
  publication-title: Genome Biol.
  doi: 10.1186/gb-2013-14-4-r36
– ident: ref_16
  doi: 10.1371/journal.pone.0110641
– volume: 314
  start-page: 1599
  year: 2015
  ident: ref_59
  article-title: Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society
  publication-title: JAMA
  doi: 10.1001/jama.2015.12783
– volume: 66
  start-page: 217
  year: 2001
  ident: ref_34
  article-title: Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1023/A:1010631915831
– volume: 10
  start-page: 634154
  year: 2019
  ident: ref_40
  article-title: Differential Functions of Splicing Factors in Breast-Cancer Initiation and Metastasis
  publication-title: bioRxiv
– volume: 180
  start-page: 208.e1
  year: 2020
  ident: ref_26
  article-title: SnapShot: Splicing Alterations in Cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2019.12.011
– volume: 31
  start-page: 421
  year: 2002
  ident: ref_9
  article-title: The potential use of saliva to detect recurrence of disease in women with breast carcinoma
  publication-title: J. Oral Pathol. Med.
  doi: 10.1034/j.1600-0714.2002.00123.x
– volume: 5
  start-page: 261
  year: 2005
  ident: ref_13
  article-title: Application of microchip assay system for the measurement of C-reactive protein in human saliva
  publication-title: Lab Chip
  doi: 10.1039/b414194f
– volume: 66
  start-page: 4774
  year: 2006
  ident: ref_51
  article-title: Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-3294
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Snippet Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however,...
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StartPage 880
SubjectTerms Adult
Age
Aged
Alternative splicing
Annotations
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast cancer
breast neoplasms
Breast Neoplasms - diagnosis
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Diagnosis
diagnostic techniques
Female
Gene expression
genes
Genetic aspects
Genetic transcription
Genomes
Health aspects
Humans
Isoforms
Mammography
messenger RNA
Metabolites
MicroRNAs
Middle Aged
neoplasm cells
patients
Proteins
Quality
RNA Splicing Factors - genetics
RNA Splicing Factors - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Saliva
Saliva - metabolism
screening
Splicing factors
Transcription
United States
women
Womens health
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Title Splicing Factor Transcript Abundance in Saliva as a Diagnostic Tool for Breast Cancer
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