Polycyclic aromatic hydrocarbon and its effects on human health: An overeview
Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less...
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Published in | Chemosphere (Oxford) Vol. 296; p. 133948 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.06.2022
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Subjects | |
Online Access | Get full text |
ISSN | 0045-6535 1879-1298 1879-1298 |
DOI | 10.1016/j.chemosphere.2022.133948 |
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Abstract | Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans.
[Display omitted]
•The primary routes of susceptibility to PAHs in the general population are breathing in outdoor and indoor air.•PAHs are moderately permanent and can be bio-accumulated.•PAH exposure may increase CVD risk, including atherosclerosis, hypertension, thrombosis, and myocardial infarction.•Studies have found a link between work-related exposure to PAHs and CVD and death.•The effect of PAHs on human health is primarily based on the duration and route of exposure and the relative toxicity of PAHs. |
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AbstractList | Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans. Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans.Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans. Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans. [Display omitted] •The primary routes of susceptibility to PAHs in the general population are breathing in outdoor and indoor air.•PAHs are moderately permanent and can be bio-accumulated.•PAH exposure may increase CVD risk, including atherosclerosis, hypertension, thrombosis, and myocardial infarction.•Studies have found a link between work-related exposure to PAHs and CVD and death.•The effect of PAHs on human health is primarily based on the duration and route of exposure and the relative toxicity of PAHs. |
ArticleNumber | 133948 |
Author | Li, Jian-Hua Saeed, Muhammad Xi, He Wang, Wei Mallah, Mukhtiar Ali Jabar, Abdul Ahmed, Bilal Naveed, Muhammad Liu, Yang Zhang, Qiao Mallah, Manthar Ali Changxing, Li Noreen, Sobia Mirjat, Ali Asghar Feng, Feifei |
Author_xml | – sequence: 1 givenname: Manthar Ali surname: Mallah fullname: Mallah, Manthar Ali organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China – sequence: 2 givenname: Li surname: Changxing fullname: Changxing, Li organization: Department of Human Anatomy, Medical College of Qinghai University, Xining, 81000, China – sequence: 3 givenname: Mukhtiar Ali surname: Mallah fullname: Mallah, Mukhtiar Ali organization: Department of Chemical Engineering, Quaid-e-Awam University of Engineering, Science & Technology, Nawabshah, 67480, Sindh, Pakistan – sequence: 4 givenname: Sobia surname: Noreen fullname: Noreen, Sobia organization: Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 6300, Pakistan – sequence: 5 givenname: Yang surname: Liu fullname: Liu, Yang organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China – sequence: 6 givenname: Muhammad surname: Saeed fullname: Saeed, Muhammad organization: The Cholestane University of Veterinary and Animal Sciences, Bahawalpur, Pakistan – sequence: 7 givenname: He surname: Xi fullname: Xi, He organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China – sequence: 8 givenname: Bilal surname: Ahmed fullname: Ahmed, Bilal organization: Department of Clinical Pharmacy, School of Pharmacy. Nanjing Medical University, Nanjing, 211166, China – sequence: 9 givenname: Feifei surname: Feng fullname: Feng, Feifei organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China – sequence: 10 givenname: Ali Asghar surname: Mirjat fullname: Mirjat, Ali Asghar organization: School of Public Health, Nanjing Medical University, Nanjing, 211166, China – sequence: 11 givenname: Wei surname: Wang fullname: Wang, Wei organization: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China – sequence: 12 givenname: Abdul surname: Jabar fullname: Jabar, Abdul organization: Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Punjab, Pakistan – sequence: 13 givenname: Muhammad orcidid: 0000-0002-2193-9266 surname: Naveed fullname: Naveed, Muhammad organization: Department of Clinical Pharmacy, School of Pharmacy. Nanjing Medical University, Nanjing, 211166, China – sequence: 14 givenname: Jian-Hua surname: Li fullname: Li, Jian-Hua email: lcx1535@163.com organization: Department of Human Anatomy, Medical College of Qinghai University, Xining, 81000, China – sequence: 15 givenname: Qiao surname: Zhang fullname: Zhang, Qiao email: zhangqiao@zzu.edu.cn organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35151703$$D View this record in MEDLINE/PubMed |
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Title | Polycyclic aromatic hydrocarbon and its effects on human health: An overeview |
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