Polycyclic aromatic hydrocarbon and its effects on human health: An overeview

Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less...

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Published inChemosphere (Oxford) Vol. 296; p. 133948
Main Authors Mallah, Manthar Ali, Changxing, Li, Mallah, Mukhtiar Ali, Noreen, Sobia, Liu, Yang, Saeed, Muhammad, Xi, He, Ahmed, Bilal, Feng, Feifei, Mirjat, Ali Asghar, Wang, Wei, Jabar, Abdul, Naveed, Muhammad, Li, Jian-Hua, Zhang, Qiao
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2022
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Online AccessGet full text
ISSN0045-6535
1879-1298
1879-1298
DOI10.1016/j.chemosphere.2022.133948

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Abstract Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans. [Display omitted] •The primary routes of susceptibility to PAHs in the general population are breathing in outdoor and indoor air.•PAHs are moderately permanent and can be bio-accumulated.•PAH exposure may increase CVD risk, including atherosclerosis, hypertension, thrombosis, and myocardial infarction.•Studies have found a link between work-related exposure to PAHs and CVD and death.•The effect of PAHs on human health is primarily based on the duration and route of exposure and the relative toxicity of PAHs.
AbstractList Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans.
Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans.Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans.
Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen aromatic rings, basically white, light-yellow, or solid compounds without color. Natural sources of pollution are marginal or less significant, such as volcanic eruptions, natural forest fires, and moorland fires that trigger lightning bursts. The significant determinants of PAH pollution are anthropogenic pollution sources, classified into four groups, i.e., industrial, mobile, domestic, and agricultural pollution sources. Humans can consume PAHs via different routes, such as inhalation, dermal touch, and ingestion. The Effect of PAHs on human health is primarily based on the duration and route of exposure, the volume or concentration of PAHs to which one is exposed, and the relative toxicity of PAHs. Many PAHs are widely referred to as carcinogens, mutagens, and teratogens and thus pose a significant danger to human health and the well-being of humans. Skin, lung, pancreas, esophagus, bladder, colon, and female breast are numerous organs prone to tumor development due to long-term PAH exposure. PAH exposure may increase the risk of lung cancer as well as cardiovascular disease (CVD), including atherosclerosis, thrombosis, hypertension, and myocardial infarction (MI). Preclinical studies have found a relationship between PAH exposure, oxidative stress, and atherosclerosis. In addition, investigations have discovered a relationship between PAH exposure at work and CVD illness and mortality development. This review aims to explain PAH briefly, its transportation, its effects on human health, and a relationship between environmental exposures to PAHs and CVD risk in humans. [Display omitted] •The primary routes of susceptibility to PAHs in the general population are breathing in outdoor and indoor air.•PAHs are moderately permanent and can be bio-accumulated.•PAH exposure may increase CVD risk, including atherosclerosis, hypertension, thrombosis, and myocardial infarction.•Studies have found a link between work-related exposure to PAHs and CVD and death.•The effect of PAHs on human health is primarily based on the duration and route of exposure and the relative toxicity of PAHs.
ArticleNumber 133948
Author Li, Jian-Hua
Saeed, Muhammad
Xi, He
Wang, Wei
Mallah, Mukhtiar Ali
Jabar, Abdul
Ahmed, Bilal
Naveed, Muhammad
Liu, Yang
Zhang, Qiao
Mallah, Manthar Ali
Changxing, Li
Noreen, Sobia
Mirjat, Ali Asghar
Feng, Feifei
Author_xml – sequence: 1
  givenname: Manthar Ali
  surname: Mallah
  fullname: Mallah, Manthar Ali
  organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China
– sequence: 2
  givenname: Li
  surname: Changxing
  fullname: Changxing, Li
  organization: Department of Human Anatomy, Medical College of Qinghai University, Xining, 81000, China
– sequence: 3
  givenname: Mukhtiar Ali
  surname: Mallah
  fullname: Mallah, Mukhtiar Ali
  organization: Department of Chemical Engineering, Quaid-e-Awam University of Engineering, Science & Technology, Nawabshah, 67480, Sindh, Pakistan
– sequence: 4
  givenname: Sobia
  surname: Noreen
  fullname: Noreen, Sobia
  organization: Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 6300, Pakistan
– sequence: 5
  givenname: Yang
  surname: Liu
  fullname: Liu, Yang
  organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China
– sequence: 6
  givenname: Muhammad
  surname: Saeed
  fullname: Saeed, Muhammad
  organization: The Cholestane University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
– sequence: 7
  givenname: He
  surname: Xi
  fullname: Xi, He
  organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China
– sequence: 8
  givenname: Bilal
  surname: Ahmed
  fullname: Ahmed, Bilal
  organization: Department of Clinical Pharmacy, School of Pharmacy. Nanjing Medical University, Nanjing, 211166, China
– sequence: 9
  givenname: Feifei
  surname: Feng
  fullname: Feng, Feifei
  organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China
– sequence: 10
  givenname: Ali Asghar
  surname: Mirjat
  fullname: Mirjat, Ali Asghar
  organization: School of Public Health, Nanjing Medical University, Nanjing, 211166, China
– sequence: 11
  givenname: Wei
  surname: Wang
  fullname: Wang, Wei
  organization: Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China
– sequence: 12
  givenname: Abdul
  surname: Jabar
  fullname: Jabar, Abdul
  organization: Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Punjab, Pakistan
– sequence: 13
  givenname: Muhammad
  orcidid: 0000-0002-2193-9266
  surname: Naveed
  fullname: Naveed, Muhammad
  organization: Department of Clinical Pharmacy, School of Pharmacy. Nanjing Medical University, Nanjing, 211166, China
– sequence: 14
  givenname: Jian-Hua
  surname: Li
  fullname: Li, Jian-Hua
  email: lcx1535@163.com
  organization: Department of Human Anatomy, Medical College of Qinghai University, Xining, 81000, China
– sequence: 15
  givenname: Qiao
  surname: Zhang
  fullname: Zhang, Qiao
  email: zhangqiao@zzu.edu.cn
  organization: Department of Toxicology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35151703$$D View this record in MEDLINE/PubMed
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Environmental exposure
PAH pollution
Human health
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Chemical contaminants
Cardiovascular diseases
Carcinogenicity
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Snippet Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable environmental significance. PAHs are chemical contaminants of fused carbon and...
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SubjectTerms agricultural pollution
Air Pollutants - analysis
Atherosclerosis
Atmospheric pollution
bladder
breasts
breathing
carbon
Carcinogenicity
Cardiovascular Diseases
Chemical contaminants
chemical pollutants
colon
color
Environmental exposure
Environmental Monitoring
esophagus
exposure pathways
Female
females
forests
Genotoxicity
Health effects
heathlands
Human health
Humans
hydrogen
hypertension
Immunotoxicity
ingestion
lightning
lung neoplasms
lungs
mortality
myocardial infarction
oxidative stress
PAH pollution
pancreas
Polycyclic aromatic hydrocarbon
polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - analysis
risk
teratogens
thrombosis
toxicity
transportation
Title Polycyclic aromatic hydrocarbon and its effects on human health: An overeview
URI https://dx.doi.org/10.1016/j.chemosphere.2022.133948
https://www.ncbi.nlm.nih.gov/pubmed/35151703
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https://www.proquest.com/docview/2675564933
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