C−H Functionalisation for Hydrogen Isotope Exchange

The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demand a range of methods for their installation in an array of molecular architectures. In this Review, we describe recent advances in synthetic C−H functionalisation for hydrogen isotope...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 57; no. 12; pp. 3022 - 3047
Main Authors Atzrodt, Jens, Derdau, Volker, Kerr, William J., Reid, Marc
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 12.03.2018
EditionInternational ed. in English
Subjects
catalysis
C−H functionalization
Deuterium
drug discovery
Hydrogen
hydrogen isotope exchange
Hydrogen isotopes
Isotopes
Tritium
C−H functionalization
catalysis
drug discovery
hydrogen isotope exchange
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ISSN1433-7851
1521-3773
1521-3773
DOI10.1002/anie.201708903

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Summary:The various applications of hydrogen isotopes (deuterium, D, and tritium, T) in the physical and life sciences demand a range of methods for their installation in an array of molecular architectures. In this Review, we describe recent advances in synthetic C−H functionalisation for hydrogen isotope exchange. Spoilt for choice: The various applications of hydrogen isotopes in the physical and life sciences demand a range of methods for the installation of deuterium and tritium in an array of molecular architectures. In this Review, recent advances in synthetic C−H functionalisation for hydrogen isotope exchange are discussed.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201708903