A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development - Dickson, Marion C.; Ludbrook, Valerie J.; Perry, Hayley C.; Wilson, Paul A.; Garthside, Sam J.; Binks, Michael H. (Inflammation research, 2015)
Keywords: 2',5'-Oligoadenylate Synthetase - genetics; 2',5'-Oligoadenylate Synthetase - metabolism; Adolescent; Adult; Allergology; Aminoquinolines - administration & dosage; Aminoquinolines - adverse effects; Biomedical and Life Sciences; Biomedicine; Biopsy; Chemokine CXCL10 - genetics; Chemokine CXCL10 - metabolism; Dermatitis - drug therapy; Dermatitis - etiology; Dermatitis - metabolism; Dermatology; Drug Discovery - methods; Humans; Immunology; Interferon Type I - genetics; Interferon Type I - metabolism; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Models, Genetic; Neurology; Original Research Paper; Pharmacology/Toxicology; Protein Processing, Post-Translational - genetics; Rheumatology; Signal Transduction - genetics; Signal Transduction - physiology; Skin - metabolism; Skin - pathology; Skin Cream - adverse effects; Surgical Tape - adverse effects; Young Adult; Tape stripping; Toll-like receptor (TLR); Interferon (IFN)