Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells - McAlary, Luke; Nan, Jeremy R.; Shyu, Clay; Sher, Mine; Plotkin, Steven S.; Cashman, Neil R. (Open biology, 2024)
Keywords: Aggregates; amyloid; Amyloid - chemistry; Amyloid - metabolism; Amyloidogenesis; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - metabolism; Amyotrophic Lateral Sclerosis - pathology; Chemical bonds; Disease; Fluorescence recovery after photobleaching; Humans; Models, Molecular; Mutants; Mutation; Neurodegenerative diseases; Neurons; Pathology; Peptides; Photobleaching; Proline; Proline - metabolism; Proteasomes; Protein Aggregates; protein aggregation; Protein Aggregation, Pathological - genetics; Protein Aggregation, Pathological - metabolism; Protein Conformation, beta-Strand; Protein Folding; protein homeostasis; Proteins; SOD1; Spinal cord; Superoxide dismutase; Superoxide Dismutase-1 - chemistry; Superoxide Dismutase-1 - genetics; Superoxide Dismutase-1 - metabolism; Toxicity; amyloid; amyotrophic lateral sclerosis; protein aggregation; protein homeostasis; SOD1