The Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Ertugliflozin in Subjects With Type 2 Diabetes Mellitus

• Published in: Journal of clinical pharmacology Vol. 57; no. 11; pp. 1432 - 1443
• Main Authors: Sahasrabudhe, V., Terra, S. G., Hickman, A., Saur, D., Shi, H., O'Gorman, M., Zhou, Z., Cutler, D. L.
• Format: Journal Article
• Language: English
• Published: England 01.11.2017
• Subjects: Aged; Blood Glucose - drug effects; Bridged Bicyclo Compounds, Heterocyclic - therapeutic use; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; ertugliflozin; Female; Glomerular Filtration Rate - physiology; Glucose - metabolism; Glucosides - metabolism; Humans; Hypoglycemic Agents - therapeutic use; Kidney - metabolism; Male; Middle Aged; renal impairment; Renal Insufficiency - metabolism; Sodium-Glucose Transporter 2 - metabolism; sodium‐glucose cotransporter 2; type 2 diabetes mellitus; type 2 diabetes mellitus; ertugliflozin; sodium-glucose cotransporter 2; renal impairment
• ISSN: 0091-2700; 1552-4604
• DOI: 10.1002/jcph.955

Ertugliflozin is a highly selective and potent inhibitor of the sodium‐glucose cotransporter 2 in development for the treatment of type 2 diabetes mellitus. The glycemic efficacy of sodium‐glucose cotransporter 2 inhibitors such as ertugliflozin depends on glucose filtration through the kidney. This phase 1, open‐label study evaluated the effect of renal impairment on the pharmacokinetics, pharmacodynamics, and tolerability of ertugliflozin (15 mg) in type 2 diabetes mellitus and healthy subjects with normal renal function (estimated glomerular filtration rate not normalized for body surface area ≥90 mL/min) and type 2 diabetes mellitus subjects with mild (60‐89 mL/min), moderate (30‐59 mL/min), or severe (<30 mL/min) renal impairment (n = 36). Blood and urine samples were collected predose and over 96 hours postdose for pharmacokinetic evaluation and measurement of urinary glucose excretion over 24 hours. Log‐linear regression analyses indicated predicted mean area under the concentration‐time curve values for mild, moderate, and severe renal function groups that were ≤70% higher relative to subjects with normal renal function. Generally consistent results were obtained with categorical analysis based on analysis of variance. The increase in ertugliflozin exposure in subjects with renal impairment is not expected to be clinically meaningful. Regression analysis of change from baseline in urinary glucose excretion over 24 hours vs estimated glomerular filtration rate showed a decrease in urinary glucose excretion with declining renal function. A single 15‐mg dose of ertugliflozin was well tolerated in all groups.