Noninvasive monitoring of blood flow using a single magnetic microsphere
Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce hig...
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| Published in | Scientific reports Vol. 9; no. 1; p. 5014 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
21.03.2019
Nature Publishing Group |
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| Online Access | Get full text |
| ISSN | 2045-2322 2045-2322 |
| DOI | 10.1038/s41598-019-41416-6 |
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| Abstract | Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter constrictions in an arteria phantom after a single passage of a microsphere. We further demonstrate the potential for clinical application by tracking a microsphere smaller than a red blood cell. |
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| AbstractList | Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter constrictions in an arteria phantom after a single passage of a microsphere. We further demonstrate the potential for clinical application by tracking a microsphere smaller than a red blood cell.Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter constrictions in an arteria phantom after a single passage of a microsphere. We further demonstrate the potential for clinical application by tracking a microsphere smaller than a red blood cell. Noninvasive medical imaging of blood flow relies on mapping the transit of a contrast medium bolus injected intravenously. This has the draw-back that the front of the bolus widens until the tissue of interest is reached and quantitative flow parameters are not easy to obtain. Here, we introduce high resolution (millimeter/millisecond) 3D magnetic tracking of a single microsphere locally probing the flow while passing through a vessel. With this, we successfully localize and evaluate diameter constrictions in an arteria phantom after a single passage of a microsphere. We further demonstrate the potential for clinical application by tracking a microsphere smaller than a red blood cell. |
| ArticleNumber | 5014 |
| Author | Rahmer, Jürgen Trahms, Lutz Radon, Patricia Eberbeck, Dietmar Liebl, Maik Gleich, Bernhard Wiekhorst, Frank |
| Author_xml | – sequence: 1 givenname: Maik surname: Liebl fullname: Liebl, Maik email: maik.liebl@ptb.de organization: Physikalisch-Technische Bundesanstalt – sequence: 2 givenname: Bernhard surname: Gleich fullname: Gleich, Bernhard organization: Philips GmbH Innovative Technologies, Research Laboratories – sequence: 3 givenname: Dietmar surname: Eberbeck fullname: Eberbeck, Dietmar organization: Physikalisch-Technische Bundesanstalt – sequence: 4 givenname: Patricia surname: Radon fullname: Radon, Patricia organization: Physikalisch-Technische Bundesanstalt – sequence: 5 givenname: Jürgen orcidid: 0000-0001-8514-4801 surname: Rahmer fullname: Rahmer, Jürgen organization: Philips GmbH Innovative Technologies, Research Laboratories – sequence: 6 givenname: Lutz surname: Trahms fullname: Trahms, Lutz organization: Physikalisch-Technische Bundesanstalt – sequence: 7 givenname: Frank surname: Wiekhorst fullname: Wiekhorst, Frank organization: Physikalisch-Technische Bundesanstalt |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30899047$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_jbm_a_37828 crossref_primary_10_1016_j_jddst_2019_101388 crossref_primary_10_1038_s41598_021_86358_0 crossref_primary_10_1515_psr_2019_0112 crossref_primary_10_1016_j_bios_2021_113007 crossref_primary_10_1126_science_adf5451 crossref_primary_10_1038_s41598_020_57923_w crossref_primary_10_1016_j_jmmm_2020_167490 crossref_primary_10_1002_app_48291 |
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| Title | Noninvasive monitoring of blood flow using a single magnetic microsphere |
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