Effect of Macitentan on the Pharmacokinetics of the Breast Cancer Resistance Protein Substrates, Rosuvastatin and Riociguat, in Healthy Male Subjects - Csonka, Dénes; Bruderer, Shirin; Schultz, Armin; Soergel, Marianne; Stepanova, Radka; Sabattini, Giancarlo; Perez-Ruixo, Juan Jose (Clinical drug investigation, 2019)
Keywords: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism; Breast cancer; Cancer therapies; Drug dosages; Drug Interactions; Drug therapy; Endothelium; Healthy Volunteers; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Metabolism; Metabolites; Middle Aged; Neoplasm Proteins - metabolism; Oral administration; Original; Original Research Article; Pharmaceuticals; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Plasma; Proteins; Pulmonary hypertension; Pyrazoles - pharmacokinetics; Pyrimidines - pharmacokinetics; Pyrimidines - pharmacology; Rosuvastatin Calcium - pharmacokinetics; Sulfonamides - pharmacology; Young Adult