PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs - Chen, Chia-Hung; Wang, Bo-Wei; Hsiao, Yu-Chun; Wu, Chun-Yi; Cheng, Fang-Ju; Hsia, Te-Chun; Chen, Chih-Yi; Wang, Yihua; Weihua, Zhang; Chou, Ruey-Hwang; Tang, Chih-Hsin; Chen, Yun-Ju; et al. (Oncogene, 2021)
Keywords: 13; 13/1; 13/109; 13/2; 13/31; 13/44; 13/51; 13/89; 13/95; 14/34; 14/5; 14/63; 38; 631/337/458/1733; 631/67/1612/1350; 631/80/39; 631/80/86/2369; 64/60; 82/80; Animals; Antitumor agents; Apoptosis; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cell Biology; Cell Line, Tumor; Drug Resistance, Neoplasm - genetics; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - genetics; ErbB Receptors - metabolism; Female; Gene Expression Regulation, Neoplastic - drug effects; Glucose; Glucose transporter; Human Genetics; Humans; Internal Medicine; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; Medicine; Medicine & Public Health; Mice; Mice, Nude; Non-small cell lung carcinoma; Oncology; Patients; Protein kinase C; Protein Kinase C-delta - genetics; Protein Kinase C-delta - metabolism; Protein Kinase Inhibitors - pharmacology; Protein Kinase Inhibitors - therapeutic use; Protein-tyrosine kinase; Small cell lung carcinoma; Sodium-Glucose Transporter 1 - genetics; Sodium-Glucose Transporter 1 - metabolism; Up-regulation; Up-Regulation - drug effects; Xenograft Model Antitumor Assays