Glucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations With Aging

Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the long-standing hypothesis that chronic GC exposure promotes brain aging/Alzheimer disease. Here, we adre...

Full description

Saved in:
Bibliographic Details
Published inEndocrinology (Philadelphia) Vol. 154; no. 8; pp. 2807 - 2820
Main Authors Chen, Kuey-Chu, Blalock, Eric M., Curran-Rauhut, Meredith A., Kadish, Inga, Blalock, Susan J., Brewer, Lawrence, Porter, Nada M., Landfield, Philip W.
Format Journal Article
LanguageEnglish
Published Chevy Chase, MD Oxford University Press 01.08.2013
Endocrine Society
Subjects
Online AccessGet full text
ISSN0013-7227
1945-7170
1945-7170
DOI10.1210/en.2013-1139

Cover

Abstract Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the long-standing hypothesis that chronic GC exposure promotes brain aging/Alzheimer disease. Here, we adrenalectomized male F344 rats at 15 months of age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid receptor–activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1. We defined the chronic GC-dependent transcriptome as 393 genes that exhibited differential expression between intermediate and low CORT groups. Short-term CORT (4 days) did not recapitulate this transcriptome. Functional processes/pathways overrepresented by chronic CORT–up-regulated genes included learning/plasticity, differentiation, glucose metabolism, and cholesterol biosynthesis, whereas processes overrepresented by CORT–down-regulated genes included inflammatory/immune/glial responses and extracellular structure. These profiles indicate that GCs chronically activate neuronal/metabolic processes while coordinately repressing a glial axis of reactivity/inflammation. We then compared the GC transcriptome with a previously defined hippocampal aging transcriptome, revealing a high proportion of common genes. Although CORT and aging moved expression of some common genes in the same direction, the majority were shifted in opposite directions by CORT and aging (eg, glial inflammatory genes down-regulated by CORT are up-regulated with aging). These results contradict the hypothesis that GCs simply promote brain aging and also suggest that the opposite direction shifts during aging reflect resistance to CORT regulation. Therefore, we propose a new model in which aging-related GC resistance develops in some target pathways, whereas GC overstimulation develops in others, together generating much of the brain aging phenotype.
AbstractList Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the long-standing hypothesis that chronic GC exposure promotes brain aging/Alzheimer disease. Here, we adrenalectomized male F344 rats at 15 months of age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid receptor-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1. We defined the chronic GC-dependent transcriptome as 393 genes that exhibited differential expression between intermediate and low CORT groups. Short-term CORT (4 days) did not recapitulate this transcriptome. Functional processes/pathways overrepresented by chronic CORT-up-regulated genes included learning/plasticity, differentiation, glucose metabolism, and cholesterol biosynthesis, whereas processes overrepresented by CORT-down-regulated genes included inflammatory/immune/glial responses and extracellular structure. These profiles indicate that GCs chronically activate neuronal/metabolic processes while coordinately repressing a glial axis of reactivity/inflammation. We then compared the GC transcriptome with a previously defined hippocampal aging transcriptome, revealing a high proportion of common genes. Although CORT and aging moved expression of some common genes in the same direction, the majority were shifted in opposite directions by CORT and aging (eg, glial inflammatory genes down-regulated by CORT are up-regulated with aging). These results contradict the hypothesis that GCs simply promote brain aging and also suggest that the opposite direction shifts during aging reflect resistance to CORT regulation. Therefore, we propose a new model in which aging-related GC resistance develops in some target pathways, whereas GC overstimulation develops in others, together generating much of the brain aging phenotype.
Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the long-standing hypothesis that chronic GC exposure promotes brain aging/Alzheimer disease. Here, we adrenalectomized male F344 rats at 15 months of age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid receptor-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1. We defined the chronic GC-dependent transcriptome as 393 genes that exhibited differential expression between intermediate and low CORT groups. Short-term CORT (4 days) did not recapitulate this transcriptome. Functional processes/pathways overrepresented by chronic CORT-up-regulated genes included learning/plasticity, differentiation, glucose metabolism, and cholesterol biosynthesis, whereas processes overrepresented by CORT-down-regulated genes included inflammatory/immune/glial responses and extracellular structure. These profiles indicate that GCs chronically activate neuronal/metabolic processes while coordinately repressing a glial axis of reactivity/inflammation. We then compared the GC transcriptome with a previously defined hippocampal aging transcriptome, revealing a high proportion of common genes. Although CORT and aging moved expression of some common genes in the same direction, the majority were shifted in opposite directions by CORT and aging (eg, glial inflammatory genes down-regulated by CORT are up-regulated with aging). These results contradict the hypothesis that GCs simply promote brain aging and also suggest that the opposite direction shifts during aging reflect resistance to CORT regulation. Therefore, we propose a new model in which aging-related GC resistance develops in some target pathways, whereas GC overstimulation develops in others, together generating much of the brain aging phenotype.Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the long-standing hypothesis that chronic GC exposure promotes brain aging/Alzheimer disease. Here, we adrenalectomized male F344 rats at 15 months of age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid receptor-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1. We defined the chronic GC-dependent transcriptome as 393 genes that exhibited differential expression between intermediate and low CORT groups. Short-term CORT (4 days) did not recapitulate this transcriptome. Functional processes/pathways overrepresented by chronic CORT-up-regulated genes included learning/plasticity, differentiation, glucose metabolism, and cholesterol biosynthesis, whereas processes overrepresented by CORT-down-regulated genes included inflammatory/immune/glial responses and extracellular structure. These profiles indicate that GCs chronically activate neuronal/metabolic processes while coordinately repressing a glial axis of reactivity/inflammation. We then compared the GC transcriptome with a previously defined hippocampal aging transcriptome, revealing a high proportion of common genes. Although CORT and aging moved expression of some common genes in the same direction, the majority were shifted in opposite directions by CORT and aging (eg, glial inflammatory genes down-regulated by CORT are up-regulated with aging). These results contradict the hypothesis that GCs simply promote brain aging and also suggest that the opposite direction shifts during aging reflect resistance to CORT regulation. Therefore, we propose a new model in which aging-related GC resistance develops in some target pathways, whereas GC overstimulation develops in others, together generating much of the brain aging phenotype.
Author Curran-Rauhut, Meredith A.
Landfield, Philip W.
Chen, Kuey-Chu
Porter, Nada M.
Kadish, Inga
Blalock, Susan J.
Blalock, Eric M.
Brewer, Lawrence
Author_xml – sequence: 1
  givenname: Kuey-Chu
  surname: Chen
  fullname: Chen, Kuey-Chu
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
– sequence: 2
  givenname: Eric M.
  surname: Blalock
  fullname: Blalock, Eric M.
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
– sequence: 3
  givenname: Meredith A.
  surname: Curran-Rauhut
  fullname: Curran-Rauhut, Meredith A.
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
– sequence: 4
  givenname: Inga
  surname: Kadish
  fullname: Kadish, Inga
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
– sequence: 5
  givenname: Susan J.
  surname: Blalock
  fullname: Blalock, Susan J.
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
– sequence: 6
  givenname: Lawrence
  surname: Brewer
  fullname: Brewer, Lawrence
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
– sequence: 7
  givenname: Nada M.
  surname: Porter
  fullname: Porter, Nada M.
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
– sequence: 8
  givenname: Philip W.
  surname: Landfield
  fullname: Landfield, Philip W.
  email: pwland@uky.edu.
  organization: 1Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27574367$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/23736296$$D View this record in MEDLINE/PubMed
BookMark eNp1ks1v1DAQxS3Uim4LN84oEkJwaIq_EicckFYFWqQiEBRxtBxnvOsqawfbAfW_x-kuBSr1ZNn-zfM8zztEe847QOgJwSeEEvwK3AnFhJWEsPYBWpCWV6UgAu-hBZ7PBaXiAB3GeJW3nHP2EB1QJlhN23qB1mfDpL32IVntbV--hRFcDy4V53YcvVabUQ3FZVAu6mDH5DdQWFd8VAMUX1SKr4vPKq1_qevy6wjaGquL5ZAgqGS9i8V3m9bFcmXd6hHaN2qI8Hi3HqFv799dnp6XF5_OPpwuL0rNBU-lpj0znaoaLRqoTK8oo6bj3EBNatx0mrUNZlTohpqedKYmVd_2FBpFG-i0YUfozVZ3nLoN9DpbCWqQY7AbFa6lV1b-f-PsWq78T8kEYZTwLPByJxD8jwlikhsbNQyDcuCnKAknpKZCcJHRZ3fQKz8Fl-1JRhiuKcWsytTTfzu6beXPEDLwfAeoqNVg8mdrG_9yohKc1fNzx1tOBx9jAHOLECznLEhwcs6CnLOQcXoH1zbdzCX7tsN9RS-2RX4a75O_iRr7DQzHxCk
CODEN ENDOAO
CitedBy_id crossref_primary_10_1016_j_psyneuen_2018_07_012
crossref_primary_10_3390_ijms24032828
crossref_primary_10_1080_19768354_2013_860916
crossref_primary_10_1016_j_jsbmb_2015_01_013
crossref_primary_10_1016_j_bbr_2018_02_009
crossref_primary_10_1152_ajplung_00424_2018
crossref_primary_10_1210_en_2014_1369
crossref_primary_10_1111_jne_13125
crossref_primary_10_1186_s12974_015_0395_4
crossref_primary_10_1016_j_pnpbp_2017_11_020
crossref_primary_10_3892_ijmm_2017_3092
crossref_primary_10_1111_jne_12339
crossref_primary_10_1016_j_neubiorev_2017_04_030
crossref_primary_10_1016_j_ejphar_2013_10_070
crossref_primary_10_1007_s11357_015_9774_0
crossref_primary_10_1016_j_neurobiolaging_2018_06_009
crossref_primary_10_1172_JCI162246
crossref_primary_10_1523_JNEUROSCI_2234_17_2017
crossref_primary_10_1016_j_toxrep_2018_06_010
crossref_primary_10_1016_j_bbi_2015_09_019
crossref_primary_10_1186_s12974_017_0911_9
crossref_primary_10_1080_15592294_2017_1334025
crossref_primary_10_1007_s10522_013_9489_5
crossref_primary_10_1111_brv_12750
crossref_primary_10_1016_j_intimp_2017_05_039
crossref_primary_10_1016_j_intimp_2022_108972
crossref_primary_10_1172_jci_insight_166306
Cites_doi 10.1523/JNEUROSCI.4098-07.2008
10.1523/JNEUROSCI.11-05-01316.1991
10.1016/S0074-7742(04)60002-X
10.1093/nar/gkg624
10.1677/joe.0.1810207
10.1016/j.tins.2008.07.003
10.1210/en.2009-0679
10.1523/JNEUROSCI.4163-06.2007
10.1124/pr.112.005892
10.1196/annals.1296.017
10.1210/er.2007-0012
10.1523/JNEUROSCI.0730-11.2011
10.1016/j.jchemneu.2011.06.007
10.1016/j.tins.2005.07.006
10.1176/ajp.2006.163.12.2164
10.1111/j.1749-6632.1994.tb39225.x
10.1523/JNEUROSCI.21-14-05089.2001
10.1210/endo-120-6-2308
10.1016/j.tins.2009.08.002
10.1016/S0924-977X(01)00119-5
10.3233/JAD-2005-8406
10.1111/j.1749-6632.2009.04988.x
10.1016/j.exger.2009.02.003
10.1126/science.6270791
10.2174/1381612043383601
10.1186/gb-2003-4-5-p3
10.1523/JNEUROSCI.17-05-01848.1997
10.1016/j.neuroscience.2011.12.007
10.1093/nar/gki475
10.1016/j.arr.2005.06.006
10.1038/nrn2639
10.1016/j.nlm.2009.11.005
10.2174/156720507780362083
10.1523/JNEUROSCI.4599-08.2009
10.1007/s10571-010-9534-8
10.1126/science.2781293
10.1073/pnas.0507526103
10.1523/JNEUROSCI.6221-11.2012
10.1016/j.brainres.2007.06.092
10.1016/j.steroids.2012.09.013
10.1111/j.1749-6632.1994.tb39210.x
10.1523/JNEUROSCI.2797-06.2006
10.1513/pats.200402-001MS
10.1523/JNEUROSCI.3836-11.2011
10.1016/S0079-6123(08)60215-0
10.4161/cc.21018
10.1189/jlb.0208108
10.1002/hipo.20905
10.1016/j.yfrne.2007.10.002
10.1073/pnas.0805556105
10.1210/endo-117-6-2505
10.1210/en.2008-1396
10.1016/j.neurobiolaging.2010.01.009
10.1016/0006-8993(89)90156-X
10.1038/75556
10.1196/annals.1332.007
10.1159/000127196
10.1080/13550280290100941
10.1016/j.mce.2005.11.012
10.1126/science.715460
10.1196/annals.1314.006
10.1523/JNEUROSCI.23-09-03807.2003
10.1002/glia.21007
10.1515/REVNEURO.2007.18.2.137
10.1038/nprot.2008.211
10.1186/gb-2007-8-9-r183
10.1074/jbc.R110.179325
10.1515/REVNEURO.2008.19.6.395
10.1002/sim.4780090710
10.1523/JNEUROSCI.10-10-03247.1990
10.1523/JNEUROSCI.05-05-01222.1985
10.1385/JMN:20:3:395
10.1523/JNEUROSCI.0910-07.2007
10.1523/JNEUROSCI.3956-09.2010
10.1016/j.jsbmb.2010.02.018
10.1242/jeb.02208
10.1016/0197-4580(92)90025-S
10.1016/j.brainres.2007.02.083
10.1073/pnas.0903563106
10.1016/j.mce.2008.08.024
10.1016/j.molcel.2012.10.013
10.1074/jbc.272.22.14087
10.1152/physrev.00041.2006
10.1038/196
10.1111/j.1365-2826.2006.01413.x
10.1016/j.yhbeh.2012.03.013
10.1016/j.arr.2005.03.003
10.1385/ENDO:29:2:191
10.1016/j.mce.2009.03.008
10.1016/j.ejphar.2007.11.070
10.1056/NEJMcibr1214546
10.1016/j.bbagen.2010.06.002
10.1016/S0079-6123(08)64585-9
10.1016/j.neuropharm.2011.09.014
10.1677/joe.0.1780339
10.1016/S0169-328X(02)00665-4
10.1196/annals.1351.001
10.1016/j.neurobiolaging.2011.02.011
10.1097/IAE.0b013e3181ad2636
10.1016/S0166-2236(00)01957-3
10.1016/j.pnpbp.2009.10.018
10.1016/j.brainres.2008.03.080
10.1016/j.neuroscience.2010.07.011
10.1016/j.ejphar.2007.11.071
10.1016/S0079-6123(06)53004-3
10.1523/JNEUROSCI.3516-10.2011
10.1210/endo.136.10.7664672
10.1073/pnas.1206059109
10.1210/edrv-7-3-284
10.1016/j.tem.2008.07.009
10.1126/science.3340858
10.3109/10253890.2011.586446
10.1101/gad.1424806
10.1371/journal.pone.0018387
10.1016/j.mce.2007.03.007
10.1016/j.coph.2010.08.001
10.3389/fnagi.2012.00024
10.1128/MCB.21.3.781-793.2001
10.1002/ana.410210603
ContentType Journal Article
Copyright Copyright © 2013 by The Endocrine Society 2013
2014 INIST-CNRS
Copyright © 2013 by The Endocrine Society
Copyright_xml – notice: Copyright © 2013 by The Endocrine Society 2013
– notice: 2014 INIST-CNRS
– notice: Copyright © 2013 by The Endocrine Society
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7QG
7QP
7QR
7T5
7TM
7TO
7U7
8FD
C1K
FR3
H94
K9.
P64
7X8
5PM
DOI 10.1210/en.2013-1139
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Animal Behavior Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Immunology Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Toxicology Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Oncogenes and Growth Factors Abstracts
Technology Research Database
Toxicology Abstracts
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Animal Behavior Abstracts
AIDS and Cancer Research Abstracts
Chemoreception Abstracts
Immunology Abstracts
Engineering Research Database
Calcium & Calcified Tissue Abstracts
MEDLINE - Academic
DatabaseTitleList MEDLINE

Oncogenes and Growth Factors Abstracts
MEDLINE - Academic

CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
EISSN 1945-7170
EndPage 2820
ExternalDocumentID PMC3713214
23736296
27574367
10_1210_en_2013_1139
10.1210/en.2013-1139
Genre Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIA NIH HHS
  grantid: R01 AG034605
– fundername: NIA NIH HHS
  grantid: AG034605
– fundername: NIA NIH HHS
  grantid: P01 AG010836
– fundername: NIA NIH HHS
  grantid: AG010836
– fundername: NIA NIH HHS
  grantid: AG037868
– fundername: NIA NIH HHS
  grantid: R01 AG037868
GroupedDBID ---
-DZ
-~X
.55
.XZ
0R~
18M
1TH
29G
2WC
34G
354
39C
4.4
48X
5GY
5RE
5RS
5YH
79B
8F7
AABZA
AACZT
AAIMJ
AAPQZ
AAPXW
AARHZ
AAUAY
AAVAP
ABDFA
ABEJV
ABGNP
ABHFT
ABJNI
ABLJU
ABMNT
ABNHQ
ABPPZ
ABPQP
ABPTD
ABQNK
ABVGC
ABWST
ABXVV
ACGFO
ACGFS
ACIWK
ACPRK
ADBBV
ADGKP
ADGZP
ADHKW
ADIYS
ADQBN
ADRTK
ADVEK
AELWJ
AEMDU
AENEX
AENZO
AETBJ
AEWNT
AFFZL
AFGWE
AFOFC
AFRAH
AFXAL
AGINJ
AGQXC
AGUTN
AHMBA
AHMMS
AJEEA
ALMA_UNASSIGNED_HOLDINGS
APIBT
ARIXL
ATGXG
BAWUL
BAYMD
BCRHZ
BEYMZ
BSWAC
BTRTY
C45
CDBKE
CJ0
CS3
DAKXR
DIK
DU5
E3Z
EBS
EJD
ENERS
F5P
FECEO
FHSFR
FLUFQ
FOEOM
FOTVD
FQBLK
GAUVT
GJXCC
GX1
H13
HF~
HZ~
IH2
KBUDW
KOP
KQ8
KSI
KSN
L7B
LMP
M5~
MHKGH
MJL
NLBLG
NOMLY
NOYVH
NVLIB
O9-
OAUYM
OBH
ODMLO
OFXIZ
OHH
OJZSN
OK1
OPAEJ
OVD
OVIDX
P2P
Q-A
REU
ROX
ROZ
TEORI
TJX
TLC
TR2
TWZ
UPT
VVN
W2D
W8F
WH7
WOQ
X7M
YBU
YHG
YOC
YSK
ZCA
ZY1
AAYXX
ABXZS
ADNBA
AEMQT
AETEA
AFYAG
AGORE
ALXQX
CITATION
NU-
.GJ
08P
3O-
53G
AAJQQ
AAKAS
AAPGJ
AAUQX
AAWDT
AAYJJ
ABEFU
ACFRR
ACIPB
ACUTJ
ACVCV
ACZBC
ADMTO
ADZCM
AFFNX
AFFQV
AGKRT
AGMDO
AJDVS
APJGH
AQKUS
AVNTJ
BPHCQ
BVXVI
C1A
EMOBN
FA8
H~9
IAO
IHR
IQODW
ITC
J5H
MBLQV
MVM
OBFPC
OHT
PQQKQ
PROAC
TMA
VQP
WHG
X52
XJT
XOL
YQI
YYP
ZCG
ZGI
ZKB
ZXP
AHGBF
AJBYB
CGR
CUY
CVF
ECM
EIF
NPM
7QG
7QP
7QR
7T5
7TM
7TO
7U7
8FD
AEHZK
C1K
FR3
H94
K9.
P64
7X8
5PM
ID FETCH-LOGICAL-c474t-c2d3fba58c78e5fda232fb44fe61608bc3980327c82fd1bf615d9d2e8a28ebcf3
ISSN 0013-7227
1945-7170
IngestDate Thu Aug 21 18:28:50 EDT 2025
Sat Sep 27 17:52:43 EDT 2025
Fri Sep 19 20:57:01 EDT 2025
Mon Jul 21 05:48:39 EDT 2025
Wed Apr 02 07:15:08 EDT 2025
Tue Jul 01 04:39:16 EDT 2025
Thu Apr 24 23:10:14 EDT 2025
Fri Feb 07 10:35:35 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords Vertebrata
Mammalia
Rat
Animal
Ageing
Rodentia
Central nervous system
Alteration
Male
Glucocorticoid
Hippocampus
Encephalon
Language English
License CC BY 4.0
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c474t-c2d3fba58c78e5fda232fb44fe61608bc3980327c82fd1bf615d9d2e8a28ebcf3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
R.B., R.A.R., and M.A.C.-R. contributed equally to the study.
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC3713214
PMID 23736296
PQID 3130622035
PQPubID 2046207
PageCount 14
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3713214
proquest_miscellaneous_1411627747
proquest_journals_3130622035
pubmed_primary_23736296
pascalfrancis_primary_27574367
crossref_primary_10_1210_en_2013_1139
crossref_citationtrail_10_1210_en_2013_1139
oup_primary_10_1210_en_2013-1139
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2013-08-01
PublicationDateYYYYMMDD 2013-08-01
PublicationDate_xml – month: 08
  year: 2013
  text: 2013-08-01
  day: 01
PublicationDecade 2010
PublicationPlace Chevy Chase, MD
PublicationPlace_xml – name: Chevy Chase, MD
– name: United States
– name: Washington
PublicationTitle Endocrinology (Philadelphia)
PublicationTitleAlternate Endocrinology
PublicationYear 2013
Publisher Oxford University Press
Endocrine Society
Publisher_xml – name: Oxford University Press
– name: Endocrine Society
References Ashburner (2020071613163287600_B77) 2000; 25
Savory (2020071613163287600_B105) 2001; 21
Hochberg (2020071613163287600_B71) 1990; 9
Yao (2020071613163287600_B117) 2009; 106
Meaney (2020071613163287600_B121) 2005; 28
Mrak (2020071613163287600_B113) 2005; 8
Adcock (2020071613163287600_B4) 2004; 1
Sotiropoulos (2020071613163287600_B59) 2011; 31
Prolla (2020071613163287600_B114) 2001; 24
Dilger (2020071613163287600_B110) 2008; 84
Gottfried-Blackmore (2020071613163287600_B119) 2010; 58
Sohrabji (2020071613163287600_B48) 2006; 29
Gross (2020071613163287600_B100) 2008; 19
De Kloet (2020071613163287600_B83) 1998; 19
Issa (2020071613163287600_B56) 1990; 10
Sapolsky (2020071613163287600_B17) 1986; 7
Beeri (2020071613163287600_B65) 2012; 33
Sofroniew (2020071613163287600_B96) 2009; 32
McReynolds (2020071613163287600_B64) 2010; 93
Kadish (2020071613163287600_B69) 2009; 29
Blalock (2020071613163287600_B73) 2011; 42
Kerr (2020071613163287600_B10) 1991; 11
Zhang (2020071613163287600_B39) 2005; 33
Reul (2020071613163287600_B21) 1985; 117
Dostert (2020071613163287600_B23) 2004; 10
Simons (2020071613163287600_B24) 2010; 10
Chrousos (2020071613163287600_B2) 2009; 1179
Nichols (2020071613163287600_B63) 1994; 746
Makino (2020071613163287600_B67) 1995; 136
Kotti (2020071613163287600_B90) 2008; 105
Kajiyama (2020071613163287600_B41) 2010; 34
Morsink (2020071613163287600_B47) 2006; 18
Hansson (2020071613163287600_B95) 2008; 1215
Nogueira (2020071613163287600_B35) 2009; 302
Blalock (2020071613163287600_B75) 2005; 4
Lonard (2020071613163287600_B25) 2007; 28
Carroll (2020071613163287600_B61) 2011; 31
de Kloet (2020071613163287600_B7) 2008; 29
Uhlenhaut (2020071613163287600_B103) 2013; 49
Samarasinghe (2020071613163287600_B30) 2012; 11
Zhao (2020071613163287600_B28) 2007; 1172
Brinton (2020071613163287600_B49) 2008; 31
Farrell (2020071613163287600_B107) 2003; 178
Guzowski (2020071613163287600_B91) 2001; 21
Magistretti (2020071613163287600_B98) 2006; 209
Penner (2020071613163287600_B92) 2011; 32
McEwen (2020071613163287600_B9) 2007; 87
Walker (2020071613163287600_B34) 2009; 150
Gemma (2020071613163287600_B111) 2007; 18
Cidlowski (2020071613163287600_B22) 2009; 29
Dallman (2020071613163287600_B14) 2006; 153
Rinholm (2020071613163287600_B99) 2011; 31
Weaver (2020071613163287600_B43) 2006; 103
Terry (2020071613163287600_B115) 1987; 21
Sapolsky (2020071613163287600_B82) 1992; 13
Griffin (2020071613163287600_B116) 2013; 368
Kasckow (2020071613163287600_B81) 2009; 44
Yau (2020071613163287600_B120) 2012; 4
Chen (2020071613163287600_B106) 1997; 272
Nixon (2020071613163287600_B101) 2013; 78
McEwen (2020071613163287600_B18) 1992; 93
Bolstad (2020071613163287600_B68) 2004; 60
Lewis-Tuffin (2020071613163287600_B104) 2006; 1069
Song (2020071613163287600_B33) 2006; 246
Dennis (2020071613163287600_B36) 2003; 4
Woolley (2020071613163287600_B50) 1997; 17
Landfield (2020071613163287600_B16) 1978; 202
Petanceska (2020071613163287600_B97) 2003; 20
Porter (2020071613163287600_B19) 1998; 1
Landfield (2020071613163287600_B20) 1981; 214
O'Callaghan (2020071613163287600_B62) 1989; 494
Huang da (2020071613163287600_B76) 2009; 4
Tischner (2020071613163287600_B5) 2007; 275
Miller (2020071613163287600_B40) 2008; 28
Swaab (2020071613163287600_B13) 2005; 4
Tasker (2020071613163287600_B31) 2011; 14
Lupien (2020071613163287600_B11) 1997; 82
Liu (2020071613163287600_B42) 2010; 30
Blalock (2020071613163287600_B74) 2010; 30
Rowe (2020071613163287600_B72) 2007; 27
Dallman (2020071613163287600_B32) 2004; 1018
McEwen (2020071613163287600_B6) 2008; 583
Blalock (2020071613163287600_B37) 2003; 23
Zamanian (2020071613163287600_B87) 2012; 32
Kerr (2020071613163287600_B55) 1989; 245
Green (2020071613163287600_B58) 2006; 26
Wang (2020071613163287600_B122) 2012; 62
Yin (2020071613163287600_B51) 2009; 150
Rosenfeld (2020071613163287600_B26) 2006; 20
Meaney (2020071613163287600_B12) 1988; 239
Datson (2020071613163287600_B46) 2008; 583
Huang da (2020071613163287600_B78) 2007; 8
Dinapoli (2020071613163287600_B85) 2010; 170
Morsink (2020071613163287600_B89) 2007; 1150
Cintra (2020071613163287600_B88) 1994; 746
Conrad (2020071613163287600_B52) 2008; 19
Sonntag (2020071613163287600_B79) 1987; 120
Webster (2020071613163287600_B108) 2004; 181
Dhabhar (2020071613163287600_B80) 1997; 65
Wei (2020071613163287600_B53) 2007; 27
Simpkins (2020071613163287600_B29) 2013; 63
Mans (2020071613163287600_B93) 2012; 202
Wilkinson (2020071613163287600_B118) 2001; 86
Buechel (2020071613163287600_B70) 2011; 6
Lupien (2020071613163287600_B57) 2009; 10
Csernansky (2020071613163287600_B60) 2006; 163
Yao (2020071613163287600_B109) 2010; 1800
Chinenov (2020071613163287600_B102) 2012; 109
Kelly (2020071613163287600_B27) 2009; 308
Vreugdenhil (2020071613163287600_B94) 2001; 11
Draghici (2020071613163287600_B38) 2003; 31
Datson (2020071613163287600_B44) 2012; 22
Seckl (2020071613163287600_B54) 2004; 1032
Barnes (2020071613163287600_B3) 2010; 120
Oakley (2020071613163287600_B1) 2011; 286
Landfield (2020071613163287600_B66) 2007; 4
O'Keefe (2020071613163287600_B86) 2002; 8
McGeer (2020071613163287600_B112) 2004; 1035
Qin (2020071613163287600_B45) 2003; 111
Sapolsky (2020071613163287600_B15) 1985; 5
Landfield (2020071613163287600_B84) 1987; 72
Joëls (2020071613163287600_B8) 2012; 64
18282566 - Eur J Pharmacol. 2008 Apr 7;583(2-3):174-85
7825905 - Ann N Y Acad Sci. 1994 Nov 30;746:42-61; discussion 61-3
1480759 - Prog Brain Res. 1992;93:365-81; discussion 382-3
18256261 - J Neurosci. 2008 Feb 6;28(6):1410-20
22498694 - Horm Behav. 2013 Feb;63(2):278-83
18805703 - Trends Endocrinol Metab. 2008 Nov;19(9):331-9
9626555 - Endocr Rev. 1998 Jun;19(3):269-301
11881742 - Trends Neurosci. 2001 Nov;24(11 Suppl):S21-31
19147677 - Endocrinology. 2009 May;150(5):2308-16
21228163 - J Neurosci. 2011 Jan 12;31(2):538-48
12476345 - J Neurovirol. 2002 Dec;8(6):496-512
18295201 - Eur J Pharmacol. 2008 Apr 7;583(2-3):272-89
23023031 - Pharmacol Rev. 2012 Oct;64(4):901-38
21483696 - PLoS One. 2011;6(4):e18387
9158068 - Neuroendocrinology. 1997 May;65(5):360-8
715460 - Science. 1978 Dec 8;202(4372):1098-102
23127816 - Steroids. 2013 Jan;78(1):59-68
17555867 - Mol Cell Endocrinol. 2007 Sep 15;275(1-2):62-70
15379669 - Curr Pharm Des. 2004;10(23):2807-16
16388891 - Mol Cell Endocrinol. 2006 Feb 26;246(1-2):142-6
18485334 - Brain Res. 2008 Jun 18;1215:1-10
16503919 - J Neuroendocrinol. 2006 Apr;18(4):239-52
20188830 - J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):76-85
18495785 - J Leukoc Biol. 2008 Oct;84(4):932-9
21458888 - Neurobiol Aging. 2012 Jul;33(7):1258-64
17151169 - Am J Psychiatry. 2006 Dec;163(12):2164-9
9162033 - J Biol Chem. 1997 May 30;272(22):14087-92
12734009 - Genome Biol. 2003;4(5):P3
23159735 - Mol Cell. 2013 Jan 10;49(1):158-71
20189687 - Neurobiol Aging. 2011 Dec;32(12):2198-210
19249343 - Exp Gerontol. 2009 May;44(5):335-43
14501024 - J Mol Neurosci. 2003;20(3):395-406
19667196 - Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14670-5
9215274 - J Clin Endocrinol Metab. 1997 Jul;82(7):2070-5
16731806 - J Exp Biol. 2006 Jun;209(Pt 12):2304-11
18067954 - Front Neuroendocrinol. 2008 May;29(2):268-72
20544861 - Glia. 2010 Aug;58(10):1257-66
19549588 - Mol Cell Endocrinol. 2009 Sep 24;308(1-2):17-25
15980575 - Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W741-8
2998738 - Endocrinology. 1985 Dec;117(6):2505-11
15474586 - Int Rev Neurobiol. 2004;60:25-58
20532976 - Cell Mol Neurobiol. 2010 Oct;30(7):1035-47
21663538 - Stress. 2011 Jul;14(4):398-406
3606042 - Ann Neurol. 1987 Jun;21(6):530-9
18685105 - Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11394-9
23425171 - N Engl J Med. 2013 Feb 21;368(8):770-1
15677396 - Ann N Y Acad Sci. 2004 Dec;1032:63-84
16257272 - Ageing Res Rev. 2005 Nov;4(4):481-512
22192838 - Neuroscience. 2012 Jan 27;202:1-9
10195096 - Nat Neurosci. 1998 May;1(1):3-4
17615391 - Physiol Rev. 2007 Jul;87(3):873-904
22553043 - J Neurosci. 2012 May 2;32(18):6391-410
11154266 - Mol Cell Biol. 2001 Feb;21(3):781-93
16785595 - Endocrine. 2006 Apr;29(2):191-7
16556968 - J Alzheimers Dis. 2005 Mar;8(4):369-75
3527687 - Endocr Rev. 1986 Aug;7(3):284-301
21613497 - J Neurosci. 2011 May 25;31(21):7840-7
18774188 - Trends Neurosci. 2008 Oct;31(10):529-37
17803971 - Brain Res. 2007 Oct 3;1172:48-59
12654501 - Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):17-23
16855130 - Ann N Y Acad Sci. 2006 Jun;1069:1-9
1542376 - Neurobiol Aging. 1992 Jan-Feb;13(1):171-4
19211887 - J Neurosci. 2009 Feb 11;29(6):1805-16
21184481 - Hippocampus. 2012 Feb;22(2):359-71
2765916 - Brain Res. 1989 Aug 7;494(1):159-61
19401723 - Nat Rev Neurosci. 2009 Jun;10(6):434-45
20427664 - J Neurosci. 2010 Apr 28;30(17):6058-71
16751179 - Genes Dev. 2006 Jun 1;20(11):1405-28
19553792 - Retina. 2009 Jun;29(6 Suppl):S21-3
21756998 - J Chem Neuroanat. 2011 Oct;42(2):118-26
17609497 - Endocr Rev. 2007 Aug;28(5):575-87
15996533 - Ageing Res Rev. 2005 May;4(2):141-94
3032584 - Endocrinology. 1987 Jun;120(6):2308-15
20801081 - Curr Opin Pharmacol. 2010 Dec;10(6):613-9
20633608 - Neuroscience. 2010 Oct 13;170(2):633-44
17376971 - J Neurosci. 2007 Mar 21;27(12):3098-110
11438584 - J Neurosci. 2001 Jul 15;21(14):5089-98
2027050 - J Neurosci. 1991 May;11(5):1316-24
11704419 - Eur Neuropsychopharmacol. 2001 Dec;11(6):423-30
3340858 - Science. 1988 Feb 12;239(4841 Pt 1):766-8
16113442 - Proc Am Thorac Soc. 2004;1(3):247-54
15681803 - Ann N Y Acad Sci. 2004 Dec;1035:104-16
17383615 - Brain Res. 2007 May 30;1150:14-20
17699665 - J Neurosci. 2007 Aug 15;27(33):8836-44
15128270 - J Endocrinol. 2004 May;181(2):207-21
2218183 - Stat Med. 1990 Jul;9(7):811-8
11158007 - J Clin Endocrinol Metab. 2001 Feb;86(2):545-50
3303130 - Prog Brain Res. 1987;72:279-300
19883713 - Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):159-65
7664672 - Endocrinology. 1995 Oct;136(10):4517-25
22801547 - Cell Cycle. 2012 Aug 1;11(15):2819-27
2781293 - Science. 1989 Sep 29;245(4925):1505-9
17784955 - Genome Biol. 2007;8(9):R183
3998818 - J Neurosci. 1985 May;5(5):1222-7
16943563 - J Neurosci. 2006 Aug 30;26(35):9047-56
10802651 - Nat Genet. 2000 May;25(1):25-9
7825872 - Ann N Y Acad Sci. 1994 Nov 30;746:145-54; discussion 154-6
9030643 - J Neurosci. 1997 Mar 1;17(5):1848-59
16484373 - Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3480-5
21149445 - J Biol Chem. 2011 Feb 4;286(5):3177-84
12967327 - J Endocrinol. 2003 Sep;178(3):339-46
17430248 - Curr Alzheimer Res. 2007 Apr;4(2):205-12
16054244 - Trends Neurosci. 2005 Sep;28(9):456-63
19819960 - Endocrinology. 2009 Dec;150(12):5498-508
15240363 - Ann N Y Acad Sci. 2004 Jun;1018:141-50
22753499 - Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11776-81
12824416 - Nucleic Acids Res. 2003 Jul 1;31(13):3775-81
20538040 - Biochim Biophys Acta. 2010 Oct;1800(10):1121-6
16876569 - Prog Brain Res. 2006;153:75-105
22952463 - Front Aging Neurosci. 2012 Aug 29;4:24
19782411 - Trends Neurosci. 2009 Dec;32(12):638-47
2170594 - J Neurosci. 1990 Oct;10(10):3247-54
12736351 - J Neurosci. 2003 May 1;23(9):3807-19
19932757 - Neurobiol Learn Mem. 2010 Mar;93(3):312-21
19906238 - Ann N Y Acad Sci. 2009 Oct;1179:153-66
17593876 - Rev Neurosci. 2007;18(2):137-48
6270791 - Science. 1981 Oct 30;214(4520):581-4
18812209 - Mol Cell Endocrinol. 2009 Apr 29;302(2):230-6
21976528 - J Neurosci. 2011 Oct 5;31(40):14436-49
19317179 - Rev Neurosci. 2008;19(6):395-411
21945289 - Neuropharmacology. 2012 Jan;62(1):527-33
19131956 - Nat Protoc. 2009;4(1):44-57
References_xml – volume: 28
  start-page: 1410
  year: 2008
  ident: 2020071613163287600_B40
  article-title: A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4098-07.2008
– volume: 11
  start-page: 1316
  year: 1991
  ident: 2020071613163287600_B10
  article-title: Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.11-05-01316.1991
– volume: 60
  start-page: 25
  year: 2004
  ident: 2020071613163287600_B68
  article-title: Experimental design and low-level analysis of microarray data
  publication-title: Int Rev Neurobiol
  doi: 10.1016/S0074-7742(04)60002-X
– volume: 31
  start-page: 3775
  year: 2003
  ident: 2020071613163287600_B38
  article-title: Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkg624
– volume: 181
  start-page: 207
  year: 2004
  ident: 2020071613163287600_B108
  article-title: Role of the hypothalamic-pituitary-adrenal axis, glucocorticoids and glucocorticoid receptors in toxic sequelae of exposure to bacterial and viral products
  publication-title: J Endocrinol
  doi: 10.1677/joe.0.1810207
– volume: 31
  start-page: 529
  year: 2008
  ident: 2020071613163287600_B49
  article-title: The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2008.07.003
– volume: 150
  start-page: 5498
  year: 2009
  ident: 2020071613163287600_B51
  article-title: Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatment
  publication-title: Endocrinology
  doi: 10.1210/en.2009-0679
– volume: 27
  start-page: 3098
  year: 2007
  ident: 2020071613163287600_B72
  article-title: Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4163-06.2007
– volume: 64
  start-page: 901
  year: 2012
  ident: 2020071613163287600_B8
  article-title: Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.112.005892
– volume: 1018
  start-page: 141
  year: 2004
  ident: 2020071613163287600_B32
  article-title: Chronic stress-induced effects of corticosterone on brain: direct and indirect
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1296.017
– volume: 28
  start-page: 575
  year: 2007
  ident: 2020071613163287600_B25
  article-title: Nuclear receptor coregulators and human disease
  publication-title: Endocr Rev
  doi: 10.1210/er.2007-0012
– volume: 31
  start-page: 7840
  year: 2011
  ident: 2020071613163287600_B59
  article-title: Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0730-11.2011
– volume: 42
  start-page: 118
  year: 2011
  ident: 2020071613163287600_B73
  article-title: Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease
  publication-title: J Chem Neuroanat
  doi: 10.1016/j.jchemneu.2011.06.007
– volume: 28
  start-page: 456
  year: 2005
  ident: 2020071613163287600_B121
  article-title: Maternal care as a model for experience-dependent chromatin plasticity?
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2005.07.006
– volume: 163
  start-page: 2164
  year: 2006
  ident: 2020071613163287600_B60
  article-title: Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.2006.163.12.2164
– volume: 746
  start-page: 145
  year: 1994
  ident: 2020071613163287600_B63
  article-title: Gene products of corticosteroid action in hippocampus
  publication-title: Ann NY Acad Sci
  doi: 10.1111/j.1749-6632.1994.tb39225.x
– volume: 21
  start-page: 5089
  year: 2001
  ident: 2020071613163287600_B91
  article-title: Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-14-05089.2001
– volume: 120
  start-page: 2308
  year: 1987
  ident: 2020071613163287600_B79
  article-title: Diminished diurnal secretion of adrenocorticotropin (ACTH), but not corticosterone, in old male rats: possible relation to increased adrenal sensitivity to ACTH in vivo
  publication-title: Endocrinology
  doi: 10.1210/endo-120-6-2308
– volume: 32
  start-page: 638
  year: 2009
  ident: 2020071613163287600_B96
  article-title: Molecular dissection of reactive astrogliosis and glial scar formation
  publication-title: Trends Neurosci
  doi: 10.1016/j.tins.2009.08.002
– volume: 11
  start-page: 423
  year: 2001
  ident: 2020071613163287600_B94
  article-title: Genetic dissection of corticosterone receptor function in the rat hippocampus
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/S0924-977X(01)00119-5
– volume: 8
  start-page: 369
  year: 2005
  ident: 2020071613163287600_B113
  article-title: Potential inflammatory biomarkers in Alzheimer's disease
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-2005-8406
– volume: 1179
  start-page: 153
  year: 2009
  ident: 2020071613163287600_B2
  article-title: Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders
  publication-title: Ann NY Acad Sci
  doi: 10.1111/j.1749-6632.2009.04988.x
– volume: 44
  start-page: 335
  year: 2009
  ident: 2020071613163287600_B81
  article-title: Glial glucocorticoid receptors in aged Fisher 344 (F344) and F344/Brown Norway rats
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2009.02.003
– volume: 214
  start-page: 581
  year: 1981
  ident: 2020071613163287600_B20
  article-title: Brain aging correlates: retardation by hormonal-pharmacological treatments
  publication-title: Science
  doi: 10.1126/science.6270791
– volume: 10
  start-page: 2807
  year: 2004
  ident: 2020071613163287600_B23
  article-title: Negative glucocorticoid receptor response elements and their role in glucocorticoid action
  publication-title: Curr Pharm Des
  doi: 10.2174/1381612043383601
– volume: 4
  start-page: P3
  year: 2003
  ident: 2020071613163287600_B36
  article-title: DAVID: database for annotation, visualization, and integrated discovery
  publication-title: Genome Biol
  doi: 10.1186/gb-2003-4-5-p3
– volume: 17
  start-page: 1848
  year: 1997
  ident: 2020071613163287600_B50
  article-title: Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.17-05-01848.1997
– volume: 202
  start-page: 1
  year: 2012
  ident: 2020071613163287600_B93
  article-title: Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2011.12.007
– volume: 33
  start-page: W741
  year: 2005
  ident: 2020071613163287600_B39
  article-title: WebGestalt: an integrated system for exploring gene sets in various biological contexts
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gki475
– volume: 4
  start-page: 481
  year: 2005
  ident: 2020071613163287600_B75
  article-title: Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2005.06.006
– volume: 10
  start-page: 434
  year: 2009
  ident: 2020071613163287600_B57
  article-title: Effects of stress throughout the lifespan on the brain, behaviour and cognition
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2639
– volume: 93
  start-page: 312
  year: 2010
  ident: 2020071613163287600_B64
  article-title: Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions
  publication-title: Neurobiol Learn Mem
  doi: 10.1016/j.nlm.2009.11.005
– volume: 4
  start-page: 205
  year: 2007
  ident: 2020071613163287600_B66
  article-title: A new glucocorticoid hypothesis of brain aging: implications for Alzheimer's disease
  publication-title: Curr Alzheimer Res
  doi: 10.2174/156720507780362083
– volume: 29
  start-page: 1805
  year: 2009
  ident: 2020071613163287600_B69
  article-title: Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4599-08.2009
– volume: 30
  start-page: 1035
  year: 2010
  ident: 2020071613163287600_B42
  article-title: cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of BALB/c mice subjected to chronic mild stress
  publication-title: Cell Mol Neurobiol
  doi: 10.1007/s10571-010-9534-8
– volume: 245
  start-page: 1505
  year: 1989
  ident: 2020071613163287600_B55
  article-title: Corticosteroid modulation of hippocampal potentials: increased effect with aging
  publication-title: Science
  doi: 10.1126/science.2781293
– volume: 103
  start-page: 3480
  year: 2006
  ident: 2020071613163287600_B43
  article-title: Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0507526103
– volume: 32
  start-page: 6391
  year: 2012
  ident: 2020071613163287600_B87
  article-title: Genomic analysis of reactive astrogliosis
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.6221-11.2012
– volume: 1172
  start-page: 48
  year: 2007
  ident: 2020071613163287600_B28
  article-title: Estrogen receptor α and β differentially regulate intracellular Ca2+ dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2007.06.092
– volume: 78
  start-page: 59
  year: 2013
  ident: 2020071613163287600_B101
  article-title: It takes two to tango: dimerisation of glucocorticoid receptor and its anti-inflammatory functions
  publication-title: Steroids
  doi: 10.1016/j.steroids.2012.09.013
– volume: 746
  start-page: 42
  year: 1994
  ident: 2020071613163287600_B88
  article-title: Glial and neuronal glucocorticoid receptor immunoreactive cell populations in developing, adult, and aging brain
  publication-title: Ann NY Acad Sci
  doi: 10.1111/j.1749-6632.1994.tb39210.x
– volume: 26
  start-page: 9047
  year: 2006
  ident: 2020071613163287600_B58
  article-title: Glucocorticoids increase amyloid-β and tau pathology in a mouse model of Alzheimer's disease
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2797-06.2006
– volume: 1
  start-page: 247
  year: 2004
  ident: 2020071613163287600_B4
  article-title: Glucocorticoids: effects on gene transcription
  publication-title: Proc Am Thorac Soc
  doi: 10.1513/pats.200402-001MS
– volume: 31
  start-page: 14436
  year: 2011
  ident: 2020071613163287600_B61
  article-title: Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3836-11.2011
– volume: 72
  start-page: 279
  year: 1987
  ident: 2020071613163287600_B84
  article-title: Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(08)60215-0
– volume: 11
  start-page: 2819
  year: 2012
  ident: 2020071613163287600_B30
  article-title: Cooperativity and complementarity: synergies in non-classical and classical glucocorticoid signaling
  publication-title: Cell Cycle
  doi: 10.4161/cc.21018
– volume: 84
  start-page: 932
  year: 2008
  ident: 2020071613163287600_B110
  article-title: Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0208108
– volume: 19
  start-page: 269
  year: 1998
  ident: 2020071613163287600_B83
  article-title: Brain corticosteroid receptor balance in health and disease
  publication-title: Endocr Rev
– volume: 22
  start-page: 359
  year: 2012
  ident: 2020071613163287600_B44
  article-title: The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrus
  publication-title: Hippocampus
  doi: 10.1002/hipo.20905
– volume: 29
  start-page: 268
  year: 2008
  ident: 2020071613163287600_B7
  article-title: Corticosteroid hormones in the central stress response: quick-and-slow
  publication-title: Front Neuroendocrinol
  doi: 10.1016/j.yfrne.2007.10.002
– volume: 105
  start-page: 11394
  year: 2008
  ident: 2020071613163287600_B90
  article-title: Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0805556105
– volume: 117
  start-page: 2505
  year: 1985
  ident: 2020071613163287600_B21
  article-title: Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation
  publication-title: Endocrinology
  doi: 10.1210/endo-117-6-2505
– volume: 150
  start-page: 2308
  year: 2009
  ident: 2020071613163287600_B34
  article-title: Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats
  publication-title: Endocrinology
  doi: 10.1210/en.2008-1396
– volume: 82
  start-page: 2070
  year: 1997
  ident: 2020071613163287600_B11
  article-title: Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity
  publication-title: J Clin Endocrinol Metab
– volume: 32
  start-page: 2198
  year: 2011
  ident: 2020071613163287600_B92
  article-title: Age-related changes in Arc transcription and DNA methylation within the hippocampus
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2010.01.009
– volume: 494
  start-page: 159
  year: 1989
  ident: 2020071613163287600_B62
  article-title: Glucocorticoids regulate the concentration of glial fibrillary acidic protein throughout the brain
  publication-title: Brain Res
  doi: 10.1016/0006-8993(89)90156-X
– volume: 25
  start-page: 25
  year: 2000
  ident: 2020071613163287600_B77
  article-title: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
  publication-title: Nat Genet
  doi: 10.1038/75556
– volume: 1035
  start-page: 104
  year: 2004
  ident: 2020071613163287600_B112
  article-title: Inflammation and the degenerative diseases of aging
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1332.007
– volume: 65
  start-page: 360
  year: 1997
  ident: 2020071613163287600_B80
  article-title: Adaptation to prolonged or repeated stress—comparison between rat strains showing intrinsic differences in reactivity to acute stress
  publication-title: Neuroendocrinology
  doi: 10.1159/000127196
– volume: 8
  start-page: 496
  year: 2002
  ident: 2020071613163287600_B86
  article-title: Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases
  publication-title: J Neurovirol
  doi: 10.1080/13550280290100941
– volume: 246
  start-page: 142
  year: 2006
  ident: 2020071613163287600_B33
  article-title: Non-genomic glucocorticoid effects to provide the basis for new drug developments
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2005.11.012
– volume: 202
  start-page: 1098
  year: 1978
  ident: 2020071613163287600_B16
  article-title: Hippocampal aging and adrenocorticoids: quantitative correlations
  publication-title: Science
  doi: 10.1126/science.715460
– volume: 1032
  start-page: 63
  year: 2004
  ident: 2020071613163287600_B54
  article-title: Glucocorticoid programming
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1314.006
– volume: 23
  start-page: 3807
  year: 2003
  ident: 2020071613163287600_B37
  article-title: Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-09-03807.2003
– volume: 58
  start-page: 1257
  year: 2010
  ident: 2020071613163287600_B119
  article-title: Microglia express functional 11β-hydroxysteroid dehydrogenase type 1
  publication-title: Glia
  doi: 10.1002/glia.21007
– volume: 18
  start-page: 137
  year: 2007
  ident: 2020071613163287600_B111
  article-title: Interleukin-1β and caspase-1: players in the regulation of age-related cognitive dysfunction
  publication-title: Rev Neurosci
  doi: 10.1515/REVNEURO.2007.18.2.137
– volume: 86
  start-page: 545
  year: 2001
  ident: 2020071613163287600_B118
  article-title: Human glucocorticoid feedback inhibition is reduced in older individuals: evening study
  publication-title: J Clin Endocrinol Metab
– volume: 4
  start-page: 44
  year: 2009
  ident: 2020071613163287600_B76
  article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2008.211
– volume: 8
  start-page: R183
  year: 2007
  ident: 2020071613163287600_B78
  article-title: The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists
  publication-title: Genome Biol
  doi: 10.1186/gb-2007-8-9-r183
– volume: 286
  start-page: 3177
  year: 2011
  ident: 2020071613163287600_B1
  article-title: Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids
  publication-title: J Biol Chem
  doi: 10.1074/jbc.R110.179325
– volume: 19
  start-page: 395
  year: 2008
  ident: 2020071613163287600_B52
  article-title: Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis
  publication-title: Rev Neurosci
  doi: 10.1515/REVNEURO.2008.19.6.395
– volume: 9
  start-page: 811
  year: 1990
  ident: 2020071613163287600_B71
  article-title: More powerful procedures for multiple significance testing
  publication-title: Stat Med
  doi: 10.1002/sim.4780090710
– volume: 10
  start-page: 3247
  year: 1990
  ident: 2020071613163287600_B56
  article-title: Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.10-10-03247.1990
– volume: 5
  start-page: 1222
  year: 1985
  ident: 2020071613163287600_B15
  article-title: Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.05-05-01222.1985
– volume: 20
  start-page: 395
  year: 2003
  ident: 2020071613163287600_B97
  article-title: Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol
  publication-title: J Mol Neurosci
  doi: 10.1385/JMN:20:3:395
– volume: 27
  start-page: 8836
  year: 2007
  ident: 2020071613163287600_B53
  article-title: Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0910-07.2007
– volume: 30
  start-page: 6058
  year: 2010
  ident: 2020071613163287600_B74
  article-title: Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3956-09.2010
– volume: 120
  start-page: 76
  year: 2010
  ident: 2020071613163287600_B3
  article-title: Mechanisms and resistance in glucocorticoid control of inflammation
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2010.02.018
– volume: 209
  start-page: 2304
  year: 2006
  ident: 2020071613163287600_B98
  article-title: Neuron-glia metabolic coupling and plasticity
  publication-title: J Exp Biol
  doi: 10.1242/jeb.02208
– volume: 13
  start-page: 171
  year: 1992
  ident: 2020071613163287600_B82
  article-title: Do glucocorticoid concentrations rise with age in the rat?
  publication-title: Neurobiol Aging
  doi: 10.1016/0197-4580(92)90025-S
– volume: 1150
  start-page: 14
  year: 2007
  ident: 2020071613163287600_B89
  article-title: Rapid glucocorticoid effects on the expression of hippocampal neurotransmission-related genes
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2007.02.083
– volume: 106
  start-page: 14670
  year: 2009
  ident: 2020071613163287600_B117
  article-title: Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0903563106
– volume: 302
  start-page: 230
  year: 2009
  ident: 2020071613163287600_B35
  article-title: Angiotensin II regulation of adrenocortical gene transcription
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2008.08.024
– volume: 49
  start-page: 158
  year: 2013
  ident: 2020071613163287600_B103
  article-title: Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.10.013
– volume: 272
  start-page: 14087
  year: 1997
  ident: 2020071613163287600_B106
  article-title: Androgen and glucocorticoid receptor heterodimer formation. A possible mechanism for mutual inhibition of transcriptional activity
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.22.14087
– volume: 87
  start-page: 873
  year: 2007
  ident: 2020071613163287600_B9
  article-title: Physiology and neurobiology of stress and adaptation: central role of the brain
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00041.2006
– volume: 1
  start-page: 3
  year: 1998
  ident: 2020071613163287600_B19
  article-title: Stress hormones and brain aging: adding injury to insult?
  publication-title: Nat Neurosci
  doi: 10.1038/196
– volume: 18
  start-page: 239
  year: 2006
  ident: 2020071613163287600_B47
  article-title: Acute activation of hippocampal glucocorticoid receptors results in different waves of gene expression throughout time
  publication-title: J Neuroendocrinol
  doi: 10.1111/j.1365-2826.2006.01413.x
– volume: 63
  start-page: 278
  year: 2013
  ident: 2020071613163287600_B29
  article-title: Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy
  publication-title: Horm Behav
  doi: 10.1016/j.yhbeh.2012.03.013
– volume: 4
  start-page: 141
  year: 2005
  ident: 2020071613163287600_B13
  article-title: The stress system in the human brain in depression and neurodegeneration
  publication-title: Ageing Res Rev
  doi: 10.1016/j.arr.2005.03.003
– volume: 29
  start-page: 191
  year: 2006
  ident: 2020071613163287600_B48
  article-title: Age-related changes in neuroprotection: is estrogen pro-inflammatory for the reproductive senescent brain?
  publication-title: Endocrine
  doi: 10.1385/ENDO:29:2:191
– volume: 308
  start-page: 17
  year: 2009
  ident: 2020071613163287600_B27
  article-title: Control of CNS neuronal excitability by estrogens via membrane-initiated signaling
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2009.03.008
– volume: 583
  start-page: 272
  year: 2008
  ident: 2020071613163287600_B46
  article-title: Central corticosteroid actions: search for gene targets
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2007.11.070
– volume: 368
  start-page: 770
  year: 2013
  ident: 2020071613163287600_B116
  article-title: Neuroinflammatory cytokine signaling and Alzheimer's disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMcibr1214546
– volume: 1800
  start-page: 1121
  year: 2010
  ident: 2020071613163287600_B109
  article-title: Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbagen.2010.06.002
– volume: 93
  start-page: 365
  year: 1992
  ident: 2020071613163287600_B18
  article-title: Re-examination of the glucocorticoid hypothesis of stress and aging
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(08)64585-9
– volume: 62
  start-page: 527
  year: 2012
  ident: 2020071613163287600_B122
  article-title: Hippocampal GR expression is increased in elderly depressed females
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2011.09.014
– volume: 178
  start-page: 339
  year: 2003
  ident: 2020071613163287600_B107
  article-title: Glucocorticoid resistance in inflammatory bowel disease
  publication-title: J Endocrinol
  doi: 10.1677/joe.0.1780339
– volume: 111
  start-page: 17
  year: 2003
  ident: 2020071613163287600_B45
  article-title: Gene expression changes in single dentate granule neurons after adrenalectomy of rats
  publication-title: Brain Res Mol Brain Res
  doi: 10.1016/S0169-328X(02)00665-4
– volume: 1069
  start-page: 1
  year: 2006
  ident: 2020071613163287600_B104
  article-title: The physiology of human glucocorticoid receptor β (hGRβ) and glucocorticoid resistance
  publication-title: Ann NY Acad Sci
  doi: 10.1196/annals.1351.001
– volume: 33
  start-page: 1258
  year: 2012
  ident: 2020071613163287600_B65
  article-title: Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2011.02.011
– volume: 29
  start-page: S21
  year: 2009
  ident: 2020071613163287600_B22
  article-title: Glucocorticoids and their actions in cells
  publication-title: Retina
  doi: 10.1097/IAE.0b013e3181ad2636
– volume: 24
  start-page: S21
  year: 2001
  ident: 2020071613163287600_B114
  article-title: Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction
  publication-title: Trends Neurosci
  doi: 10.1016/S0166-2236(00)01957-3
– volume: 34
  start-page: 159
  year: 2010
  ident: 2020071613163287600_B41
  article-title: Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus
  publication-title: Prog Neuropsychopharmacol Biol Psychiatry
  doi: 10.1016/j.pnpbp.2009.10.018
– volume: 1215
  start-page: 1
  year: 2008
  ident: 2020071613163287600_B95
  article-title: Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2008.03.080
– volume: 170
  start-page: 633
  year: 2010
  ident: 2020071613163287600_B85
  article-title: Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.07.011
– volume: 583
  start-page: 174
  year: 2008
  ident: 2020071613163287600_B6
  article-title: Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2007.11.071
– volume: 153
  start-page: 75
  year: 2006
  ident: 2020071613163287600_B14
  article-title: Glucocorticoids, chronic stress, and obesity
  publication-title: Prog Brain Res
  doi: 10.1016/S0079-6123(06)53004-3
– volume: 31
  start-page: 538
  year: 2011
  ident: 2020071613163287600_B99
  article-title: Regulation of oligodendrocyte development and myelination by glucose and lactate
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3516-10.2011
– volume: 136
  start-page: 4517
  year: 1995
  ident: 2020071613163287600_B67
  article-title: Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress
  publication-title: Endocrinology
  doi: 10.1210/endo.136.10.7664672
– volume: 109
  start-page: 11776
  year: 2012
  ident: 2020071613163287600_B102
  article-title: Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1206059109
– volume: 7
  start-page: 284
  year: 1986
  ident: 2020071613163287600_B17
  article-title: The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis
  publication-title: Endocr Rev
  doi: 10.1210/edrv-7-3-284
– volume: 19
  start-page: 331
  year: 2008
  ident: 2020071613163287600_B100
  article-title: Tissue-specific glucocorticoid action: a family affair
  publication-title: Trends Endocrinol Metab
  doi: 10.1016/j.tem.2008.07.009
– volume: 239
  start-page: 766
  year: 1988
  ident: 2020071613163287600_B12
  article-title: Effect of neonatal handling on age-related impairments associated with the hippocampus
  publication-title: Science
  doi: 10.1126/science.3340858
– volume: 14
  start-page: 398
  year: 2011
  ident: 2020071613163287600_B31
  article-title: Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis
  publication-title: Stress
  doi: 10.3109/10253890.2011.586446
– volume: 20
  start-page: 1405
  year: 2006
  ident: 2020071613163287600_B26
  article-title: Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
  publication-title: Genes Dev
  doi: 10.1101/gad.1424806
– volume: 6
  start-page: e18387
  year: 2011
  ident: 2020071613163287600_B70
  article-title: Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0018387
– volume: 275
  start-page: 62
  year: 2007
  ident: 2020071613163287600_B5
  article-title: Glucocorticoids in the control of neuroinflammation
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2007.03.007
– volume: 10
  start-page: 613
  year: 2010
  ident: 2020071613163287600_B24
  article-title: Glucocorticoid receptor cofactors as therapeutic targets
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2010.08.001
– volume: 4
  start-page: 24
  year: 2012
  ident: 2020071613163287600_B120
  article-title: Local amplification of glucocorticoids in the aging brain and impaired spatial memory
  publication-title: Front Aging Neurosci
  doi: 10.3389/fnagi.2012.00024
– volume: 21
  start-page: 781
  year: 2001
  ident: 2020071613163287600_B105
  article-title: Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.21.3.781-793.2001
– volume: 21
  start-page: 530
  year: 1987
  ident: 2020071613163287600_B115
  article-title: Neocortical cell counts in normal human adult aging
  publication-title: Ann Neurol
  doi: 10.1002/ana.410210603
– reference: 20633608 - Neuroscience. 2010 Oct 13;170(2):633-44
– reference: 17615391 - Physiol Rev. 2007 Jul;87(3):873-904
– reference: 15996533 - Ageing Res Rev. 2005 May;4(2):141-94
– reference: 12824416 - Nucleic Acids Res. 2003 Jul 1;31(13):3775-81
– reference: 15474586 - Int Rev Neurobiol. 2004;60:25-58
– reference: 9030643 - J Neurosci. 1997 Mar 1;17(5):1848-59
– reference: 9215274 - J Clin Endocrinol Metab. 1997 Jul;82(7):2070-5
– reference: 17430248 - Curr Alzheimer Res. 2007 Apr;4(2):205-12
– reference: 20538040 - Biochim Biophys Acta. 2010 Oct;1800(10):1121-6
– reference: 3527687 - Endocr Rev. 1986 Aug;7(3):284-301
– reference: 3340858 - Science. 1988 Feb 12;239(4841 Pt 1):766-8
– reference: 3032584 - Endocrinology. 1987 Jun;120(6):2308-15
– reference: 19147677 - Endocrinology. 2009 May;150(5):2308-16
– reference: 22498694 - Horm Behav. 2013 Feb;63(2):278-83
– reference: 2170594 - J Neurosci. 1990 Oct;10(10):3247-54
– reference: 19317179 - Rev Neurosci. 2008;19(6):395-411
– reference: 22952463 - Front Aging Neurosci. 2012 Aug 29;4:24
– reference: 17383615 - Brain Res. 2007 May 30;1150:14-20
– reference: 16484373 - Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3480-5
– reference: 10802651 - Nat Genet. 2000 May;25(1):25-9
– reference: 15128270 - J Endocrinol. 2004 May;181(2):207-21
– reference: 1480759 - Prog Brain Res. 1992;93:365-81; discussion 382-3
– reference: 19549588 - Mol Cell Endocrinol. 2009 Sep 24;308(1-2):17-25
– reference: 3606042 - Ann Neurol. 1987 Jun;21(6):530-9
– reference: 19211887 - J Neurosci. 2009 Feb 11;29(6):1805-16
– reference: 16785595 - Endocrine. 2006 Apr;29(2):191-7
– reference: 1542376 - Neurobiol Aging. 1992 Jan-Feb;13(1):171-4
– reference: 21149445 - J Biol Chem. 2011 Feb 4;286(5):3177-84
– reference: 21483696 - PLoS One. 2011;6(4):e18387
– reference: 22753499 - Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11776-81
– reference: 715460 - Science. 1978 Dec 8;202(4372):1098-102
– reference: 19667196 - Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14670-5
– reference: 14501024 - J Mol Neurosci. 2003;20(3):395-406
– reference: 16943563 - J Neurosci. 2006 Aug 30;26(35):9047-56
– reference: 23127816 - Steroids. 2013 Jan;78(1):59-68
– reference: 21228163 - J Neurosci. 2011 Jan 12;31(2):538-48
– reference: 6270791 - Science. 1981 Oct 30;214(4520):581-4
– reference: 16054244 - Trends Neurosci. 2005 Sep;28(9):456-63
– reference: 17151169 - Am J Psychiatry. 2006 Dec;163(12):2164-9
– reference: 19131956 - Nat Protoc. 2009;4(1):44-57
– reference: 21976528 - J Neurosci. 2011 Oct 5;31(40):14436-49
– reference: 23023031 - Pharmacol Rev. 2012 Oct;64(4):901-38
– reference: 2781293 - Science. 1989 Sep 29;245(4925):1505-9
– reference: 18685105 - Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11394-9
– reference: 7825905 - Ann N Y Acad Sci. 1994 Nov 30;746:42-61; discussion 61-3
– reference: 16388891 - Mol Cell Endocrinol. 2006 Feb 26;246(1-2):142-6
– reference: 10195096 - Nat Neurosci. 1998 May;1(1):3-4
– reference: 23159735 - Mol Cell. 2013 Jan 10;49(1):158-71
– reference: 17609497 - Endocr Rev. 2007 Aug;28(5):575-87
– reference: 21184481 - Hippocampus. 2012 Feb;22(2):359-71
– reference: 16876569 - Prog Brain Res. 2006;153:75-105
– reference: 19932757 - Neurobiol Learn Mem. 2010 Mar;93(3):312-21
– reference: 11704419 - Eur Neuropsychopharmacol. 2001 Dec;11(6):423-30
– reference: 18805703 - Trends Endocrinol Metab. 2008 Nov;19(9):331-9
– reference: 15379669 - Curr Pharm Des. 2004;10(23):2807-16
– reference: 22801547 - Cell Cycle. 2012 Aug 1;11(15):2819-27
– reference: 16751179 - Genes Dev. 2006 Jun 1;20(11):1405-28
– reference: 15677396 - Ann N Y Acad Sci. 2004 Dec;1032:63-84
– reference: 19401723 - Nat Rev Neurosci. 2009 Jun;10(6):434-45
– reference: 15240363 - Ann N Y Acad Sci. 2004 Jun;1018:141-50
– reference: 17376971 - J Neurosci. 2007 Mar 21;27(12):3098-110
– reference: 12734009 - Genome Biol. 2003;4(5):P3
– reference: 11158007 - J Clin Endocrinol Metab. 2001 Feb;86(2):545-50
– reference: 22553043 - J Neurosci. 2012 May 2;32(18):6391-410
– reference: 18495785 - J Leukoc Biol. 2008 Oct;84(4):932-9
– reference: 12654501 - Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):17-23
– reference: 18067954 - Front Neuroendocrinol. 2008 May;29(2):268-72
– reference: 15681803 - Ann N Y Acad Sci. 2004 Dec;1035:104-16
– reference: 19553792 - Retina. 2009 Jun;29(6 Suppl):S21-3
– reference: 23425171 - N Engl J Med. 2013 Feb 21;368(8):770-1
– reference: 20189687 - Neurobiol Aging. 2011 Dec;32(12):2198-210
– reference: 16855130 - Ann N Y Acad Sci. 2006 Jun;1069:1-9
– reference: 16257272 - Ageing Res Rev. 2005 Nov;4(4):481-512
– reference: 9162033 - J Biol Chem. 1997 May 30;272(22):14087-92
– reference: 11154266 - Mol Cell Biol. 2001 Feb;21(3):781-93
– reference: 9158068 - Neuroendocrinology. 1997 May;65(5):360-8
– reference: 18812209 - Mol Cell Endocrinol. 2009 Apr 29;302(2):230-6
– reference: 21945289 - Neuropharmacology. 2012 Jan;62(1):527-33
– reference: 11881742 - Trends Neurosci. 2001 Nov;24(11 Suppl):S21-31
– reference: 18485334 - Brain Res. 2008 Jun 18;1215:1-10
– reference: 2998738 - Endocrinology. 1985 Dec;117(6):2505-11
– reference: 18295201 - Eur J Pharmacol. 2008 Apr 7;583(2-3):272-89
– reference: 17593876 - Rev Neurosci. 2007;18(2):137-48
– reference: 7825872 - Ann N Y Acad Sci. 1994 Nov 30;746:145-54; discussion 154-6
– reference: 19249343 - Exp Gerontol. 2009 May;44(5):335-43
– reference: 17699665 - J Neurosci. 2007 Aug 15;27(33):8836-44
– reference: 9626555 - Endocr Rev. 1998 Jun;19(3):269-301
– reference: 3998818 - J Neurosci. 1985 May;5(5):1222-7
– reference: 15980575 - Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W741-8
– reference: 21458888 - Neurobiol Aging. 2012 Jul;33(7):1258-64
– reference: 16556968 - J Alzheimers Dis. 2005 Mar;8(4):369-75
– reference: 2027050 - J Neurosci. 1991 May;11(5):1316-24
– reference: 21613497 - J Neurosci. 2011 May 25;31(21):7840-7
– reference: 19819960 - Endocrinology. 2009 Dec;150(12):5498-508
– reference: 16731806 - J Exp Biol. 2006 Jun;209(Pt 12):2304-11
– reference: 2765916 - Brain Res. 1989 Aug 7;494(1):159-61
– reference: 12967327 - J Endocrinol. 2003 Sep;178(3):339-46
– reference: 7664672 - Endocrinology. 1995 Oct;136(10):4517-25
– reference: 17555867 - Mol Cell Endocrinol. 2007 Sep 15;275(1-2):62-70
– reference: 20801081 - Curr Opin Pharmacol. 2010 Dec;10(6):613-9
– reference: 18282566 - Eur J Pharmacol. 2008 Apr 7;583(2-3):174-85
– reference: 20188830 - J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):76-85
– reference: 18256261 - J Neurosci. 2008 Feb 6;28(6):1410-20
– reference: 20427664 - J Neurosci. 2010 Apr 28;30(17):6058-71
– reference: 19883713 - Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):159-65
– reference: 12476345 - J Neurovirol. 2002 Dec;8(6):496-512
– reference: 21756998 - J Chem Neuroanat. 2011 Oct;42(2):118-26
– reference: 17803971 - Brain Res. 2007 Oct 3;1172:48-59
– reference: 21663538 - Stress. 2011 Jul;14(4):398-406
– reference: 17784955 - Genome Biol. 2007;8(9):R183
– reference: 16113442 - Proc Am Thorac Soc. 2004;1(3):247-54
– reference: 12736351 - J Neurosci. 2003 May 1;23(9):3807-19
– reference: 19782411 - Trends Neurosci. 2009 Dec;32(12):638-47
– reference: 20544861 - Glia. 2010 Aug;58(10):1257-66
– reference: 19906238 - Ann N Y Acad Sci. 2009 Oct;1179:153-66
– reference: 2218183 - Stat Med. 1990 Jul;9(7):811-8
– reference: 3303130 - Prog Brain Res. 1987;72:279-300
– reference: 16503919 - J Neuroendocrinol. 2006 Apr;18(4):239-52
– reference: 11438584 - J Neurosci. 2001 Jul 15;21(14):5089-98
– reference: 20532976 - Cell Mol Neurobiol. 2010 Oct;30(7):1035-47
– reference: 22192838 - Neuroscience. 2012 Jan 27;202:1-9
– reference: 18774188 - Trends Neurosci. 2008 Oct;31(10):529-37
SSID ssj0014443
Score 2.2525485
Snippet Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover,...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
oup
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2807
SubjectTerms Adrenalectomy
Aging
Aging - genetics
Alzheimer's disease
Animals
Biological and medical sciences
Biosynthesis
Blood levels
Body Weight - drug effects
Brain
CA1 Region, Hippocampal - metabolism
Cholesterol
Corticosterone
Corticosterone - blood
Corticosterone - pharmacology
DNA microarrays
Drinking - drug effects
Drug Implants
Eating - drug effects
Fundamental and applied biological sciences. Psychology
Gene expression
Gene regulation
Genes
Glial Fibrillary Acidic Protein - genetics
Glial Fibrillary Acidic Protein - metabolism
Glucocorticoid receptors
Glucocorticoids
Glucocorticoids - pharmacology
Glucose metabolism
Hippocampus
Hypotheses
Immunohistochemistry
Inflammation
Lipid metabolism
Male
Males
Neurodegenerative diseases
Neuroendocrinology
Neuronal-glial interactions
Oligonucleotide Array Sequence Analysis
Phenotypes
Rats
Rats, Inbred F344
Receptors, Glucocorticoid - genetics
Receptors, Glucocorticoid - metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction - genetics
Transcriptome - drug effects
Transcriptomes
Vertebrates: endocrinology
Title Glucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations With Aging
URI https://www.ncbi.nlm.nih.gov/pubmed/23736296
https://www.proquest.com/docview/3130622035
https://www.proquest.com/docview/1411627747
https://pubmed.ncbi.nlm.nih.gov/PMC3713214
Volume 154
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1945-7170
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0014443
  issn: 0013-7227
  databaseCode: KQ8
  dateStart: 19970101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1945-7170
  dateEnd: 20240930
  omitProxy: true
  ssIdentifier: ssj0014443
  issn: 0013-7227
  databaseCode: DIK
  dateStart: 19970101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 1945-7170
  dateEnd: 20240930
  omitProxy: true
  ssIdentifier: ssj0014443
  issn: 0013-7227
  databaseCode: GX1
  dateStart: 19970101
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkBASQrBxKYzJSLCXylMuTpzwNpWNwS5IqJX6FjkXL5W6NNBGqPwGfjTnxEmajFYavLRVYjlRv8_H5xyfCyHvhIpho4sUS7jBGfdDn0lHcgZ2WKgMGftcokP_8so9G_MvE2fS6_1uRS0Vy_Ao-rUxr-R_UIVrgCtmyf4Dss2kcAF-A77wCQjD550w_oTx5mA-wo35NGZ1Q9vlIJ3mOWxSsNQxlBx2o1I2zG_KCiE3sCcMAPgyGA47Ev-UK4YZlxg1NCiPz6v4OJ34dl3vbrUDP4vnMJ92yKOGik4ZrDaZpxh523gWhlXix3mRrNgwLRrLfyZnLSm89sdirSiZsW-ySAsdRYKNRPEd1vuCjKeLVAu2a9l2WWD7CK92WWgp63OHgR2pD2SSDddq0awLTFcc9NqC1tPNcv_aAcCELblwVD7YNHWppG6h7auvwen44iIYnUxGh_l3hj3I8Ky-ashyj9y3hOtiP4yPn8-bMynOdbpG_aJVGgXmQLUf11FwdNLko1wuYMUp3Splky1zOyS3peOMnpDHlXFCjzXTnpJeku2SveNMAnVW9JCW4cIl7LvkwWUVlbFH0m08pC0e0g4P6TSjyEOKPPxAb7OQtlhIkYW0ZOEzMj49GQ3PWNXBg0Vc8CWLrNhWoXS8SHiJo2IJ-rsKOVeJa7qGF0a27xm2JSLPUrEZKlCvYz-2Ek9aXhJGyn5OdrJ5lrwk1PKUpaQhYuXEYDIboROBpRHBN_eFb6o-GdR_exBV5e2xy8osQDMXQAKBESBIAYLUJ--b0bku67JlHAUEtw1heshBB95msCUcUM9d0Sf7Nd5BJTwWgQ26o2tZhu30ydvmNoh2PK-TWTIvFmCVm6ZrgX0GU7zQ9FhPbgtQPX23T0SHOM0ALBvfvZNN07J8vC1M7E726g7PfU0ertfvPtlZ_iiSN6CEL8ODcm38Ad0H4kY
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Glucocorticoid-dependent+hippocampal+transcriptome+in+male+rats%3A+pathway-specific+alterations+with+aging&rft.jtitle=Endocrinology+%28Philadelphia%29&rft.au=Chen%2C+Kuey-Chu&rft.au=Blalock%2C+Eric+M&rft.au=Curran-Rauhut%2C+Meredith+A&rft.au=Kadish%2C+Inga&rft.date=2013-08-01&rft.issn=1945-7170&rft.eissn=1945-7170&rft.volume=154&rft.issue=8&rft.spage=2807&rft_id=info:doi/10.1210%2Fen.2013-1139&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0013-7227&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0013-7227&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0013-7227&client=summon