Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer

Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor encoded by the NFE2L2 gene , which can accelerate the detoxification of electrophil...

Full description

Saved in:
Bibliographic Details
Published inBritish journal of cancer Vol. 126; no. 9; pp. 1244 - 1252
Main Authors Camiña, Nuria, Penning, Trevor M.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 18.05.2022
Nature Publishing Group
Subjects
631/67/1612
692/4028/67
Adaptor proteins
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinogens
Detoxification
DNA Methylation
Drug Resistance
Epidemiology
Epigenesis, Genetic
Epigenetics
Histones
Humans
Kelch-Like ECH-Associated Protein 1 - genetics
Kelch-Like ECH-Associated Protein 1 - metabolism
Lung cancer
Lung Neoplasms - genetics
miRNA
Molecular Medicine
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
Oncology
Oxidative stress
Oxidative Stress - genetics
Review
Review Article
Signal transduction
Tumorigenesis
Online AccessGet full text
ISSN0007-0920
1532-1827
1532-1827
DOI10.1038/s41416-021-01642-0

Cover

Abstract Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor encoded by the NFE2L2 gene , which can accelerate the detoxification of electrophilic carcinogens and prevent cancer and on the other hand in certain exposure contexts may exacerbate the carcinogenic process. NRF2-target genes activated under these conditions can be used as biomarkers of stress signalling, while activation of NRF2 can also reveal the epigenetic mechanisms that modulate NFE2L2 expression. Epigenetic mechanisms that regulate NFE2L2 and the gene for its adaptor protein KEAP1 include DNA methylation, histone modifications and microRNA. Understanding the activation of the NRF2-KEAP1 signalling pathway in human lung cancer, its epigenetic regulation and its role in oncogenesis is the subject of this review.
AbstractList Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor encoded by the NFE2L2 gene, which can accelerate the detoxification of electrophilic carcinogens and prevent cancer and on the other hand in certain exposure contexts may exacerbate the carcinogenic process. NRF2-target genes activated under these conditions can be used as biomarkers of stress signalling, while activation of NRF2 can also reveal the epigenetic mechanisms that modulate NFE2L2 expression. Epigenetic mechanisms that regulate NFE2L2 and the gene for its adaptor protein KEAP1 include DNA methylation, histone modifications and microRNA. Understanding the activation of the NRF2-KEAP1 signalling pathway in human lung cancer, its epigenetic regulation and its role in oncogenesis is the subject of this review.
Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor encoded by the NFE2L2 gene , which can accelerate the detoxification of electrophilic carcinogens and prevent cancer and on the other hand in certain exposure contexts may exacerbate the carcinogenic process. NRF2-target genes activated under these conditions can be used as biomarkers of stress signalling, while activation of NRF2 can also reveal the epigenetic mechanisms that modulate NFE2L2 expression. Epigenetic mechanisms that regulate NFE2L2 and the gene for its adaptor protein KEAP1 include DNA methylation, histone modifications and microRNA. Understanding the activation of the NRF2-KEAP1 signalling pathway in human lung cancer, its epigenetic regulation and its role in oncogenesis is the subject of this review.
Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor encoded by the NFE2L2 gene, which can accelerate the detoxification of electrophilic carcinogens and prevent cancer and on the other hand in certain exposure contexts may exacerbate the carcinogenic process. NRF2-target genes activated under these conditions can be used as biomarkers of stress signalling, while activation of NRF2 can also reveal the epigenetic mechanisms that modulate NFE2L2 expression. Epigenetic mechanisms that regulate NFE2L2 and the gene for its adaptor protein KEAP1 include DNA methylation, histone modifications and microRNA. Understanding the activation of the NRF2-KEAP1 signalling pathway in human lung cancer, its epigenetic regulation and its role in oncogenesis is the subject of this review.Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor encoded by the NFE2L2 gene, which can accelerate the detoxification of electrophilic carcinogens and prevent cancer and on the other hand in certain exposure contexts may exacerbate the carcinogenic process. NRF2-target genes activated under these conditions can be used as biomarkers of stress signalling, while activation of NRF2 can also reveal the epigenetic mechanisms that modulate NFE2L2 expression. Epigenetic mechanisms that regulate NFE2L2 and the gene for its adaptor protein KEAP1 include DNA methylation, histone modifications and microRNA. Understanding the activation of the NRF2-KEAP1 signalling pathway in human lung cancer, its epigenetic regulation and its role in oncogenesis is the subject of this review.
Author Penning, Trevor M.
Camiña, Nuria
Author_xml – sequence: 1
  givenname: Nuria
  orcidid: 0000-0002-0714-7705
  surname: Camiña
  fullname: Camiña, Nuria
  organization: Department of Systems Pharmacology & Translational Therapeutics, Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania
– sequence: 2
  givenname: Trevor M.
  orcidid: 0000-0002-3937-1066
  surname: Penning
  fullname: Penning, Trevor M.
  email: penning@upenn.edu
  organization: Department of Systems Pharmacology & Translational Therapeutics, Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34845361$$D View this record in MEDLINE/PubMed
BookMark eNqNUU1v1DAUtFAR3Rb-AAdkiQsXw_NHPnxBqqq2ICqoEJwtx3nJuso6wU6o9t_jdhcKPVScrCfPzJs3c0QOwhiQkJcc3nKQ9bukuOIlA8EZ8FIJBk_IihdSMF6L6oCsAKBioAUckqOUrvOooa6ekUOpalXIkq_I1QUGnL2jNrQUJ9_vx4j9MtjZj4GOHZ3XSD9_PRfs09nJFaeTndc3dkt9oOtlYwMdltBTZ4PD-Jw87eyQ8MX-PSbfz8--nX5gl18uPp6eXDKnKjUzxzlAB0XT6qrtbNvYymKlsSudFtKVsmu5brWSgnOsG910IMsWNQoQTeFAHhO5013CZLc3dhjMFP3Gxq3hYG7zMbt8TM7H3OVjblnvd6xpaTbYOgxztPfM0Xrz70_wa9OPP40GJbSUWeDNXiCOPxZMs9n45HAYbMBxSUaUoGrJtaoy9PUD6PW4xJBDyagi11TIqsioV387-mPld0UZIHYAF8eUInb_d2f9gOT8fFdnvsoPj1P3waa8J_QY720_wvoFff3EAA
CitedBy_id crossref_primary_10_1093_nar_gkad614
crossref_primary_10_1016_j_phymed_2023_154943
crossref_primary_10_3390_antiox12030641
crossref_primary_10_3389_fonc_2022_1016894
crossref_primary_10_1002_advs_202202039
crossref_primary_10_1002_qua_27274
crossref_primary_10_1016_j_hlife_2023_12_002
crossref_primary_10_1007_s12035_023_03370_3
crossref_primary_10_1155_2022_7845503
crossref_primary_10_1016_j_apsb_2024_10_015
crossref_primary_10_3390_nu16132045
crossref_primary_10_3390_biom15010113
crossref_primary_10_3390_cancers15153980
crossref_primary_10_1016_j_fbio_2023_103518
crossref_primary_10_3390_nu16213741
crossref_primary_10_3389_fonc_2022_968804
crossref_primary_10_1134_S1990519X2470024X
crossref_primary_10_3389_fonc_2024_1381467
crossref_primary_10_1016_j_jtho_2023_07_016
crossref_primary_10_31857_S0041377124010044
Cites_doi 10.1155/2019/9372182
10.1146/annurev.pa.34.040194.001031
10.1021/tx050217c
10.1186/s13045-016-0311-0
10.1089/ars.2014.6074
10.1038/bjc.2016.363
10.1158/1078-0432.CCR-14-1087
10.3390/ht7020012
10.1155/2019/6175804
10.2147/CIA.S158513
10.1016/j.tibs.2008.12.008
10.1016/j.molmed.2016.05.002
10.1158/0008-5472.CAN-07-5003
10.1158/1078-0432.CCR-09-3352
10.3389/fendo.2018.00093
10.3892/ol.2013.1427
10.1016/j.etp.2005.05.010
10.1136/thorax.58.12.1071
10.1073/pnas.0914036107
10.1016/j.freeradbiomed.2015.05.034
10.1016/j.freeradbiomed.2015.06.021
10.1126/scisignal.2004088
10.3389/fphys.2020.00694
10.3389/fonc.2017.00085
10.1016/j.cub.2014.03.034
10.4137/IJTR.S19985
10.1021/acschembio.6b00651
10.1093/carcin/bgn095
10.1073/pnas.1305687110
10.1007/s00280-016-3225-1
10.1158/0008-5472.CAN-04-4539
10.1038/s41419-019-2031-1
10.1038/ncomms12914
10.1056/NEJMp1607591
10.1007/s40495-014-0013-7
10.1016/j.biocel.2009.12.022
10.3390/molecules26051417
10.18632/aging.103068
10.1038/nature11404
10.1021/tx100052d
10.29252/rbmb.9.1.33
10.1021/acs.chemrestox.8b00250
10.1016/j.cotox.2016.10.008
10.1128/MCB.26.1.221-229.2006
10.1371/journal.pmed.0030420
10.1158/0008-5472.CAN-10-2939
10.1038/s41598-018-26269-9
10.1093/carcin/bgp231
10.1016/j.cell.2018.03.035
10.1016/j.taap.2014.04.027
10.1038/onc.2017.236
10.3390/ijms21020545
10.1016/j.redox.2020.101475
10.1038/nature10189
10.1016/j.abb.2016.08.005
10.1186/1471-2164-9-259
10.1093/annonc/mdz072.015
10.1002/med.21257
10.1111/j.1349-7006.2012.02216.x
10.1038/nrc3572
10.1165/rcmb.2013-0159RC
10.1158/2159-8290.CD-17-0716
10.1016/j.semcancer.2021.05.016
10.1016/j.freeradbiomed.2015.06.013
10.1016/j.plipres.2017.06.001
10.1016/j.molcel.2009.04.029
10.1038/s41598-017-11471-y
10.1016/j.omto.2018.10.002
10.3390/cancers12103023
10.1016/j.redox.2012.10.001
10.1158/1940-6207.CAPR-08-0047
10.1016/j.molcel.2006.01.013
10.1016/j.bbrc.2008.06.004
10.1093/carcin/bgp100
10.1146/annurev.pa.35.040195.001515
10.1038/s41467-019-12164-y
10.1158/2159-8290.CD-12-0095
10.1089/ars.2010.3273
10.1038/s41598-019-40963-2
10.1016/j.semcancer.2021.06.003
10.4049/jimmunol.1301984
10.1006/bbrc.1997.6943
10.1038/s41598-017-14520-8
10.1158/1078-0432.CCR-17-3416
10.1089/ars.2010.3221
10.1021/acs.chemrestox.9b00399
10.3390/ijms20112697
10.1016/j.bbrc.2012.10.010
10.1074/jbc.M112028200
10.1021/tx500298n
10.1016/j.febslet.2014.05.057
10.1101/799676
10.1016/B978-0-12-398339-8.00002-1
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer Nature Limited 2021
2021. The Author(s), under exclusive licence to Springer Nature Limited.
The Author(s), under exclusive licence to Springer Nature Limited 2021.
Copyright_xml – notice: The Author(s), under exclusive licence to Springer Nature Limited 2021
– notice: 2021. The Author(s), under exclusive licence to Springer Nature Limited.
– notice: The Author(s), under exclusive licence to Springer Nature Limited 2021.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7RV
7TO
7U9
7X7
7XB
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AN0
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB0
LK8
M0S
M1P
M7P
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
ADTOC
UNPAY
DOI 10.1038/s41416-021-01642-0
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Nursing & Allied Health Database
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
British Nursing Database
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Nursing & Allied Health Premium
Proquest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
Unpaywall for CDI: Periodical Content
Unpaywall
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Public Health
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
British Nursing Index with Full Text
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE

MEDLINE - Academic

ProQuest Central Student
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: UNPAY
  name: Unpaywall
  url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/
  sourceTypes: Open Access Repository
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1532-1827
EndPage 1252
ExternalDocumentID oai:pubmedcentral.nih.gov:9042933
PMC9042933
34845361
10_1038_s41416_021_01642_0
Genre Journal Article
Review
GrantInformation_xml – fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH)
  grantid: P30-ES013508; R01-ES029294
  funderid: https://doi.org/10.13039/100000002
– fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH)
– fundername: NIEHS NIH HHS
  grantid: P30 ES013508
– fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH)
  grantid: R01-ES029294
– fundername: NIEHS NIH HHS
  grantid: R01 ES029294
– fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH)
  grantid: P30-ES013508
– fundername: ;
– fundername: ;
  grantid: P30-ES013508; R01-ES029294
GroupedDBID ---
0R~
23N
36B
39C
4.4
406
53G
5GY
5RE
6J9
70F
7RV
7X7
88E
8AO
8C1
8FI
8FJ
8R4
8R5
AACDK
AANZL
AASML
AATNV
AAWTL
AAYZH
AAZLF
ABAKF
ABLJU
ABOCM
ABUWG
ABZZP
ACAOD
ACGFO
ACGFS
ACKTT
ACPRK
ACRQY
ACZOJ
ADBBV
ADFRT
ADHDB
AEFQL
AEJRE
AEMSY
AENEX
AEVLU
AEXYK
AFBBN
AFKRA
AFRAH
AFSHS
AGAYW
AGHAI
AGQEE
AHMBA
AHSBF
AIGIU
AILAN
AJRNO
ALFFA
ALMA_UNASSIGNED_HOLDINGS
AMYLF
AN0
AOIJS
ASPBG
AVWKF
AXYYD
AZFZN
BAWUL
BBNVY
BENPR
BHPHI
BKEYQ
BKKNO
BNQBC
BPHCQ
BVXVI
CCPQU
CS3
DIK
DNIVK
DPUIP
DU5
E3Z
EAP
EBLON
EBS
EE.
EIOEI
EMB
ESX
EX3
F5P
FDQFY
FEDTE
FERAY
FIGPU
FRJ
FSGXE
FYUFA
GX1
HCIFZ
HMCUK
HVGLF
HYE
HZ~
IH2
IWAJR
JSO
JZLTJ
KQ8
M1P
M7P
NAPCQ
NQJWS
O9-
OK1
P2P
PQQKQ
PROAC
PSQYO
Q2X
RNT
RNTTT
ROL
RPM
SNX
SNYQT
SOHCF
SOJ
SRMVM
SWTZT
TAOOD
TBHMF
TDRGL
TR2
UKHRP
W2D
WH7
WOW
~02
AAFWJ
AAYXX
ABBRH
ABDBE
ABFSG
ABRTQ
ACSTC
AEZWR
AFDZB
AFHIU
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
PUEGO
-Q-
.55
.GJ
8WZ
A6W
ABAWZ
ABDBF
ACUHS
AI.
B0M
CAG
CGR
COF
CUY
CVF
EAD
EAS
EBC
EBD
ECM
EIF
EJD
EMK
EMOBN
EPL
FIZPM
J5H
M41
NPM
PHGZT
SV3
TUS
UDS
VH1
X7M
Y6R
ZGI
~8M
3V.
7TO
7U9
7XB
8FE
8FH
8FK
AZQEC
DWQXO
GNUQQ
H94
K9.
LK8
PHGZM
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
7X8
5PM
ADTOC
UNPAY
ID FETCH-LOGICAL-c474t-c1100f05bd97dfadba7ae79ef6c923c63fd19d943211e8b9bf036de9e202b5c03
IEDL.DBID 7X7
ISSN 0007-0920
1532-1827
IngestDate Wed Aug 20 00:20:48 EDT 2025
Tue Sep 30 17:18:09 EDT 2025
Fri Sep 05 05:29:54 EDT 2025
Fri Jul 25 08:59:33 EDT 2025
Thu Apr 03 07:03:58 EDT 2025
Wed Oct 01 05:02:07 EDT 2025
Thu Apr 24 22:50:28 EDT 2025
Fri Feb 21 02:39:37 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 9
Language English
License 2021. The Author(s), under exclusive licence to Springer Nature Limited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-c1100f05bd97dfadba7ae79ef6c923c63fd19d943211e8b9bf036de9e202b5c03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-0714-7705
0000-0002-3937-1066
OpenAccessLink https://proxy.k.utb.cz/login?url=https://www.ncbi.nlm.nih.gov/pmc/articles/9042933
PMID 34845361
PQID 2655325375
PQPubID 41855
PageCount 9
ParticipantIDs unpaywall_primary_10_1038_s41416_021_01642_0
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9042933
proquest_miscellaneous_2604831947
proquest_journals_2655325375
pubmed_primary_34845361
crossref_primary_10_1038_s41416_021_01642_0
crossref_citationtrail_10_1038_s41416_021_01642_0
springer_journals_10_1038_s41416_021_01642_0
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-05-18
PublicationDateYYYYMMDD 2022-05-18
PublicationDate_xml – month: 05
  year: 2022
  text: 2022-05-18
  day: 18
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle British journal of cancer
PublicationTitleAbbrev Br J Cancer
PublicationTitleAlternate Br J Cancer
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Sharifi-Rad, Anil Kumar, Zucca, Varoni, Dini, Panzarini (CR4) 2020; 11
Gao, Aksoy, Dogrusoz, Dresdner, Gross, Sumer (CR98) 2013; 6
Chen, Solomides, Simpkins, Simpkins (CR45) 2017; 79
Bialk, Wang, Banas, Kmiec (CR51) 2018; 11
Grossman, Heath, Ferretti, Varmus, Lowy, Kibbe (CR54) 2016; 375
Liguori, Russo, Curcio, Bulli, Aran, Della-Morte (CR3) 2018; 13
Nebert (CR35) 2017; 67
DeNicola, Karreth, Humpton, Gopinathan, Wei, Frese (CR66) 2011; 475
Holland, Fishbein (CR7) 2010; 13
MacLeod, Acosta-Jimenez, Coates, McMahon, Carey, Honda (CR39) 2016; 115
Robledinos-Anton, Fernandez-Gines, Manda, Cuadrado (CR16) 2019; 2019
Wang, An, Ji, Jiao, Sun, Zhou (CR72) 2008; 373
Chaudhuri, Chabon, Lovejoy, Newman, Stehr, Azad (CR53) 2017; 7
Thai, Statt, Chen, Liang, Campbell, Wu (CR42) 2013; 49
Solis, Behrens, Dong, Suraokar, Ozburn, Moran (CR73) 2010; 16
Karlsson, Jönsson, Lauss, Brunnström, Jönsson, Borg (CR57) 2014; 20
DeBlasi, DeNicola (CR92) 2020; 12
Shen, Jiang, Long, Chen, Ren, Wong (CR20) 2015; 23
Suzuki, Maher, Yamamoto (CR76) 2011; 71
Stiborová, Martínek, Svobodová, Šístková, Dvořák, Ulrichová (CR27) 2010; 23
Hofman, Malcekova, Skarka, Novotna, Wsol (CR43) 2014; 278
Nafstad, Håheim, Oftedal, Gram, Holme, Hjermann (CR23) 2003; 58
Deng, Parekh, Chow, Simpkins (CR44) 2002; 277
CR50
Borgerding, Klus (CR30) 2005; 57
Telkoparan-Akillilar, Panieri, Cevik, Suzen, Saso (CR84) 2021; 26
Hammerman, Lawrence, Voet, Jing, Cibulskis, Sivachenko (CR58) 2012; 489
Chen, Sun, Wang, Jiang, Huang, Fang (CR94) 2009; 34
Dinkova-Kostova, Holtzclaw, Kensler (CR11) 2005; 18
Zhang, Shih, Rinna, Forman (CR21) 2011; 43
Méndez, Díaz-Muñoz (CR65) 2018; 9
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji (CR55) 2006; 21
Sivinski, Zhang, Chapman (CR86) 2021; 76
Dayalan Naidu, Muramatsu, Saito, Asami, Honda, Hosoya (CR96) 2018; 8
Yates, Tran, Dolan, Osburn, Shin, McCulloch (CR64) 2009; 30
Kitamura, Onodera, Murakami, Suzuki, Motohashi (CR87) 2017; 36
Schmidlin, Shakya, Dodson, Chapman, Zhang (CR91) 2021; 76
Best, Ding, Kersbergen, Dong, Song, Xie (CR59) 2019; 10
Hayes, McMahon, Chowdhry, Dinkova-Kostova (CR90) 2010; 13
Sasaki, Suzuki, Shitara, Okuda, Hikosaka, Moriyama (CR56) 2013; 6
Ogura, Tong, Mio, Maruyama, Kurokawa, Sato (CR13) 2010; 107
Dinkova-Kostova, Kostov, Canning (CR12) 2017; 617
Noakes (CR33) 2015; 8
Ohta, Iijima, Miyamoto, Nakahara, Tanaka, Ohtsuji (CR52) 2008; 68
Fabrizio, Sparaneo, Castellana, Mazza, Trombetta, Graziano (CR82) 2019; 30
Elshaer, ElManawy, Hammad, Namani, Wang, Tang (CR71) 2020; 12
Murray, Mesaros, Arlt, Seidel, Blair, Penning (CR28) 2018; 31
Murray, de la Vega, Hayes, Duan, Penning (CR29) 2019; 32
Zhang, Shu, Kong (CR68) 2015; 1
Cheng, Wu, Guo, Kong (CR70) 2016; 1
Wang, Sun, Villeneuve, Zhang, Zhao, Li (CR47) 2008; 29
Tkachev, Menshchikova, Zenkov (CR10) 2011; 76
Burczynski, Lin, Penning (CR38) 1999; 59
Guo, Yu, Zhang, Kong (CR69) 2015; 88
Cerami, Gao, Dogrusoz, Gross, Sumer, Aksoy (CR97) 2012; 2
Schieber, Chandel (CR2) 2014; 24
Kensler, Wakabayashi (CR62) 2009; 31
He, Ichinose, Yoshida, Arashidani, Yoshida, Takano (CR25) 2017; 7
Baird, Llères, Swift, Dinkova-Kostova (CR95) 2013; 110
Duan, Wang, Cao, Dan, Li, Fan (CR77) 2019; 10
Sridhar, Schembri, Zeskind, Shah, Gustafson, Steiling (CR41) 2008; 9
Hankinson (CR34) 1995; 35
Sanchez-Vega, Mina, Armenia, Chatila, Luna, La (CR60) 2018; 173
Frank, Scheffler, Merkelbach-Bruse, Ihle, Kron, Rauer (CR48) 2018; 24
Li, Xu, Tang, Xu, Ye, Shen (CR80) 2014; 588
Canning, Sorrell, Bullock (CR9) 2015; 88
Unoki, Akiyama, Kumagai (CR17) 2020; 21
Hayes, McMahon (CR63) 2009; 34
Kobayashi, Kang, Watai, Tong, Shibata, Uchida (CR6) 2006; 26
Tsay, Tchou-Wong, Greenberg, Pass, Rom (CR32) 2013; 33
CR88
Inoue, Suzuki, Mitsuishi, Miki, Suzuki, Sugawara (CR93) 2012; 103
Fabrizio, Sparaneo, Centra, Trombetta, Storlazzi, Graziano (CR74) 2019; 20
Kubo, Chhunchha, Singh, Sasaki, Singh (CR19) 2017; 7
Tian, Wu, Liu, Han, Zhang, Chu (CR49) 2016; 9
Eaton, Gallagher (CR61) 1994; 34
Penning (CR37) 2014; 27
Liby, Hock, Yore, Suh, Place, Risingsong (CR85) 2005; 65
Park, Choi, Bae, Kim, Park, Yoo (CR67) 2016; 7
Sakanyan (CR5) 2018; 7
Snezhkina, Kudryavtseva, Kardymon, Savvateeva, Melnikova, Krasnov (CR1) 2019; 2019
Itoh, Chiba, Takahashi, Ishii, Igarashi, Katoh (CR14) 1997; 236
Taheri, Asadzadeh Aghdaei, Irani, Modarressi, Zahra (CR78) 2020; 9
Menegon, Columbano, Giordano (CR83) 2016; 22
Singh, Misra, Thimmulappa, Lee, Ames, Hoque (CR46) 2006; 3
CR26
Taguchi, Yamamoto (CR18) 2017; 7
Zheng, Gonçalves, Abiko, Li, Kumagai, Aschner (CR31) 2020; 34
Yin, Liu, Xu, Shi, Zhai, Liu (CR81) 2018; 40
Fajersztajn, Veras, Barrozo, Saldiva (CR24) 2013; 13
Tebay, Robertson, Durant, Vitale, Penning, Dinkova-Kostova (CR36) 2015; 88
Kansanen, Kuosmanen, Leinonen, Levonen (CR15) 2013; 1
Guo, Wu, Yan, Li, Sun, Zhou (CR75) 2012; 428
Magesh, Chen, Hu (CR8) 2012; 32
Singh, Venkannagari, Oh, Zhang, Rohde, Liu (CR89) 2016; 11
Bakulski, Dou, Lin, London, Colacino (CR22) 2019; 9
Michaeloudes, Mercado, Clarke, Bhavsar, Adcock, Barnes (CR79) 2014; 192
Penning, Lerman (CR40) 2008; 1
E Kubo (1642_CR19) 2017; 7
1642_CR88
DL Eaton (1642_CR61) 1994; 34
M Elshaer (1642_CR71) 2020; 12
H Sasaki (1642_CR56) 2013; 6
C Zhang (1642_CR68) 2015; 1
S Sridhar (1642_CR41) 2008; 9
JR Murray (1642_CR28) 2018; 31
K Taguchi (1642_CR18) 2017; 7
JM DeBlasi (1642_CR92) 2020; 12
M Stiborová (1642_CR27) 2010; 23
F Zheng (1642_CR31) 2020; 34
O Hankinson (1642_CR34) 1995; 35
P Thai (1642_CR42) 2013; 49
D Guo (1642_CR75) 2012; 428
J Chen (1642_CR45) 2017; 79
F-G Duan (1642_CR77) 2019; 10
T Suzuki (1642_CR76) 2011; 71
I Liguori (1642_CR3) 2018; 13
GM DeNicola (1642_CR66) 2011; 475
H Kitamura (1642_CR87) 2017; 36
S Menegon (1642_CR83) 2016; 22
V Sakanyan (1642_CR5) 2018; 7
AT Dinkova-Kostova (1642_CR11) 2005; 18
C Michaeloudes (1642_CR79) 2014; 192
PS Hammerman (1642_CR58) 2012; 489
1642_CR26
X-J Wang (1642_CR47) 2008; 29
KM Bakulski (1642_CR22) 2019; 9
S-M Park (1642_CR67) 2016; 7
AA Chaudhuri (1642_CR53) 2017; 7
M He (1642_CR25) 2017; 7
M Borgerding (1642_CR30) 2005; 57
I Méndez (1642_CR65) 2018; 9
B Padmanabhan (1642_CR55) 2006; 21
CJ Schmidlin (1642_CR91) 2021; 76
R Holland (1642_CR7) 2010; 13
JD Hayes (1642_CR90) 2010; 13
ME Burczynski (1642_CR38) 1999; 59
A Singh (1642_CR89) 2016; 11
Y Yin (1642_CR81) 2018; 40
W Chen (1642_CR94) 2009; 34
L Baird (1642_CR95) 2013; 110
J Gao (1642_CR98) 2013; 6
L Fajersztajn (1642_CR24) 2013; 13
P Telkoparan-Akillilar (1642_CR84) 2021; 26
JJ Tsay (1642_CR32) 2013; 33
D Cheng (1642_CR70) 2016; 1
N Robledinos-Anton (1642_CR16) 2019; 2019
SA Best (1642_CR59) 2019; 10
T Ogura (1642_CR13) 2010; 107
Z Li (1642_CR80) 2014; 588
R Frank (1642_CR48) 2018; 24
F Sanchez-Vega (1642_CR60) 2018; 173
Z Taheri (1642_CR78) 2020; 9
T Unoki (1642_CR17) 2020; 21
R Wang (1642_CR72) 2008; 373
TW Kensler (1642_CR62) 2009; 31
LM Solis (1642_CR73) 2010; 16
P Nafstad (1642_CR23) 2003; 58
AV Snezhkina (1642_CR1) 2019; 2019
RL Grossman (1642_CR54) 2016; 375
J Sivinski (1642_CR86) 2021; 76
S Dayalan Naidu (1642_CR96) 2018; 8
JR Murray (1642_CR29) 2019; 32
R Noakes (1642_CR33) 2015; 8
MS Yates (1642_CR64) 2009; 30
T Shen (1642_CR20) 2015; 23
P Bialk (1642_CR51) 2018; 11
1642_CR50
D Inoue (1642_CR93) 2012; 103
DW Nebert (1642_CR35) 2017; 67
AT Dinkova-Kostova (1642_CR12) 2017; 617
Y Tian (1642_CR49) 2016; 9
T Ohta (1642_CR52) 2008; 68
LE Tebay (1642_CR36) 2015; 88
K Liby (1642_CR85) 2005; 65
E Cerami (1642_CR97) 2012; 2
TM Penning (1642_CR40) 2008; 1
A Kobayashi (1642_CR6) 2006; 26
S Magesh (1642_CR8) 2012; 32
VO Tkachev (1642_CR10) 2011; 76
Y Guo (1642_CR69) 2015; 88
M Schieber (1642_CR2) 2014; 24
M Sharifi-Rad (1642_CR4) 2020; 11
JD Hayes (1642_CR63) 2009; 34
FP Fabrizio (1642_CR82) 2019; 30
A Karlsson (1642_CR57) 2014; 20
AK MacLeod (1642_CR39) 2016; 115
P Canning (1642_CR9) 2015; 88
FP Fabrizio (1642_CR74) 2019; 20
A Singh (1642_CR46) 2006; 3
HB Deng (1642_CR44) 2002; 277
TM Penning (1642_CR37) 2014; 27
E Kansanen (1642_CR15) 2013; 1
J Hofman (1642_CR43) 2014; 278
K Itoh (1642_CR14) 1997; 236
H Zhang (1642_CR21) 2011; 43
References_xml – volume: 2019
  start-page: 9372182
  year: 2019
  ident: CR16
  article-title: Activators and inhibitors of NRF2: a review of their potential for clinical development
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2019/9372182
– volume: 34
  start-page: 135
  year: 1994
  end-page: 72.
  ident: CR61
  article-title: Mechanisms of aflatoxin carcinogenesis
  publication-title: Annu Rev Pharm Toxicol
  doi: 10.1146/annurev.pa.34.040194.001031
– volume: 18
  start-page: 1779
  year: 2005
  end-page: 91
  ident: CR11
  article-title: The role of Keap1 in cellular protective responses
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx050217c
– volume: 9
  start-page: 83
  year: 2016
  ident: CR49
  article-title: Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-016-0311-0
– volume: 40
  start-page: 3479
  year: 2018
  end-page: 88.
  ident: CR81
  article-title: miR‑144‑3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2
  publication-title: Oncol Rep
– volume: 23
  start-page: 651
  year: 2015
  end-page: 64
  ident: CR20
  article-title: A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2014.6074
– volume: 115
  start-page: 1530
  year: 2016
  end-page: 9
  ident: CR39
  article-title: Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer
  publication-title: Br J cancer
  doi: 10.1038/bjc.2016.363
– volume: 20
  start-page: 6127
  year: 2014
  end-page: 40
  ident: CR57
  article-title: Genome-wide DNA methylation analysis of lung carcinoma reveals one neuroendocrine and four adenocarcinoma epitypes associated with patient outcome
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-14-1087
– volume: 7
  start-page: 12
  year: 2018
  ident: CR5
  article-title: Reactive chemicals and electrophilic stress in cancer: a minireview
  publication-title: High Throughput
  doi: 10.3390/ht7020012
– volume: 2019
  start-page: 6175804
  year: 2019
  ident: CR1
  article-title: ROS generation and antioxidant defense systems in normal and malignant cells
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2019/6175804
– volume: 13
  start-page: 757
  year: 2018
  end-page: 72.
  ident: CR3
  article-title: Oxidative stress, aging, and diseases
  publication-title: Clin Inter Aging
  doi: 10.2147/CIA.S158513
– volume: 34
  start-page: 176
  year: 2009
  end-page: 88
  ident: CR63
  article-title: NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
  publication-title: Trends Biochem Sci
  doi: 10.1016/j.tibs.2008.12.008
– volume: 22
  start-page: 578
  year: 2016
  end-page: 93.
  ident: CR83
  article-title: The dual roles of NRF2 in cancer
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2016.05.002
– volume: 68
  start-page: 1303
  year: 2008
  ident: CR52
  article-title: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-5003
– volume: 16
  start-page: 3743
  year: 2010
  ident: CR73
  article-title: Nrf2 and Keap1 abnormalities in non–small cell lung carcinoma and association with clinicopathologic features
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-09-3352
– volume: 9
  start-page: 93
  year: 2018
  ident: CR65
  article-title: Circadian and metabolic perspectives in the role played by NADPH in cancer
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2018.00093
– volume: 6
  start-page: 719
  year: 2013
  end-page: 21
  ident: CR56
  article-title: Keap1 mutations in lung cancer patients
  publication-title: Oncol Lett
  doi: 10.3892/ol.2013.1427
– volume: 57
  start-page: 43
  year: 2005
  end-page: 73
  ident: CR30
  article-title: Analysis of complex mixtures—cigarette smoke
  publication-title: Exp Toxicol Pathol
  doi: 10.1016/j.etp.2005.05.010
– ident: CR88
– volume: 58
  start-page: 1071
  year: 2003
  end-page: 6
  ident: CR23
  article-title: Lung cancer and air pollution: a 27 year follow up of 16 209 Norwegian men
  publication-title: Thorax
  doi: 10.1136/thorax.58.12.1071
– volume: 107
  start-page: 2842
  year: 2010
  end-page: 7
  ident: CR13
  article-title: Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0914036107
– volume: 88
  start-page: 101
  year: 2015
  end-page: 7
  ident: CR9
  article-title: Structural basis of Keap1 interactions with Nrf2
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2015.05.034
– volume: 88
  start-page: 108
  year: 2015
  end-page: 46.
  ident: CR36
  article-title: Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2015.06.021
– volume: 6
  start-page: pl1
  year: 2013
  ident: CR98
  article-title: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2004088
– volume: 11
  start-page: 1
  year: 2020
  end-page: 21
  ident: CR4
  article-title: Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases
  publication-title: Front Physiol
  doi: 10.3389/fphys.2020.00694
– volume: 7
  start-page: 85
  year: 2017
  ident: CR18
  article-title: The KEAP1-NRF2 system in cancer
  publication-title: Front Oncol
  doi: 10.3389/fonc.2017.00085
– volume: 24
  start-page: R453
  year: 2014
  end-page: R62.
  ident: CR2
  article-title: ROS function in redox signaling and oxidative stress
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2014.03.034
– volume: 8
  start-page: 7
  year: 2015
  end-page: 18
  ident: CR33
  article-title: The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism
  publication-title: Int J Tryptophan Res
  doi: 10.4137/IJTR.S19985
– volume: 11
  start-page: 3214
  year: 2016
  end-page: 25.
  ident: CR89
  article-title: Small molecule Inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors
  publication-title: ACS Chem Biol
  doi: 10.1021/acschembio.6b00651
– volume: 29
  start-page: 1235
  year: 2008
  end-page: 43
  ident: CR47
  article-title: Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgn095
– volume: 110
  start-page: 15259
  year: 2013
  ident: CR95
  article-title: Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1305687110
– volume: 79
  start-page: 369
  year: 2017
  end-page: 80
  ident: CR45
  article-title: The role of Nrf2 and ATF2 in resistance to platinum-based chemotherapy
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-016-3225-1
– volume: 65
  start-page: 4789
  year: 2005
  ident: CR85
  article-title: The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of Heme oxygenase-1 and Nrf2/ARE signaling
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-4539
– volume: 10
  start-page: 821
  year: 2019
  ident: CR77
  article-title: MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-2031-1
– volume: 7
  year: 2016
  ident: CR67
  article-title: Histone variant H3F3A promotes lung cancer cell migration through intronic regulation
  publication-title: Nat Commun
  doi: 10.1038/ncomms12914
– volume: 375
  start-page: 1109
  year: 2016
  end-page: 12
  ident: CR54
  article-title: Toward a shared vision for cancer genomic data
  publication-title: N. Engl J Med
  doi: 10.1056/NEJMp1607591
– volume: 76
  start-page: 407
  year: 2011
  end-page: 22
  ident: CR10
  article-title: Mechanism of the Nrf2/Keap1/ARE signaling system
  publication-title: Biochemistry
– volume: 1
  start-page: 21
  year: 2015
  end-page: 30
  ident: CR68
  article-title: MicroRNAs: new players in cancer prevention targeting Nrf2, oxidative stress and inflammatory pathways
  publication-title: Curr Pharm Rep
  doi: 10.1007/s40495-014-0013-7
– volume: 43
  start-page: 1059
  year: 2011
  end-page: 64
  ident: CR21
  article-title: Exacerbation of tobacco smoke mediated apoptosis by resveratrol: an unexpected consequence of its antioxidant action
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2009.12.022
– volume: 26
  start-page: 1417
  year: 2021
  ident: CR84
  article-title: Therapeutic targeting of the NRF2 signaling pathway in cancer
  publication-title: Molecules
  doi: 10.3390/molecules26051417
– volume: 12
  start-page: 7183
  year: 2020
  end-page: 206.
  ident: CR71
  article-title: Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas
  publication-title: Aging
  doi: 10.18632/aging.103068
– volume: 489
  start-page: 519
  year: 2012
  end-page: 25
  ident: CR58
  article-title: Comprehensive genomic characterization of squamous cell lung cancers
  publication-title: Nature
  doi: 10.1038/nature11404
– volume: 23
  start-page: 1192
  year: 2010
  end-page: 201
  ident: CR27
  article-title: Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx100052d
– volume: 9
  start-page: 33
  year: 2020
  end-page: 9
  ident: CR78
  article-title: Evaluation of the epigenetic demethylation of NRF2, a master transcription factor for antioxidant enzymes, in colorectal cancer
  publication-title: Rep Biochem Mol Biol
  doi: 10.29252/rbmb.9.1.33
– volume: 31
  start-page: 1277
  year: 2018
  end-page: 88.
  ident: CR28
  article-title: Role of human aldo-keto reductases in the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone
  publication-title: Chem Res Toxicol
  doi: 10.1021/acs.chemrestox.8b00250
– volume: 1
  start-page: 134
  year: 2016
  end-page: 8
  ident: CR70
  article-title: Regulation of Keap1–Nrf2 signaling: the role of epigenetics
  publication-title: Curr Opin Toxicol
  doi: 10.1016/j.cotox.2016.10.008
– volume: 33
  start-page: 1247
  year: 2013
  end-page: 56
  ident: CR32
  article-title: Aryl hydrocarbon receptor and lung cancer
  publication-title: Anticancer Res
– volume: 26
  start-page: 221
  year: 2006
  end-page: 9
  ident: CR6
  article-title: Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.26.1.221-229.2006
– volume: 3
  start-page: e420
  year: 2006
  ident: CR46
  article-title: Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.0030420
– volume: 71
  start-page: 1700
  year: 2011
  end-page: 9
  ident: CR76
  article-title: Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-2939
– volume: 8
  year: 2018
  ident: CR96
  article-title: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-26269-9
– volume: 31
  start-page: 90
  year: 2009
  end-page: 9
  ident: CR62
  article-title: Nrf2: friend or foe for chemoprevention?
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp231
– volume: 173
  start-page: 321
  year: 2018
  end-page: 37.e10
  ident: CR60
  article-title: Oncogenic signaling pathways in The Cancer Genome Atlas
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.035
– volume: 278
  start-page: 238
  year: 2014
  end-page: 48
  ident: CR43
  article-title: Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2014.04.027
– volume: 36
  start-page: 6315
  year: 2017
  end-page: 24.
  ident: CR87
  article-title: IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model
  publication-title: Oncogene
  doi: 10.1038/onc.2017.236
– volume: 21
  start-page: 545
  year: 2020
  ident: CR17
  article-title: Nrf2 activation and its coordination with the protective defense systems in response to electrophilic stress
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21020545
– volume: 34
  start-page: 101475
  year: 2020
  ident: CR31
  article-title: Redox toxicology of environmental chemicals causing oxidative stress
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2020.101475
– volume: 475
  start-page: 106
  year: 2011
  end-page: 9
  ident: CR66
  article-title: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
  publication-title: Nature
  doi: 10.1038/nature10189
– volume: 617
  start-page: 84
  year: 2017
  end-page: 93
  ident: CR12
  article-title: Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
  publication-title: Arch Biochem Biophys
  doi: 10.1016/j.abb.2016.08.005
– volume: 9
  year: 2008
  ident: CR41
  article-title: Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-9-259
– volume: 30
  start-page: ii5
  year: 2019
  ident: CR82
  article-title: 17P - REDOXI-miRNA of Keap1/Nrf2 axis in lung tumors
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdz072.015
– volume: 32
  start-page: 687
  year: 2012
  end-page: 726
  ident: CR8
  article-title: Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents
  publication-title: Med Res Rev
  doi: 10.1002/med.21257
– ident: CR50
– volume: 103
  start-page: 760
  year: 2012
  end-page: 6
  ident: CR93
  article-title: Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2012.02216.x
– volume: 13
  start-page: 674
  year: 2013
  end-page: 8
  ident: CR24
  article-title: Air pollution: a potentially modifiable risk factor for lung cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3572
– volume: 49
  start-page: 204
  year: 2013
  end-page: 11
  ident: CR42
  article-title: Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2013-0159RC
– volume: 7
  start-page: 1394
  year: 2017
  ident: CR53
  article-title: Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-17-0716
– volume: 76
  start-page: 110
  year: 2021
  end-page: 19
  ident: CR91
  article-title: The intricacies of NRF2 regulation in cancer
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2021.05.016
– volume: 88
  start-page: 337
  year: 2015
  end-page: 49
  ident: CR69
  article-title: Epigenetic regulation of Keap1-Nrf2 signaling
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2015.06.013
– volume: 67
  start-page: 38
  year: 2017
  end-page: 57
  ident: CR35
  article-title: Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals
  publication-title: Prog Lipid Res
  doi: 10.1016/j.plipres.2017.06.001
– ident: CR26
– volume: 34
  start-page: 663
  year: 2009
  end-page: 73
  ident: CR94
  article-title: Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2009.04.029
– volume: 7
  year: 2017
  ident: CR25
  article-title: Urban PM2.5 exacerbates allergic inflammation in the murine lung via a TLR2/TLR4/MyD88-signaling pathway
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-11471-y
– volume: 11
  start-page: 75
  year: 2018
  end-page: 89
  ident: CR51
  article-title: Functional gene knockout of NRF2 increases chemosensitivity of human lung cancer A549 cells in vitro and in a xenograft mouse model
  publication-title: Mol Ther Oncol
  doi: 10.1016/j.omto.2018.10.002
– volume: 12
  start-page: 3023
  year: 2020
  ident: CR92
  article-title: Dissecting the crosstalk between NRF2 signaling and metabolic processes in cancer
  publication-title: Cancers
  doi: 10.3390/cancers12103023
– volume: 1
  start-page: 45
  year: 2013
  end-page: 9
  ident: CR15
  article-title: The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2012.10.001
– volume: 1
  start-page: 80
  year: 2008
  ident: CR40
  article-title: Genomics of smoking exposure and cessation: lessons for cancer prevention and treatment
  publication-title: Cancer Prev Res
  doi: 10.1158/1940-6207.CAPR-08-0047
– volume: 21
  start-page: 689
  year: 2006
  end-page: 700
  ident: CR55
  article-title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.01.013
– volume: 373
  start-page: 151
  year: 2008
  end-page: 4
  ident: CR72
  article-title: Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
  publication-title: Biochem. Biophys. Res Commun
  doi: 10.1016/j.bbrc.2008.06.004
– volume: 30
  start-page: 1024
  year: 2009
  end-page: 31
  ident: CR64
  article-title: Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp100
– volume: 35
  start-page: 307
  year: 1995
  end-page: 40
  ident: CR34
  article-title: The aryl hydrocarbon receptor complex
  publication-title: Annu Rev Pharm Toxicol
  doi: 10.1146/annurev.pa.35.040195.001515
– volume: 10
  year: 2019
  ident: CR59
  article-title: Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-12164-y
– volume: 2
  start-page: 401
  year: 2012
  ident: CR97
  article-title: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-12-0095
– volume: 13
  start-page: 1749
  year: 2010
  end-page: 61
  ident: CR7
  article-title: Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2010.3273
– volume: 9
  year: 2019
  ident: CR22
  article-title: DNA methylation signature of smoking in lung cancer is enriched for exposure signatures in newborn and adult blood
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-40963-2
– volume: 76
  start-page: 61
  year: 2021
  end-page: 73
  ident: CR86
  article-title: Targeting NRF2 to treat cancer
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2021.06.003
– volume: 192
  start-page: 4913
  year: 2014
  end-page: 20.
  ident: CR79
  article-title: Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301984
– volume: 59
  start-page: 607
  year: 1999
  end-page: 14
  ident: CR38
  article-title: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase
  publication-title: Cancer Res
– volume: 236
  start-page: 313
  year: 1997
  end-page: 22
  ident: CR14
  article-title: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.1997.6943
– volume: 7
  year: 2017
  ident: CR19
  article-title: Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-14520-8
– volume: 24
  start-page: 3087
  year: 2018
  end-page: 96
  ident: CR48
  article-title: Clinical and pathological characteristics of KEAP1- and NFE2L2-mutated non-small cell lung carcinoma (NSCLC)
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-17-3416
– volume: 13
  start-page: 1713
  year: 2010
  end-page: 48
  ident: CR90
  article-title: Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2010.3221
– volume: 32
  start-page: 2538
  year: 2019
  end-page: 51.
  ident: CR29
  article-title: Induction of the antioxidant response by the transcription factor NRF2 increases bioactivation of the mutagenic air pollutant 3-nitrobenzanthrone in human lung cells
  publication-title: Chem Res Toxicol
  doi: 10.1021/acs.chemrestox.9b00399
– volume: 20
  start-page: 2697
  year: 2019
  end-page: 712
  ident: CR74
  article-title: Methylation density pattern of KEAP1 gene in lung cancer cell lines detected by quantitative methylation specific PCR and pyrosequencing
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20112697
– volume: 428
  start-page: 80
  year: 2012
  end-page: 5
  ident: CR75
  article-title: A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2012.10.010
– volume: 277
  start-page: 15035
  year: 2002
  end-page: 43.
  ident: CR44
  article-title: Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells*
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112028200
– volume: 27
  start-page: 1901
  year: 2014
  end-page: 17
  ident: CR37
  article-title: Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx500298n
– volume: 588
  start-page: 3000
  year: 2014
  end-page: 7
  ident: CR80
  article-title: The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2014.05.057
– volume: 9
  start-page: 93
  year: 2018
  ident: 1642_CR65
  publication-title: Front Endocrinol
  doi: 10.3389/fendo.2018.00093
– volume: 20
  start-page: 2697
  year: 2019
  ident: 1642_CR74
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20112697
– volume: 76
  start-page: 61
  year: 2021
  ident: 1642_CR86
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2021.06.003
– volume: 79
  start-page: 369
  year: 2017
  ident: 1642_CR45
  publication-title: Cancer Chemother Pharmacol
  doi: 10.1007/s00280-016-3225-1
– volume: 31
  start-page: 90
  year: 2009
  ident: 1642_CR62
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp231
– volume: 34
  start-page: 176
  year: 2009
  ident: 1642_CR63
  publication-title: Trends Biochem Sci
  doi: 10.1016/j.tibs.2008.12.008
– volume: 588
  start-page: 3000
  year: 2014
  ident: 1642_CR80
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2014.05.057
– volume: 7
  start-page: 12
  year: 2018
  ident: 1642_CR5
  publication-title: High Throughput
  doi: 10.3390/ht7020012
– volume: 7
  year: 2017
  ident: 1642_CR19
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-14520-8
– volume: 10
  start-page: 821
  year: 2019
  ident: 1642_CR77
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-2031-1
– volume: 30
  start-page: ii5
  year: 2019
  ident: 1642_CR82
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdz072.015
– volume: 9
  start-page: 83
  year: 2016
  ident: 1642_CR49
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-016-0311-0
– volume: 76
  start-page: 407
  year: 2011
  ident: 1642_CR10
  publication-title: Biochemistry
– volume: 21
  start-page: 545
  year: 2020
  ident: 1642_CR17
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21020545
– volume: 24
  start-page: R453
  year: 2014
  ident: 1642_CR2
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2014.03.034
– volume: 10
  year: 2019
  ident: 1642_CR59
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-12164-y
– volume: 8
  year: 2018
  ident: 1642_CR96
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-26269-9
– volume: 8
  start-page: 7
  year: 2015
  ident: 1642_CR33
  publication-title: Int J Tryptophan Res
  doi: 10.4137/IJTR.S19985
– volume: 192
  start-page: 4913
  year: 2014
  ident: 1642_CR79
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301984
– volume: 1
  start-page: 134
  year: 2016
  ident: 1642_CR70
  publication-title: Curr Opin Toxicol
  doi: 10.1016/j.cotox.2016.10.008
– volume: 9
  start-page: 33
  year: 2020
  ident: 1642_CR78
  publication-title: Rep Biochem Mol Biol
  doi: 10.29252/rbmb.9.1.33
– ident: 1642_CR50
  doi: 10.1101/799676
– volume: 12
  start-page: 7183
  year: 2020
  ident: 1642_CR71
  publication-title: Aging
  doi: 10.18632/aging.103068
– volume: 31
  start-page: 1277
  year: 2018
  ident: 1642_CR28
  publication-title: Chem Res Toxicol
  doi: 10.1021/acs.chemrestox.8b00250
– volume: 68
  start-page: 1303
  year: 2008
  ident: 1642_CR52
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-5003
– volume: 2019
  start-page: 6175804
  year: 2019
  ident: 1642_CR1
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2019/6175804
– volume: 11
  start-page: 75
  year: 2018
  ident: 1642_CR51
  publication-title: Mol Ther Oncol
  doi: 10.1016/j.omto.2018.10.002
– volume: 67
  start-page: 38
  year: 2017
  ident: 1642_CR35
  publication-title: Prog Lipid Res
  doi: 10.1016/j.plipres.2017.06.001
– volume: 173
  start-page: 321
  year: 2018
  ident: 1642_CR60
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.035
– volume: 3
  start-page: e420
  year: 2006
  ident: 1642_CR46
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.0030420
– volume: 2019
  start-page: 9372182
  year: 2019
  ident: 1642_CR16
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2019/9372182
– volume: 13
  start-page: 757
  year: 2018
  ident: 1642_CR3
  publication-title: Clin Inter Aging
  doi: 10.2147/CIA.S158513
– volume: 7
  year: 2016
  ident: 1642_CR67
  publication-title: Nat Commun
  doi: 10.1038/ncomms12914
– volume: 475
  start-page: 106
  year: 2011
  ident: 1642_CR66
  publication-title: Nature
  doi: 10.1038/nature10189
– volume: 18
  start-page: 1779
  year: 2005
  ident: 1642_CR11
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx050217c
– volume: 9
  year: 2019
  ident: 1642_CR22
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-40963-2
– volume: 34
  start-page: 101475
  year: 2020
  ident: 1642_CR31
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2020.101475
– volume: 35
  start-page: 307
  year: 1995
  ident: 1642_CR34
  publication-title: Annu Rev Pharm Toxicol
  doi: 10.1146/annurev.pa.35.040195.001515
– volume: 375
  start-page: 1109
  year: 2016
  ident: 1642_CR54
  publication-title: N. Engl J Med
  doi: 10.1056/NEJMp1607591
– volume: 57
  start-page: 43
  year: 2005
  ident: 1642_CR30
  publication-title: Exp Toxicol Pathol
  doi: 10.1016/j.etp.2005.05.010
– ident: 1642_CR26
– volume: 88
  start-page: 337
  year: 2015
  ident: 1642_CR69
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2015.06.013
– volume: 24
  start-page: 3087
  year: 2018
  ident: 1642_CR48
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-17-3416
– volume: 6
  start-page: pl1
  year: 2013
  ident: 1642_CR98
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2004088
– volume: 71
  start-page: 1700
  year: 2011
  ident: 1642_CR76
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-2939
– volume: 428
  start-page: 80
  year: 2012
  ident: 1642_CR75
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2012.10.010
– volume: 7
  year: 2017
  ident: 1642_CR25
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-11471-y
– volume: 20
  start-page: 6127
  year: 2014
  ident: 1642_CR57
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-14-1087
– volume: 76
  start-page: 110
  year: 2021
  ident: 1642_CR91
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2021.05.016
– volume: 40
  start-page: 3479
  year: 2018
  ident: 1642_CR81
  publication-title: Oncol Rep
– volume: 12
  start-page: 3023
  year: 2020
  ident: 1642_CR92
  publication-title: Cancers
  doi: 10.3390/cancers12103023
– volume: 26
  start-page: 221
  year: 2006
  ident: 1642_CR6
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.26.1.221-229.2006
– volume: 1
  start-page: 21
  year: 2015
  ident: 1642_CR68
  publication-title: Curr Pharm Rep
  doi: 10.1007/s40495-014-0013-7
– volume: 278
  start-page: 238
  year: 2014
  ident: 1642_CR43
  publication-title: Toxicol Appl Pharmacol
  doi: 10.1016/j.taap.2014.04.027
– volume: 2
  start-page: 401
  year: 2012
  ident: 1642_CR97
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-12-0095
– volume: 32
  start-page: 2538
  year: 2019
  ident: 1642_CR29
  publication-title: Chem Res Toxicol
  doi: 10.1021/acs.chemrestox.9b00399
– volume: 58
  start-page: 1071
  year: 2003
  ident: 1642_CR23
  publication-title: Thorax
  doi: 10.1136/thorax.58.12.1071
– volume: 23
  start-page: 1192
  year: 2010
  ident: 1642_CR27
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx100052d
– volume: 617
  start-page: 84
  year: 2017
  ident: 1642_CR12
  publication-title: Arch Biochem Biophys
  doi: 10.1016/j.abb.2016.08.005
– volume: 43
  start-page: 1059
  year: 2011
  ident: 1642_CR21
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2009.12.022
– volume: 107
  start-page: 2842
  year: 2010
  ident: 1642_CR13
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0914036107
– volume: 30
  start-page: 1024
  year: 2009
  ident: 1642_CR64
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgp100
– ident: 1642_CR88
  doi: 10.1016/B978-0-12-398339-8.00002-1
– volume: 110
  start-page: 15259
  year: 2013
  ident: 1642_CR95
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1305687110
– volume: 6
  start-page: 719
  year: 2013
  ident: 1642_CR56
  publication-title: Oncol Lett
  doi: 10.3892/ol.2013.1427
– volume: 16
  start-page: 3743
  year: 2010
  ident: 1642_CR73
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-09-3352
– volume: 59
  start-page: 607
  year: 1999
  ident: 1642_CR38
  publication-title: Cancer Res
– volume: 1
  start-page: 80
  year: 2008
  ident: 1642_CR40
  publication-title: Cancer Prev Res
  doi: 10.1158/1940-6207.CAPR-08-0047
– volume: 29
  start-page: 1235
  year: 2008
  ident: 1642_CR47
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgn095
– volume: 11
  start-page: 1
  year: 2020
  ident: 1642_CR4
  publication-title: Front Physiol
  doi: 10.3389/fphys.2020.00694
– volume: 373
  start-page: 151
  year: 2008
  ident: 1642_CR72
  publication-title: Biochem. Biophys. Res Commun
  doi: 10.1016/j.bbrc.2008.06.004
– volume: 13
  start-page: 1749
  year: 2010
  ident: 1642_CR7
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2010.3273
– volume: 9
  year: 2008
  ident: 1642_CR41
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-9-259
– volume: 7
  start-page: 85
  year: 2017
  ident: 1642_CR18
  publication-title: Front Oncol
  doi: 10.3389/fonc.2017.00085
– volume: 65
  start-page: 4789
  year: 2005
  ident: 1642_CR85
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-4539
– volume: 23
  start-page: 651
  year: 2015
  ident: 1642_CR20
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2014.6074
– volume: 277
  start-page: 15035
  year: 2002
  ident: 1642_CR44
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M112028200
– volume: 13
  start-page: 1713
  year: 2010
  ident: 1642_CR90
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2010.3221
– volume: 27
  start-page: 1901
  year: 2014
  ident: 1642_CR37
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx500298n
– volume: 236
  start-page: 313
  year: 1997
  ident: 1642_CR14
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.1997.6943
– volume: 34
  start-page: 135
  year: 1994
  ident: 1642_CR61
  publication-title: Annu Rev Pharm Toxicol
  doi: 10.1146/annurev.pa.34.040194.001031
– volume: 26
  start-page: 1417
  year: 2021
  ident: 1642_CR84
  publication-title: Molecules
  doi: 10.3390/molecules26051417
– volume: 22
  start-page: 578
  year: 2016
  ident: 1642_CR83
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2016.05.002
– volume: 103
  start-page: 760
  year: 2012
  ident: 1642_CR93
  publication-title: Cancer Sci
  doi: 10.1111/j.1349-7006.2012.02216.x
– volume: 88
  start-page: 108
  year: 2015
  ident: 1642_CR36
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2015.06.021
– volume: 34
  start-page: 663
  year: 2009
  ident: 1642_CR94
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2009.04.029
– volume: 7
  start-page: 1394
  year: 2017
  ident: 1642_CR53
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-17-0716
– volume: 115
  start-page: 1530
  year: 2016
  ident: 1642_CR39
  publication-title: Br J cancer
  doi: 10.1038/bjc.2016.363
– volume: 36
  start-page: 6315
  year: 2017
  ident: 1642_CR87
  publication-title: Oncogene
  doi: 10.1038/onc.2017.236
– volume: 21
  start-page: 689
  year: 2006
  ident: 1642_CR55
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2006.01.013
– volume: 11
  start-page: 3214
  year: 2016
  ident: 1642_CR89
  publication-title: ACS Chem Biol
  doi: 10.1021/acschembio.6b00651
– volume: 88
  start-page: 101
  year: 2015
  ident: 1642_CR9
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2015.05.034
– volume: 1
  start-page: 45
  year: 2013
  ident: 1642_CR15
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2012.10.001
– volume: 13
  start-page: 674
  year: 2013
  ident: 1642_CR24
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3572
– volume: 49
  start-page: 204
  year: 2013
  ident: 1642_CR42
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2013-0159RC
– volume: 32
  start-page: 687
  year: 2012
  ident: 1642_CR8
  publication-title: Med Res Rev
  doi: 10.1002/med.21257
– volume: 33
  start-page: 1247
  year: 2013
  ident: 1642_CR32
  publication-title: Anticancer Res
– volume: 489
  start-page: 519
  year: 2012
  ident: 1642_CR58
  publication-title: Nature
  doi: 10.1038/nature11404
SSID ssj0009087
Score 2.5181992
SecondaryResourceType review_article
Snippet Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor...
SourceID unpaywall
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1244
SubjectTerms 631/67/1612
692/4028/67
Adaptor proteins
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinogens
Detoxification
DNA Methylation
Drug Resistance
Epidemiology
Epigenesis, Genetic
Epigenetics
Histones
Humans
Kelch-Like ECH-Associated Protein 1 - genetics
Kelch-Like ECH-Associated Protein 1 - metabolism
Lung cancer
Lung Neoplasms - genetics
miRNA
Molecular Medicine
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
Oncology
Oxidative stress
Oxidative Stress - genetics
Review
Review Article
Signal transduction
Tumorigenesis
SummonAdditionalLinks – databaseName: Unpaywall
  dbid: UNPAY
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9swED-6FPbxsO8Pb93QYG-rEtuSLesxjIay0RDKAt2TkWSJhrlOSBNK99dP568tK5T1xWB0xj7uTvqZu_sdwCfl4187EdMiVpxyaw2V_kqZSYVD_r0sxQbnk2l6POdfz5KzPYi6Xpi6aN_oxbAqL4bV4ryurVxdmFFXJzaSuIUydg_2U8wpDWB_Pp2NfzQwV9BQ1lSMPpBj6rGzaBtlQpaNLnnk4QfFogQkloppuHsY3UCYNwsl-2zpI3iwrVbq-kqV5V8H0uQJnHaqNHUoP4fbjR6aX_-wPN5J16fwuIWnZNwsPYM9Wz2H-ydtAv4FzJCm2q8RVRXErpDKs75dNyPtvZHJ0hEPKsn0dBLTb0fjWURw6vGVuiaLitQjAUnpdxhi0N_WL2E-Ofr-5Zi2Qxmo4YJvqEGOORcmupCicKrQSigrpHWp8VjRpMwVkSwkZ_7P0mZaaufPyMJKG4exTkzIXsGgWlb2DRAES4hf0ihTPI1NxpxmSgqLjENO6ACizjq5aRnLcXBGmdeZc5bljUVzb9G8tmgeBvC5f2bV8HXcKn3QGT1vY_cyj9PEO0_CRBLAx37ZRx2mUlRll1uUQSr-SHIRwOvGR_rXMZ7xhKVRAGLHe3oBZPTeXfHGr5m9W3sHcNj52Z_Puk2Lw94X_0Ppt3cTfwcPY2z5QMba7AAGm_XWvvdAbKM_tKH3G3itKpE
  priority: 102
  providerName: Unpaywall
Title Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer
URI https://link.springer.com/article/10.1038/s41416-021-01642-0
https://www.ncbi.nlm.nih.gov/pubmed/34845361
https://www.proquest.com/docview/2655325375
https://www.proquest.com/docview/2604831947
https://pubmed.ncbi.nlm.nih.gov/PMC9042933
https://www.ncbi.nlm.nih.gov/pmc/articles/9042933
UnpaywallVersion submittedVersion
Volume 126
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: KQ8
  dateStart: 19990101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: KQ8
  dateStart: 19470101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20241002
  omitProxy: true
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: DIK
  dateStart: 19470101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: GX1
  dateStart: 19470101
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVLSH
  databaseName: SpringerLink Journals
  customDbUrl:
  mediaType: online
  eissn: 1532-1827
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: AFBBN
  dateStart: 19970101
  isFulltext: true
  providerName: Library Specific Holdings
– providerCode: PRVAQN
  databaseName: PubMed Central
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20241002
  omitProxy: true
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: RPM
  dateStart: 19470101
  isFulltext: true
  titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/
  providerName: National Library of Medicine
– providerCode: PRVPQU
  databaseName: Health & Medical Collection (ProQuest)
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20241002
  omitProxy: true
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: 7X7
  dateStart: 20200101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl: http://www.proquest.com/pqcentral?accountid=15518
  eissn: 1532-1827
  dateEnd: 20241002
  omitProxy: true
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: BENPR
  dateStart: 20200101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9swED-2FvbxMPY9b23RYG-rqC3JlvQ00pJQNhpCWSB7MrIssUJwsnxQ-t9PZztOQyH0RcZIxpbuTvezTvodwDcT7L_wktGSGUGFc5bqUFJuM-mRf09leMD5aphdjsXPSTppF9yW7bbKzZxYT9TlzOIa-RnL0pSzlMv0x_wfxaxRGF1tU2g8hcMkQBXUajmRW9LdWDWcmbgcp1ncHpqJuTpbiiRAEYobFJBkitF41zE9QJsPN012kdOX8Hxdzc3drZlO7zmnwWt41aJK0mvU4A08cdVbeHbVxs3fwQjZpUMdMVVJ3BwZOOvbRZOJPsiGzDwJWJAMrweM_ur3RgnBZMW35o7cVKTO5EemYWIgFtVk8R7Gg_7vi0va5lKgVkixohap4XycFqWWpTdlYaRxUjuf2QDxbMZ9mehSCx5-CJ0qdOGDayuddixmRWpj_gEOqlnlPgFBjIOwI0uUERmzivuCGy0dEgV5WUSQbAYyty3ROOa7mOZ1wJurvBn8PAx-Xg9-HkfwvXtm3tBs7G19tJFP3prcMt8qSARfu-pgLBgBMZWbrbENMugnWsgIPjbi7F7HhRIpz5II5I6guwZIxL1bU938rQm5NXp1ziM43ajE9rP29eK0U5tHdPrz_k5_gRcMT2Ygsaw6goPVYu2OA15aFSe1UYRSXSQncHjeH46uw3U8HPX-_AepkhGt
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9swFD50HazbQ9l93rpNg-1pFbUl2bIeSilbQ7o0oYwW8ubJsswKwclyIeRP7TdOx7c0FMJe-mIwki86Okf6pKPzHYDP2tl_mktGM6YFFdYaqtyVchPJHPn34ggDnPuDqHstfgzD4Q78bWJh8FhlMyaWA3U2NrhHfsSiMOQs5DI8mfyhmDUKvatNCo1KLXp2tXRLttnx-XfXv18Y65xdfevSOqsANUKKOTVIkpb7YZopmeU6S7XUViqbR8aBHRPxPAtUpgR3SyMbpyrN3SCfWWWZz9LQ-Ny99wE8FNwXyNUvh3JN8uvHFUcnbv8p5tdBOj6Pj2YicNCH4oEIJLVi1N-cCO-g27uHNFtP7RPYWxQTvVrq0ejWZNh5Cvs1iiWnldo9gx1bPIdH_dpP_wIukc3alRFdZMROkPGzvJ1Wme-dLpBxThz2JIOfHUZ7Z6eXAcHkyEu9IjcFKTMHkpEbiIhBtZy-hOt7kfIr2C3GhX0DBDEVwpwoiLWImIl5nnKtpEViolymHgSNIBNTE5tjfo1RUjrYeZxUwk-c8JNS-Invwdf2mUlF67G19kHTP0lt4rNkrZAefGqLnXGix0UXdrzAOsjYHyghPXhddWf7OS5iEfIo8EBudHRbAYm_N0uKm98lAbhCFMG5B4eNSqx_a1srDlu1-Y9Gv93e6I-w173qXyQX54PeO3jMMCoESW3jA9idTxf2vcNq8_RDaSAEft23Rf4DcPpLrg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxEB6VIhU4IN4sFDASnKiVXdu7Xh8QqmijltAoQlTKbfF6bagUbUIeivLX-HV49pEQVYq49LLSyt6HxzP2Z8_4G4B32tt_7iSjBdOCCmsNVf5KuUmkQ_69NMEDzhf95OxSfBnGwz34056FwbDKdkysBupibHCPvMOSOOYs5jLuuCYsYnDS_TT5TTGDFHpa23QatYr07Grpl2-zj-cnvq_fM9Y9_f75jDYZBqgRUsypQcI0F8Z5oWThdJFrqa1U1iXGAx-TcFdEqlCC-2WSTXOVOz_gF1ZZFrI8NiH3770FtyUXHMPJ5FBuCH_DtObrxK1AxcLmwE7I085MRB4GUQyOQIIrRsPtSfEa0r0esLn22t6DO4tyoldLPRr9MzF2H8D9BtGS41oFH8KeLR_BwUXjs38MA2S29mVElwWxE2T_rG6n9meTOoyMHfE4lPS_dRntnR4PIoKJkpd6Ra5KUmURJCM_KBGDKjp9Apc3IuWnsF-OS_scCOIrhDxJlGqRMJNyl3OtpEWSIifzAKJWkJlpSM4x18Yoq5ztPM1q4Wde-Fkl_CwM4MP6mUlN8bGz9mHbP1lj7rNso5wBvF0Xe0NF74su7XiBdZC9P1JCBvCs7s7157hIRcyTKAC51dHrCkgCvl1SXv2qyMAVIgrOAzhqVWLzW7tacbRWm_9o9IvdjX4DB94Ws6_n_d5LuMvwgAjy26aHsD-fLuwrD9vm-evKPgj8uGmD_As_rE_p
linkToUnpaywall http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9swED-6FPbxsO8Pb93QYG-rEtuSLesxjIay0RDKAt2TkWSJhrlOSBNK99dP568tK5T1xWB0xj7uTvqZu_sdwCfl4187EdMiVpxyaw2V_kqZSYVD_r0sxQbnk2l6POdfz5KzPYi6Xpi6aN_oxbAqL4bV4ryurVxdmFFXJzaSuIUydg_2U8wpDWB_Pp2NfzQwV9BQ1lSMPpBj6rGzaBtlQpaNLnnk4QfFogQkloppuHsY3UCYNwsl-2zpI3iwrVbq-kqV5V8H0uQJnHaqNHUoP4fbjR6aX_-wPN5J16fwuIWnZNwsPYM9Wz2H-ydtAv4FzJCm2q8RVRXErpDKs75dNyPtvZHJ0hEPKsn0dBLTb0fjWURw6vGVuiaLitQjAUnpdxhi0N_WL2E-Ofr-5Zi2Qxmo4YJvqEGOORcmupCicKrQSigrpHWp8VjRpMwVkSwkZ_7P0mZaaufPyMJKG4exTkzIXsGgWlb2DRAES4hf0ihTPI1NxpxmSgqLjENO6ACizjq5aRnLcXBGmdeZc5bljUVzb9G8tmgeBvC5f2bV8HXcKn3QGT1vY_cyj9PEO0_CRBLAx37ZRx2mUlRll1uUQSr-SHIRwOvGR_rXMZ7xhKVRAGLHe3oBZPTeXfHGr5m9W3sHcNj52Z_Puk2Lw94X_0Ppt3cTfwcPY2z5QMba7AAGm_XWvvdAbKM_tKH3G3itKpE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+and+epigenetic+regulation+of+the+NRF2-KEAP1+pathway+in+human+lung+cancer&rft.jtitle=British+journal+of+cancer&rft.au=Cami%C3%B1a%2C+Nuria&rft.au=Penning%2C+Trevor+M&rft.date=2022-05-18&rft.eissn=1532-1827&rft.volume=126&rft.issue=9&rft.spage=1244&rft_id=info:doi/10.1038%2Fs41416-021-01642-0&rft_id=info%3Apmid%2F34845361&rft.externalDocID=34845361
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-0920&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-0920&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-0920&client=summon