Four-Point Computed Tomography Scores for Evaluation of Occult Peritoneal Metastasis in Patients with Gastric Cancer: A Region-to-Region Comparison with Staging Laparoscopy

• Published in: Annals of surgical oncology Vol. 27; no. 4; pp. 1103 - 1109
• Main Authors: Li, Zi-Yu, Tang, Lei, Li, Zhe-Min, Li, Yan-Ling, Fu, Jia, Zhang, Yan, Li, Xiao-Ting, Ying, Xiang-Ji, Ji, Jia-Fu
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2020; Springer Nature B.V
• Subjects: Computed tomography; Diagnosis; Gastric cancer; Humans; Laparoscopy; Medicine; Medicine & Public Health; Metastases; Metastasis; Neoplasm Metastasis; Neoplasm Staging; Omentum; Oncology; Peritoneal Neoplasms - diagnosis; Peritoneal Neoplasms - diagnostic imaging; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - secondary; Peritoneal Surface Malignancy; Peritoneum; Prospective Studies; Radiometry - methods; ROC Curve; Sensitivity and Specificity; Stomach Neoplasms - diagnosis; Stomach Neoplasms - diagnostic imaging; Stomach Neoplasms - pathology; Surgery; Surgical Oncology; Tomography, X-Ray Computed; Value added
• ISSN: 1068-9265; 1534-4681; 1534-4681
• DOI: 10.1245/s10434-019-07812-y

Background Preoperative diagnosis of peritoneal metastasis with gastric cancer remains challenging. This study explored the abnormal computed tomography (CT) signs of occult peritoneal metastasis (OPM) and evaluated it by region-to-region comparison using staging laparoscopy, from which a 4-point CT score system was developed. Methods Patients with advanced gastric cancer (stage cT ≥ 2M0) diagnosed by CT were enrolled in the study. Occult peritoneal metastasis detected during staging laparoscopy was compared with preoperative CT to investigate the presence of abnormal signs by a region-to-region comparison. A 4-point CT score system was developed to define the radiologic characteristics. Subsequently, the diagnostic efficacy of the CT score system was prospectively verified. Results In this study, 57 OPM regions were detected by staging laparoscopy in 33 of the 385 enrolled patients. The greater omentum was the most frequent site of OPM (38.60%, 22/57), which usually exhibited a smudge-like ground-glass opacity (S-GGO) (90.91%, 20/22) with a mean CT score of 2.14. The parietal and perihepatic peritoneum was the second most common site (22.81%, 13/57). A 4-point CT score system was developed based on the results. A cutoff CT score of 2 or higher was associated with a false-negative rate of 2% (2/99). This CT score system had a sensitivity of 87.5% and a specificity of 76.4% for an OPM-positive diagnosis (area under the curve, 0.848). The agreement between two radiologists on the assigned final score was 76.2% (kappa, 0.5). Conclusions Patients with OPM mostly exhibited S-GGO on CT, which should be interpreted cautiously. The 4-point CT score system may improve the pretreatment evaluation of occult peritoneal metastasis, and staging laparoscopy might not be necessary for patients with a score lower than 2.