Factors associated with sputum culture conversion in patients with pulmonary tuberculosis
The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment. A total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), th...
Saved in:
| Published in | Medicina (Kaunas, Lithuania) Vol. 53; no. 6; pp. 386 - 393 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Sp. z o.o
2017
MDPI AG |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1010-660X 1648-9144 1648-9144 |
| DOI | 10.1016/j.medici.2018.01.005 |
Cover
| Abstract | The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment.
A total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), they were asked about smoking, alcohol use, living conditions and education. Body mass index (BMI) measurements, laboratory tests (C reactive protein [CRP], vitamin D, albumin) were performed, and chest X-ray was done. After 1 month of treatment sputum culture was repeated.
Culture conversion after 1 month of treatment was found in 38.5% cases. None of investigated social factors appeared to have an effect on conversion, but worse overall health status (as reported in SGRQ) and longer duration of tobacco smoking were detected in the “no conversion” group. Concentrations of albumin, CRP, X-ray score and the time it took Mycobacterium tuberculosis culture to grow also differed. Patients who scored 30 or more on SGRQ were more than 7 times as likely to have no conversion. However, the most important factor predicting sputum culture conversion was sputum smear grade at the beginning of treatment: patients with grade of 2+ or more had more than 20-fold higher relative risk for no conversion. Using receiver operating characteristic curve analysis, we also developed a risk score for no conversion.
The most important factors in predicting sputum culture conversion after 1 month of treatment were grades of acid-fast bacilli in sputum smears at time of diagnosis and scores of SGRQ. |
|---|---|
| AbstractList | The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment.
A total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), they were asked about smoking, alcohol use, living conditions and education. Body mass index (BMI) measurements, laboratory tests (C reactive protein [CRP], vitamin D, albumin) were performed, and chest X-ray was done. After 1 month of treatment sputum culture was repeated.
Culture conversion after 1 month of treatment was found in 38.5% cases. None of investigated social factors appeared to have an effect on conversion, but worse overall health status (as reported in SGRQ) and longer duration of tobacco smoking were detected in the “no conversion” group. Concentrations of albumin, CRP, X-ray score and the time it took Mycobacterium tuberculosis culture to grow also differed. Patients who scored 30 or more on SGRQ were more than 7 times as likely to have no conversion. However, the most important factor predicting sputum culture conversion was sputum smear grade at the beginning of treatment: patients with grade of 2+ or more had more than 20-fold higher relative risk for no conversion. Using receiver operating characteristic curve analysis, we also developed a risk score for no conversion.
The most important factors in predicting sputum culture conversion after 1 month of treatment were grades of acid-fast bacilli in sputum smears at time of diagnosis and scores of SGRQ. The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment.OBJECTIVEThe aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment.A total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), they were asked about smoking, alcohol use, living conditions and education. Body mass index (BMI) measurements, laboratory tests (C reactive protein [CRP], vitamin D, albumin) were performed, and chest X-ray was done. After 1 month of treatment sputum culture was repeated.MATERIALS AND METHODSA total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), they were asked about smoking, alcohol use, living conditions and education. Body mass index (BMI) measurements, laboratory tests (C reactive protein [CRP], vitamin D, albumin) were performed, and chest X-ray was done. After 1 month of treatment sputum culture was repeated.Culture conversion after 1 month of treatment was found in 38.5% cases. None of investigated social factors appeared to have an effect on conversion, but worse overall health status (as reported in SGRQ) and longer duration of tobacco smoking were detected in the "no conversion" group. Concentrations of albumin, CRP, X-ray score and the time it took Mycobacterium tuberculosis culture to grow also differed. Patients who scored 30 or more on SGRQ were more than 7 times as likely to have no conversion. However, the most important factor predicting sputum culture conversion was sputum smear grade at the beginning of treatment: patients with grade of 2+ or more had more than 20-fold higher relative risk for no conversion. Using receiver operating characteristic curve analysis, we also developed a risk score for no conversion.RESULTSCulture conversion after 1 month of treatment was found in 38.5% cases. None of investigated social factors appeared to have an effect on conversion, but worse overall health status (as reported in SGRQ) and longer duration of tobacco smoking were detected in the "no conversion" group. Concentrations of albumin, CRP, X-ray score and the time it took Mycobacterium tuberculosis culture to grow also differed. Patients who scored 30 or more on SGRQ were more than 7 times as likely to have no conversion. However, the most important factor predicting sputum culture conversion was sputum smear grade at the beginning of treatment: patients with grade of 2+ or more had more than 20-fold higher relative risk for no conversion. Using receiver operating characteristic curve analysis, we also developed a risk score for no conversion.The most important factors in predicting sputum culture conversion after 1 month of treatment were grades of acid-fast bacilli in sputum smears at time of diagnosis and scores of SGRQ.CONCLUSIONSThe most important factors in predicting sputum culture conversion after 1 month of treatment were grades of acid-fast bacilli in sputum smears at time of diagnosis and scores of SGRQ. Objective: The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment. Materials and methods: A total of 52 patients with new drug susceptible pulmonary TB were included in the study. Patients completed St. George respiratory questionnaire (SGRQ), they were asked about smoking, alcohol use, living conditions and education. Body mass index (BMI) measurements, laboratory tests (C reactive protein [CRP], vitamin D, albumin) were performed, and chest X-ray was done. After 1 month of treatment sputum culture was repeated. Results: Culture conversion after 1 month of treatment was found in 38.5% cases. None of investigated social factors appeared to have an effect on conversion, but worse overall health status (as reported in SGRQ) and longer duration of tobacco smoking were detected in the “no conversion” group. Concentrations of albumin, CRP, X-ray score and the time it took Mycobacterium tuberculosis culture to grow also differed. Patients who scored 30 or more on SGRQ were more than 7 times as likely to have no conversion. However, the most important factor predicting sputum culture conversion was sputum smear grade at the beginning of treatment: patients with grade of 2+ or more had more than 20-fold higher relative risk for no conversion. Using receiver operating characteristic curve analysis, we also developed a risk score for no conversion. Conclusions: The most important factors in predicting sputum culture conversion after 1 month of treatment were grades of acid-fast bacilli in sputum smears at time of diagnosis and scores of SGRQ. Keywords: Smoking, Smear grade, St. George respiratory questionnaire, Tuberculosis, Culture conversion |
| Author | Žemaitis, Marius Miliauskas, Skaidrius Musteikienė, Greta Zaveckienė, Jurgita Vitkauskienė, Astra |
| Author_xml | – sequence: 1 givenname: Greta surname: Musteikienė fullname: Musteikienė, Greta email: greta.musteikiene@lsmuni.lt organization: Department of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania – sequence: 2 givenname: Skaidrius surname: Miliauskas fullname: Miliauskas, Skaidrius organization: Department of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania – sequence: 3 givenname: Jurgita surname: Zaveckienė fullname: Zaveckienė, Jurgita organization: Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania – sequence: 4 givenname: Marius surname: Žemaitis fullname: Žemaitis, Marius organization: Department of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania – sequence: 5 givenname: Astra surname: Vitkauskienė fullname: Vitkauskienė, Astra organization: Department of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29496377$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU1v1jAQhC1URD_gHyCUI5eEdeLYCQckVFFaqRIXkOBkOesN-FUSB9tp1X-PS1oOHODklfXM7GrmlB0tfiHGXnKoOHD55lDNZB26qgbeVcArgPYJO-FSdGXPhTjKM3AopYSvx-w0xgNAU7eqfsaO6170slHqhH27MJh8iIWJ0aMziWxx69KPIq5b2uYCtyltgQr0yw2F6PxSuKVYTXK0pLij6zbNfjHhrkjbQCFLfHTxOXs6minSi4f3jH25-PD5_LK8_vTx6vz9dYlCiVQObS1BoTGjrXE0AGA5RyN6tO0oESW3lmy-e-hHxBG6jttWEAnkahjqoTljV7uv9eag1-DmfIn2xunfHz581yYkhxNpY7quRtuohoQQxM0o-1raYSQFg-CYvV7vXmvwPzeKSc8uIk2TWchvUeeooVGgGpnRVw_oNuQi_ix-jDYDb3cAg48x0KjRpZybX1IwbtIc9H2P-qD3Hu_NOw1c5x6zWPwlfvT_j-zdLqMc-I2joCPmojCTgTDlRNy_DX4BldS8Jw |
| CitedBy_id | crossref_primary_10_1128_CMR_00141_20 crossref_primary_10_3390_antibiotics13121216 crossref_primary_10_22207_JPAM_14_4_22 crossref_primary_10_1186_s40360_018_0279_1 crossref_primary_10_24018_ejbiomed_2023_2_1_42 crossref_primary_10_1016_j_chest_2023_08_021 crossref_primary_10_1371_journal_pone_0304507 crossref_primary_10_17816_EID312900 crossref_primary_10_1111_tmi_13355 |
| Cites_doi | 10.1016/S0140-6736(10)61889-2 10.1016/S0035-9203(02)90103-3 10.1590/S1806-37132014000300010 10.4068/cmj.2015.51.2.86 10.5588/ijtld.12.0122 10.1136/thx.2010.136242 10.1371/journal.pone.0077979 10.1016/j.clnu.2013.11.014 10.1183/09031936.00174907 10.1097/QAD.0b013e32833a2a4a 10.1371/journal.pone.0094890 10.5588/ijtld.15.0690 10.5588/ijtld.13.0602 10.1017/S0950268814002386 10.1186/s12879-016-1736-3 10.1016/S1473-3099(15)70053-8 10.3945/ajcn.115.113886 10.5588/ijtld.14.0516 10.1371/journal.pone.0070032 10.3904/kjim.2003.18.3.138 10.1139/cjpp-2014-0386 |
| ContentType | Journal Article |
| Copyright | 2018 The Lithuanian University of Health Sciences Copyright © 2018 The Lithuanian University of Health Sciences. Production and hosting by Elsevier Sp. z o.o. All rights reserved. |
| Copyright_xml | – notice: 2018 The Lithuanian University of Health Sciences – notice: Copyright © 2018 The Lithuanian University of Health Sciences. Production and hosting by Elsevier Sp. z o.o. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 DOA |
| DOI | 10.1016/j.medici.2018.01.005 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic DOAJ Open Access Full Text |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1648-9144 |
| EndPage | 393 |
| ExternalDocumentID | oai_doaj_org_article_aa882cd373e444e1af6926dbfe70b41c 29496377 10_1016_j_medici_2018_01_005 S1010660X18300089 |
| Genre | Journal Article |
| GroupedDBID | 0R~ 0SF 29M 2WC 4.4 457 53G 5GY 5VS 6I. 7X7 8FI 8FJ AACTN AADQD AAEDT AAEDW AAFTH AAFWJ AAIKJ AALRI AAXUO ABMAC ABUWG ACGFS ADBBV ADEZE AFKRA AFPKN AFZYC AGHFR AHDRD AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BCNDV BENPR CCPQU DIK EBS EJD EMOBN F5P FDB FYUFA GROUPED_DOAJ HMCUK HYE IAO IPNFZ KQ8 M41 MODMG NCXOZ O9- OK1 PIMPY RIG ROL RPM SSZ UKHRP XSB AAYWO AAYXX ADVLN ALIPV CITATION IHR ITC OVT PGMZT PHGZM PHGZT NPM 7X8 |
| ID | FETCH-LOGICAL-c474t-b52607caafd2cfa000d11ca49cd5f6cc61dded257b9fccf0881d54ee4c17bb2b3 |
| IEDL.DBID | DOA |
| ISSN | 1010-660X 1648-9144 |
| IngestDate | Wed Aug 27 01:31:54 EDT 2025 Fri Sep 05 08:39:13 EDT 2025 Wed Feb 19 02:43:48 EST 2025 Tue Jul 01 03:11:40 EDT 2025 Thu Apr 24 22:50:41 EDT 2025 Fri Feb 23 02:27:18 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Culture conversion Tuberculosis Smear grade St. George respiratory questionnaire Smoking |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 http://www.elsevier.com/tdm/userlicense/1.0 Copyright © 2018 The Lithuanian University of Health Sciences. Production and hosting by Elsevier Sp. z o.o. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c474t-b52607caafd2cfa000d11ca49cd5f6cc61dded257b9fccf0881d54ee4c17bb2b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/aa882cd373e444e1af6926dbfe70b41c |
| PMID | 29496377 |
| PQID | 2010370736 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_aa882cd373e444e1af6926dbfe70b41c proquest_miscellaneous_2010370736 pubmed_primary_29496377 crossref_citationtrail_10_1016_j_medici_2018_01_005 crossref_primary_10_1016_j_medici_2018_01_005 elsevier_sciencedirect_doi_10_1016_j_medici_2018_01_005 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2017 2017-00-00 20170101 2017-01-01 |
| PublicationDateYYYYMMDD | 2017-01-01 |
| PublicationDate_xml | – year: 2017 text: 2017 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Medicina (Kaunas, Lithuania) |
| PublicationTitleAlternate | Medicina (Kaunas) |
| PublicationYear | 2017 |
| Publisher | Elsevier Sp. z o.o MDPI AG |
| Publisher_xml | – name: Elsevier Sp. z o.o – name: MDPI AG |
| References | Selvaraj, Harishankar, Afsal (bib0280) 2015; 93 Ralph, Ardian, Wiguna, Maguire, Becker, Drogumuller (bib0250) 2010; 65 Uzundağ Işeri, Dulkar, Selçuk Sönmez, Yilmaz Aydin, Yilmaz (bib0245) 2009; 58 Fox, Ellard, Mitchison (bib0205) 1999; 3 Putri, Burhan, Nawas, Soepandi, Sutoyo, Agustin (bib0225) 2014; 18 Zachariah, Spielmann, Harries, Salaniponi (bib0320) 2002; 96 Bhargava, Chatterjee, Jain, Chatterjee, Kataria, Bhargava (bib0325) 2013; 8 Beauté, de Colombani, Dara, Ehsani, Hovhannesyan, Ködmön (bib0175) 2016 Hanrahan, Golub, Mohapi, Tshabangu, Modisenyane, Chaisson (bib0330) 2010; 24 Plit, Theron, Fickl, Van Rensburg, Pendel, Anderson (bib0270) 1998; 2 Daley, Jagannathan, John, Sarojini, Latha, Vieth (bib0290) 2015; 15 Rathored, Sharma, Singh, Banavaliker, Sreenivas, Srivastava (bib0305) 2012; 16 Kim, Kim, Kwon, Yoon, Lee, Kim (bib0315) 2008; 32 Lee, Chang (bib0265) 2003; 18 Yohanes, Abera, Ali (bib0340) 2012; 12 Dominguez-Castellano, Muniain, Rodriguez-Bano, Garcia, Rios, Galvez (bib0215) 2003; 7 Davidaviciene, Danila, Naujokaitė, Nargėla, Sakalauskas, Sosnovskaja (bib0195) 2009 Mahishale, Patil, Lolly, Eti, Khan (bib0260) 2015; 51 Wallis, Johnson (bib0210) 2006 Mesquita, Gil-Santana, Ramalho, Tonomura, Silva, Oliveira (bib0255) 2016; 16 Ralph, Waramori, Pontororing, Kenangalem, Wiguna, Tjitra (bib0295) 2013; 8 [Internet; cited 14.06.17]. Lithuania: Vilnius (bib0180) 2014 Moraes, Ramalho, Delogo, Miranda, Mesquita, Oliveira (bib0240) 2014; 40 Kim, Kim, Kim, Lee, Hong, Lee (bib0275) 2016; 20 Arnedo-Pena, Juan-Cerdan, Romeu-Garcia, Garcia-Ferrer, Holguin-Gomez, Iborra-Millet (bib0235) 2015; 143 2014 m. 141 cases of HIV infection diagnosed in Lithuania in 2014 [Lietuvoje nustatytas 141 ŽIV infekcijos atvejis]. Available from Unsematham, Kateruttanakul (bib0230) 2013; 96 Volkmann, Moonan, Miramontes, Oeltmann (bib0335) 2015; 19 Zumla, Wallis, Doherty, Klein, Parida, Olesen (bib0200) 2008 Kim, Park, Cho, Yoon, Song, Lee (bib0310) 2014; 33 Tukvadze, Sanikidze, Kipiani, Hebbar, Easley, Shenvi (bib0285) 2015; 102 Martineau, Timms, Bothamley, Hanifa, Islam, Claxton (bib0300) 2011; 377 Magee, Kempker, Kipiani, Tukvadze, Howards, Narayan (bib0220) 2014; 9 In 2015 HIV infection was diagnosed in 157 patients [2015 metais ŽIV infekcija diagnozuota 157 asmenims]. Available from Lee (10.1016/j.medici.2018.01.005_bib0265) 2003; 18 Yohanes (10.1016/j.medici.2018.01.005_bib0340) 2012; 12 Kim (10.1016/j.medici.2018.01.005_bib0310) 2014; 33 Zumla (10.1016/j.medici.2018.01.005_bib0200) 2008 Fox (10.1016/j.medici.2018.01.005_bib0205) 1999; 3 Davidaviciene (10.1016/j.medici.2018.01.005_bib0195) 2009 Uzundağ Işeri (10.1016/j.medici.2018.01.005_bib0245) 2009; 58 Magee (10.1016/j.medici.2018.01.005_bib0220) 2014; 9 Zachariah (10.1016/j.medici.2018.01.005_bib0320) 2002; 96 Beauté (10.1016/j.medici.2018.01.005_bib0175) 2016 Lithuania: Vilnius (10.1016/j.medici.2018.01.005_bib0180) 2014 Arnedo-Pena (10.1016/j.medici.2018.01.005_bib0235) 2015; 143 Ralph (10.1016/j.medici.2018.01.005_bib0250) 2010; 65 Mahishale (10.1016/j.medici.2018.01.005_bib0260) 2015; 51 Kim (10.1016/j.medici.2018.01.005_bib0315) 2008; 32 Putri (10.1016/j.medici.2018.01.005_bib0225) 2014; 18 Unsematham (10.1016/j.medici.2018.01.005_bib0230) 2013; 96 Rathored (10.1016/j.medici.2018.01.005_bib0305) 2012; 16 Volkmann (10.1016/j.medici.2018.01.005_bib0335) 2015; 19 Daley (10.1016/j.medici.2018.01.005_bib0290) 2015; 15 Moraes (10.1016/j.medici.2018.01.005_bib0240) 2014; 40 Martineau (10.1016/j.medici.2018.01.005_bib0300) 2011; 377 Plit (10.1016/j.medici.2018.01.005_bib0270) 1998; 2 Kim (10.1016/j.medici.2018.01.005_bib0275) 2016; 20 Dominguez-Castellano (10.1016/j.medici.2018.01.005_bib0215) 2003; 7 10.1016/j.medici.2018.01.005_bib0190 Tukvadze (10.1016/j.medici.2018.01.005_bib0285) 2015; 102 Ralph (10.1016/j.medici.2018.01.005_bib0295) 2013; 8 Hanrahan (10.1016/j.medici.2018.01.005_bib0330) 2010; 24 Mesquita (10.1016/j.medici.2018.01.005_bib0255) 2016; 16 Wallis (10.1016/j.medici.2018.01.005_bib0210) 2006 Selvaraj (10.1016/j.medici.2018.01.005_bib0280) 2015; 93 Bhargava (10.1016/j.medici.2018.01.005_bib0325) 2013; 8 10.1016/j.medici.2018.01.005_bib0185 |
| References_xml | – start-page: 95 year: 2006 end-page: 113 ident: bib0210 article-title: Surrogate markers to assess clinical efficacy of new antituberculous drugs. The development of new antituberculosis drugs – volume: 93 start-page: 377 year: 2015 end-page: 384 ident: bib0280 article-title: Vitamin D: immuno-modulation and tuberculosis treatment publication-title: Can J Physiol Pharmacol – volume: 65 start-page: 863 year: 2010 end-page: 869 ident: bib0250 article-title: A simple, valid, numerical score for grading chest X-ray severity in adult smear-positive pulmonary tuberculosis publication-title: Thorax – year: 2016 ident: bib0175 article-title: WHO Regional Office for Europe and ECDC – year: 2009 ident: bib0195 article-title: Methodical recommendations of diagnosis and treatment of pulmonary tuberculosis publication-title: Lietuvos Rotary komitetas – volume: 51 start-page: 86 year: 2015 end-page: 90 ident: bib0260 article-title: Prevalence of smoking and its impact on treatment outcomes in newly diagnosed pulmonary tuberculosis patients: a hospital-based prospective study publication-title: Chonnam Med J – volume: 9 start-page: e94890 year: 2014 ident: bib0220 article-title: Diabetes mellitus, smoking status, and rate of sputum culture conversion in patients with multidrug-resistant tuberculosis: a cohort study from the country of Georgia publication-title: PLOS ONE – reference: 2014 m. 141 cases of HIV infection diagnosed in Lithuania in 2014 [Lietuvoje nustatytas 141 ŽIV infekcijos atvejis]. Available from: – volume: 33 start-page: 1081 year: 2014 end-page: 1086 ident: bib0310 article-title: Low serum 25-hydroxyvitamin D level: an independent risk factor for tuberculosis? publication-title: Clin Nutr – reference: In 2015 HIV infection was diagnosed in 157 patients [2015 metais ŽIV infekcija diagnozuota 157 asmenims]. Available from: – volume: 16 start-page: 368 year: 2016 ident: bib0255 article-title: Associations between systemic inflammation, mycobacterial loads in sputum and radiological improvement after treatment initiation in pulmonary TB patients from Brazil: a prospective cohort study publication-title: BMC Infect Dis – volume: 377 start-page: 242 year: 2011 end-page: 250 ident: bib0300 article-title: High-dose vitamin D 3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial publication-title: Lancet – year: 2014 ident: bib0180 article-title: Lithuanian National Tuberculosis Register. Annual report – reference: [Internet; cited 14.06.17]. – volume: 102 start-page: 1059 year: 2015 end-page: 1069 ident: bib0285 article-title: High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial publication-title: Am J Clin Nutr – volume: 96 start-page: 644 year: 2013 end-page: 649 ident: bib0230 article-title: Factors predicting sputum smear conversion and treatment outcomes in new smear-positive pulmonary tuberculosis publication-title: J Med Assoc Thai – volume: 20 start-page: 524 year: 2016 end-page: 529 ident: bib0275 article-title: Mortality and predictors in pulmonary tuberculosis with respiratory failure requiring mechanical ventilation publication-title: Int J Tuberc Lung Dis – volume: 24 start-page: 1501 year: 2010 end-page: 1508 ident: bib0330 article-title: Body mass index and risk of tuberculosis and death publication-title: AIDS – volume: 143 start-page: 1731 year: 2015 end-page: 1741 ident: bib0235 article-title: Vitamin D status and incidence of tuberculosis infection conversion in contacts of pulmonary tuberculosis patients: a prospective cohort study publication-title: Epidemiol Infect – volume: 19 start-page: 111 year: 2015 end-page: 119 ident: bib0335 article-title: Tuberculosis and excess alcohol use in the United States, 1997–2012 publication-title: Int J Tuberc Lung Dis – volume: 12 start-page: 325 year: 2012 end-page: 330 ident: bib0340 article-title: Smear positive pulmonary tuberculosis among suspected patients attending Metehara sugar factory hospital; eastern Ethiopia publication-title: Afr Health Sci – volume: 3 start-page: S231 year: 1999 end-page: S279 ident: bib0205 article-title: Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946–1986, with relevant subsequent publications publication-title: Int J Tuberc Lung Dis – volume: 16 start-page: 1522 year: 2012 end-page: 1528 ident: bib0305 article-title: Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25 (OH) D publication-title: Int J Tuberc Lung Dis – volume: 40 start-page: 269 year: 2014 end-page: 278 ident: bib0240 article-title: Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment publication-title: J Bras Pneumol – volume: 58 start-page: 44 year: 2009 end-page: 52 ident: bib0245 article-title: Factors that effect sputum culture conversion rate in hospitalized patients with pulmonary tuberculosis who were applied directly observation therapy and non-directly observation therapy publication-title: Tuberk Toraks – volume: 8 start-page: e70032 year: 2013 ident: bib0295 article-title: -Arginine and vitamin D adjunctive therapies in pulmonary tuberculosis: a randomised, double-blind, placebo-controlled trial publication-title: PLOS ONE – volume: 7 start-page: 432 year: 2003 end-page: 438 ident: bib0215 article-title: Factors associated with time to sputum smear conversion in active pulmonary tuberculosis publication-title: Int J Tuberc Lung Dis – volume: 8 start-page: e77979 year: 2013 ident: bib0325 article-title: Nutritional status of adult patients with pulmonary tuberculosis in rural central India and its association with mortality publication-title: PLOS ONE – volume: 2 start-page: 590 year: 1998 end-page: 596 ident: bib0270 article-title: Influence of antimicrobial chemotherapy and smoking status on the plasma concentrations of vitamin C, vitamin E, beta-carotene, acute phase reactants, iron and lipid peroxides in patients with pulmonary tuberculosis publication-title: Int J Tuberc Lung Dis – volume: 96 start-page: 291 year: 2002 end-page: 294 ident: bib0320 article-title: Moderate to severe malnutrition in patients with tuberculosis is a risk factor associated with early death publication-title: Trans R Soc Trop Med Hyg – volume: 32 start-page: 1031 year: 2008 end-page: 1036 ident: bib0315 article-title: Nutritional deficit as a negative prognostic factor in patients with miliary tuberculosis publication-title: Eur Respir J – volume: 18 start-page: 138 year: 2003 end-page: 145 ident: bib0265 article-title: Changes of plasma interleukin-1 receptor antagonist, interleukin-8 and other serologic markers during chemotherapy in patients with active pulmonary tuberculosis publication-title: Korean J Intern Med – year: 2008 ident: bib0200 article-title: Joint TDR/EC expert consultation on biomarkers in tuberculosis: report of the joint TDR/EC expert consultation to evaluate the potential roles of biomarkers in the management of HIV-infected and HIV-uninfected patients with tuberculosis – volume: 15 start-page: 528 year: 2015 end-page: 534 ident: bib0290 article-title: Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial publication-title: Lancet Infect Dis – volume: 18 start-page: 564 year: 2014 end-page: 570 ident: bib0225 article-title: Body mass index predictive of sputum culture conversion among MDR-TB patients in Indonesia publication-title: Int J Tuberc Lung Dis – year: 2008 ident: 10.1016/j.medici.2018.01.005_bib0200 – volume: 377 start-page: 242 issue: 9761 year: 2011 ident: 10.1016/j.medici.2018.01.005_bib0300 article-title: High-dose vitamin D 3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(10)61889-2 – year: 2014 ident: 10.1016/j.medici.2018.01.005_bib0180 – volume: 96 start-page: 291 issue: 3 year: 2002 ident: 10.1016/j.medici.2018.01.005_bib0320 article-title: Moderate to severe malnutrition in patients with tuberculosis is a risk factor associated with early death publication-title: Trans R Soc Trop Med Hyg doi: 10.1016/S0035-9203(02)90103-3 – start-page: 95 year: 2006 ident: 10.1016/j.medici.2018.01.005_bib0210 – volume: 40 start-page: 269 issue: 3 year: 2014 ident: 10.1016/j.medici.2018.01.005_bib0240 article-title: Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment publication-title: J Bras Pneumol doi: 10.1590/S1806-37132014000300010 – year: 2009 ident: 10.1016/j.medici.2018.01.005_bib0195 article-title: Methodical recommendations of diagnosis and treatment of pulmonary tuberculosis – volume: 51 start-page: 86 issue: 2 year: 2015 ident: 10.1016/j.medici.2018.01.005_bib0260 article-title: Prevalence of smoking and its impact on treatment outcomes in newly diagnosed pulmonary tuberculosis patients: a hospital-based prospective study publication-title: Chonnam Med J doi: 10.4068/cmj.2015.51.2.86 – volume: 16 start-page: 1522 issue: 11 year: 2012 ident: 10.1016/j.medici.2018.01.005_bib0305 article-title: Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25 (OH) D publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.12.0122 – volume: 3 start-page: S231 issue: 10s2 year: 1999 ident: 10.1016/j.medici.2018.01.005_bib0205 article-title: Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946–1986, with relevant subsequent publications publication-title: Int J Tuberc Lung Dis – volume: 65 start-page: 863 issue: 10 year: 2010 ident: 10.1016/j.medici.2018.01.005_bib0250 article-title: A simple, valid, numerical score for grading chest X-ray severity in adult smear-positive pulmonary tuberculosis publication-title: Thorax doi: 10.1136/thx.2010.136242 – volume: 8 start-page: e77979 issue: 10 year: 2013 ident: 10.1016/j.medici.2018.01.005_bib0325 article-title: Nutritional status of adult patients with pulmonary tuberculosis in rural central India and its association with mortality publication-title: PLOS ONE doi: 10.1371/journal.pone.0077979 – volume: 33 start-page: 1081 issue: 6 year: 2014 ident: 10.1016/j.medici.2018.01.005_bib0310 article-title: Low serum 25-hydroxyvitamin D level: an independent risk factor for tuberculosis? publication-title: Clin Nutr doi: 10.1016/j.clnu.2013.11.014 – volume: 32 start-page: 1031 issue: 4 year: 2008 ident: 10.1016/j.medici.2018.01.005_bib0315 article-title: Nutritional deficit as a negative prognostic factor in patients with miliary tuberculosis publication-title: Eur Respir J doi: 10.1183/09031936.00174907 – volume: 2 start-page: 590 issue: 7 year: 1998 ident: 10.1016/j.medici.2018.01.005_bib0270 article-title: Influence of antimicrobial chemotherapy and smoking status on the plasma concentrations of vitamin C, vitamin E, beta-carotene, acute phase reactants, iron and lipid peroxides in patients with pulmonary tuberculosis publication-title: Int J Tuberc Lung Dis – volume: 24 start-page: 1501 issue: 10 year: 2010 ident: 10.1016/j.medici.2018.01.005_bib0330 article-title: Body mass index and risk of tuberculosis and death publication-title: AIDS doi: 10.1097/QAD.0b013e32833a2a4a – volume: 9 start-page: e94890 issue: 4 year: 2014 ident: 10.1016/j.medici.2018.01.005_bib0220 article-title: Diabetes mellitus, smoking status, and rate of sputum culture conversion in patients with multidrug-resistant tuberculosis: a cohort study from the country of Georgia publication-title: PLOS ONE doi: 10.1371/journal.pone.0094890 – volume: 20 start-page: 524 issue: 4 year: 2016 ident: 10.1016/j.medici.2018.01.005_bib0275 article-title: Mortality and predictors in pulmonary tuberculosis with respiratory failure requiring mechanical ventilation publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.15.0690 – volume: 18 start-page: 564 issue: 5 year: 2014 ident: 10.1016/j.medici.2018.01.005_bib0225 article-title: Body mass index predictive of sputum culture conversion among MDR-TB patients in Indonesia publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.13.0602 – volume: 58 start-page: 44 issue: 1 year: 2009 ident: 10.1016/j.medici.2018.01.005_bib0245 article-title: Factors that effect sputum culture conversion rate in hospitalized patients with pulmonary tuberculosis who were applied directly observation therapy and non-directly observation therapy publication-title: Tuberk Toraks – volume: 143 start-page: 1731 issue: 08 year: 2015 ident: 10.1016/j.medici.2018.01.005_bib0235 article-title: Vitamin D status and incidence of tuberculosis infection conversion in contacts of pulmonary tuberculosis patients: a prospective cohort study publication-title: Epidemiol Infect doi: 10.1017/S0950268814002386 – volume: 16 start-page: 368 issue: 1 year: 2016 ident: 10.1016/j.medici.2018.01.005_bib0255 article-title: Associations between systemic inflammation, mycobacterial loads in sputum and radiological improvement after treatment initiation in pulmonary TB patients from Brazil: a prospective cohort study publication-title: BMC Infect Dis doi: 10.1186/s12879-016-1736-3 – volume: 15 start-page: 528 issue: 5 year: 2015 ident: 10.1016/j.medici.2018.01.005_bib0290 article-title: Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(15)70053-8 – volume: 102 start-page: 1059 issue: 5 year: 2015 ident: 10.1016/j.medici.2018.01.005_bib0285 article-title: High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial publication-title: Am J Clin Nutr doi: 10.3945/ajcn.115.113886 – volume: 19 start-page: 111 issue: 1 year: 2015 ident: 10.1016/j.medici.2018.01.005_bib0335 article-title: Tuberculosis and excess alcohol use in the United States, 1997–2012 publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.14.0516 – volume: 8 start-page: e70032 issue: 8 year: 2013 ident: 10.1016/j.medici.2018.01.005_bib0295 article-title: l-Arginine and vitamin D adjunctive therapies in pulmonary tuberculosis: a randomised, double-blind, placebo-controlled trial publication-title: PLOS ONE doi: 10.1371/journal.pone.0070032 – volume: 7 start-page: 432 issue: 5 year: 2003 ident: 10.1016/j.medici.2018.01.005_bib0215 article-title: Factors associated with time to sputum smear conversion in active pulmonary tuberculosis publication-title: Int J Tuberc Lung Dis – ident: 10.1016/j.medici.2018.01.005_bib0190 – volume: 18 start-page: 138 issue: 3 year: 2003 ident: 10.1016/j.medici.2018.01.005_bib0265 article-title: Changes of plasma interleukin-1 receptor antagonist, interleukin-8 and other serologic markers during chemotherapy in patients with active pulmonary tuberculosis publication-title: Korean J Intern Med doi: 10.3904/kjim.2003.18.3.138 – volume: 93 start-page: 377 issue: 5 year: 2015 ident: 10.1016/j.medici.2018.01.005_bib0280 article-title: Vitamin D: immuno-modulation and tuberculosis treatment publication-title: Can J Physiol Pharmacol doi: 10.1139/cjpp-2014-0386 – ident: 10.1016/j.medici.2018.01.005_bib0185 – year: 2016 ident: 10.1016/j.medici.2018.01.005_bib0175 – volume: 12 start-page: 325 issue: 3 year: 2012 ident: 10.1016/j.medici.2018.01.005_bib0340 article-title: Smear positive pulmonary tuberculosis among suspected patients attending Metehara sugar factory hospital; eastern Ethiopia publication-title: Afr Health Sci – volume: 96 start-page: 644 issue: 6 year: 2013 ident: 10.1016/j.medici.2018.01.005_bib0230 article-title: Factors predicting sputum smear conversion and treatment outcomes in new smear-positive pulmonary tuberculosis publication-title: J Med Assoc Thai |
| SSID | ssj0032572 |
| Score | 2.1298919 |
| Snippet | The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment.
A total of 52... The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment.OBJECTIVEThe aim... Objective: The aim of this study was to determine what factors are associated with sputum culture conversion after 1 month of tuberculosis (TB) treatment.... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 386 |
| SubjectTerms | Culture conversion Smear grade Smoking St. George respiratory questionnaire Tuberculosis |
| Title | Factors associated with sputum culture conversion in patients with pulmonary tuberculosis |
| URI | https://dx.doi.org/10.1016/j.medici.2018.01.005 https://www.ncbi.nlm.nih.gov/pubmed/29496377 https://www.proquest.com/docview/2010370736 https://doaj.org/article/aa882cd373e444e1af6926dbfe70b41c |
| Volume | 53 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3BatwwEBUlh5JLaJu03bYJKvRqatmyJB_bkiUE0lMD25OQRhJsSLzL2j7k7zuS7CU9hL3kaiRbjJ6fRprRG0K-8aC4MqotTAkmXskJhQVbFSKKS4Uoz9LEy8k3v8XVLb9eNasnpb5iTliWB86G-24M-oDgall7zrlnJoi2Es4GL0vLGUT2Ldty3kxlDq4RiDnOiSwjRLmaL82lzK4ctY5pXSpJdsbSdU8WpaTd_9_a9Jzvmdag5RtyMjmP9Ece9FvyynfvyOubKTx-Sv4uc_Ucaiaje0fjQSvtt-MwPtAss-FpSjVP52R03dFJWrXPTbfjPSLT7B7pMFq_wy6bft2fkdvl5Z9fV8VUO6EALvlQ2AY3KhKMCa6CYJD4HGNgeAuuCQJAMOQ1h2aybQAIyDXMNdx7DkxaW9n6PTnqNp3_SKgS3EivFIDznDFhXah56Y0yQcm6NQtSz8bTMAmLx_oW93rOILvT2eQ6mlyXTKPJF6TY99pmYY0D7X_Gedm3jbLY6QGCRU9g0YfAsiBynlU9eRjZc8BXrQ98_usMAo0_YIyqmM5vxj42KmuJTCkW5ENGx36QVcuR4KT89BKD_0yOq-hTpPOfL-Ro2I3-HD2iwV4k8P8Dr9kLBg |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Factors+associated+with+sputum+culture+conversion+in+patients+with+pulmonary+tuberculosis&rft.jtitle=Medicina+%28Kaunas%2C+Lithuania%29&rft.au=Musteikien%C4%97%2C+Greta&rft.au=Miliauskas%2C+Skaidrius&rft.au=Zaveckien%C4%97%2C+Jurgita&rft.au=%C5%BDemaitis%2C+Marius&rft.date=2017&rft.pub=Elsevier+Sp.+z+o.o&rft.issn=1010-660X&rft.eissn=1648-9144&rft.volume=53&rft.issue=6&rft.spage=386&rft.epage=393&rft_id=info:doi/10.1016%2Fj.medici.2018.01.005&rft.externalDocID=S1010660X18300089 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1010-660X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1010-660X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1010-660X&client=summon |