HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupt...

Full description

Saved in:

Bibliographic Details
Published in	Nature genetics Vol. 54; no. 5; pp. 670 - 683
Main Authors	Lu, Xiaodong, Fong, Ka-wing, Gritsina, Galina, Wang, Fang, Baca, Sylvan C., Brea, Lourdes T., Berchuck, Jacob E., Spisak, Sandor, Ross, Jenny, Morrissey, Colm, Corey, Eva, Chandel, Navdeep S., Catalona, William J., Yang, Ximing, Freedman, Matthew L., Zhao, Jonathan C., Yu, Jindan
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.05.2022 Nature Publishing Group
Subjects	631/208/177 631/67/1059/602 692/699/67/589/466 Age Agriculture Androgen receptors Androgens Animal Genetics and Genomics Binding sites Biomedical and Life Sciences Biomedicine Biosynthesis Cancer Research Castration Cell cycle Cell division Cell Line, Tumor Deacetylation Enhancers Enzymes Epigenesis, Genetic Epigenetics Fatty acids Fatty-acid synthase Gene expression Gene Function Genomes Histone deacetylase Histone Deacetylases - metabolism Histones Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Hoxb13 gene Human Genetics Human tissues Humans Kinases Lipids Lipogenesis Male Metabolism Metastases Metastasis Motility Mutation Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Receptors, Androgen - genetics Receptors, Androgen - metabolism Roles Sterols Transcription Factors - genetics Tumorigenesis Tumors Xenografts Xenotransplantation
Online Access	Get full text
ISSN	1061-4036 1546-1718 1546-1718
DOI	10.1038/s41588-022-01045-8

Cover

Abstract	HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupted by the HOXB13 G84E mutation that has been associated with early-onset PCa. Independently of AR, HOXB13 recruits HDAC3 to lipogenic enhancers to catalyze histone deacetylation and suppress lipogenic regulators such as fatty acid synthase. Analysis of human tissues reveals that the HOXB13 gene is hypermethylated and downregulated in approximately 30% of metastatic castration-resistant PCa. HOXB13 loss or G84E mutation leads to lipid accumulation in PCa cells, thereby promoting cell motility and xenograft tumor metastasis, which is mitigated by pharmaceutical inhibition of fatty acid synthase. In summary, we present evidence that HOXB13 recruits HDAC3 to suppress de novo lipogenesis and inhibit tumor metastasis and that lipogenic pathway inhibitors may be useful to treat HOXB13-low PCa. HOXB13 suppresses a lipogenic transcriptional program in prostate cancer (PCa) through HDAC3 recruitment to enhancers. Loss of HOXB13 leads to lipid accumulation in PCa cells, promoting cell motility in vitro and xenograft tumor metastasis in vivo.
AbstractList	HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupted by the HOXB13 G84E mutation that has been associated with early-onset PCa. Independently of AR, HOXB13 recruits HDAC3 to lipogenic enhancers to catalyze histone deacetylation and suppress lipogenic regulators such as fatty acid synthase. Analysis of human tissues reveals that the HOXB13 gene is hypermethylated and downregulated in approximately 30% of metastatic castration-resistant PCa. HOXB13 loss or G84E mutation leads to lipid accumulation in PCa cells, thereby promoting cell motility and xenograft tumor metastasis, which is mitigated by pharmaceutical inhibition of fatty acid synthase. In summary, we present evidence that HOXB13 recruits HDAC3 to suppress de novo lipogenesis and inhibit tumor metastasis and that lipogenic pathway inhibitors may be useful to treat HOXB13-low PCa. HOXB13 suppresses a lipogenic transcriptional program in prostate cancer (PCa) through HDAC3 recruitment to enhancers. Loss of HOXB13 leads to lipid accumulation in PCa cells, promoting cell motility in vitro and xenograft tumor metastasis in vivo. HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupted by the HOXB13 G84E mutation that has been associated with early-onset PCa. Independently of AR, HOXB13 recruits HDAC3 to lipogenic enhancers to catalyze histone deacetylation and suppress lipogenic regulators such as fatty acid synthase. Analysis of human tissues reveals that the HOXB13 gene is hypermethylated and downregulated in approximately 30% of metastatic castration-resistant PCa. HOXB13 loss or G84E mutation leads to lipid accumulation in PCa cells, thereby promoting cell motility and xenograft tumor metastasis, which is mitigated by pharmaceutical inhibition of fatty acid synthase. In summary, we present evidence that HOXB13 recruits HDAC3 to suppress de novo lipogenesis and inhibit tumor metastasis and that lipogenic pathway inhibitors may be useful to treat HOXB13-low PCa. HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupted by the HOXB13 G84E mutation that has been associated with early-onset PCa. Independently of AR, HOXB13 recruits HDAC3 to lipogenic enhancers to catalyze histone deacetylation and suppress lipogenic regulators such as fatty acid synthase. Analysis of human tissues reveals that the HOXB13 gene is hypermethylated and downregulated in approximately 30% of metastatic castration-resistant PCa. HOXB13 loss or G84E mutation leads to lipid accumulation in PCa cells, thereby promoting cell motility and xenograft tumor metastasis, which is mitigated by pharmaceutical inhibition of fatty acid synthase. In summary, we present evidence that HOXB13 recruits HDAC3 to suppress de novo lipogenesis and inhibit tumor metastasis and that lipogenic pathway inhibitors may be useful to treat HOXB13-low PCa.HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupted by the HOXB13 G84E mutation that has been associated with early-onset PCa. Independently of AR, HOXB13 recruits HDAC3 to lipogenic enhancers to catalyze histone deacetylation and suppress lipogenic regulators such as fatty acid synthase. Analysis of human tissues reveals that the HOXB13 gene is hypermethylated and downregulated in approximately 30% of metastatic castration-resistant PCa. HOXB13 loss or G84E mutation leads to lipid accumulation in PCa cells, thereby promoting cell motility and xenograft tumor metastasis, which is mitigated by pharmaceutical inhibition of fatty acid synthase. In summary, we present evidence that HOXB13 recruits HDAC3 to suppress de novo lipogenesis and inhibit tumor metastasis and that lipogenic pathway inhibitors may be useful to treat HOXB13-low PCa. HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which is disrupted by HOXB13 G84E mutation that has been associated with early-onset PCa. Independently of AR, HOXB13 recruits HDAC3 to lipogenic enhancers to catalyze histone deacetylation and suppress lipogenic regulators such as fatty acid synthase (FASN). Analysis of human tissues reveals that the HOXB13 gene is hypermethylated and downregulated in approximately 30% of metastatic castration-resistant PCa. HOXB13 loss or G84E mutation leads to lipid accumulation in PCa cells, thereby promoting cell motility and xenograft tumor metastasis, which is mitigated by pharmaceutical inhibition of FASN. In summary, we present evidence that HOXB13 recruits HDAC3 to suppress de novo lipogenesis and inhibit tumor metastasis and that lipogenic pathway inhibitors may be useful to treat HOXB13-low PCa.
Author	Ross, Jenny Zhao, Jonathan C. Spisak, Sandor Berchuck, Jacob E. Baca, Sylvan C. Wang, Fang Catalona, William J. Brea, Lourdes T. Fong, Ka-wing Corey, Eva Lu, Xiaodong Gritsina, Galina Yu, Jindan Yang, Ximing Morrissey, Colm Chandel, Navdeep S. Freedman, Matthew L.
AuthorAffiliation	3 Department of Pathology, Northwestern University, Chicago, IL, USA 5 Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University, Chicago, IL, USA 9 Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA 4 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA 8 Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA 6 Department of Urology, Northwestern University, Chicago, IL, USA 7 Department of Urology, University of Washington, Seattle, USA 1 Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA 2 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
AuthorAffiliation_xml	– name: 6 Department of Urology, Northwestern University, Chicago, IL, USA – name: 2 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA – name: 3 Department of Pathology, Northwestern University, Chicago, IL, USA – name: 9 Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA – name: 1 Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA – name: 4 Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA – name: 5 Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University, Chicago, IL, USA – name: 7 Department of Urology, University of Washington, Seattle, USA – name: 8 Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA
Author_xml	– sequence: 1 givenname: Xiaodong orcidid: 0000-0003-4731-0762 surname: Lu fullname: Lu, Xiaodong organization: Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine – sequence: 2 givenname: Ka-wing surname: Fong fullname: Fong, Ka-wing organization: Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine – sequence: 3 givenname: Galina orcidid: 0000-0002-3404-7961 surname: Gritsina fullname: Gritsina, Galina organization: Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine – sequence: 4 givenname: Fang surname: Wang fullname: Wang, Fang organization: Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine – sequence: 5 givenname: Sylvan C. surname: Baca fullname: Baca, Sylvan C. organization: Department of Medical Oncology, Dana-Farber Cancer Institute – sequence: 6 givenname: Lourdes T. orcidid: 0000-0001-9727-7185 surname: Brea fullname: Brea, Lourdes T. organization: Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine – sequence: 7 givenname: Jacob E. orcidid: 0000-0002-7607-2428 surname: Berchuck fullname: Berchuck, Jacob E. organization: Department of Medical Oncology, Dana-Farber Cancer Institute – sequence: 8 givenname: Sandor orcidid: 0000-0002-7834-4642 surname: Spisak fullname: Spisak, Sandor organization: Department of Medical Oncology, Dana-Farber Cancer Institute – sequence: 9 givenname: Jenny surname: Ross fullname: Ross, Jenny organization: Department of Pathology, Northwestern University – sequence: 10 givenname: Colm surname: Morrissey fullname: Morrissey, Colm organization: Department of Urology, University of Washington – sequence: 11 givenname: Eva orcidid: 0000-0002-9244-3807 surname: Corey fullname: Corey, Eva organization: Department of Urology, University of Washington – sequence: 12 givenname: Navdeep S. surname: Chandel fullname: Chandel, Navdeep S. organization: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University, Department of Biochemistry and Molecular Genetics, Northwestern University – sequence: 13 givenname: William J. surname: Catalona fullname: Catalona, William J. organization: Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Department of Urology, Northwestern University – sequence: 14 givenname: Ximing surname: Yang fullname: Yang, Ximing organization: Department of Pathology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center, Northwestern University – sequence: 15 givenname: Matthew L. surname: Freedman fullname: Freedman, Matthew L. organization: Department of Medical Oncology, Dana-Farber Cancer Institute, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute – sequence: 16 givenname: Jonathan C. orcidid: 0000-0002-3163-380X surname: Zhao fullname: Zhao, Jonathan C. email: jonathan-zhao@northwestern.edu organization: Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine – sequence: 17 givenname: Jindan orcidid: 0000-0002-2326-0409 surname: Yu fullname: Yu, Jindan email: jindan-yu@northwestern.edu organization: Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Department of Biochemistry and Molecular Genetics, Northwestern University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35468964$$D View this record in MEDLINE/PubMed
BookMark	eNp9kUtv1TAQhS1URB_wB1ggS2zYGPyOs0FqL4-LVKkbkNhZrjPJdZXYwU4q8e_x5ZYCXXRlW_7OzJk5p-gopggIvWT0LaPCvCuSKWMI5ZxQRqUi5gk6YUpqwhpmjuqdakYkFfoYnZZyQymTkppn6FhUyLRanqDd9ur7BRO4rPOcoRQouAMc023CY5jTABFKKHjZ5bQOO7z9cL4RZIIuuAU6DHPYE0vwOMOc05DdNIU44BBxfZalUti76CE_R097NxZ4cXeeoW-fPn7dbMnl1ecvm_NL4mUjF-K8cl3XMGacF_01tFLInnWG9c60XHfetEZD14FSLXNOO6Nk0zfMSdFy7pQ4Q-8Pdef1uvr0EJfsRjvnMLn80yYX7P8_MezskG5ty1gjta4F3twVyOnHCmWxUygextFFSGuxXCultGi4qOjrB-hNWnOs41VK67YRvOWVevWvo3srf0KoAD8Avq6sZOjvEUbtPml7SNrWpO3vpK2pIvNA5ENdd0j7qcL4uFQcpKX2iQPkv7YfUf0CjHi-ZA
CitedBy_id	crossref_primary_10_1016_j_isci_2024_109246 crossref_primary_10_1038_s41388_024_03011_6 crossref_primary_10_1038_s41388_023_02718_2 crossref_primary_10_1073_pnas_2317694121 crossref_primary_10_1186_s12967_023_04743_x crossref_primary_10_3390_cancers17020262 crossref_primary_10_1016_j_semcancer_2023_01_004 crossref_primary_10_3390_uro3020012 crossref_primary_10_1002_path_6216 crossref_primary_10_1002_path_6258 crossref_primary_10_1016_j_labinv_2023_100120 crossref_primary_10_1158_2767_9764_CRC_23_0248 crossref_primary_10_1002_mog2_59 crossref_primary_10_3389_fimmu_2024_1392145 crossref_primary_10_1016_j_molcel_2022_11_010 crossref_primary_10_1158_0008_5472_CAN_23_0555 crossref_primary_10_1016_j_celrep_2025_115312 crossref_primary_10_3390_nu15234858 crossref_primary_10_1016_j_cmet_2022_09_023 crossref_primary_10_1016_j_phrs_2024_107493 crossref_primary_10_1093_bioadv_vbad104 crossref_primary_10_3389_fonc_2022_963007 crossref_primary_10_1016_j_isci_2023_107931 crossref_primary_10_1007_s11684_024_1119_x crossref_primary_10_1038_s41556_023_01298_3 crossref_primary_10_1038_s43018_023_00539_6 crossref_primary_10_3892_ijo_2024_5692 crossref_primary_10_1007_s10555_023_10152_9 crossref_primary_10_1016_j_envpol_2023_121394 crossref_primary_10_1038_s41467_024_53734_z crossref_primary_10_1080_10286020_2025_2464695 crossref_primary_10_1158_1541_7786_MCR_23_0086 crossref_primary_10_1016_j_ejmech_2024_117230 crossref_primary_10_1083_jcb_202402035 crossref_primary_10_1016_j_tice_2023_102277 crossref_primary_10_1016_j_trecan_2024_01_004 crossref_primary_10_3390_cells13231999 crossref_primary_10_1016_j_compbiolchem_2024_108323 crossref_primary_10_1016_j_urolonc_2023_03_005 crossref_primary_10_3389_fonc_2023_1079037 crossref_primary_10_1038_s44324_024_00021_6 crossref_primary_10_1158_0008_5472_CAN_22_2433 crossref_primary_10_1016_j_euo_2023_09_012 crossref_primary_10_1016_j_stem_2024_05_008 crossref_primary_10_1186_s12964_024_02000_2 crossref_primary_10_3892_ijo_2023_5575 crossref_primary_10_1097_MD_0000000000035120
Cites_doi	10.1038/nprot.2013.150 10.1093/emboj/19.16.4342 10.1038/nature04431 10.1038/s41467-018-07475-5 10.1016/j.ccell.2019.03.001 10.1038/nm.2744 10.1073/pnas.1808834116 10.1016/j.molcel.2009.10.020 10.1172/JCI122367 10.1186/s13072-019-0316-3 10.1158/0008-5472.CAN-12-3468 10.1038/s41588-017-0026-3 10.1038/nmeth.4396 10.1038/nm.3975 10.1038/ng.3419 10.1038/s41422-019-0204-1 10.1038/s41588-017-0027-2 10.1002/(SICI)1097-0045(19991101)41:3<203::AID-PROS8>3.0.CO;2-J 10.1074/jbc.M111.327023 10.1016/j.ebiom.2016.12.012 10.1186/s13072-015-0014-8 10.1038/377454a0 10.1073/pnas.94.24.12975 10.1016/j.cell.2009.06.049 10.1002/pros.23313 10.1093/annonc/mdv004 10.1038/377397a0 10.1128/MCB.21.18.6091-6101.2001 10.1016/j.cmet.2014.01.019 10.1038/nsmb.2476 10.4161/epi.3.6.7273 10.1158/0008-5472.CAN-04-1330 10.1093/nar/gky1106 10.1038/sj.bjc.6602261 10.1016/j.cell.2008.05.024 10.1038/ng.2862 10.1016/j.molcel.2013.10.022 10.1242/dev.00432 10.1056/NEJMoa1110000 10.1126/science.1198125 10.1038/s41588-020-0664-8 10.1073/pnas.1718811115 10.1016/j.ebiom.2015.06.020 10.1016/j.ajpath.2013.08.018 10.1038/s41588-017-0037-0 10.1038/ng.3523 10.1038/onc.2017.385 10.7554/eLife.53600 10.1002/pros.23747 10.1038/s41568-019-0143-7 10.1186/s13059-017-1306-z 10.1038/387043a0 10.1016/j.ygeno.2011.06.003 10.1016/j.ccell.2019.10.005 10.1038/s41588-020-0648-8 10.1038/emboj.2008.51 10.1038/s41596-019-0202-2 10.1186/1471-2407-12-540 10.1530/ERC-15-0556
ContentType	Journal Article
Copyright	The Author(s), under exclusive licence to Springer Nature America, Inc. 2022 2022. The Author(s), under exclusive licence to Springer Nature America, Inc. Copyright Nature Publishing Group May 2022
Copyright_xml	– notice: The Author(s), under exclusive licence to Springer Nature America, Inc. 2022 – notice: 2022. The Author(s), under exclusive licence to Springer Nature America, Inc. – notice: Copyright Nature Publishing Group May 2022
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7X8 5PM
DOI	10.1038/s41588-022-01045-8
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts ProQuest Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database ProQuest Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE Research Library Prep MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Agriculture Biology
EISSN	1546-1718
EndPage	683
ExternalDocumentID	PMC9117466 35468964 10_1038_s41588_022_01045_8
Genre	Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: U.S. Department of Health & Human Services \| NIH \| Center for Scientific Review (NIH Center for Scientific Review) grantid: T32 CA009560 funderid: https://doi.org/10.13039/100005440 – fundername: U.S. Department of Defense (United States Department of Defense) grantid: W81XWH-17-1-0405; W81XWH-17-1-0578; W81XWH- 19-1-0565; W81XWH-21-1-0234 funderid: https://doi.org/10.13039/100000005 – fundername: U.S. Department of Health & Human Services \| NIH \| National Cancer Institute (NCI) grantid: P50CA180995; R01CA257446; R01CA227918; T32CA09560; P50CA180995; R35 CA197532; P50CA180995; R01CA257446; R50CA211271; R01CA251555; P50CA97186; PO1CA163227 funderid: https://doi.org/10.13039/100000054 – fundername: Prostate Cancer Foundation (PCF) grantid: 2017CHAL2008 funderid: https://doi.org/10.13039/100000892 – fundername: NCI NIH HHS grantid: R35 CA197532 – fundername: NCI NIH HHS grantid: T32 CA009172 – fundername: NCI NIH HHS grantid: P50 CA180995 – fundername: NCI NIH HHS grantid: R01 CA251555 – fundername: NCI NIH HHS grantid: P01 CA163227 – fundername: NCI NIH HHS grantid: R01 CA227918 – fundername: NCI NIH HHS grantid: P30 CA060553 – fundername: NCI NIH HHS grantid: P50 CA097186 – fundername: NCI NIH HHS grantid: R50 CA211271 – fundername: NCI NIH HHS grantid: R01 CA257446
GroupedDBID	--- -DZ -~X .55 .GJ 0R~ 123 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AAHBH AARCD AAYOK AAYZH AAZLF ABAWZ ABCQX ABDBF ABDPE ABEFU ABJNI ABLJU ABOCM ABTAH ABUWG ACBWK ACGFO ACGFS ACIWK ACMJI ACNCT ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AGAYW AGCDD AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR IOV ISR ITC L7B LGEZI LK8 LOTEE M0L M1P M2O M7P MVM N9A NADUK NNMJJ NXXTH ODYON P2P PKN PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SOJ SV3 TAOOD TBHMF TDRGL TN5 TSG TUS UKHRP VQA X7M XJT XOL Y6R YHZ ZGI ZXP ZY4 ~8M ~KM AAYXX ABFSG ACMFV ACSTC AETEA AEZWR AFANA AFHIU AHWEU AIXLP ALPWD ATHPR CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NFIDA NPM 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U RC3 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c474t-ac5add7118ac3fbe9434f1d81fa8926dc8986edde5591aa6a8547f71a43922a53
IEDL.DBID	8C1
ISSN	1061-4036 1546-1718
IngestDate	Thu Aug 21 18:38:29 EDT 2025 Fri Sep 05 12:09:38 EDT 2025 Sat Aug 23 13:05:33 EDT 2025 Thu Apr 03 06:57:48 EDT 2025 Tue Jul 01 01:50:17 EDT 2025 Thu Apr 24 22:59:38 EDT 2025 Fri Feb 21 02:39:12 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Language	English
License	2022. The Author(s), under exclusive licence to Springer Nature America, Inc. Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c474t-ac5add7118ac3fbe9434f1d81fa8926dc8986edde5591aa6a8547f71a43922a53
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 J.Y. and X.L. conceived the project and designed the experiments. J.C.Z., S.C.B., M.L.F., and J.Y. conducted bioinformatic and statistical analyses. F.W. and G.G. assisted with in vivo mouse experiment. K.F. performed IP-MS experiment and tissue microarray acquisition. J.R., X.L., and X.Y. performed HOXB13 and FASN IHC scoring. L.T.B. validated key experiments. J.E.B. carried out MeDIP-seq experiment. S.S. generated G84E isogenic 22Rv1. E.C. provided LuCaP PDX tissues. C.M. generated CRPC TMAs. X.L., J.C.Z., and J.Y. wrote the original manuscript. N.S.C., W.J.C., and M.L.F. consulted on the project and edited the manuscript. Author Contributions
ORCID	0000-0002-7834-4642 0000-0002-3404-7961 0000-0002-3163-380X 0000-0002-2326-0409 0000-0001-9727-7185 0000-0002-9244-3807 0000-0003-4731-0762 0000-0002-7607-2428
OpenAccessLink	https://pubmed.ncbi.nlm.nih.gov/PMC9117466
PMID	35468964
PQID	2666973292
PQPubID	33429
PageCount	14
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_9117466 proquest_miscellaneous_2655563723 proquest_journals_2666973292 pubmed_primary_35468964 crossref_primary_10_1038_s41588_022_01045_8 crossref_citationtrail_10_1038_s41588_022_01045_8 springer_journals_10_1038_s41588_022_01045_8
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2022-05-01
PublicationDateYYYYMMDD	2022-05-01
PublicationDate_xml	– month: 05 year: 2022 text: 2022-05-01 day: 01
PublicationDecade	2020
PublicationPlace	New York
PublicationPlace_xml	– name: New York – name: United States
PublicationTitle	Nature genetics
PublicationTitleAbbrev	Nat Genet
PublicationTitleAlternate	Nat Genet
PublicationYear	2022
Publisher	Nature Publishing Group US Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group US – name: Nature Publishing Group
References	Guo (CR40) 2012; 287 Xu (CR53) 2019; 29 Nguyen (CR43) 2017; 77 Spisak (CR24) 2015; 21 Ventura (CR52) 2015; 2 VanOpstall (CR21) 2020; 9 Poulose (CR2) 2018; 50 Perez-Riverol (CR60) 2019; 47 Whitington (CR22) 2016; 48 Kote-Jarai (CR51) 2015; 26 Butler, Centenera, Swinnen (CR3) 2016; 23 Pomerantz (CR16) 2015; 47 Yu (CR46) 2013; 183 Chen (CR9) 2018; 50 Chen (CR18) 2018; 115 Wang (CR42) 2009; 138 Sun (CR39) 2013; 52 Mitra, Chao, Urasaki, Goodman, Le (CR7) 2012; 12 Jung, Kim, Zhang, Lee, Jeng (CR20) 2004; 64 Guenther, Barak, Lazar (CR31) 2001; 21 Fong, Zhao, Song, Zheng, Yu (CR54) 2018; 9 Chen (CR10) 2018; 50 Li (CR41) 2000; 19 Mazrooei (CR23) 2019; 36 Huang (CR12) 2014; 46 Kent, Leone (CR36) 2019; 19 Chen, Evans (CR30) 1995; 377 Wang (CR37) 2013; 8 Vire (CR47) 2006; 439 Huang (CR48) 2017; 18 Jin, Zhao, Ogden, Bergan, Yu (CR49) 2013; 73 Song (CR56) 2019; 129 Heuer (CR50) 2017; 16 Pomerantz (CR38) 2020; 52 Feng (CR35) 2011; 331 Sreenath, Orosz, Fujita, Bieberich (CR13) 1999; 41 Johng (CR26) 2019; 79 Economides, Capecchi (CR15) 2003; 130 Swinnen, Ulrix, Heyns, Verhoeven (CR5) 1997; 94 Takeshima, Yamashita, Shimazu, Ushijima (CR44) 2011; 98 Norris (CR17) 2009; 36 Sun (CR34) 2012; 18 Abbas, Gupta (CR28) 2008; 3 Knutson (CR33) 2008; 27 Zhao (CR45) 2020; 52 Berger (CR11) 2008; 133 Corces (CR55) 2017; 14 Li, Ge, Lu (CR57) 2019; 12 Zadra (CR1) 2019; 116 Horlein (CR29) 1995; 377 Ewing (CR25) 2012; 366 Shen, Burgener, Bratman, De Carvalho (CR59) 2019; 14 Han (CR6) 2018; 37 Augello (CR19) 2019; 35 Swinnen, Esquenet, Goossens, Heyns, Verhoeven (CR4) 1997; 57 Diez-Villanueva, Mallona, Peinado (CR58) 2015; 8 Heinzel (CR27) 1997; 387 You (CR32) 2013; 20 Yue (CR8) 2014; 19 Edwards (CR14) 2005; 92 SK Knutson (1045_CR33) 2008; 27 S Yue (1045_CR8) 2014; 19 LN Kent (1045_CR36) 2019; 19 C Guo (1045_CR40) 2012; 287 G Zadra (1045_CR1) 2019; 116 MR Corces (1045_CR55) 2017; 14 JV Swinnen (1045_CR5) 1997; 94 T Heinzel (1045_CR27) 1997; 387 Z Sun (1045_CR39) 2013; 52 MM Pomerantz (1045_CR16) 2015; 47 Z Sun (1045_CR34) 2012; 18 SG Zhao (1045_CR45) 2020; 52 Q Huang (1045_CR12) 2014; 46 CM Ewing (1045_CR25) 2012; 366 A Abbas (1045_CR28) 2008; 3 MA Augello (1045_CR19) 2019; 35 J Li (1045_CR41) 2000; 19 N Poulose (1045_CR2) 2018; 50 JD Chen (1045_CR30) 1995; 377 D Feng (1045_CR35) 2011; 331 H Takeshima (1045_CR44) 2011; 98 E Vire (1045_CR47) 2006; 439 T Sreenath (1045_CR13) 1999; 41 W Han (1045_CR6) 2018; 37 YP Yu (1045_CR46) 2013; 183 KW Fong (1045_CR54) 2018; 9 R Ventura (1045_CR52) 2015; 2 B Xu (1045_CR53) 2019; 29 R Mitra (1045_CR7) 2012; 12 Z Wang (1045_CR42) 2009; 138 JD Norris (1045_CR17) 2009; 36 P Mazrooei (1045_CR23) 2019; 36 HM Nguyen (1045_CR43) 2017; 77 S Edwards (1045_CR14) 2005; 92 Y Perez-Riverol (1045_CR60) 2019; 47 LM Butler (1045_CR3) 2016; 23 AJ Horlein (1045_CR29) 1995; 377 S Wang (1045_CR37) 2013; 8 JV Swinnen (1045_CR4) 1997; 57 M Chen (1045_CR10) 2018; 50 C Jung (1045_CR20) 2004; 64 YH Huang (1045_CR48) 2017; 18 T Whitington (1045_CR22) 2016; 48 MF Berger (1045_CR11) 2008; 133 TS Heuer (1045_CR50) 2017; 16 A Diez-Villanueva (1045_CR58) 2015; 8 SH You (1045_CR32) 2013; 20 Y Li (1045_CR57) 2019; 12 KD Economides (1045_CR15) 2003; 130 SY Shen (1045_CR59) 2019; 14 Z Kote-Jarai (1045_CR51) 2015; 26 MM Pomerantz (1045_CR38) 2020; 52 MG Guenther (1045_CR31) 2001; 21 J Chen (1045_CR9) 2018; 50 Z Chen (1045_CR18) 2018; 115 S Spisak (1045_CR24) 2015; 21 C VanOpstall (1045_CR21) 2020; 9 B Song (1045_CR56) 2019; 129 D Johng (1045_CR26) 2019; 79 HJ Jin (1045_CR49) 2013; 73 36154669 - J Urol. 2022 Dec;208(6):1340-1342. doi: 10.1097/JU.0000000000002980
References_xml	– volume: 8 start-page: 2502 year: 2013 end-page: 2515 ident: CR37 article-title: Target analysis by integration of transcriptome and ChIP-seq data with BETA publication-title: Nat. Protoc. doi: 10.1038/nprot.2013.150 – volume: 19 start-page: 4342 year: 2000 end-page: 4350 ident: CR41 article-title: Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 publication-title: EMBO J. doi: 10.1093/emboj/19.16.4342 – volume: 439 start-page: 871 year: 2006 end-page: 874 ident: CR47 article-title: The Polycomb group protein EZH2 directly controls DNA methylation publication-title: Nature doi: 10.1038/nature04431 – volume: 9 year: 2018 ident: CR54 article-title: TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression publication-title: Nat. Commun. doi: 10.1038/s41467-018-07475-5 – volume: 35 start-page: 603 year: 2019 end-page: 617 e8 ident: CR19 article-title: CHD1 loss alters AR binding at lineage-specific enhancers and modulates distinct transcriptional programs to drive prostate tumorigenesis publication-title: Cancer Cell doi: 10.1016/j.ccell.2019.03.001 – volume: 18 start-page: 934 year: 2012 end-page: 942 ident: CR34 article-title: Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration publication-title: Nat. Med. doi: 10.1038/nm.2744 – volume: 116 start-page: 631 year: 2019 end-page: 640 ident: CR1 article-title: Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1808834116 – volume: 36 start-page: 405 year: 2009 end-page: 416 ident: CR17 article-title: The homeodomain protein HOXB13 regulates the cellular response to androgens publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.10.020 – volume: 129 start-page: 569 year: 2019 end-page: 582 ident: CR56 article-title: Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression publication-title: J. Clin. Invest. doi: 10.1172/JCI122367 – volume: 12 start-page: 71 year: 2019 ident: CR57 article-title: The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization publication-title: Epigenetics Chromatin doi: 10.1186/s13072-019-0316-3 – volume: 73 start-page: 3725 year: 2013 end-page: 3736 ident: CR49 article-title: Androgen receptor-independent function of FoxA1 in prostate cancer metastasis publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-3468 – volume: 50 start-page: 219 year: 2018 end-page: 228 ident: CR9 article-title: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer publication-title: Nat. Genet. doi: 10.1038/s41588-017-0026-3 – volume: 14 start-page: 959 year: 2017 end-page: 962 ident: CR55 article-title: An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues publication-title: Nat. Methods doi: 10.1038/nmeth.4396 – volume: 21 start-page: 1357 year: 2015 end-page: 1363 ident: CR24 article-title: CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants publication-title: Nat. Med. doi: 10.1038/nm.3975 – volume: 47 start-page: 1346 year: 2015 end-page: 1351 ident: CR16 article-title: The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis publication-title: Nat. Genet. doi: 10.1038/ng.3419 – volume: 29 start-page: 773 year: 2019 end-page: 775 ident: CR53 article-title: Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression publication-title: Cell Res. doi: 10.1038/s41422-019-0204-1 – volume: 50 start-page: 206 year: 2018 end-page: 218 ident: CR10 article-title: An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer publication-title: Nat. Genet. doi: 10.1038/s41588-017-0027-2 – volume: 41 start-page: 203 year: 1999 end-page: 207 ident: CR13 article-title: Androgen-independent expression of in the mouse prostate publication-title: Prostate doi: 10.1002/(SICI)1097-0045(19991101)41:3<203::AID-PROS8>3.0.CO;2-J – volume: 287 start-page: 12111 year: 2012 end-page: 12120 ident: CR40 article-title: Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.327023 – volume: 16 start-page: 51 year: 2017 end-page: 62 ident: CR50 article-title: FASN inhibition and taxane treatment combine to enhance anti-tumor efficacy in diverse xenograft tumor models through disruption of tubulin palmitoylation and microtubule organization and FASN inhibition-mediated effects on oncogenic signaling and gene expression publication-title: eBioMedicine doi: 10.1016/j.ebiom.2016.12.012 – volume: 8 start-page: 22 year: 2015 ident: CR58 article-title: Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer publication-title: Epigenetics Chromatin doi: 10.1186/s13072-015-0014-8 – volume: 377 start-page: 454 year: 1995 end-page: 457 ident: CR30 article-title: A transcriptional co-repressor that interacts with nuclear hormone receptors publication-title: Nature doi: 10.1038/377454a0 – volume: 94 start-page: 12975 year: 1997 end-page: 12980 ident: CR5 article-title: Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.94.24.12975 – volume: 138 start-page: 1019 year: 2009 end-page: 1031 ident: CR42 article-title: Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes publication-title: Cell doi: 10.1016/j.cell.2009.06.049 – volume: 77 start-page: 654 year: 2017 end-page: 671 ident: CR43 article-title: LuCaP prostate cancer patient-derived xenografts reflect the molecular heterogeneity of advanced disease and serve as models for evaluating cancer therapeutics publication-title: Prostate doi: 10.1002/pros.23313 – volume: 26 start-page: 756 year: 2015 end-page: 761 ident: CR51 article-title: Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes publication-title: Ann. Oncol. doi: 10.1093/annonc/mdv004 – volume: 377 start-page: 397 year: 1995 end-page: 404 ident: CR29 article-title: Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor publication-title: Nature doi: 10.1038/377397a0 – volume: 21 start-page: 6091 year: 2001 end-page: 6101 ident: CR31 article-title: The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.18.6091-6101.2001 – volume: 19 start-page: 393 year: 2014 end-page: 406 ident: CR8 article-title: Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness publication-title: Cell Metab. doi: 10.1016/j.cmet.2014.01.019 – volume: 20 start-page: 182 year: 2013 end-page: 187 ident: CR32 article-title: Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2476 – volume: 3 start-page: 300 year: 2008 end-page: 309 ident: CR28 article-title: The role of histone deacetylases in prostate cancer publication-title: Epigenetics doi: 10.4161/epi.3.6.7273 – volume: 64 start-page: 9185 year: 2004 end-page: 9192 ident: CR20 article-title: HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-1330 – volume: 47 start-page: D442 year: 2019 end-page: D450 ident: CR60 article-title: The PRIDE database and related tools and resources in 2019: improving support for quantification data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1106 – volume: 92 start-page: 376 year: 2005 end-page: 381 ident: CR14 article-title: Expression analysis onto microarrays of randomly selected cDNA clones highlights HOXB13 as a marker of human prostate cancer publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602261 – volume: 133 start-page: 1266 year: 2008 end-page: 1276 ident: CR11 article-title: Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences publication-title: Cell doi: 10.1016/j.cell.2008.05.024 – volume: 46 start-page: 126 year: 2014 end-page: 135 ident: CR12 article-title: A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding publication-title: Nat. Genet. doi: 10.1038/ng.2862 – volume: 52 start-page: 769 year: 2013 end-page: 782 ident: CR39 article-title: Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.10.022 – volume: 130 start-page: 2061 year: 2003 end-page: 2069 ident: CR15 article-title: Hoxb13 is required for normal differentiation and secretory function of the ventral prostate publication-title: Development doi: 10.1242/dev.00432 – volume: 366 start-page: 141 year: 2012 end-page: 149 ident: CR25 article-title: Germline mutations in HOXB13 and prostate-cancer risk publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1110000 – volume: 331 start-page: 1315 year: 2011 end-page: 1319 ident: CR35 article-title: A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism publication-title: Science doi: 10.1126/science.1198125 – volume: 52 start-page: 790 year: 2020 end-page: 799 ident: CR38 article-title: Prostate cancer reactivates developmental epigenomic programs during metastatic progression publication-title: Nat. Genet. doi: 10.1038/s41588-020-0664-8 – volume: 115 start-page: 6810 year: 2018 end-page: 6815 ident: CR18 article-title: Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1718811115 – volume: 2 start-page: 808 year: 2015 end-page: 824 ident: CR52 article-title: Inhibition of de novo palmitate synthesis by fatty acid synthase induces apoptosis in tumor cells by remodeling cell membranes, inhibiting signaling pathways, and reprogramming gene expression publication-title: eBioMedicine doi: 10.1016/j.ebiom.2015.06.020 – volume: 57 start-page: 1086 year: 1997 end-page: 1090 ident: CR4 article-title: Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP publication-title: Cancer Res. – volume: 183 start-page: 1960 year: 2013 end-page: 1970 ident: CR46 article-title: Whole-genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2013.08.018 – volume: 50 start-page: 169 year: 2018 end-page: 171 ident: CR2 article-title: Genetics of lipid metabolism in prostate cancer publication-title: Nat. Genet. doi: 10.1038/s41588-017-0037-0 – volume: 48 start-page: 387 year: 2016 end-page: 397 ident: CR22 article-title: Gene regulatory mechanisms underpinning prostate cancer susceptibility publication-title: Nat. Genet. doi: 10.1038/ng.3523 – volume: 37 start-page: 710 year: 2018 end-page: 721 ident: CR6 article-title: Reactivation of androgen receptor-regulated lipid biosynthesis drives the progression of castration-resistant prostate cancer publication-title: Oncogene doi: 10.1038/onc.2017.385 – volume: 9 start-page: e53600 year: 2020 ident: CR21 article-title: MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans publication-title: eLife doi: 10.7554/eLife.53600 – volume: 79 start-page: 414 year: 2019 end-page: 424 ident: CR26 article-title: HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer publication-title: Prostate doi: 10.1002/pros.23747 – volume: 19 start-page: 326 year: 2019 end-page: 338 ident: CR36 article-title: The broken cycle: E2F dysfunction in cancer publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0143-7 – volume: 18 year: 2017 ident: CR48 article-title: DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A publication-title: Genome Biol. doi: 10.1186/s13059-017-1306-z – volume: 387 start-page: 43 year: 1997 end-page: 48 ident: CR27 article-title: A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression publication-title: Nature doi: 10.1038/387043a0 – volume: 98 start-page: 182 year: 2011 end-page: 188 ident: CR44 article-title: Effects of genome architecture and epigenetic factors on susceptibility of promoter CpG islands to aberrant DNA methylation induction publication-title: Genomics doi: 10.1016/j.ygeno.2011.06.003 – volume: 36 start-page: 674 year: 2019 end-page: 689 e6 ident: CR23 article-title: Cistrome partitioning reveals convergence of somatic mutations and risk variants on master transcription regulators in primary prostate tumors publication-title: Cancer Cell doi: 10.1016/j.ccell.2019.10.005 – volume: 52 start-page: 778 year: 2020 end-page: 789 ident: CR45 article-title: The DNA methylation landscape of advanced prostate cancer publication-title: Nat. Genet. doi: 10.1038/s41588-020-0648-8 – volume: 27 start-page: 1017 year: 2008 end-page: 1028 ident: CR33 article-title: Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks publication-title: EMBO J. doi: 10.1038/emboj.2008.51 – volume: 14 start-page: 2749 year: 2019 end-page: 2780 ident: CR59 article-title: Preparation of cfMeDIP-seq libraries for methylome profiling of plasma cell-free DNA publication-title: Nat. Protoc. doi: 10.1038/s41596-019-0202-2 – volume: 12 year: 2012 ident: CR7 article-title: Detection of lipid-rich prostate circulating tumour cells with coherent anti-Stokes Raman scattering microscopy publication-title: BMC Cancer doi: 10.1186/1471-2407-12-540 – volume: 23 start-page: R219 year: 2016 end-page: R227 ident: CR3 article-title: Androgen control of lipid metabolism in prostate cancer: novel insights and future applications publication-title: Endocr. Relat. Cancer doi: 10.1530/ERC-15-0556 – volume: 387 start-page: 43 year: 1997 ident: 1045_CR27 publication-title: Nature doi: 10.1038/387043a0 – volume: 41 start-page: 203 year: 1999 ident: 1045_CR13 publication-title: Prostate doi: 10.1002/(SICI)1097-0045(19991101)41:3<203::AID-PROS8>3.0.CO;2-J – volume: 36 start-page: 674 year: 2019 ident: 1045_CR23 publication-title: Cancer Cell doi: 10.1016/j.ccell.2019.10.005 – volume: 115 start-page: 6810 year: 2018 ident: 1045_CR18 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1718811115 – volume: 183 start-page: 1960 year: 2013 ident: 1045_CR46 publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2013.08.018 – volume: 50 start-page: 169 year: 2018 ident: 1045_CR2 publication-title: Nat. Genet. doi: 10.1038/s41588-017-0037-0 – volume: 19 start-page: 326 year: 2019 ident: 1045_CR36 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0143-7 – volume: 129 start-page: 569 year: 2019 ident: 1045_CR56 publication-title: J. Clin. Invest. doi: 10.1172/JCI122367 – volume: 36 start-page: 405 year: 2009 ident: 1045_CR17 publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.10.020 – volume: 377 start-page: 397 year: 1995 ident: 1045_CR29 publication-title: Nature doi: 10.1038/377397a0 – volume: 377 start-page: 454 year: 1995 ident: 1045_CR30 publication-title: Nature doi: 10.1038/377454a0 – volume: 18 start-page: 934 year: 2012 ident: 1045_CR34 publication-title: Nat. Med. doi: 10.1038/nm.2744 – volume: 37 start-page: 710 year: 2018 ident: 1045_CR6 publication-title: Oncogene doi: 10.1038/onc.2017.385 – volume: 9 year: 2018 ident: 1045_CR54 publication-title: Nat. Commun. doi: 10.1038/s41467-018-07475-5 – volume: 52 start-page: 790 year: 2020 ident: 1045_CR38 publication-title: Nat. Genet. doi: 10.1038/s41588-020-0664-8 – volume: 331 start-page: 1315 year: 2011 ident: 1045_CR35 publication-title: Science doi: 10.1126/science.1198125 – volume: 3 start-page: 300 year: 2008 ident: 1045_CR28 publication-title: Epigenetics doi: 10.4161/epi.3.6.7273 – volume: 439 start-page: 871 year: 2006 ident: 1045_CR47 publication-title: Nature doi: 10.1038/nature04431 – volume: 73 start-page: 3725 year: 2013 ident: 1045_CR49 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-3468 – volume: 29 start-page: 773 year: 2019 ident: 1045_CR53 publication-title: Cell Res. doi: 10.1038/s41422-019-0204-1 – volume: 130 start-page: 2061 year: 2003 ident: 1045_CR15 publication-title: Development doi: 10.1242/dev.00432 – volume: 12 start-page: 71 year: 2019 ident: 1045_CR57 publication-title: Epigenetics Chromatin doi: 10.1186/s13072-019-0316-3 – volume: 366 start-page: 141 year: 2012 ident: 1045_CR25 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1110000 – volume: 57 start-page: 1086 year: 1997 ident: 1045_CR4 publication-title: Cancer Res. – volume: 20 start-page: 182 year: 2013 ident: 1045_CR32 publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2476 – volume: 8 start-page: 22 year: 2015 ident: 1045_CR58 publication-title: Epigenetics Chromatin doi: 10.1186/s13072-015-0014-8 – volume: 21 start-page: 6091 year: 2001 ident: 1045_CR31 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.18.6091-6101.2001 – volume: 77 start-page: 654 year: 2017 ident: 1045_CR43 publication-title: Prostate doi: 10.1002/pros.23313 – volume: 116 start-page: 631 year: 2019 ident: 1045_CR1 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1808834116 – volume: 94 start-page: 12975 year: 1997 ident: 1045_CR5 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.94.24.12975 – volume: 48 start-page: 387 year: 2016 ident: 1045_CR22 publication-title: Nat. Genet. doi: 10.1038/ng.3523 – volume: 79 start-page: 414 year: 2019 ident: 1045_CR26 publication-title: Prostate doi: 10.1002/pros.23747 – volume: 50 start-page: 219 year: 2018 ident: 1045_CR9 publication-title: Nat. Genet. doi: 10.1038/s41588-017-0026-3 – volume: 133 start-page: 1266 year: 2008 ident: 1045_CR11 publication-title: Cell doi: 10.1016/j.cell.2008.05.024 – volume: 9 start-page: e53600 year: 2020 ident: 1045_CR21 publication-title: eLife doi: 10.7554/eLife.53600 – volume: 138 start-page: 1019 year: 2009 ident: 1045_CR42 publication-title: Cell doi: 10.1016/j.cell.2009.06.049 – volume: 2 start-page: 808 year: 2015 ident: 1045_CR52 publication-title: eBioMedicine doi: 10.1016/j.ebiom.2015.06.020 – volume: 8 start-page: 2502 year: 2013 ident: 1045_CR37 publication-title: Nat. Protoc. doi: 10.1038/nprot.2013.150 – volume: 50 start-page: 206 year: 2018 ident: 1045_CR10 publication-title: Nat. Genet. doi: 10.1038/s41588-017-0027-2 – volume: 46 start-page: 126 year: 2014 ident: 1045_CR12 publication-title: Nat. Genet. doi: 10.1038/ng.2862 – volume: 47 start-page: 1346 year: 2015 ident: 1045_CR16 publication-title: Nat. Genet. doi: 10.1038/ng.3419 – volume: 35 start-page: 603 year: 2019 ident: 1045_CR19 publication-title: Cancer Cell doi: 10.1016/j.ccell.2019.03.001 – volume: 18 year: 2017 ident: 1045_CR48 publication-title: Genome Biol. doi: 10.1186/s13059-017-1306-z – volume: 47 start-page: D442 year: 2019 ident: 1045_CR60 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1106 – volume: 16 start-page: 51 year: 2017 ident: 1045_CR50 publication-title: eBioMedicine doi: 10.1016/j.ebiom.2016.12.012 – volume: 26 start-page: 756 year: 2015 ident: 1045_CR51 publication-title: Ann. Oncol. doi: 10.1093/annonc/mdv004 – volume: 12 year: 2012 ident: 1045_CR7 publication-title: BMC Cancer doi: 10.1186/1471-2407-12-540 – volume: 19 start-page: 393 year: 2014 ident: 1045_CR8 publication-title: Cell Metab. doi: 10.1016/j.cmet.2014.01.019 – volume: 92 start-page: 376 year: 2005 ident: 1045_CR14 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602261 – volume: 23 start-page: R219 year: 2016 ident: 1045_CR3 publication-title: Endocr. Relat. Cancer doi: 10.1530/ERC-15-0556 – volume: 21 start-page: 1357 year: 2015 ident: 1045_CR24 publication-title: Nat. Med. doi: 10.1038/nm.3975 – volume: 52 start-page: 778 year: 2020 ident: 1045_CR45 publication-title: Nat. Genet. doi: 10.1038/s41588-020-0648-8 – volume: 64 start-page: 9185 year: 2004 ident: 1045_CR20 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-1330 – volume: 14 start-page: 2749 year: 2019 ident: 1045_CR59 publication-title: Nat. Protoc. doi: 10.1038/s41596-019-0202-2 – volume: 52 start-page: 769 year: 2013 ident: 1045_CR39 publication-title: Mol. Cell doi: 10.1016/j.molcel.2013.10.022 – volume: 27 start-page: 1017 year: 2008 ident: 1045_CR33 publication-title: EMBO J. doi: 10.1038/emboj.2008.51 – volume: 98 start-page: 182 year: 2011 ident: 1045_CR44 publication-title: Genomics doi: 10.1016/j.ygeno.2011.06.003 – volume: 14 start-page: 959 year: 2017 ident: 1045_CR55 publication-title: Nat. Methods doi: 10.1038/nmeth.4396 – volume: 19 start-page: 4342 year: 2000 ident: 1045_CR41 publication-title: EMBO J. doi: 10.1093/emboj/19.16.4342 – volume: 287 start-page: 12111 year: 2012 ident: 1045_CR40 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.327023 – reference: 36154669 - J Urol. 2022 Dec;208(6):1340-1342. doi: 10.1097/JU.0000000000002980
SSID	ssj0014408
Score	2.6076424
Snippet	HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth....
SourceID	pubmedcentral proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	670
SubjectTerms	631/208/177 631/67/1059/602 692/699/67/589/466 Age Agriculture Androgen receptors Androgens Animal Genetics and Genomics Binding sites Biomedical and Life Sciences Biomedicine Biosynthesis Cancer Research Castration Cell cycle Cell division Cell Line, Tumor Deacetylation Enhancers Enzymes Epigenesis, Genetic Epigenetics Fatty acids Fatty-acid synthase Gene expression Gene Function Genomes Histone deacetylase Histone Deacetylases - metabolism Histones Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Hoxb13 gene Human Genetics Human tissues Humans Kinases Lipids Lipogenesis Male Metabolism Metastases Metastasis Motility Mutation Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteins Receptors, Androgen - genetics Receptors, Androgen - metabolism Roles Sterols Transcription Factors - genetics Tumorigenesis Tumors Xenografts Xenotransplantation
Title	HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer
URI	https://link.springer.com/article/10.1038/s41588-022-01045-8 https://www.ncbi.nlm.nih.gov/pubmed/35468964 https://www.proquest.com/docview/2666973292 https://www.proquest.com/docview/2655563723 https://pubmed.ncbi.nlm.nih.gov/PMC9117466
Volume	54
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED-xTUi8IL7JGJWReANrJHFs5wm1ZVWFREGISX2LXMfeKo0kLC0S_z13TpqpTOwpD3YUO3e-D9_d7wDemthb4TLLyVzgQviUr1Rc8kyI5IMXXrpw3_FlIefn4vMyW_YXbm2fVrmTiUFQl7WlO_JTVCSSkGXy5GPzi1PXKIqu9i00DuCIakCJw_V0SPGguGVXCifJT6Iw5XFXZq5PW1RcyCOUy04eScb1vmK6ZW3eTpr8J3IaFNLsETzsLUk27kj_GO656gnc73pL_nkKl_Ovy0mcsnbbhFxX17LSsar-XbOrdVNfkIxbt6zv08Pmn8bTlIc6ErRBmWsIpZMKHBnBXoYcrp-4DLauWEOFIjiLWeKY62dwPjv7MZ3zvq0Ct0KJDTc2Q6Gm0LMwNvUrRwhxPi517I3OE1lanWvpUOyhsxEbI43OhPIqNmi7JInJ0udwWNWVewnMJsJbY1ZlrrwgU0_KEiWANkjkFB2VCOLdPy1sjzlOrS-uihD7TnXR0aFAOhSBDoWO4N3wTtMhbtw5-2RHqqI_fW1xwysRvBmG8dxQMMRUrt7SnIyw0VSSRvCio-zwuTQTUudSRKD2aD5MIEzu_ZFqfRmwuVF3KCFlBO933HGzrP_v4vjuXbyCB0ngVMqzPIHDzfXWvUZbaLMawYFaqlFg-xEcjWeTyQKfk7PFt-9_AUDQCRM
linkProvider	ProQuest
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqVgguiDcpBYwEJ7BKHMdxDhXqUyltF4RaaW-p17HpSiUJzS6of47fxozzqJaK3nqOoziZ1-fMzDeEvNWhM8LGhiFcYEK4iE2SsGCxEPyjE05a_7_jaCSzE_F5HI-XyJ--FwbLKnuf6B11URn8R74OgUQis0zKP9U_GU6NwuxqP0JDd6MVig1PMdY1dhzYy99whGs29ndA3u8439s93s5YN2WAGZGIGdMmBhtPAGhrE7mJRcI0FxYqdFqlXBZGpUpa8AKAvUOtpVaxSFwSagjlnGucGgEhYAVgRwRWtbK1O_r6bchj4Dxnn2-VeFLDROlq2-iu1hsInaClWE2PZ6KYqcXQeA3vXi_b_Cd360Pi3gNyv8OydLNVvodkyZaPyJ12uuXlY3KWfRlvhRFt5rWvtrUNLSwtq18VPZ_W1Xf0stOGdpOCaLazuR0x38kCKJjaGnlCscWSIvGmryL7Adug05LW2KoCq6hBnb14Qk5u5ZM_JctlVdrnhBounNF6UqSJEwg2pSzABykNahbBUSkgYf9Nc9OxnuPwjfPcZ98jlbdyyEEOuZdDrgLyfrinbjk_bly91osq7-y_ya-0NSBvhstguZiO0aWt5rgmRna2hEcBedZKdnhcFAupUikCkizIfFiArOCLV8rpmWcHh-iVCCkD8qHXjqtt_f8tVm9-i9fkbnZ8dJgf7o8OXpB73GstVn2ukeXZxdy-BGQ2m7zq1J-S09u2uL_Sq0l2
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqIhAXxJuUAkaCE1jbOI7tHBAqXVZbCoUDlfYWvI5NVypJaHZB_Wv8OmacR7VU9NZjZEdxMu_MzDeEvDCxt8KllqG7wITwCZuruGCpEHzHCy9d-N_x6VBOj8SHWTrbIH_6Xhgsq-x1YlDURWXxH_kIDIlEZJmMj3xXFvFlPHlb_2Q4QQozrf04jZZFDtzZbwjfmjf7Y6D1S84n77_uTVk3YYBZocSSGZuCfCtwso1N_NwhWJqPCx17ozMuC6szLR1oAPC7Y2Ok0alQXsUGzDjnBidGgPq_phK4BllSsyHYw5xp24YnMUbDFOlW2-KuRw0YTeBPrKPHaChlet0oXvB0LxZs_pO1DcZwcpvc6rxYutuy3R2y4cq75Ho71_LsHjmefp69ixParOpQZ-saWjhaVr8qerKoq--oXxcN7WYE0el4dy9hoYcF_F_qakQIxeZKipCboX7sBxyDLkpaY5MK7KIWufX0Pjm6kg_-gGyWVekeEWq58NaYeZEpL9DNlLIA7aMNMFgCQVJE4v6b5rbDO8exGyd5yLsnOm_pkAMd8kCHXEfk1XBP3aJ9XLp7uydV3kl-k5_zaUSeD8sgs5iIMaWrVrgnRVw2xZOIPGwpOzwuSYXUmRQRUWs0HzYgHvj6Srk4DrjgYLeUkDIir3vuOD_W_99i6_K3eEZugJzlH_cPDx6TmzwwLZZ7bpPN5enKPQGXbDl_Gnifkm9XLWx_Ac5cRxI
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HOXB13+suppresses+de+novo+lipogenesis+through+HDAC3-mediated+epigenetic+reprogramming+in+prostate+cancer&rft.jtitle=Nature+genetics&rft.au=Lu%2C+Xiaodong&rft.au=Fong%2C+Ka-wing&rft.au=Gritsina%2C+Galina&rft.au=Wang%2C+Fang&rft.date=2022-05-01&rft.pub=Nature+Publishing+Group+US&rft.issn=1061-4036&rft.eissn=1546-1718&rft.volume=54&rft.issue=5&rft.spage=670&rft.epage=683&rft_id=info:doi/10.1038%2Fs41588-022-01045-8&rft.externalDocID=10_1038_s41588_022_01045_8
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon