Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects

Background Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer. Methods Using the Korean National Health Insurance database, subjects who participated in the health examination program between 20...

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Published inBritish journal of cancer Vol. 127; no. 3; pp. 549 - 557
Main Authors Park, Byung Kyu, Seo, Jeong Hun, Chung, Jae Bock, Choi, Jung Kyu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.08.2022
Nature Publishing Group
Subjects
692/4028/67/1504/1713
692/499
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Cancer Research
Cohort analysis
Cohort Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Drug Resistance
Epidemiology
Humans
Life Style
Molecular Medicine
Obesity
Obesity - complications
Obesity - epidemiology
Oncology
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - etiology
Population studies
Population-based studies
Proportional Hazards Models
Republic of Korea - epidemiology
Risk Factors
Smoking
Republic of Korea
Online AccessGet full text
ISSN0007-0920
1532-1827
1532-1827
DOI10.1038/s41416-022-01807-5

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Abstract Background Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer. Methods Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model. Results During 11.5 years follow-up, 22,543 of 7,445,947 participants were newly diagnosed with pancreatic cancer. Compared with normal-weight subjects, pancreatic cancer risk was increased in those with severe obesity (BMI ≥ 28 kg/m 2 ) (HR = 1.16; 95% CI, 1.11–1.23). Subjects with diabetes had an increased risk compared with those without diabetes (HR = 1.48; 95% CI, 1.43–1.53). Current smokers had a higher risk than never smokers (HR = 1.43; 95% CI, 1.38–1.48). Current smoking combined with diabetes increased the risk compared with never smokers without diabetes (HR = 2.13; 95% CI, 2.00–2.28). Current smoking combined with BMI ≥ 25 kg/m 2 had an increased risk compared with never smokers with BMI < 23 kg/m 2 (HR = 1.55; 95% CI, 1.46–1.65). Conclusion Smoking, obesity, and diabetes are significant risk factors for pancreatic cancer in Koreans. Lifestyle modifications for smoking and obesity would be beneficial for pancreatic cancer prevention.
AbstractList Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer. Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model. During 11.5 years follow-up, 22,543 of 7,445,947 participants were newly diagnosed with pancreatic cancer. Compared with normal-weight subjects, pancreatic cancer risk was increased in those with severe obesity (BMI ≥ 28 kg/m ) (HR = 1.16; 95% CI, 1.11-1.23). Subjects with diabetes had an increased risk compared with those without diabetes (HR = 1.48; 95% CI, 1.43-1.53). Current smokers had a higher risk than never smokers (HR = 1.43; 95% CI, 1.38-1.48). Current smoking combined with diabetes increased the risk compared with never smokers without diabetes (HR = 2.13; 95% CI, 2.00-2.28). Current smoking combined with BMI ≥ 25 kg/m had an increased risk compared with never smokers with BMI < 23 kg/m (HR = 1.55; 95% CI, 1.46-1.65). Smoking, obesity, and diabetes are significant risk factors for pancreatic cancer in Koreans. Lifestyle modifications for smoking and obesity would be beneficial for pancreatic cancer prevention.
Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer.BACKGROUNDLarge-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer.Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model.METHODSUsing the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model.During 11.5 years follow-up, 22,543 of 7,445,947 participants were newly diagnosed with pancreatic cancer. Compared with normal-weight subjects, pancreatic cancer risk was increased in those with severe obesity (BMI ≥ 28 kg/m2) (HR = 1.16; 95% CI, 1.11-1.23). Subjects with diabetes had an increased risk compared with those without diabetes (HR = 1.48; 95% CI, 1.43-1.53). Current smokers had a higher risk than never smokers (HR = 1.43; 95% CI, 1.38-1.48). Current smoking combined with diabetes increased the risk compared with never smokers without diabetes (HR = 2.13; 95% CI, 2.00-2.28). Current smoking combined with BMI ≥ 25 kg/m2 had an increased risk compared with never smokers with BMI < 23 kg/m2 (HR = 1.55; 95% CI, 1.46-1.65).RESULTSDuring 11.5 years follow-up, 22,543 of 7,445,947 participants were newly diagnosed with pancreatic cancer. Compared with normal-weight subjects, pancreatic cancer risk was increased in those with severe obesity (BMI ≥ 28 kg/m2) (HR = 1.16; 95% CI, 1.11-1.23). Subjects with diabetes had an increased risk compared with those without diabetes (HR = 1.48; 95% CI, 1.43-1.53). Current smokers had a higher risk than never smokers (HR = 1.43; 95% CI, 1.38-1.48). Current smoking combined with diabetes increased the risk compared with never smokers without diabetes (HR = 2.13; 95% CI, 2.00-2.28). Current smoking combined with BMI ≥ 25 kg/m2 had an increased risk compared with never smokers with BMI < 23 kg/m2 (HR = 1.55; 95% CI, 1.46-1.65).Smoking, obesity, and diabetes are significant risk factors for pancreatic cancer in Koreans. Lifestyle modifications for smoking and obesity would be beneficial for pancreatic cancer prevention.CONCLUSIONSmoking, obesity, and diabetes are significant risk factors for pancreatic cancer in Koreans. Lifestyle modifications for smoking and obesity would be beneficial for pancreatic cancer prevention.
Background Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer. Methods Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model. Results During 11.5 years follow-up, 22,543 of 7,445,947 participants were newly diagnosed with pancreatic cancer. Compared with normal-weight subjects, pancreatic cancer risk was increased in those with severe obesity (BMI ≥ 28 kg/m 2 ) (HR = 1.16; 95% CI, 1.11–1.23). Subjects with diabetes had an increased risk compared with those without diabetes (HR = 1.48; 95% CI, 1.43–1.53). Current smokers had a higher risk than never smokers (HR = 1.43; 95% CI, 1.38–1.48). Current smoking combined with diabetes increased the risk compared with never smokers without diabetes (HR = 2.13; 95% CI, 2.00–2.28). Current smoking combined with BMI ≥ 25 kg/m 2 had an increased risk compared with never smokers with BMI < 23 kg/m 2 (HR = 1.55; 95% CI, 1.46–1.65). Conclusion Smoking, obesity, and diabetes are significant risk factors for pancreatic cancer in Koreans. Lifestyle modifications for smoking and obesity would be beneficial for pancreatic cancer prevention.
BackgroundLarge-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer.MethodsUsing the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model.ResultsDuring 11.5 years follow-up, 22,543 of 7,445,947 participants were newly diagnosed with pancreatic cancer. Compared with normal-weight subjects, pancreatic cancer risk was increased in those with severe obesity (BMI ≥ 28 kg/m2) (HR = 1.16; 95% CI, 1.11–1.23). Subjects with diabetes had an increased risk compared with those without diabetes (HR = 1.48; 95% CI, 1.43–1.53). Current smokers had a higher risk than never smokers (HR = 1.43; 95% CI, 1.38–1.48). Current smoking combined with diabetes increased the risk compared with never smokers without diabetes (HR = 2.13; 95% CI, 2.00–2.28). Current smoking combined with BMI ≥ 25 kg/m2 had an increased risk compared with never smokers with BMI < 23 kg/m2 (HR = 1.55; 95% CI, 1.46–1.65).ConclusionSmoking, obesity, and diabetes are significant risk factors for pancreatic cancer in Koreans. Lifestyle modifications for smoking and obesity would be beneficial for pancreatic cancer prevention.
Author Chung, Jae Bock
Park, Byung Kyu
Seo, Jeong Hun
Choi, Jung Kyu
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Snippet Background Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for...
Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer....
BackgroundLarge-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic...
Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic...
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SubjectTerms 692/4028/67/1504/1713
692/499
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Cancer Research
Cohort analysis
Cohort Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Drug Resistance
Epidemiology
Humans
Life Style
Molecular Medicine
Obesity
Obesity - complications
Obesity - epidemiology
Oncology
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - etiology
Population studies
Population-based studies
Proportional Hazards Models
Republic of Korea - epidemiology
Risk Factors
Smoking
Title Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects
URI https://link.springer.com/article/10.1038/s41416-022-01807-5
https://www.ncbi.nlm.nih.gov/pubmed/35444288
https://www.proquest.com/docview/2697205316
https://www.proquest.com/docview/2653268161
https://pubmed.ncbi.nlm.nih.gov/PMC9345883
Volume 127
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