Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies

Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Si...

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Published inBiogerontology (Dordrecht) Vol. 22; no. 2; pp. 215 - 236
Main Authors Saul, Nadine, Möller, Steffen, Cirulli, Francesca, Berry, Alessandra, Luyten, Walter, Fuellen, Georg
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.04.2021
Springer Nature B.V
Subjects
Aging
Animal models
Animals
Biomedical and Life Sciences
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Biology
Cognitive ability
Developmental Biology
Gene expression
Geriatrics/Gerontology
Life Sciences
Longevity
Phenotypes
Quality of Life
Research Article
Database
Aging
Phenotypes
Healthspan
Compounds
C. elegans
Online AccessGet full text
ISSN1389-5729
1573-6768
1573-6768
DOI10.1007/s10522-021-09913-2

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Abstract Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valuable than length of life, we aim to fill this gap with the “Healthy Worm Database” ( http://healthy-worm-database.eu ). Literature describing health-related compound studies in the aging model Caenorhabditis elegans was screened, and data for 440 compounds collected. The database considers 189 publications describing 89 different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for promising compounds for further investigations, this database also offers insights into the research field of studies on healthy aging based on a frequently used model organism. Some weaknesses of C. elegans -based aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as well as the convenience-based use of young worms as the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential shortcomings in current aging research.
AbstractList Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valuable than length of life, we aim to fill this gap with the "Healthy Worm Database" ( http://healthy-worm-database.eu ). Literature describing health-related compound studies in the aging model Caenorhabditis elegans was screened, and data for 440 compounds collected. The database considers 189 publications describing 89 different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for promising compounds for further investigations, this database also offers insights into the research field of studies on healthy aging based on a frequently used model organism. Some weaknesses of C. elegans-based aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as well as the convenience-based use of young worms as the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential shortcomings in current aging research.
Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valuable than length of life, we aim to fill this gap with the "Healthy Worm Database" ( http://healthy-worm-database.eu ). Literature describing health-related compound studies in the aging model Caenorhabditis elegans was screened, and data for 440 compounds collected. The database considers 189 publications describing 89 different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for promising compounds for further investigations, this database also offers insights into the research field of studies on healthy aging based on a frequently used model organism. Some weaknesses of C. elegans-based aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as well as the convenience-based use of young worms as the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential shortcomings in current aging research.Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valuable than length of life, we aim to fill this gap with the "Healthy Worm Database" ( http://healthy-worm-database.eu ). Literature describing health-related compound studies in the aging model Caenorhabditis elegans was screened, and data for 440 compounds collected. The database considers 189 publications describing 89 different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for promising compounds for further investigations, this database also offers insights into the research field of studies on healthy aging based on a frequently used model organism. Some weaknesses of C. elegans-based aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as well as the convenience-based use of young worms as the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential shortcomings in current aging research.
Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valuable than length of life, we aim to fill this gap with the “Healthy Worm Database” ( http://healthy-worm-database.eu ). Literature describing health-related compound studies in the aging model Caenorhabditis elegans was screened, and data for 440 compounds collected. The database considers 189 publications describing 89 different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for promising compounds for further investigations, this database also offers insights into the research field of studies on healthy aging based on a frequently used model organism. Some weaknesses of C. elegans -based aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as well as the convenience-based use of young worms as the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential shortcomings in current aging research.
Author Fuellen, Georg
Saul, Nadine
Cirulli, Francesca
Berry, Alessandra
Luyten, Walter
Möller, Steffen
Author_xml – sequence: 1
  givenname: Nadine
  orcidid: 0000-0002-6798-0918
  surname: Saul
  fullname: Saul, Nadine
  email: nadine.saul@gmx.de
  organization: Molecular Genetics Group, Institute of Biology, Humboldt University of Berlin
– sequence: 2
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  surname: Möller
  fullname: Möller, Steffen
  organization: Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center
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  fullname: Cirulli, Francesca
  organization: Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità
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  surname: Berry
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  fullname: Fuellen, Georg
  organization: Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33683565$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords Database
Aging
Phenotypes
Healthspan
Compounds
C. elegans
Language English
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Snippet Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or...
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SubjectTerms Aging
Animal models
Animals
Biomedical and Life Sciences
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Biology
Cognitive ability
Developmental Biology
Gene expression
Geriatrics/Gerontology
Life Sciences
Longevity
Phenotypes
Quality of Life
Research Article
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Title Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies
URI https://link.springer.com/article/10.1007/s10522-021-09913-2
https://www.ncbi.nlm.nih.gov/pubmed/33683565
https://www.proquest.com/docview/2502559764
https://www.proquest.com/docview/2499006720
https://pubmed.ncbi.nlm.nih.gov/PMC7973913
Volume 22
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