Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles

Ischemic exercise conducted as low-load blood flow restricted resistance exercise (BFRE) can lead to muscle remodelling and promote muscle growth, possibly through activation of muscle precursor cells. Cell activation can be triggered by blood borne extracellular vesicles (EVs) as these nano-sized p...

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Published inScientific reports Vol. 10; no. 1; p. 5835
Main Authors Just, Jesper, Yan, Yan, Farup, Jean, Sieljacks, Peter, Sloth, Mette, Venø, Morten, Gu, Tingting, de Paoli, Frank Vincenzo, Nyengaard, Jens Randel, Bæk, Rikke, Jørgensen, Malene Møller, Kjems, Jørgen, Vissing, Kristian, Drasbek, Kim Ryun
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.04.2020
Nature Publishing Group
Subjects
13/1
13/100
13/31
13/51
14/28
14/63
38/61
38/90
38/91
631/443
692/4017
82/29
Blood cells
Blood flow
Blotting, Western
Cell activation
Cell proliferation
Extracellular vesicles
Extracellular Vesicles - metabolism
Extracellular Vesicles - physiology
Extracellular Vesicles - ultrastructure
Flow Cytometry
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Ischemia
Male
MicroRNAs - genetics
MicroRNAs - metabolism
Microscopy, Electron, Transmission
miRNA
multidisciplinary
Muscle Proteins - metabolism
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Musculoskeletal system
Protein turnover
Regional Blood Flow - physiology
Resistance Training
Science
Science (multidisciplinary)
Signal transduction
Skeletal muscle
Surface markers
Young Adult
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-62456-3

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Abstract Ischemic exercise conducted as low-load blood flow restricted resistance exercise (BFRE) can lead to muscle remodelling and promote muscle growth, possibly through activation of muscle precursor cells. Cell activation can be triggered by blood borne extracellular vesicles (EVs) as these nano-sized particles are involved in long distance signalling. In this study, EVs isolated from plasma of healthy human subjects performing a single bout of BFRE were investigated for their change in EV surface profiles and miRNA cargos as well as their impact on skeletal muscle precursor cell proliferation. We found that after BFRE, five EV surface markers and 12 miRNAs were significantly altered. Furthermore, target prediction and functional enrichment analysis of the miRNAs revealed several target genes that are associated to biological pathways involved in skeletal muscle protein turnover. Interestingly, EVs from BFRE plasma increased the proliferation of muscle precursor cells. In addition, alterations in surface markers and miRNAs indicated that the combination of exercise and ischemic conditioning during BFRE can stimulate blood cells to release EVs. These results support that BFRE promotes EV release to engage in muscle remodelling and/or growth processes.
AbstractList Ischemic exercise conducted as low-load blood flow restricted resistance exercise (BFRE) can lead to muscle remodelling and promote muscle growth, possibly through activation of muscle precursor cells. Cell activation can be triggered by blood borne extracellular vesicles (EVs) as these nano-sized particles are involved in long distance signalling. In this study, EVs isolated from plasma of healthy human subjects performing a single bout of BFRE were investigated for their change in EV surface profiles and miRNA cargos as well as their impact on skeletal muscle precursor cell proliferation. We found that after BFRE, five EV surface markers and 12 miRNAs were significantly altered. Furthermore, target prediction and functional enrichment analysis of the miRNAs revealed several target genes that are associated to biological pathways involved in skeletal muscle protein turnover. Interestingly, EVs from BFRE plasma increased the proliferation of muscle precursor cells. In addition, alterations in surface markers and miRNAs indicated that the combination of exercise and ischemic conditioning during BFRE can stimulate blood cells to release EVs. These results support that BFRE promotes EV release to engage in muscle remodelling and/or growth processes.
Ischemic exercise conducted as low-load blood flow restricted resistance exercise (BFRE) can lead to muscle remodelling and promote muscle growth, possibly through activation of muscle precursor cells. Cell activation can be triggered by blood borne extracellular vesicles (EVs) as these nano-sized particles are involved in long distance signalling. In this study, EVs isolated from plasma of healthy human subjects performing a single bout of BFRE were investigated for their change in EV surface profiles and miRNA cargos as well as their impact on skeletal muscle precursor cell proliferation. We found that after BFRE, five EV surface markers and 12 miRNAs were significantly altered. Furthermore, target prediction and functional enrichment analysis of the miRNAs revealed several target genes that are associated to biological pathways involved in skeletal muscle protein turnover. Interestingly, EVs from BFRE plasma increased the proliferation of muscle precursor cells. In addition, alterations in surface markers and miRNAs indicated that the combination of exercise and ischemic conditioning during BFRE can stimulate blood cells to release EVs. These results support that BFRE promotes EV release to engage in muscle remodelling and/or growth processes.Ischemic exercise conducted as low-load blood flow restricted resistance exercise (BFRE) can lead to muscle remodelling and promote muscle growth, possibly through activation of muscle precursor cells. Cell activation can be triggered by blood borne extracellular vesicles (EVs) as these nano-sized particles are involved in long distance signalling. In this study, EVs isolated from plasma of healthy human subjects performing a single bout of BFRE were investigated for their change in EV surface profiles and miRNA cargos as well as their impact on skeletal muscle precursor cell proliferation. We found that after BFRE, five EV surface markers and 12 miRNAs were significantly altered. Furthermore, target prediction and functional enrichment analysis of the miRNAs revealed several target genes that are associated to biological pathways involved in skeletal muscle protein turnover. Interestingly, EVs from BFRE plasma increased the proliferation of muscle precursor cells. In addition, alterations in surface markers and miRNAs indicated that the combination of exercise and ischemic conditioning during BFRE can stimulate blood cells to release EVs. These results support that BFRE promotes EV release to engage in muscle remodelling and/or growth processes.
ArticleNumber 5835
Author Kjems, Jørgen
Gu, Tingting
Drasbek, Kim Ryun
Just, Jesper
Vissing, Kristian
Sloth, Mette
Venø, Morten
Nyengaard, Jens Randel
Sieljacks, Peter
Jørgensen, Malene Møller
Bæk, Rikke
Yan, Yan
Farup, Jean
de Paoli, Frank Vincenzo
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Snippet Ischemic exercise conducted as low-load blood flow restricted resistance exercise (BFRE) can lead to muscle remodelling and promote muscle growth, possibly...
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631/443
692/4017
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Blood cells
Blood flow
Blotting, Western
Cell activation
Cell proliferation
Extracellular vesicles
Extracellular Vesicles - metabolism
Extracellular Vesicles - physiology
Extracellular Vesicles - ultrastructure
Flow Cytometry
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Ischemia
Male
MicroRNAs - genetics
MicroRNAs - metabolism
Microscopy, Electron, Transmission
miRNA
multidisciplinary
Muscle Proteins - metabolism
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Musculoskeletal system
Protein turnover
Regional Blood Flow - physiology
Resistance Training
Science
Science (multidisciplinary)
Signal transduction
Skeletal muscle
Surface markers
Young Adult
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Title Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles
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