Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development - Vanova, Tereza; Sedmik, Jiri; Raska, Jan; Amruz Cerna, Katerina; Taus, Petr; Pospisilova, Veronika; Nezvedova, Marketa; Fedorova, Veronika; Kadakova, Sona; Klimova, Hana; Capandova, Michaela; Orviska, Petra; et al. (Cell reports (Cambridge), 2023)
Keywords: Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer’s disease; cerebral organoids; CP: Developmental biology; CP: Neuroscience; development; Humans; induced pluripotent stem cells; Induced Pluripotent Stem Cells - pathology; Mutation - genetics; Neurons; Organoids - pathology; Presenilin-1 - genetics; Presenilin-2 - genetics; single-cell mRNA sequencing; cerebral organoids; development; Alzheimer’s disease; CP: Neuroscience; induced pluripotent stem cells; single-cell mRNA sequencing; CP: Developmental biology