Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer - Matés, José M.; Di Paola, Floriana J.; Campos-Sandoval, José A.; Mazurek, Sybille; Márquez, Javier (Seminars in cell & developmental biology, 2020)
Keywords: Antineoplastic Agents - pharmacology; Cancer; Cell Proliferation - drug effects; Cellular Reprogramming - drug effects; Combination therapy; Enzyme Inhibitors - pharmacology; Glutaminase - antagonists & inhibitors; Glutaminase - metabolism; Glutaminase inhibitors; Glutamine - antagonists & inhibitors; Glutamine - metabolism; Glutamine imaging; Glutaminolysis; Humans; Metabolomics; Neoplasms - diagnosis; Neoplasms - drug therapy; Neoplasms - metabolism; Gln; OXPHOS; IDH; GLS; Glu; NF-κB; PI3K; GLUD; SDH; mTOR; TNBC; Glutamine imaging; MS; PKB; LGA; GAC; GAB; PDAC; TCA; ROS; GABA; ERK; NADPH; Metabolomics; FH; GLS2; Combination therapy; PPP; Glutaminase inhibitors; GBM; NADH; PDH; NEAAs; GA; AKG; GSH; HIF; KGA; NSCLC; PKM2; 2-HG; TME; AcCoA; GFAT; PC; GCS; Glutaminolysis; KRAS; PET; Glc; Cancer