Population Pharmacokinetics of Imipenem in Critically Ill Patients: A Parametric and Nonparametric Model Converge on CKD-EPI Estimated Glomerular Filtration Rate as an Impactful Covariate - de Velde, Femke; de Winter, Brenda C. M.; Neely, Michael N.; Yamada, Walter M.; Koch, Birgit C. P.; Harbarth, Stephan; von Dach, Elodie; van Gelder, Teun; Huttner, Angela; Mouton, Johan W. (Clinical pharmacokinetics, 2020)
Keywords: Adult; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial agents; Creatinine; Critical Illness; Drug dosages; Female; Glomerular Filtration Rate; Humans; Imipenem - pharmacokinetics; Imipenem - therapeutic use; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Nonparametric statistics; Original; Original Research Article; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Population; Renal Insufficiency, Chronic - drug therapy; Therapeutic drug monitoring