Precise Slow Oscillation–Spindle Coupling Promotes Memory Consolidation in Younger and Older Adults

Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO; 0.5–1 Hz), sleep spindles (SP), and their coupling across the adult human lifespan and ask whether observed alterations relate to the abil...

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Published inScientific reports Vol. 9; no. 1; p. 1940
Main Authors Muehlroth, Beate E., Sander, Myriam C., Fandakova, Yana, Grandy, Thomas H., Rasch, Björn, Shing, Yee Lee, Werkle-Bergner, Markus
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.02.2019
Nature Publishing Group
Subjects
59/57
631/378/1595/2167
631/378/1595/2638
631/378/2612
631/378/2649
631/477/2811
Activity patterns
Adults
Animal memory
Cognitive ability
Cortex (entorhinal)
Humanities and Social Sciences
Life span
Memory
multidisciplinary
Older people
Oscillations
Prefrontal cortex
Preservation
Rhythms
Science
Science (multidisciplinary)
Sleep
Thalamus
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-018-36557-z

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Abstract Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO; 0.5–1 Hz), sleep spindles (SP), and their coupling across the adult human lifespan and ask whether observed alterations relate to the ability to retain associative memories across sleep. We demonstrate that older adults do not show the fine-tuned coupling of fast SPs (12.5–16 Hz) to the SO peak present in younger adults but, instead, are characterized most by a slow SP power increase (9–12.5 Hz) at the end of the SO up-state. This slow SP power increase, typical for older adults, coincides with worse memory consolidation in young age already, whereas the tight precision of SO–fast SP coupling promotes memory consolidation across younger and older adults. Crucially, brain integrity in source regions of SO and SP generation, including the medial prefrontal cortex, thalamus, hippocampus and entorhinal cortex, reinforces this beneficial SO–SP coupling in old age. Our results reveal that cognitive functioning is not only determined by maintaining structural brain integrity across the adult lifespan, but also by the preservation of precisely timed neural interactions during sleep that enable the consolidation of declarative memories.
AbstractList Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO; 0.5-1 Hz), sleep spindles (SP), and their coupling across the adult human lifespan and ask whether observed alterations relate to the ability to retain associative memories across sleep. We demonstrate that older adults do not show the fine-tuned coupling of fast SPs (12.5-16 Hz) to the SO peak present in younger adults but, instead, are characterized most by a slow SP power increase (9-12.5 Hz) at the end of the SO up-state. This slow SP power increase, typical for older adults, coincides with worse memory consolidation in young age already, whereas the tight precision of SO-fast SP coupling promotes memory consolidation across younger and older adults. Crucially, brain integrity in source regions of SO and SP generation, including the medial prefrontal cortex, thalamus, hippocampus and entorhinal cortex, reinforces this beneficial SO-SP coupling in old age. Our results reveal that cognitive functioning is not only determined by maintaining structural brain integrity across the adult lifespan, but also by the preservation of precisely timed neural interactions during sleep that enable the consolidation of declarative memories.Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO; 0.5-1 Hz), sleep spindles (SP), and their coupling across the adult human lifespan and ask whether observed alterations relate to the ability to retain associative memories across sleep. We demonstrate that older adults do not show the fine-tuned coupling of fast SPs (12.5-16 Hz) to the SO peak present in younger adults but, instead, are characterized most by a slow SP power increase (9-12.5 Hz) at the end of the SO up-state. This slow SP power increase, typical for older adults, coincides with worse memory consolidation in young age already, whereas the tight precision of SO-fast SP coupling promotes memory consolidation across younger and older adults. Crucially, brain integrity in source regions of SO and SP generation, including the medial prefrontal cortex, thalamus, hippocampus and entorhinal cortex, reinforces this beneficial SO-SP coupling in old age. Our results reveal that cognitive functioning is not only determined by maintaining structural brain integrity across the adult lifespan, but also by the preservation of precisely timed neural interactions during sleep that enable the consolidation of declarative memories.
Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO; 0.5–1 Hz), sleep spindles (SP), and their coupling across the adult human lifespan and ask whether observed alterations relate to the ability to retain associative memories across sleep. We demonstrate that older adults do not show the fine-tuned coupling of fast SPs (12.5–16 Hz) to the SO peak present in younger adults but, instead, are characterized most by a slow SP power increase (9–12.5 Hz) at the end of the SO up-state. This slow SP power increase, typical for older adults, coincides with worse memory consolidation in young age already, whereas the tight precision of SO–fast SP coupling promotes memory consolidation across younger and older adults. Crucially, brain integrity in source regions of SO and SP generation, including the medial prefrontal cortex, thalamus, hippocampus and entorhinal cortex, reinforces this beneficial SO–SP coupling in old age. Our results reveal that cognitive functioning is not only determined by maintaining structural brain integrity across the adult lifespan, but also by the preservation of precisely timed neural interactions during sleep that enable the consolidation of declarative memories.
ArticleNumber 1940
Author Grandy, Thomas H.
Muehlroth, Beate E.
Werkle-Bergner, Markus
Fandakova, Yana
Shing, Yee Lee
Sander, Myriam C.
Rasch, Björn
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30760741$$D View this record in MEDLINE/PubMed
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Snippet Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations...
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StartPage 1940
SubjectTerms 59/57
631/378/1595/2167
631/378/1595/2638
631/378/2612
631/378/2649
631/477/2811
Activity patterns
Adults
Animal memory
Cognitive ability
Cortex (entorhinal)
Humanities and Social Sciences
Life span
Memory
multidisciplinary
Older people
Oscillations
Prefrontal cortex
Preservation
Rhythms
Science
Science (multidisciplinary)
Sleep
Thalamus
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Title Precise Slow Oscillation–Spindle Coupling Promotes Memory Consolidation in Younger and Older Adults
URI https://link.springer.com/article/10.1038/s41598-018-36557-z
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