Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype
Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy pe...
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| Published in | Nature microbiology Vol. 1; no. 5; p. 16031 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
04.04.2016
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2058-5276 2058-5276 |
| DOI | 10.1038/nmicrobiol.2016.31 |
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| Abstract | Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy people examined are enriched with oral taxa (here called pneumotype
SPT
) and this finding is associated with increased numbers of lymphocytes and neutrophils in bronchoalveolar lavage. Here, we have characterized the inflammatory phenotype using a multi-omic approach. By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, we observed that pneumotype
SPT
was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. The cellular immune responses observed in the lower airways of humans with pneumotype
SPT
indicate a role for the aspiration-derived microbiota in regulating the basal inflammatory status at the pulmonary mucosal surface.
Enrichment of oral microbiota in the bronchoalveolar lavage of apparently healthy people is associated with a pro-inflammatory phenotype, suggesting that aspiration-derived microbiota play a role in regulating basal inflammatory status. |
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| AbstractList | Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy people examined are enriched with oral taxa (here called pneumotypeSPT) and this finding is associated with increased numbers of lymphocytes and neutrophils in bronchoalveolar lavage. Here, we have characterized the inflammatory phenotype using a multi-omic approach. By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, we observed that pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. The cellular immune responses observed in the lower airways of humans with pneumotypeSPT indicate a role for the aspiration-derived microbiota in regulating the basal inflammatory status at the pulmonary mucosal surface. Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy people examined are enriched with oral taxa (here called pneumotype SPT ) and this finding is associated with increased numbers of lymphocytes and neutrophils in bronchoalveolar lavage. Here, we have characterized the inflammatory phenotype using a multi-omic approach. By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, we observed that pneumotype SPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. The cellular immune responses observed in the lower airways of humans with pneumotype SPT indicate a role for the aspiration-derived microbiota in regulating the basal inflammatory status at the pulmonary mucosal surface. Enrichment of oral microbiota in the bronchoalveolar lavage of apparently healthy people is associated with a pro-inflammatory phenotype, suggesting that aspiration-derived microbiota play a role in regulating basal inflammatory status. Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy people examined are enriched with oral taxa (here called pneumotypeSPT) and this finding is associated with increased numbers of lymphocytes and neutrophils in bronchoalveolar lavage. Here, we have characterized the inflammatory phenotype using a multi-omic approach. By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, we observed that pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. The cellular immune responses observed in the lower airways of humans with pneumotypeSPT indicate a role for the aspiration-derived microbiota in regulating the basal inflammatory status at the pulmonary mucosal surface.Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy people examined are enriched with oral taxa (here called pneumotypeSPT) and this finding is associated with increased numbers of lymphocytes and neutrophils in bronchoalveolar lavage. Here, we have characterized the inflammatory phenotype using a multi-omic approach. By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, we observed that pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. The cellular immune responses observed in the lower airways of humans with pneumotypeSPT indicate a role for the aspiration-derived microbiota in regulating the basal inflammatory status at the pulmonary mucosal surface. |
| ArticleNumber | 16031 |
| Author | Sterman, Daniel H. Koralov, Sergei B. Ghedin, Elodie Keller, Brian C. Wikoff, William R. Artacho, Alejandro Collman, Ronald G. Morris, Alison Tsay, Jun-Chieh J. Huang, Laurence Weiden, Michael D. Blaser, Martin J. Li, Yonghua Rom, William N. Clemente, Jose C. Wu, Benjamin G. Ubeda, Carles Shen, Nan Diaz, Phillip Segal, Leopoldo N. |
| AuthorAffiliation | 10 Department of Molecular and Cellular Biology & Genome Center, University of California, Davis, California, USA 12 Department of Medicine and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 5 Department of Pathology, New York University School of Medicine, New York, New York, USA 8 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania, USA 9 Department of Medicine, University of California San Francisco, San Francisco, California, USA 7 Department of Biology, Center for Genomics & Systems Biology, College of Global Public Health, New York University, New York, New York, USA 2 Department of Medicine, New York University School of Medicine, New York, New York, USA 11 Center for Public Health Research, FISABIO, Valencia, Spain 3 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA 4 Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA 6 D |
| AuthorAffiliation_xml | – name: 10 Department of Molecular and Cellular Biology & Genome Center, University of California, Davis, California, USA – name: 6 Division of Pulmonary and Critical Care Medicine, The Ohio State University, Columbus, Ohio, USA – name: 7 Department of Biology, Center for Genomics & Systems Biology, College of Global Public Health, New York University, New York, New York, USA – name: 12 Department of Medicine and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA – name: 4 Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA – name: 5 Department of Pathology, New York University School of Medicine, New York, New York, USA – name: 3 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA – name: 11 Center for Public Health Research, FISABIO, Valencia, Spain – name: 9 Department of Medicine, University of California San Francisco, San Francisco, California, USA – name: 1 Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA – name: 2 Department of Medicine, New York University School of Medicine, New York, New York, USA – name: 8 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania, USA |
| Author_xml | – sequence: 1 givenname: Leopoldo N. surname: Segal fullname: Segal, Leopoldo N. email: leopoldo.segal@nyumc.org organization: Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, Department of Medicine, New York University School of Medicine, New York, New York – sequence: 2 givenname: Jose C. orcidid: 0000-0002-3970-9856 surname: Clemente fullname: Clemente, Jose C. organization: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York – sequence: 3 givenname: Jun-Chieh J. orcidid: 0000-0002-2282-2510 surname: Tsay fullname: Tsay, Jun-Chieh J. organization: Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, Department of Medicine, New York University School of Medicine, New York, New York – sequence: 4 givenname: Sergei B. surname: Koralov fullname: Koralov, Sergei B. organization: Department of Pathology, New York University School of Medicine, New York, New York – sequence: 5 givenname: Brian C. surname: Keller fullname: Keller, Brian C. organization: Division of Pulmonary and Critical Care Medicine, The Ohio State University, Columbus, Ohio – sequence: 6 givenname: Benjamin G. surname: Wu fullname: Wu, Benjamin G. organization: Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, Department of Medicine, New York University School of Medicine, New York, New York – sequence: 7 givenname: Yonghua surname: Li fullname: Li, Yonghua organization: Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, Department of Medicine, New York University School of Medicine, New York, New York – sequence: 8 givenname: Nan surname: Shen fullname: Shen, Nan organization: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York – sequence: 9 givenname: Elodie surname: Ghedin fullname: Ghedin, Elodie organization: Department of Biology, Center for Genomics & Systems Biology, College of Global Public Health, New York University, New York, New York – sequence: 10 givenname: Alison surname: Morris fullname: Morris, Alison organization: Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania – sequence: 11 givenname: Phillip surname: Diaz fullname: Diaz, Phillip organization: Division of Pulmonary and Critical Care Medicine, The Ohio State University, Columbus, Ohio – sequence: 12 givenname: Laurence surname: Huang fullname: Huang, Laurence organization: Department of Medicine, University of California San Francisco, San Francisco, California – sequence: 13 givenname: William R. surname: Wikoff fullname: Wikoff, William R. organization: Department of Molecular and Cellular Biology & Genome Center, University of California, Davis, California – sequence: 14 givenname: Carles surname: Ubeda fullname: Ubeda, Carles organization: Center for Public Health Research, FISABIO, Valencia – sequence: 15 givenname: Alejandro surname: Artacho fullname: Artacho, Alejandro organization: Center for Public Health Research, FISABIO, Valencia – sequence: 16 givenname: William N. surname: Rom fullname: Rom, William N. organization: Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, Department of Medicine, New York University School of Medicine, New York, New York – sequence: 17 givenname: Daniel H. surname: Sterman fullname: Sterman, Daniel H. organization: Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, Department of Medicine, New York University School of Medicine, New York, New York – sequence: 18 givenname: Ronald G. surname: Collman fullname: Collman, Ronald G. organization: Department of Medicine and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania – sequence: 19 givenname: Martin J. surname: Blaser fullname: Blaser, Martin J. organization: Department of Medicine, New York University School of Medicine, New York, New York – sequence: 20 givenname: Michael D. surname: Weiden fullname: Weiden, Michael D. email: michael.weiden@nyumc.org organization: Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, Department of Medicine, New York University School of Medicine, New York, New York |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27572644$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1513/AnnalsATS.201306-162MG 10.1038/ismej.2010.133 10.1186/gb-2011-12-6-r60 10.1371/journal.pone.0047305 10.1194/jlr.M700505-JLR200 10.1093/bioinformatics/btq461 10.1128/AEM.00062-07 10.1016/j.chom.2014.09.013 10.1073/pnas.1019378108 10.1016/j.chom.2014.02.005 10.1378/chest.130.4.1096 10.1513/AnnalsATS.201501-029OC 10.1128/JCM.00035-14 10.1016/j.cell.2014.09.053 10.1038/nature09944 10.1093/bioinformatics/btp636 10.1371/journal.pcbi.1002687 10.1378/chest.06-2280 10.1074/jbc.M113.481523 10.1164/rccm.201210-1934OC 10.1378/chest.109.2.316 10.1016/S0022-3476(85)80291-2 10.1093/bioinformatics/btu494 10.1186/2049-2618-1-19 10.1016/j.cellsig.2014.03.020 10.1164/rccm.201111-2075OC 10.1016/j.chom.2008.09.009 10.1038/nmeth.1650 10.1164/rccm.201211-2145OC 10.1038/nbt.2676 10.1111/j.1532-5415.1999.tb05216.x 10.1164/rccm.201210-1913OC 10.1074/jbc.272.23.14571 10.1186/2049-2618-2-28 10.1164/rccm.201104-0655OC 10.1371/journal.pone.0008157 10.1038/nature03985 10.1101/gr.1239303 10.1016/S1542-3565(04)00347-7 10.1093/bioinformatics/btf877 10.1164/rccm.201210-1937OC 10.1074/jbc.M005813200 10.1038/ismej.2012.8 10.1096/fj.12-225664 10.1042/bj20030407 10.1038/nmeth.f.303 10.1378/chest.111.5.1266 10.1371/journal.pone.0078470 10.1111/j.1440-1843.2010.01875.x 10.1111/j.1365-313X.2007.03387.x 10.3390/v5030806 10.1016/0002-9343(78)90574-0 10.1371/journal.pone.0057639 10.1093/nar/gkv380 10.1164/rccm.201409-1583OC 10.1371/journal.pone.0016384 10.1165/rcmb.2011-0253OC |
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| References | Dickson (CR36) 2015; 12 Erb-Downward (CR2) 2011; 6 Calvano (CR54) 2005; 437 Kim, Baumann (CR12) 1997; 272 Gevers (CR37) 2014; 15 Cvejic (CR6) 2011; 16 Wang (CR31) 2009; 50 Pathak (CR16) 2013; 288 Parks, Tyson, Hugenholtz, Beiko (CR48) 2014; 30 Reiner, Yekutieli, Benjamini (CR55) 2003; 19 Gleeson, Eggli, Maxwell (CR5) 1997; 111 Pragman, Kim, Reilly, Wendt, Isaacson (CR21) 2012; 7 Huang (CR9) 2014; 52 Teramoto (CR25) 1999; 47 Lozupone (CR20) 2013; 187 Tunney (CR23) 2013; 187 Wikoff (CR50) 2013; 8 Arumugam (CR18) 2011; 473 Caporaso (CR41) 2010; 7 Charlson (CR1) 2011; 184 Zhao (CR49) 2013; 8 Fiehn (CR51) 2008; 53 Knights (CR46) 2011; 8 Langille (CR47) 2013; 31 Lee (CR11) 2013; 27 Field, Underwood, Brant, Cowie (CR26) 1996; 109 Koh (CR28) 2007; 131 Ivanov (CR32) 2008; 4 Scott, O'Loughlin, Gall (CR27) 1985; 106 Lozupone, Lladser, Knights, Stombaugh, Knight (CR45) 2011; 5 Cui (CR38) 2015; 191 Caporaso (CR44) 2010; 26 Zauberman, Lapter, Zipori (CR13) 2001; 276 Ichinohe (CR33) 2011; 108 Leopold (CR29) 2009; 4 Rascon-Aguilar (CR7) 2006; 130 Dickson (CR34) 2014; 2 Xia, Sinelnikov, Han, Wishart (CR52) 2015; 43(W1) Morse (CR24) 2004; 2 Huxley, Viroslav, Gray, Pierce (CR17) 1978; 64 Yang, Li, Fu, Wu, Li (CR15) 2014; 26 Twigg (CR35) 2014; 11 Knights (CR19) 2014; 16 Friedman, Alm (CR10) 2012; 8 Foster, Costa, Langenback (CR30) 1987; 63 Goodrich (CR57) 2014; 159 Morris (CR4) 2013; 187 Sze (CR22) 2012; 185 Wang, Garrity, Tiedje, Cole (CR43) 2007; 73 Segal (CR3) 2013; 1 Segata (CR56) 2011; 12 Edgar (CR42) 2010; 26 Heinrich (CR14) 2003; 374 Willner (CR39) 2012; 46 Semple (CR53) 2013; 187 Caporaso (CR40) 2012; 6 Shannon (CR58) 2003; 13 Koskella, Meaden (CR8) 2013; 5 J Friedman (BFnmicrobiol201631_CR10) 2012; 8 JH Lee (BFnmicrobiol201631_CR11) 2013; 27 C Lozupone (BFnmicrobiol201631_CR45) 2011; 5 D Knights (BFnmicrobiol201631_CR46) 2011; 8 JG Caporaso (BFnmicrobiol201631_CR41) 2010; 7 ES Charlson (BFnmicrobiol201631_CR1) 2011; 184 K Gleeson (BFnmicrobiol201631_CR5) 1997; 111 L Cui (BFnmicrobiol201631_CR38) 2015; 191 B Koskella (BFnmicrobiol201631_CR8) 2013; 5 RP Dickson (BFnmicrobiol201631_CR36) 2015; 12 D Gevers (BFnmicrobiol201631_CR37) 2014; 15 L Wang (BFnmicrobiol201631_CR31) 2009; 50 S Teramoto (BFnmicrobiol201631_CR25) 1999; 47 L Cvejic (BFnmicrobiol201631_CR6) 2011; 16 H Kim (BFnmicrobiol201631_CR12) 1997; 272 AA Pragman (BFnmicrobiol201631_CR21) 2012; 7 N Segata (BFnmicrobiol201631_CR56) 2011; 12 A Morris (BFnmicrobiol201631_CR4) 2013; 187 A Reiner (BFnmicrobiol201631_CR55) 2003; 19 JG Caporaso (BFnmicrobiol201631_CR44) 2010; 26 D Knights (BFnmicrobiol201631_CR19) 2014; 16 WM Foster (BFnmicrobiol201631_CR30) 1987; 63 PC Heinrich (BFnmicrobiol201631_CR14) 2003; 374 HL Twigg (BFnmicrobiol201631_CR35) 2014; 11 M Arumugam (BFnmicrobiol201631_CR18) 2011; 473 JK Goodrich (BFnmicrobiol201631_CR57) 2014; 159 A Zauberman (BFnmicrobiol201631_CR13) 2001; 276 EJ Huxley (BFnmicrobiol201631_CR17) 1978; 64 WJ Koh (BFnmicrobiol201631_CR28) 2007; 131 YJ Huang (BFnmicrobiol201631_CR9) 2014; 52 G Zhao (BFnmicrobiol201631_CR49) 2013; 8 J Xia (BFnmicrobiol201631_CR52) 2015; 43(W1) RP Dickson (BFnmicrobiol201631_CR34) 2014; 2 C Lozupone (BFnmicrobiol201631_CR20) 2013; 187 RR Pathak (BFnmicrobiol201631_CR16) 2013; 288 DH Parks (BFnmicrobiol201631_CR48) 2014; 30 LN Segal (BFnmicrobiol201631_CR3) 2013; 1 II Ivanov (BFnmicrobiol201631_CR32) 2008; 4 CA Morse (BFnmicrobiol201631_CR24) 2004; 2 PL Leopold (BFnmicrobiol201631_CR29) 2009; 4 O Fiehn (BFnmicrobiol201631_CR51) 2008; 53 T Ichinohe (BFnmicrobiol201631_CR33) 2011; 108 WR Wikoff (BFnmicrobiol201631_CR50) 2013; 8 P Shannon (BFnmicrobiol201631_CR58) 2003; 13 MA Sze (BFnmicrobiol201631_CR22) 2012; 185 PL Semple (BFnmicrobiol201631_CR53) 2013; 187 MM Tunney (BFnmicrobiol201631_CR23) 2013; 187 Q Wang (BFnmicrobiol201631_CR43) 2007; 73 SK Field (BFnmicrobiol201631_CR26) 1996; 109 JG Caporaso (BFnmicrobiol201631_CR40) 2012; 6 I E Rascon-Aguilar (BFnmicrobiol201631_CR7) 2006; 130 P Yang (BFnmicrobiol201631_CR15) 2014; 26 J R Erb-Downward (BFnmicrobiol201631_CR2) 2011; 6 MG Langille (BFnmicrobiol201631_CR47) 2013; 31 RB Scott (BFnmicrobiol201631_CR27) 1985; 106 RC Edgar (BFnmicrobiol201631_CR42) 2010; 26 D Willner (BFnmicrobiol201631_CR39) 2012; 46 SE Calvano (BFnmicrobiol201631_CR54) 2005; 437 |
| References_xml | – volume: 11 start-page: S72 year: 2014 end-page: S73 ident: CR35 article-title: Comparison of whole and acellular bronchoalveolar lavage to oral wash microbiomes. Should acellular bronchoalveolar lavage be the standard? publication-title: Ann. Am. Thorac. Soc. doi: 10.1513/AnnalsATS.201306-162MG – volume: 5 start-page: 169 year: 2011 end-page: 172 ident: CR45 article-title: UniFrac: an effective distance metric for microbial community comparison publication-title: ISME J doi: 10.1038/ismej.2010.133 – volume: 12 start-page: R60 year: 2011 ident: CR56 article-title: Metagenomic biomarker discovery and explanation publication-title: Genome Biol. doi: 10.1186/gb-2011-12-6-r60 – volume: 7 start-page: e47305 year: 2012 ident: CR21 article-title: The lung microbiome in moderate and severe chronic obstructive pulmonary disease publication-title: PLoS ONE doi: 10.1371/journal.pone.0047305 – volume: 50 start-page: 204 year: 2009 end-page: 213 ident: CR31 article-title: Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation publication-title: J. Lipid Res. doi: 10.1194/jlr.M700505-JLR200 – volume: 26 start-page: 2460 year: 2010 end-page: 2461 ident: CR42 article-title: Search and clustering orders of magnitude faster than BLAST publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq461 – volume: 73 start-page: 5261 year: 2007 end-page: 5267 ident: CR43 article-title: Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.00062-07 – volume: 16 start-page: 433 year: 2014 end-page: 437 ident: CR19 article-title: Rethinking ‘enterotypes’ publication-title: Cell Host Microbe doi: 10.1016/j.chom.2014.09.013 – volume: 108 start-page: 5354 year: 2011 end-page: 5359 ident: CR33 article-title: Microbiota regulates immune defense against respiratory tract influenza A virus infection publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1019378108 – volume: 15 start-page: 382 year: 2014 end-page: 392 ident: CR37 article-title: The treatment-naive microbiome in new-onset Crohn's disease publication-title: Cell Host Microbe doi: 10.1016/j.chom.2014.02.005 – volume: 130 start-page: 1096 year: 2006 end-page: 1101 ident: CR7 article-title: Role of gastroesophageal reflux symptoms in exacerbations of COPD publication-title: Chest doi: 10.1378/chest.130.4.1096 – volume: 12 start-page: 821 year: 2015 end-page: 830 ident: CR36 article-title: Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography publication-title: Ann. Am. Thorac. Soc. doi: 10.1513/AnnalsATS.201501-029OC – volume: 52 start-page: 2813 year: 2014 end-page: 2823 ident: CR9 article-title: Airway microbiome dynamics in exacerbations of chronic obstructive pulmonary disease publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.00035-14 – volume: 159 start-page: 789 year: 2014 end-page: 799 ident: CR57 article-title: Human genetics shape the gut microbiome publication-title: Cell doi: 10.1016/j.cell.2014.09.053 – volume: 473 start-page: 174 year: 2011 end-page: 180 ident: CR18 article-title: Enterotypes of the human gut microbiome publication-title: Nature doi: 10.1038/nature09944 – volume: 26 start-page: 266 year: 2010 end-page: 267 ident: CR44 article-title: PyNAST: a flexible tool for aligning sequences to a template alignment publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp636 – volume: 8 start-page: e1002687 year: 2012 ident: CR10 article-title: Inferring correlation networks from genomic survey data publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1002687 – volume: 131 start-page: 1825 year: 2007 end-page: 1830 ident: CR28 article-title: Prevalence of gastroesophageal reflux disease in patients with nontuberculous mycobacterial lung disease publication-title: Chest doi: 10.1378/chest.06-2280 – volume: 288 start-page: 29821 year: 2013 end-page: 29835 ident: CR16 article-title: Loss of phosphatase and tensin homolog (PTEN) induces leptin-mediated leptin gene expression: feed-forward loop operating in the lung publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.481523 – volume: 187 start-page: 1249 year: 2013 end-page: 1258 ident: CR53 article-title: Regulatory T cells attenuate mycobacterial stasis in alveolar and blood-derived macrophages from patients with tuberculosis publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201210-1934OC – volume: 109 start-page: 316 year: 1996 end-page: 322 ident: CR26 article-title: Prevalence of gastroesophageal reflux symptoms in asthma publication-title: Chest doi: 10.1378/chest.109.2.316 – volume: 106 start-page: 223 year: 1985 end-page: 227 ident: CR27 article-title: Gastroesophageal reflux in patients with cystic fibrosis publication-title: J. Pediatr. doi: 10.1016/S0022-3476(85)80291-2 – volume: 30 start-page: 3123 year: 2014 end-page: 3124 ident: CR48 article-title: STAMP: statistical analysis of taxonomic and functional profiles publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu494 – volume: 1 start-page: 19 year: 2013 ident: CR3 article-title: Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation publication-title: Microbiome doi: 10.1186/2049-2618-1-19 – volume: 26 start-page: 1853 year: 2014 end-page: 1862 ident: CR15 article-title: Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2014.03.020 – volume: 185 start-page: 1073 year: 2012 end-page: 1080 ident: CR22 article-title: The lung tissue microbiome in chronic obstructive pulmonary disease publication-title: Am. J. Respir. Crit. Care Med doi: 10.1164/rccm.201111-2075OC – volume: 4 start-page: 337 year: 2008 end-page: 349 ident: CR32 article-title: Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine publication-title: Cell Host Microbe doi: 10.1016/j.chom.2008.09.009 – volume: 8 start-page: 761 year: 2011 end-page: 763 ident: CR46 article-title: Bayesian community-wide culture-independent microbial source tracking publication-title: Nature Methods doi: 10.1038/nmeth.1650 – volume: 187 start-page: 1110 year: 2013 end-page: 1117 ident: CR20 article-title: Widespread colonization of the lung by in HIV infection publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201211-2145OC – volume: 31 start-page: 814 year: 2013 end-page: 821 ident: CR47 article-title: Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences publication-title: Nature Biotechnol. doi: 10.1038/nbt.2676 – volume: 47 start-page: 1273 year: 1999 end-page: 1274 ident: CR25 article-title: Obstructive sleep apnea syndrome may be a significant cause of gastroesophageal reflux disease in older people publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.1999.tb05216.x – volume: 187 start-page: 1067 year: 2013 end-page: 1075 ident: CR4 article-title: Comparison of the respiratory microbiome in healthy non-smokers and smokers publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201210-1913OC – volume: 272 start-page: 14571 year: 1997 end-page: 14579 ident: CR12 article-title: The carboxyl-terminal region of STAT3 controls gene induction by the mouse haptoglobin promoter publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.23.14571 – volume: 2 start-page: 28 year: 2014 ident: CR34 article-title: Cell-associated bacteria in the human lung microbiome publication-title: Microbiome doi: 10.1186/2049-2618-2-28 – volume: 184 start-page: 957 year: 2011 end-page: 963 ident: CR1 article-title: Topographical continuity of bacterial populations in the healthy human respiratory tract publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201104-0655OC – volume: 4 start-page: e8157 year: 2009 ident: CR29 article-title: Smoking is associated with shortened airway cilia publication-title: PLoS ONE doi: 10.1371/journal.pone.0008157 – volume: 437 start-page: 1032 year: 2005 end-page: 1037 ident: CR54 article-title: A network-based analysis of systemic inflammation in humans publication-title: Nature doi: 10.1038/nature03985 – volume: 13 start-page: 2498 year: 2003 end-page: 2504 ident: CR58 article-title: Cytoscape: a software environment for integrated models of biomolecular interaction networks publication-title: Genome Res. doi: 10.1101/gr.1239303 – volume: 2 start-page: 761 year: 2004 end-page: 768 ident: CR24 article-title: Is there a relationship between obstructive sleep apnea and gastroesophageal reflux disease? publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/S1542-3565(04)00347-7 – volume: 19 start-page: 368 year: 2003 end-page: 375 ident: CR55 article-title: Identifying differentially expressed genes using false discovery rate controlling procedures publication-title: Bioinformatics doi: 10.1093/bioinformatics/btf877 – volume: 63 start-page: 996 year: 1987 end-page: 1002 ident: CR30 article-title: Ozone exposure alters tracheobronchial mucociliary function in humans publication-title: J. Appl. Phys – volume: 187 start-page: 1118 year: 2013 end-page: 1126 ident: CR23 article-title: Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201210-1937OC – volume: 276 start-page: 24719 year: 2001 end-page: 24725 ident: CR13 article-title: Smad proteins suppress CCAAT/enhancer-binding protein (C/EBP) β- and STAT3-mediated transcriptional activation of the haptoglobin promoter publication-title: J. Biol. Chem. doi: 10.1074/jbc.M005813200 – volume: 6 start-page: 1621 year: 2012 end-page: 1624 ident: CR40 article-title: Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms publication-title: ISME J. doi: 10.1038/ismej.2012.8 – volume: 27 start-page: 2553 year: 2013 end-page: 2563 ident: CR11 article-title: Signal transducer and activator of transcription-3 ( ) plays a critical role in implantation via progesterone receptor in uterus publication-title: FASEB J. doi: 10.1096/fj.12-225664 – volume: 374 start-page: 1 year: 2003 end-page: 20 ident: CR14 article-title: Principles of interleukin (IL)-6-type cytokine signalling and its regulation publication-title: Biochem. J. doi: 10.1042/bj20030407 – volume: 7 start-page: 335 year: 2010 end-page: 336 ident: CR41 article-title: QIIME allows analysis of high-throughput community sequencing data publication-title: Nature Methods doi: 10.1038/nmeth.f.303 – volume: 111 start-page: 1266 year: 1997 end-page: 1272 ident: CR5 article-title: Quantitative aspiration during sleep in normal subjects publication-title: Chest doi: 10.1378/chest.111.5.1266 – volume: 8 start-page: e78470 year: 2013 ident: CR49 article-title: Identification of novel viruses using VirusHunter—an automated data analysis pipeline publication-title: PLoS ONE doi: 10.1371/journal.pone.0078470 – volume: 16 start-page: 269 year: 2011 end-page: 275 ident: CR6 article-title: Laryngeal penetration and aspiration in individuals with stable COPD publication-title: Respirology doi: 10.1111/j.1440-1843.2010.01875.x – volume: 53 start-page: 691 year: 2008 end-page: 704 ident: CR51 article-title: Quality control for plant metabolomics: reporting MSI-compliant studies publication-title: Plant J. doi: 10.1111/j.1365-313X.2007.03387.x – volume: 5 start-page: 806 year: 2013 end-page: 823 ident: CR8 article-title: Understanding bacteriophage specificity in natural microbial communities publication-title: Viruses doi: 10.3390/v5030806 – volume: 64 start-page: 564 year: 1978 end-page: 568 ident: CR17 article-title: Pharyngeal aspiration in normal adults and patients with depressed consciousness publication-title: Am. J. Med. doi: 10.1016/0002-9343(78)90574-0 – volume: 8 start-page: e57639 year: 2013 ident: CR50 article-title: Pharmacometabolomics reveals racial differences in response to atenolol treatment publication-title: PLoS ONE doi: 10.1371/journal.pone.0057639 – volume: 43(W1) start-page: W251 year: 2015 end-page: W257 ident: CR52 article-title: MetaboAnalyst 3.0—making metabolomics more meaningful publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv380 – volume: 191 start-page: 932 year: 2015 end-page: 942 ident: CR38 article-title: Topographic diversity of the respiratory tract mycobiome and alteration in HIV and lung disease publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201409-1583OC – volume: 6 start-page: e16384 year: 2011 ident: CR2 article-title: Analysis of the lung microbiome in the ‘healthy’ smoker and in COPD publication-title: PLoS ONE doi: 10.1371/journal.pone.0016384 – volume: 46 start-page: 127 year: 2012 end-page: 131 ident: CR39 article-title: Case studies of the spatial heterogeneity of DNA viruses in the cystic fibrosis lung publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2011-0253OC – volume: 8 start-page: e57639 year: 2013 ident: BFnmicrobiol201631_CR50 publication-title: PLoS ONE doi: 10.1371/journal.pone.0057639 – volume: 19 start-page: 368 year: 2003 ident: BFnmicrobiol201631_CR55 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btf877 – volume: 64 start-page: 564 year: 1978 ident: BFnmicrobiol201631_CR17 publication-title: Am. J. Med. doi: 10.1016/0002-9343(78)90574-0 – volume: 12 start-page: R60 year: 2011 ident: BFnmicrobiol201631_CR56 publication-title: Genome Biol. doi: 10.1186/gb-2011-12-6-r60 – volume: 13 start-page: 2498 year: 2003 ident: BFnmicrobiol201631_CR58 publication-title: Genome Res. doi: 10.1101/gr.1239303 – volume: 106 start-page: 223 year: 1985 ident: BFnmicrobiol201631_CR27 publication-title: J. Pediatr. doi: 10.1016/S0022-3476(85)80291-2 – volume: 187 start-page: 1110 year: 2013 ident: BFnmicrobiol201631_CR20 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201211-2145OC – volume: 11 start-page: S72 year: 2014 ident: BFnmicrobiol201631_CR35 publication-title: Ann. Am. Thorac. Soc. doi: 10.1513/AnnalsATS.201306-162MG – volume: 15 start-page: 382 year: 2014 ident: BFnmicrobiol201631_CR37 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2014.02.005 – volume: 1 start-page: 19 year: 2013 ident: BFnmicrobiol201631_CR3 publication-title: Microbiome doi: 10.1186/2049-2618-1-19 – volume: 6 start-page: e16384 year: 2011 ident: BFnmicrobiol201631_CR2 publication-title: PLoS ONE doi: 10.1371/journal.pone.0016384 – volume: 63 start-page: 996 year: 1987 ident: BFnmicrobiol201631_CR30 publication-title: J. Appl. Phys – volume: 53 start-page: 691 year: 2008 ident: BFnmicrobiol201631_CR51 publication-title: Plant J. doi: 10.1111/j.1365-313X.2007.03387.x – volume: 27 start-page: 2553 year: 2013 ident: BFnmicrobiol201631_CR11 publication-title: FASEB J. doi: 10.1096/fj.12-225664 – volume: 185 start-page: 1073 year: 2012 ident: BFnmicrobiol201631_CR22 publication-title: Am. J. Respir. Crit. Care Med doi: 10.1164/rccm.201111-2075OC – volume: 16 start-page: 269 year: 2011 ident: BFnmicrobiol201631_CR6 publication-title: Respirology doi: 10.1111/j.1440-1843.2010.01875.x – volume: 6 start-page: 1621 year: 2012 ident: BFnmicrobiol201631_CR40 publication-title: ISME J. doi: 10.1038/ismej.2012.8 – volume: 4 start-page: e8157 year: 2009 ident: BFnmicrobiol201631_CR29 publication-title: PLoS ONE doi: 10.1371/journal.pone.0008157 – volume: 130 start-page: 1096 year: 2006 ident: BFnmicrobiol201631_CR7 publication-title: Chest doi: 10.1378/chest.130.4.1096 – volume: 8 start-page: e1002687 year: 2012 ident: BFnmicrobiol201631_CR10 publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1002687 – volume: 111 start-page: 1266 year: 1997 ident: BFnmicrobiol201631_CR5 publication-title: Chest doi: 10.1378/chest.111.5.1266 – volume: 4 start-page: 337 year: 2008 ident: BFnmicrobiol201631_CR32 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2008.09.009 – volume: 46 start-page: 127 year: 2012 ident: BFnmicrobiol201631_CR39 publication-title: Am. J. Respir. Cell Mol. Biol. doi: 10.1165/rcmb.2011-0253OC – volume: 159 start-page: 789 year: 2014 ident: BFnmicrobiol201631_CR57 publication-title: Cell doi: 10.1016/j.cell.2014.09.053 – volume: 109 start-page: 316 year: 1996 ident: BFnmicrobiol201631_CR26 publication-title: Chest doi: 10.1378/chest.109.2.316 – volume: 276 start-page: 24719 year: 2001 ident: BFnmicrobiol201631_CR13 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M005813200 – volume: 26 start-page: 266 year: 2010 ident: BFnmicrobiol201631_CR44 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp636 – volume: 2 start-page: 761 year: 2004 ident: BFnmicrobiol201631_CR24 publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/S1542-3565(04)00347-7 – volume: 187 start-page: 1067 year: 2013 ident: BFnmicrobiol201631_CR4 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201210-1913OC – volume: 108 start-page: 5354 year: 2011 ident: BFnmicrobiol201631_CR33 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1019378108 – volume: 31 start-page: 814 year: 2013 ident: BFnmicrobiol201631_CR47 publication-title: Nature Biotechnol. doi: 10.1038/nbt.2676 – volume: 2 start-page: 28 year: 2014 ident: BFnmicrobiol201631_CR34 publication-title: Microbiome doi: 10.1186/2049-2618-2-28 – volume: 288 start-page: 29821 year: 2013 ident: BFnmicrobiol201631_CR16 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.481523 – volume: 473 start-page: 174 year: 2011 ident: BFnmicrobiol201631_CR18 publication-title: Nature doi: 10.1038/nature09944 – volume: 30 start-page: 3123 year: 2014 ident: BFnmicrobiol201631_CR48 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu494 – volume: 43(W1) start-page: W251 year: 2015 ident: BFnmicrobiol201631_CR52 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv380 – volume: 374 start-page: 1 year: 2003 ident: BFnmicrobiol201631_CR14 publication-title: Biochem. J. doi: 10.1042/bj20030407 – volume: 12 start-page: 821 year: 2015 ident: BFnmicrobiol201631_CR36 publication-title: Ann. Am. Thorac. Soc. doi: 10.1513/AnnalsATS.201501-029OC – volume: 184 start-page: 957 year: 2011 ident: BFnmicrobiol201631_CR1 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201104-0655OC – volume: 5 start-page: 169 year: 2011 ident: BFnmicrobiol201631_CR45 publication-title: ISME J doi: 10.1038/ismej.2010.133 – volume: 52 start-page: 2813 year: 2014 ident: BFnmicrobiol201631_CR9 publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.00035-14 – volume: 187 start-page: 1118 year: 2013 ident: BFnmicrobiol201631_CR23 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201210-1937OC – volume: 26 start-page: 1853 year: 2014 ident: BFnmicrobiol201631_CR15 publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2014.03.020 – volume: 26 start-page: 2460 year: 2010 ident: BFnmicrobiol201631_CR42 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq461 – volume: 7 start-page: 335 year: 2010 ident: BFnmicrobiol201631_CR41 publication-title: Nature Methods doi: 10.1038/nmeth.f.303 – volume: 7 start-page: e47305 year: 2012 ident: BFnmicrobiol201631_CR21 publication-title: PLoS ONE doi: 10.1371/journal.pone.0047305 – volume: 73 start-page: 5261 year: 2007 ident: BFnmicrobiol201631_CR43 publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.00062-07 – volume: 47 start-page: 1273 year: 1999 ident: BFnmicrobiol201631_CR25 publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.1999.tb05216.x – volume: 8 start-page: 761 year: 2011 ident: BFnmicrobiol201631_CR46 publication-title: Nature Methods doi: 10.1038/nmeth.1650 – volume: 191 start-page: 932 year: 2015 ident: BFnmicrobiol201631_CR38 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201409-1583OC – volume: 437 start-page: 1032 year: 2005 ident: BFnmicrobiol201631_CR54 publication-title: Nature doi: 10.1038/nature03985 – volume: 272 start-page: 14571 year: 1997 ident: BFnmicrobiol201631_CR12 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.23.14571 – volume: 5 start-page: 806 year: 2013 ident: BFnmicrobiol201631_CR8 publication-title: Viruses doi: 10.3390/v5030806 – volume: 16 start-page: 433 year: 2014 ident: BFnmicrobiol201631_CR19 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2014.09.013 – volume: 131 start-page: 1825 year: 2007 ident: BFnmicrobiol201631_CR28 publication-title: Chest doi: 10.1378/chest.06-2280 – volume: 50 start-page: 204 year: 2009 ident: BFnmicrobiol201631_CR31 publication-title: J. Lipid Res. doi: 10.1194/jlr.M700505-JLR200 – volume: 8 start-page: e78470 year: 2013 ident: BFnmicrobiol201631_CR49 publication-title: PLoS ONE doi: 10.1371/journal.pone.0078470 – volume: 187 start-page: 1249 year: 2013 ident: BFnmicrobiol201631_CR53 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201210-1934OC |
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| Title | Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype |
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