Safety and efficacy of up to 60 h of iv istaroxime in pre‐cardiogenic shock patients: Design of the SEISMiC trial - Biegus, Jan; Mebazaa, Alexander; Metra, Marco; Pagnesi, Matteo; Chioncel, Ovidiu; Davison, Beth; Filippatos, Gerasimos; Tycińska, Agnieszka; Novosadova, Maria; Gulati, Gaurav; Barros, Marianela; Diaz, Maria Luz; et al. (ESC Heart Failure, 2025)
Keywords: Acute coronary syndromes; Blood Pressure; Cardiac arrhythmia; cardiac calcitrope; cardiogenic shock; Cardiomyopathy; Cardiotonic Agents - administration & dosage; Cardiotonic Agents - adverse effects; Cardiovascular disease; central haemodynamics; Double-Blind Method; Drug dosages; Ejection fraction; Etiocholanolone - administration & dosage; Etiocholanolone - adverse effects; Etiocholanolone - analogs & derivatives; Female; Heart failure; Heart rate; Heart transplants; Hemodynamics - drug effects; Humans; Hypotension; Informed consent; Infusions, Intravenous; inotrope; istaroxime; Lactose; Male; Middle Aged; Multicenter Studies as Topic; Pilot Projects; pre‐cardiogenic shock; Randomized Controlled Trials as Topic; Shock, Cardiogenic - drug therapy; Shock, Cardiogenic - physiopathology; Study Design; Time Factors; Treatment Outcome; cardiogenic shock; pre‐cardiogenic shock; istaroxime; central haemodynamics; inotrope; cardiac calcitrope