Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia - Shao, Zhicheng; Noh, Haneul; Bin Kim, Woong; Ni, Peiyan; Nguyen, Christine; Cote, Sarah E.; Noyes, Elizabeth; Zhao, Joyce; Parsons, Teagan; Park, James M.; Zheng, Kelvin; Park, Joshua J.; et al. (Nature neuroscience, 2019)
Keywords: 13/100; 13/51; 631/136; 631/378; 692/699; Abnormalities; Analysis; Animal Genetics and Genomics; Animals; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Cadherins - genetics; Cadherins - metabolism; Care and treatment; Density; Female; GABA; Gene expression; Genes; Genome-wide association studies; Humans; Induced Pluripotent Stem Cells; Interneurons; Interneurons - metabolism; Interneurons - pathology; Kinases; Male; Mental disorders; Mice; Mice, Knockout; Neurobiology; Neurons; Neurophysiology; Neurosciences; Pathogenesis; Pluripotency; Prefrontal cortex; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Protein kinase C; Protein kinases; Proteins; Protocadherin; Risk factors; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - pathology; Signal Transduction - physiology; Stem cell transplantation; Stem cells; Synapses - genetics; Synapses - metabolism; Synaptic density; γ-Aminobutyric acid