Association between brain health outcomes and metabolic risk factors in persons with diabetes

• Published in: Annals of clinical and translational neurology Vol. 10; no. 10; pp. 1891 - 1898
• Main Authors: Reynolds, Evan L., Votruba, Kristen, Jack, Clifford R., Beare, Richard, Reid, Robert I., Preboske, Gregory M., Waseta, Camille, Pop‐Busui, Rodica, Nelson, Robert G., Callaghan, Brian C., Feldman, Eva L.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.10.2023; John Wiley and Sons Inc; Wiley
• Subjects: Anisotropy; Blood pressure; Body mass index; Brain - diagnostic imaging; Brain - metabolism; Brief Communication; Brief Communications; Cognition & reasoning; Cross-Sectional Studies; Dementia; Diabetes; Diabetes Mellitus, Type 2 - complications; Executive function; High density lipoprotein; Humans; Memory; Metabolism; Middle Aged; Morphology; Native North Americans; Obesity; Outcome Assessment, Health Care; Population; Regression analysis; Risk Factors; United States; United States
• ISSN: 2328-9503; 2328-9503
• DOI: 10.1002/acn3.51859

We performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p  = 0.64, n  = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n  = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n  = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n  = 45).