Rapid Diagnostic Testing for SARS-CoV-2

RDTs for SARS-CoV-2 — either molecular nucleic acid amplification tests or antigen-based immunoassays to detect proteins — are approved for persons with Covid-19 symptoms and asymptomatic persons with known exposure to SARS-CoV-2 or those in a high-transmission setting. Antigen-based tests have lowe...

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Published inThe New England journal of medicine Vol. 386; no. 3; pp. 264 - 272
Main Author Drain, Paul K
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 20.01.2022
Subjects
Online AccessGet full text
ISSN0028-4793
1533-4406
1533-4406
DOI10.1056/NEJMcp2117115

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Abstract RDTs for SARS-CoV-2 — either molecular nucleic acid amplification tests or antigen-based immunoassays to detect proteins — are approved for persons with Covid-19 symptoms and asymptomatic persons with known exposure to SARS-CoV-2 or those in a high-transmission setting. Antigen-based tests have lower sensitivity than PCR tests, but they may correlate better with replication-competent virus.
AbstractList Key Clinical PointsRapid Diagnostic Testing for SARS-CoV-2Rapid diagnostic tests (RDTs) that are authorized by the Food and Drug Administration to diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are either nucleic acid amplification tests to detect genes or antigen-based immunoassays to detect proteins of SARS-CoV-2.RDTs are approved for use in persons with symptoms of coronavirus disease 2019 (Covid-19) and in asymptomatic persons who are close contacts of a person with Covid-19 or who have been in a potential high-risk transmission setting.Symptomatic persons should undergo testing as soon as possible, quarantine while awaiting test results, and consider retesting if they have a negative RDT, particularly if they have a high pretest probability of infection.Asymptomatic persons with a known exposure to SARS-CoV-2 should undergo testing 5 to 7 days after exposure, and if the RDT is negative, they should undergo testing again 2 days later.Persons with a known exposure to SARS-CoV-2 who are not fully vaccinated should quarantine while awaiting test results, and persons who test positive should isolate, contact a health care provider or public health department, and inform close contacts about the infection.
RDTs for SARS-CoV-2 — either molecular nucleic acid amplification tests or antigen-based immunoassays to detect proteins — are approved for persons with Covid-19 symptoms and asymptomatic persons with known exposure to SARS-CoV-2 or those in a high-transmission setting. Antigen-based tests have lower sensitivity than PCR tests, but they may correlate better with replication-competent virus.
Author Drain, Paul K
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Snippet RDTs for SARS-CoV-2 — either molecular nucleic acid amplification tests or antigen-based immunoassays to detect proteins — are approved for persons with...
Key Clinical PointsRapid Diagnostic Testing for SARS-CoV-2Rapid diagnostic tests (RDTs) that are authorized by the Food and Drug Administration to diagnose...
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SubjectTerms Adult
Algorithms
Antibodies, Viral - blood
Antigens
Antigens, Viral - blood
Asymptomatic
Clinical Medicine
Clinical Medicine General
Clinical Practice
Coronavirus
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 - transmission
COVID-19 Nucleic Acid Testing
COVID-19 Serological Testing
COVID-19 vaccines
Diabetes Mellitus, Type 2 - complications
Diagnostic tests
Diagnostics
Disease transmission
FDA approval
Female
Genes, Viral
Health care
Humans
Infections
Infectious Disease
Infectious Disease General
Laboratories
Medical diagnosis
Pandemics
Pathogens
Pathophysiology
Public health
Quarantine
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
Sensitivity and Specificity
Severe acute respiratory syndrome coronavirus 2
SubjectTermsDisplay Clinical Medicine
Clinical Medicine General
Coronavirus
Diagnostics
Infectious Disease
Infectious Disease General
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