Normalized activation in the somatosensory cortex 30 years following nerve repair in children: an fMRI study
The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In 28 patients with a complete median nerve injury sustained at the ages of 1–13 years (n = 13)...
Saved in:
| Published in | The European journal of neuroscience Vol. 42; no. 4; pp. 2022 - 2027 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
France
Blackwell Publishing Ltd
01.08.2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0953-816X 1460-9568 1460-9568 |
| DOI | 10.1111/ejn.12917 |
Cover
| Abstract | The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In 28 patients with a complete median nerve injury sustained at the ages of 1–13 years (n = 13) and 14–20 years (n = 15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve‐innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1–13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (P = 0.001) to the outcome in subjects injured at a later age; however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14–20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence.
Cortical activation was assessed, using fMRI at 3T, 28 years after a median nerve injury. The cortical activation pattern was compared with clinical outcome and electroneurography. Patients injured before the age of 14 years had an activation pattern similar to healthy controls and an excellent clinical outcome. Those injured at age 14–20 years showed more extended activation of contralateral somatosensory areas, as well as loss of ipsilateral inhibition and poor clinical outcome. Electroneurographical parameters did not differ between the two age groups. Cerebral changes in both hemispheres may explain the superior clinical outcome following a median nerve injury in childhood. |
|---|---|
| AbstractList | The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In 28 patients with a complete median nerve injury sustained at the ages of 1-13 years (n = 13) and 14-20 years (n = 15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve-innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (P = 0.001) to the outcome in subjects injured at a later age; however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In 28 patients with a complete median nerve injury sustained at the ages of 1-13 years (n = 13) and 14-20 years (n = 15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve-innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (P = 0.001) to the outcome in subjects injured at a later age; however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence.The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In 28 patients with a complete median nerve injury sustained at the ages of 1-13 years (n = 13) and 14-20 years (n = 15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve-innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (P = 0.001) to the outcome in subjects injured at a later age; however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In twenty-eight patients with a complete median nerve injury sustained at the ages of 1-13 years (n=13) and 14-20 years (n=15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1-13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (p=0.001) to the outcome in subjects injured at a later age, however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14-20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. This article is protected by copyright. All rights reserved. The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In 28 patients with a complete median nerve injury sustained at the ages of 1–13 years (n = 13) and 14–20 years (n = 15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging (fMRI) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve‐innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1–13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior (P = 0.001) to the outcome in subjects injured at a later age; however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14–20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. Cortical activation was assessed, using fMRI at 3T, 28 years after a median nerve injury. The cortical activation pattern was compared with clinical outcome and electroneurography. Patients injured before the age of 14 years had an activation pattern similar to healthy controls and an excellent clinical outcome. Those injured at age 14–20 years showed more extended activation of contralateral somatosensory areas, as well as loss of ipsilateral inhibition and poor clinical outcome. Electroneurographical parameters did not differ between the two age groups. Cerebral changes in both hemispheres may explain the superior clinical outcome following a median nerve injury in childhood. The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the mechanism behind this difference is unknown. In 28 patients with a complete median nerve injury sustained at the ages of 1–13 years ( n = 13) and 14–20 years ( n = 15), the cortical activation during tactile finger stimulation of the injured and healthy hands was monitored at a median time since injury of 28 years using functional magnetic resonance imaging ( fMRI ) at 3 Tesla. The results from the fMRI were compared with the clinical outcome and electroneurography. The cortical activation pattern following sensory stimulation of the median nerve‐innervated fingers was dependent on the patient's age at injury. Those injured at a young age (1–13 years) had an activation pattern similar to that of healthy controls. Furthermore, they showed a clinical outcome significantly superior ( P = 0.001) to the outcome in subjects injured at a later age; however, electroneurographical parameters did not differ between the groups. In subjects injured at age 14–20 years, a more extended activation of the contralateral hemisphere was seen in general. Interestingly, these patients also displayed changes in the ipsilateral hemisphere where a reduced inhibition of somatosensory areas was seen. This loss of ipsilateral inhibition correlated to increasing age at injury as well as to poor recovery of sensory functions in the hand. In conclusion, cerebral changes in both brain hemispheres may explain differences in clinical outcome following a median nerve injury in childhood or adolescence. |
| Author | Dahlin, Lars B. Rosén, Birgitta Björkman, Anders Andersson, Gert Chemnitz, Anette Weibull, Andreas |
| Author_xml | – sequence: 1 givenname: Anette surname: Chemnitz fullname: Chemnitz, Anette email: : Anette Chemnitz, as above., Anette.Chemnitz@med.lu.se organization: Department of Clinical Sciences Malmö - Hand Surgery, Lund University, Skåne University Hospital, SE - 20502, Malmö, Sweden – sequence: 2 givenname: Andreas surname: Weibull fullname: Weibull, Andreas organization: Department of Medical Radiation Physics, Lund University, Skåne University Hospital, Malmö, Sweden – sequence: 3 givenname: Birgitta surname: Rosén fullname: Rosén, Birgitta organization: Department of Clinical Sciences Malmö - Hand Surgery, Lund University, Skåne University Hospital, SE - 20502, Malmö, Sweden – sequence: 4 givenname: Gert surname: Andersson fullname: Andersson, Gert organization: Department of Clinical Neurophysiology, Lund University, Skåne University Hospital, Malmö, Sweden – sequence: 5 givenname: Lars B. surname: Dahlin fullname: Dahlin, Lars B. organization: Department of Clinical Sciences Malmö - Hand Surgery, Lund University, Skåne University Hospital, SE - 20502, Malmö, Sweden – sequence: 6 givenname: Anders surname: Björkman fullname: Björkman, Anders organization: Department of Clinical Sciences Malmö - Hand Surgery, Lund University, Skåne University Hospital, SE - 20502, Malmö, Sweden |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25865600$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1u1DAUhSNURKeFBS-AvIRFWjuJnYQdqtpSVAapgNrdleNcMy5OnNpJh-FpeBaeDHd-ukDghb35zrn3-Bwke73rMUleMnrE4jnG2_6IZTUrnyQzVgia1lxUe8mM1jxPKyZu9pODEG4ppZUo-LNkP-OV4ILSWdLNne-kNT-xJVKN5l6OxvXE9GRcIAmuk6ML2AfnV0Q5P-IPktPfv1YofSDaWeuWpv9GevT3SDwO0vgHsVoY23rs3xLZE_3x6oKEcWpXz5OnWtqAL7bvYfL17PTLyfv08tP5xcm7y1QVZV6mpaBalQVVOXJNs0LoopIxWIG54rzkrGxk29Sy5hJ1LcqmoVJrzjPZNExonR8mcuMbljhMDQzedNKvwEkDQ0whLXgMMYNagJ0gIETKGrUOH0CLlpfx36CgFOPV1NAUlIHAPMtoplqVqzjj9WbG4N3dhGGEzgSF1soe3RSAlZRTWteMRvTVFp2aDtvHdXY1ROB4AyjvQvCoQZlxvczopbHAKDwUDbFoWBcdFW_-UuxM_8Vu3ZfG4ur_IJx-mO8U6UZhQmz8USH9dxCxIA7X83OoPt_Mz0RxBdf5H7v0yZ4 |
| CitedBy_id | crossref_primary_10_52581_1814_1471_83_01 crossref_primary_10_1016_j_neures_2017_12_004 crossref_primary_10_1155_2021_8819380 crossref_primary_10_1371_journal_pone_0196243 crossref_primary_10_1002_14651858_CD012574_pub2 crossref_primary_10_1038_s41598_018_22792_x crossref_primary_10_3389_fneur_2016_00240 crossref_primary_10_1016_j_neulet_2016_06_018 crossref_primary_10_3389_fnhum_2020_00166 crossref_primary_10_1002_14651858_CD012574 crossref_primary_10_1016_j_neuroimage_2019_116291 crossref_primary_10_1055_s_0044_1792169 crossref_primary_10_1302_2058_5241_2_160071 crossref_primary_10_1080_08990220_2016_1230094 crossref_primary_10_1177_17589983221118399 crossref_primary_10_1016_j_jos_2017_06_012 crossref_primary_10_3389_fnimg_2022_919694 crossref_primary_10_1097_WNR_0000000000001909 crossref_primary_10_3389_fnagi_2022_862107 crossref_primary_10_1016_j_jhsa_2021_11_022 crossref_primary_10_1186_s12883_018_1152_y crossref_primary_10_5014_ajot_2020_036665 |
| Cites_doi | 10.1097/01.prs.0000172896.86594.07 10.1016/j.expneurol.2009.12.001 10.1093/brain/awg033 10.1098/rstb.2000.0563 10.2106/JBJS.L.00074 10.1097/00005373-200110000-00011 10.1016/S0363-5023(83)80199-3 10.1371/journal.pone.0016150 10.1523/JNEUROSCI.5536-05.2006 10.1038/369554a0 10.1073/pnas.1100815108 10.3171/jns.2003.99.1.0100 10.1016/j.mri.2008.04.007 10.1016/S0030-5898(20)30185-1 10.1093/cercor/bhp282 10.1097/WNR.0b013e32835b6efd 10.1146/annurev.ne.14.030191.001033 10.1007/s10548-011-0196-8 10.1016/0014-4886(80)90006-0 10.1093/brain/awp231 10.3171/2009.10.JNS09698 10.1016/j.neuroimage.2011.11.085 10.1002/ddrr.64 10.1016/S0749-0712(21)00502-3 10.1016/j.jhsb.2003.09.018 10.1016/j.clineuro.2006.11.006 10.1093/cercor/bhq165 10.1016/S0140-6736(01)06001-9 10.1016/S0749-0712(03)00003-9 |
| ContentType | Journal Article |
| Copyright | 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. |
| Copyright_xml | – notice: 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd – notice: 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. |
| CorporateAuthor | Handkirurgi, Malmö Institutionen för translationell medicin Institutionen för kliniska vetenskaper, Lund Department of Translational Medicine Lunds universitet Lund University Department of Clinical Sciences, Lund Hand Surgery, Malmö Faculty of Medicine Medical Radiation Physics, Malmö Section IV Medicinska fakulteten Medicinsk strålningsfysik, Malmö Clinical Neurophysiology Sektion IV Klinisk neurofysiologi |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Hand Surgery, Malmö – name: Handkirurgi, Malmö – name: Medicinsk strålningsfysik, Malmö – name: Klinisk neurofysiologi – name: Institutionen för kliniska vetenskaper, Lund – name: Lunds universitet – name: Department of Clinical Sciences, Lund – name: Clinical Neurophysiology – name: Sektion IV – name: Lund University – name: Section IV – name: Department of Translational Medicine – name: Medical Radiation Physics, Malmö – name: Institutionen för translationell medicin |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 ADTPV AGCHP AOWAS D8T D95 ZZAVC |
| DOI | 10.1111/ejn.12917 |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic SwePub SWEPUB Lunds universitet full text SwePub Articles SWEPUB Freely available online SWEPUB Lunds universitet SwePub Articles full text |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1460-9568 |
| EndPage | 2027 |
| ExternalDocumentID | oai_portal_research_lu_se_publications_f6d57816_400e_40b9_b401_6e32202cdc3c 25865600 10_1111_ejn_12917 EJN12917 ark_67375_WNG_8SXNF64R_W |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Promobilia – fundername: Skåne University Hospital – fundername: Swedish Medical Research Council – fundername: Medical Faculty, Lund University – fundername: Region Skåne (ALF) – fundername: Carlsson's Foundation |
| GroupedDBID | --- -~X .3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 29G 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEML ABIVO ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACFBH ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACRPL ACSCC ACUHS ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFEBI AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHEFC AIACR AIDQK AIDYY AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM EAD EAP EAS EBC EBD EBS EBX EJD EMB EMK EMOBN EPS ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GAKWD GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 Q~Q R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 W8V W99 WBKPD WHG WIH WIJ WIK WNSPC WOHZO WOW WQJ WXI WXSBR WYISQ XG1 YFH ZGI ZZTAW ~IA ~WT AAHHS ACCFJ ADZOD AEEZP AEQDE AEUQT AFPWT AIWBW AJBDE RIG WRC WUP AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 ADTPV AGCHP AOWAS D8T D95 ZZAVC |
| ID | FETCH-LOGICAL-c4737-760fc740c3e5f0246f48a1464e3c557517badb9a95aef967bb0aff552abb16ff3 |
| IEDL.DBID | DR2 |
| ISSN | 0953-816X 1460-9568 |
| IngestDate | Tue Sep 09 23:49:53 EDT 2025 Fri Jul 11 01:04:43 EDT 2025 Thu Apr 03 07:06:22 EDT 2025 Tue Jul 01 03:02:10 EDT 2025 Thu Apr 24 22:51:37 EDT 2025 Wed Jan 22 16:33:02 EST 2025 Sun Sep 21 06:19:04 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | cortical plasticity peripheral nerve injury functional recovery MRI |
| Language | English |
| License | 2015 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4737-760fc740c3e5f0246f48a1464e3c557517badb9a95aef967bb0aff552abb16ff3 |
| Notes | istex:9E172ABDC7CE80242F072396140A6C0BE1DA4636 Region Skåne (ALF) Swedish Medical Research Council Skåne University Hospital Promobilia Medical Faculty, Lund University ArticleID:EJN12917 Carlsson's Foundation ark:/67375/WNG-8SXNF64R-W ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://lup.lub.lu.se/record/5342063 |
| PMID | 25865600 |
| PQID | 1705009910 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | swepub_primary_oai_portal_research_lu_se_publications_f6d57816_400e_40b9_b401_6e32202cdc3c proquest_miscellaneous_1705009910 pubmed_primary_25865600 crossref_citationtrail_10_1111_ejn_12917 crossref_primary_10_1111_ejn_12917 wiley_primary_10_1111_ejn_12917_EJN12917 istex_primary_ark_67375_WNG_8SXNF64R_W |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | August 2015 |
| PublicationDateYYYYMMDD | 2015-08-01 |
| PublicationDate_xml | – month: 08 year: 2015 text: August 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | France |
| PublicationPlace_xml | – name: France |
| PublicationTitle | The European journal of neuroscience |
| PublicationTitleAlternate | Eur J Neurosci |
| PublicationYear | 2015 |
| Publisher | Blackwell Publishing Ltd |
| Publisher_xml | – name: Blackwell Publishing Ltd |
| References | Lundborg, G. & Rosen, B. (2001) Sensory relearning after nerve repair. Lancet, 358, 809-810. Ragert, P., Nierhaus, T., Cohen, L.G. & Villringer, A. (2011) Interhemispheric int eractions between the human primary somatosensory cortices. PLoS One, 6, e16150. Iwamura, Y., Iriki, A. & Tanaka, M. (1994) Bilateral hand representation in the postcentral somatosensory cortex. Nature, 369, 554-556. Allan, C.H. (2000) Functional results of primary nerve repair. Hand Clin., 16, 67-72. Hlushchuk, Y. & Hari, R. (2006) Transient suppression of ipsilateral primary somatosensory cortex during tactile finger stimulation. J. Neurosci., 26, 5819-5824. Taylor, K.S., Anastakis, D.J. & Davis, K.D. (2009) Cutting your nerve changes your brain. Brain, 132, 3122-3133. Li, N., Downey, J.E., Bar-Shir, A., Gilad, A.A., Walczak, P., Kim, H., Joel, S.E., Pekar, J.J., Thakor, N.V. & Pelled, G. (2011) Optogenetic-guided cortical plasticity after nerve injury. Proc. Natl. Acad. Sci. USA, 108, 8838-8843. Chemnitz, A., Bjorkman, A., Dahlin, L.B. & Rosen, B. (2013b) Functional outcome thirty years after median and ulnar nerve repair in childhood and adolescence. J. Bone Joint Surg. Am., 95, 329-337. Rosen, B. & Lundborg, G. (2003) A new model instrument for outcome after nerve repair. Hand Clin., 19, 463-470. Johnston, M.V. (2009) Plasticity in the developing brain: implications for rehabilitation. Dev. Disabil. Res. Rev., 15, 94-101. Pascual-Leone, A., Freitas, C., Oberman, L., Horvath, J.C., Halko, M., Eldaief, M., Bashir, S., Vernet, M., Shafi, M., Westover, B., Vahabzadeh-Hagh, A.M. & Rotenberg, A. (2011) Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI. Brain Topogr., 24, 302-315. Pestronk, A., Drachman, D.B. & Griffin, J.W. (1980) Effects of aging on nerve sprouting and regeneration. Exp. Neurol., 70, 65-82. Jaquet, J.B., Luijsterburg, A.J., Kalmijn, S., Kuypers, P.D., Hofman, A. & Hovius, S.E. (2001) Median, ulnar, and combined median-ulnar nerve injuries: functional outcome and return to productivity. J. Trauma, 51, 687-692. Ruijs, A.C., Jaquet, J.B., Kalmijn, S., Giele, H. & Hovius, S.E. (2005) Median and ulnar nerve injuries: a meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair. Plast. Reconstr. Surg., 116, 484-494. Buhmann, C., Glauche, V., Sturenburg, H.J., Oechsner, M., Weiller, C. & Buchel, C. (2003) Pharmacologically modulated fMRI-cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain, 126, 451-461. Weibull, A., Bjorkman, A., Hall, H., Rosen, B., Lundborg, G. & Svensson, J. (2008) Optimizing the mapping of finger areas in primary somatosensory cortex using functional MRI. Magn. Reson. Imaging, 26, 1342-1351. Westerhausen, R., Luders, E., Specht, K., Ofte, S.H., Toga, A.W., Thompson, P.M., Helland, T. & Hugdahl, K. (2010) Structural and functional reorganization of the corpus callosum between the age of 6 and 8 years. Cereb. Cortex, 21, 1012-1017. Hoke, A. & Brushart, T. (2010) Introduction to special issue: challenges and opportunities for regeneration in the peripheral nervous system. Exp. Neurol., 223, 1-4. Almquist, E.E., Smith, O.A. & Fry, L. (1983) Nerve conduction velocity, microscopic, and electron microscopy studies comparing repaired adult and baby monkey median nerves. J. Hand. Surg.-Am., 8, 406-410. Asato, M.R., Terwilliger, R., Woo, J. & Luna, B. (2010) White matter development in adolescence: a DTI study. Cereb. Cortex, 20, 2122-2131. Schafer, K., Blankenburg, F., Kupers, R., Gruner, J.M., Law, I., Lauritzen, M. & Larsson, H.B. (2012) Negative BOLD signal changes in ipsilateral primary somatosensory cortex are associated with perfusion decreases and behavioral evidence for functional inhibition. NeuroImage, 59, 3119-3127. Frykman, G.K. (1976) Peripheral nerve injuries in children. Orthop. Clin. N. Am., 7, 701-716. Chemnitz, A., Andersson, G., Rosen, B., Dahlin, L.B. & Bjorkman, A. (2013a) Poor electroneurography but excellent hand function 31 years after nerve repair in childhood. NeuroReport, 24, 6-9. Fornander, L., Nyman, T., Hansson, T., Ragnehed, M. & Brismar, T. (2009) Age- and time-dependent effects on functional outcome and cortical activation pattern in patients with median nerve injury: a functional magnetic resonance imaging study. J. Neurosurg., 113, 122-128. Talairach, J. & Tournoux, P. (1988) Co-Planar Stereotaxic Atlas of the Human Brain: An Approach to Cerebral Imaging. G. Thieme; Thieme Medical Publishers, Stuttgart, New York. Vordemvenne, T., Langer, M., Ochman, S., Raschke, M. & Schult, M. (2007) Long-term results after primary microsurgical repair of ulnar and median nerve injuries. A comparison of common score systems. Clin. Neurol. Neurosur., 109, 263-271. Hansson, T. & Brismar, T. (2003) Loss of sensory discrimination after median nerve injury and activation in the primary somatosensory cortex on functional magnetic resonance imaging. J. Neurosurg., 99, 100-105. Kaas, J.H. (1991) Plasticity of sensory and motor maps in adult mammals. Annu. Rev. Neurosci., 14, 137-167. Lundborg, G., Rosen, B., Dahlin, L., Holmberg, J. & Rosen, I. (2004) Tubular repair of the median or ulnar nerve in the human forearm: a 5-year follow-up. J. Hand. Surg.-Brit. Eur., 29, 100-107. Iwamura, Y. (2000) Bilateral receptive field neurons and callosal connections in the somatosensory cortex. Philos. T. Roy. Soc. B., 355, 267-273. 1991; 14 2000; 355 2004; 29 2013b; 95 2005; 116 2010; 223 2009; 132 1983; 8 2009; 113 1980; 70 2003; 19 2012; 59 2011; 6 2007; 109 1976; 7 2003; 99 2010; 21 2010; 20 1994; 369 2011; 108 2000; 16 2013a; 24 2006; 26 2008; 26 2011; 24 2003; 126 2001; 51 2009; 15 2001; 358 1988 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_30_1 Frykman G.K. (e_1_2_6_9_1) 1976; 7 e_1_2_6_19_1 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1 e_1_2_6_21_1 e_1_2_6_20_1 Talairach J. (e_1_2_6_27_1) 1988 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_22_1 e_1_2_6_29_1 Allan C.H. (e_1_2_6_2_1) 2000; 16 e_1_2_6_28_1 e_1_2_6_26_1 |
| References_xml | – reference: Johnston, M.V. (2009) Plasticity in the developing brain: implications for rehabilitation. Dev. Disabil. Res. Rev., 15, 94-101. – reference: Lundborg, G. & Rosen, B. (2001) Sensory relearning after nerve repair. Lancet, 358, 809-810. – reference: Chemnitz, A., Bjorkman, A., Dahlin, L.B. & Rosen, B. (2013b) Functional outcome thirty years after median and ulnar nerve repair in childhood and adolescence. J. Bone Joint Surg. Am., 95, 329-337. – reference: Fornander, L., Nyman, T., Hansson, T., Ragnehed, M. & Brismar, T. (2009) Age- and time-dependent effects on functional outcome and cortical activation pattern in patients with median nerve injury: a functional magnetic resonance imaging study. J. Neurosurg., 113, 122-128. – reference: Iwamura, Y. (2000) Bilateral receptive field neurons and callosal connections in the somatosensory cortex. Philos. T. Roy. Soc. B., 355, 267-273. – reference: Chemnitz, A., Andersson, G., Rosen, B., Dahlin, L.B. & Bjorkman, A. (2013a) Poor electroneurography but excellent hand function 31 years after nerve repair in childhood. NeuroReport, 24, 6-9. – reference: Li, N., Downey, J.E., Bar-Shir, A., Gilad, A.A., Walczak, P., Kim, H., Joel, S.E., Pekar, J.J., Thakor, N.V. & Pelled, G. (2011) Optogenetic-guided cortical plasticity after nerve injury. Proc. Natl. Acad. Sci. USA, 108, 8838-8843. – reference: Lundborg, G., Rosen, B., Dahlin, L., Holmberg, J. & Rosen, I. (2004) Tubular repair of the median or ulnar nerve in the human forearm: a 5-year follow-up. J. Hand. Surg.-Brit. Eur., 29, 100-107. – reference: Schafer, K., Blankenburg, F., Kupers, R., Gruner, J.M., Law, I., Lauritzen, M. & Larsson, H.B. (2012) Negative BOLD signal changes in ipsilateral primary somatosensory cortex are associated with perfusion decreases and behavioral evidence for functional inhibition. NeuroImage, 59, 3119-3127. – reference: Taylor, K.S., Anastakis, D.J. & Davis, K.D. (2009) Cutting your nerve changes your brain. Brain, 132, 3122-3133. – reference: Kaas, J.H. (1991) Plasticity of sensory and motor maps in adult mammals. Annu. Rev. Neurosci., 14, 137-167. – reference: Ragert, P., Nierhaus, T., Cohen, L.G. & Villringer, A. (2011) Interhemispheric int eractions between the human primary somatosensory cortices. PLoS One, 6, e16150. – reference: Jaquet, J.B., Luijsterburg, A.J., Kalmijn, S., Kuypers, P.D., Hofman, A. & Hovius, S.E. (2001) Median, ulnar, and combined median-ulnar nerve injuries: functional outcome and return to productivity. J. Trauma, 51, 687-692. – reference: Hlushchuk, Y. & Hari, R. (2006) Transient suppression of ipsilateral primary somatosensory cortex during tactile finger stimulation. J. Neurosci., 26, 5819-5824. – reference: Pascual-Leone, A., Freitas, C., Oberman, L., Horvath, J.C., Halko, M., Eldaief, M., Bashir, S., Vernet, M., Shafi, M., Westover, B., Vahabzadeh-Hagh, A.M. & Rotenberg, A. (2011) Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI. Brain Topogr., 24, 302-315. – reference: Allan, C.H. (2000) Functional results of primary nerve repair. Hand Clin., 16, 67-72. – reference: Rosen, B. & Lundborg, G. (2003) A new model instrument for outcome after nerve repair. Hand Clin., 19, 463-470. – reference: Pestronk, A., Drachman, D.B. & Griffin, J.W. (1980) Effects of aging on nerve sprouting and regeneration. Exp. Neurol., 70, 65-82. – reference: Ruijs, A.C., Jaquet, J.B., Kalmijn, S., Giele, H. & Hovius, S.E. (2005) Median and ulnar nerve injuries: a meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair. Plast. Reconstr. Surg., 116, 484-494. – reference: Buhmann, C., Glauche, V., Sturenburg, H.J., Oechsner, M., Weiller, C. & Buchel, C. (2003) Pharmacologically modulated fMRI-cortical responsiveness to levodopa in drug-naive hemiparkinsonian patients. Brain, 126, 451-461. – reference: Hansson, T. & Brismar, T. (2003) Loss of sensory discrimination after median nerve injury and activation in the primary somatosensory cortex on functional magnetic resonance imaging. J. Neurosurg., 99, 100-105. – reference: Westerhausen, R., Luders, E., Specht, K., Ofte, S.H., Toga, A.W., Thompson, P.M., Helland, T. & Hugdahl, K. (2010) Structural and functional reorganization of the corpus callosum between the age of 6 and 8 years. Cereb. Cortex, 21, 1012-1017. – reference: Talairach, J. & Tournoux, P. (1988) Co-Planar Stereotaxic Atlas of the Human Brain: An Approach to Cerebral Imaging. G. Thieme; Thieme Medical Publishers, Stuttgart, New York. – reference: Frykman, G.K. (1976) Peripheral nerve injuries in children. Orthop. Clin. N. Am., 7, 701-716. – reference: Almquist, E.E., Smith, O.A. & Fry, L. (1983) Nerve conduction velocity, microscopic, and electron microscopy studies comparing repaired adult and baby monkey median nerves. J. Hand. Surg.-Am., 8, 406-410. – reference: Hoke, A. & Brushart, T. (2010) Introduction to special issue: challenges and opportunities for regeneration in the peripheral nervous system. Exp. Neurol., 223, 1-4. – reference: Weibull, A., Bjorkman, A., Hall, H., Rosen, B., Lundborg, G. & Svensson, J. (2008) Optimizing the mapping of finger areas in primary somatosensory cortex using functional MRI. Magn. Reson. Imaging, 26, 1342-1351. – reference: Iwamura, Y., Iriki, A. & Tanaka, M. (1994) Bilateral hand representation in the postcentral somatosensory cortex. Nature, 369, 554-556. – reference: Vordemvenne, T., Langer, M., Ochman, S., Raschke, M. & Schult, M. (2007) Long-term results after primary microsurgical repair of ulnar and median nerve injuries. A comparison of common score systems. Clin. Neurol. Neurosur., 109, 263-271. – reference: Asato, M.R., Terwilliger, R., Woo, J. & Luna, B. (2010) White matter development in adolescence: a DTI study. Cereb. Cortex, 20, 2122-2131. – volume: 7 start-page: 701 year: 1976 end-page: 716 article-title: Peripheral nerve injuries in children publication-title: Orthop. Clin. N. Am. – volume: 109 start-page: 263 year: 2007 end-page: 271 article-title: Long‐term results after primary microsurgical repair of ulnar and median nerve injuries. A comparison of common score systems publication-title: Clin. Neurol. Neurosur. – volume: 108 start-page: 8838 year: 2011 end-page: 8843 article-title: Optogenetic‐guided cortical plasticity after nerve injury publication-title: Proc. Natl. Acad. Sci. USA – volume: 6 start-page: e16150 year: 2011 article-title: Interhemispheric int eractions between the human primary somatosensory cortices publication-title: PLoS One – volume: 24 start-page: 302 year: 2011 end-page: 315 article-title: Characterizing brain cortical plasticity and network dynamics across the age‐span in health and disease with TMS‐EEG and TMS‐fMRI publication-title: Brain Topogr. – volume: 126 start-page: 451 year: 2003 end-page: 461 article-title: Pharmacologically modulated fMRI–cortical responsiveness to levodopa in drug‐naive hemiparkinsonian patients publication-title: Brain – volume: 132 start-page: 3122 year: 2009 end-page: 3133 article-title: Cutting your nerve changes your brain publication-title: Brain – volume: 21 start-page: 1012 year: 2010 end-page: 1017 article-title: Structural and functional reorganization of the corpus callosum between the age of 6 and 8 years publication-title: Cereb. Cortex – volume: 99 start-page: 100 year: 2003 end-page: 105 article-title: Loss of sensory discrimination after median nerve injury and activation in the primary somatosensory cortex on functional magnetic resonance imaging publication-title: J. Neurosurg. – volume: 116 start-page: 484 year: 2005 end-page: 494 article-title: Median and ulnar nerve injuries: a meta‐analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair publication-title: Plast. Reconstr. Surg. – volume: 355 start-page: 267 year: 2000 end-page: 273 article-title: Bilateral receptive field neurons and callosal connections in the somatosensory cortex publication-title: Philos. T. Roy. Soc. B – volume: 14 start-page: 137 year: 1991 end-page: 167 article-title: Plasticity of sensory and motor maps in adult mammals publication-title: Annu. Rev. Neurosci. – volume: 15 start-page: 94 year: 2009 end-page: 101 article-title: Plasticity in the developing brain: implications for rehabilitation publication-title: Dev. Disabil. Res. Rev. – volume: 29 start-page: 100 year: 2004 end-page: 107 article-title: Tubular repair of the median or ulnar nerve in the human forearm: a 5‐year follow‐up publication-title: J. Hand. Surg.‐Brit. Eur. – volume: 95 start-page: 329 year: 2013b end-page: 337 article-title: Functional outcome thirty years after median and ulnar nerve repair in childhood and adolescence publication-title: J. Bone Joint Surg. Am. – volume: 8 start-page: 406 year: 1983 end-page: 410 article-title: Nerve conduction velocity, microscopic, and electron microscopy studies comparing repaired adult and baby monkey median nerves publication-title: J. Hand. Surg.‐Am. – volume: 20 start-page: 2122 year: 2010 end-page: 2131 article-title: White matter development in adolescence: a DTI study publication-title: Cereb. Cortex – volume: 26 start-page: 5819 year: 2006 end-page: 5824 article-title: Transient suppression of ipsilateral primary somatosensory cortex during tactile finger stimulation publication-title: J. Neurosci. – volume: 59 start-page: 3119 year: 2012 end-page: 3127 article-title: Negative BOLD signal changes in ipsilateral primary somatosensory cortex are associated with perfusion decreases and behavioral evidence for functional inhibition publication-title: NeuroImage – volume: 26 start-page: 1342 year: 2008 end-page: 1351 article-title: Optimizing the mapping of finger areas in primary somatosensory cortex using functional MRI publication-title: Magn. Reson. Imaging – volume: 19 start-page: 463 year: 2003 end-page: 470 article-title: A new model instrument for outcome after nerve repair publication-title: Hand Clin. – volume: 369 start-page: 554 year: 1994 end-page: 556 article-title: Bilateral hand representation in the postcentral somatosensory cortex publication-title: Nature – volume: 24 start-page: 6 year: 2013a end-page: 9 article-title: Poor electroneurography but excellent hand function 31 years after nerve repair in childhood publication-title: NeuroReport – volume: 70 start-page: 65 year: 1980 end-page: 82 article-title: Effects of aging on nerve sprouting and regeneration publication-title: Exp. Neurol. – year: 1988 – volume: 358 start-page: 809 year: 2001 end-page: 810 article-title: Sensory relearning after nerve repair publication-title: Lancet – volume: 16 start-page: 67 year: 2000 end-page: 72 article-title: Functional results of primary nerve repair publication-title: Hand Clin. – volume: 223 start-page: 1 year: 2010 end-page: 4 article-title: Introduction to special issue: challenges and opportunities for regeneration in the peripheral nervous system publication-title: Exp. Neurol. – volume: 51 start-page: 687 year: 2001 end-page: 692 article-title: Median, ulnar, and combined median‐ulnar nerve injuries: functional outcome and return to productivity publication-title: J. Trauma – volume: 113 start-page: 122 year: 2009 end-page: 128 article-title: Age‐ and time‐dependent effects on functional outcome and cortical activation pattern in patients with median nerve injury: a functional magnetic resonance imaging study publication-title: J. Neurosurg. – ident: e_1_2_6_25_1 doi: 10.1097/01.prs.0000172896.86594.07 – ident: e_1_2_6_12_1 doi: 10.1016/j.expneurol.2009.12.001 – ident: e_1_2_6_5_1 doi: 10.1093/brain/awg033 – ident: e_1_2_6_13_1 doi: 10.1098/rstb.2000.0563 – ident: e_1_2_6_7_1 doi: 10.2106/JBJS.L.00074 – ident: e_1_2_6_15_1 doi: 10.1097/00005373-200110000-00011 – ident: e_1_2_6_3_1 doi: 10.1016/S0363-5023(83)80199-3 – ident: e_1_2_6_23_1 doi: 10.1371/journal.pone.0016150 – ident: e_1_2_6_11_1 doi: 10.1523/JNEUROSCI.5536-05.2006 – ident: e_1_2_6_14_1 doi: 10.1038/369554a0 – volume-title: Co‐Planar Stereotaxic Atlas of the Human Brain: An Approach to Cerebral Imaging year: 1988 ident: e_1_2_6_27_1 – ident: e_1_2_6_18_1 doi: 10.1073/pnas.1100815108 – ident: e_1_2_6_10_1 doi: 10.3171/jns.2003.99.1.0100 – ident: e_1_2_6_30_1 doi: 10.1016/j.mri.2008.04.007 – volume: 7 start-page: 701 year: 1976 ident: e_1_2_6_9_1 article-title: Peripheral nerve injuries in children publication-title: Orthop. Clin. N. Am. doi: 10.1016/S0030-5898(20)30185-1 – ident: e_1_2_6_4_1 doi: 10.1093/cercor/bhp282 – ident: e_1_2_6_6_1 doi: 10.1097/WNR.0b013e32835b6efd – ident: e_1_2_6_17_1 doi: 10.1146/annurev.ne.14.030191.001033 – ident: e_1_2_6_21_1 doi: 10.1007/s10548-011-0196-8 – ident: e_1_2_6_22_1 doi: 10.1016/0014-4886(80)90006-0 – ident: e_1_2_6_28_1 doi: 10.1093/brain/awp231 – ident: e_1_2_6_8_1 doi: 10.3171/2009.10.JNS09698 – ident: e_1_2_6_26_1 doi: 10.1016/j.neuroimage.2011.11.085 – ident: e_1_2_6_16_1 doi: 10.1002/ddrr.64 – volume: 16 start-page: 67 year: 2000 ident: e_1_2_6_2_1 article-title: Functional results of primary nerve repair publication-title: Hand Clin. doi: 10.1016/S0749-0712(21)00502-3 – ident: e_1_2_6_20_1 doi: 10.1016/j.jhsb.2003.09.018 – ident: e_1_2_6_29_1 doi: 10.1016/j.clineuro.2006.11.006 – ident: e_1_2_6_31_1 doi: 10.1093/cercor/bhq165 – ident: e_1_2_6_19_1 doi: 10.1016/S0140-6736(01)06001-9 – ident: e_1_2_6_24_1 doi: 10.1016/S0749-0712(03)00003-9 |
| SSID | ssj0008645 |
| Score | 2.2719421 |
| Snippet | The clinical outcome following a peripheral nerve injury in the upper extremity is generally better in young children than in teenagers and in adults, but the... |
| SourceID | swepub proquest pubmed crossref wiley istex |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2022 |
| SubjectTerms | Adolescent Age Factors Basic Medicine Child Child, Preschool cortical plasticity Electric Stimulation Female Functional Laterality - physiology functional recovery Humans Image Processing, Computer-Assisted Infant Longitudinal Studies Magnetic Resonance Imaging Male Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper MRI Neural Conduction - physiology Neurosciences Neurovetenskaper Oxygen - blood Peripheral Nerve Injuries - pathology Peripheral Nerve Injuries - physiopathology Peripheral Nerve Injuries - surgery peripheral nerve injury Recovery of Function - physiology Retrospective Studies Severity of Illness Index Somatosensory Cortex - blood supply Somatosensory Cortex - physiopathology Young Adult |
| Title | Normalized activation in the somatosensory cortex 30 years following nerve repair in children: an fMRI study |
| URI | https://api.istex.fr/ark:/67375/WNG-8SXNF64R-W/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fejn.12917 https://www.ncbi.nlm.nih.gov/pubmed/25865600 https://www.proquest.com/docview/1705009910 |
| Volume | 42 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLam8QAvXDYu3QAZhCZeUiVxYifwNI2VMWl9KEyrEJJlO7Yo65KpacW6X8Nv4ZdxjtOEDQ0J8RJFihPFx-fyHfv4MyGvskKIPNIwAk6wIIljG-SKFwHXBuxPK4jhmCgeDfnBcXI4Tsdr5G27F6bhh-gm3NAyvL9GA1e6vmLk9lvZh2AV4U7yiHHkzX83-k0dlXF_QDHSqQVZxMcrViGs4unevBaLbqFYL24Cmh2L6HUA6yPQ4B750v57U3hy2l_Mdd9c_kHr-J-du0_urpAp3W1U6QFZs-UG2dwtISs_W9Id6mtF_ST8Brm9154Tt0nOhgh7p5NLW1DcJdHM8dJJSQFb0roCSFzVkCxXsyU1WNp7QVn488cSTKymDtSw-g7hk5ZYeklnEB0nM3y53WX-hqqSuqPRB-qZcB-S48H-p72DYHWIQ2ASwUQgeOiMSELDbOoAEHCXZArcc2KZSXHRR2hV6FzlqbIu50LrUDmXprHSOuLOsUdkvaxK-4RQpYxOmWNaW5UIE2rmOIgrjzOdOBVFPfK6HU5pVgzneNDGVLaZDohVerH2yMuu6XlD63FTox2vE10LNTvFOjiRypPhe5l9HA8HPBnJkx550SqNBOHjkosqbbWoJZIVIQiPwh553GhT97U4zZD5CJ58btSre4KU3032JVeUT1_ldCFrK8-vzOVKxwvwtxGX4IctXHQuNaTLklvw0mFsCsMMyMTr2d97KfcPh_5m69-bbpM7ABzTphDyKVmfzxb2GYCzuX7urfAX6PA3jw |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9QwELZK-1BeOFqO5TQIVbxkldNOEC9V1WVbunkorbpCQpbt2GLpNqn2EN3-Gn4Lv4wZZxNaVCTESxQpTpRM5vhmPP5MyJu04DwLFPwByyMvDkPjZZIVHlMa7E9JiOGYKA5y1j-O94fJcIW8b9bC1PwQbcENLcP5azRwLEhfsXLzrexCtAr4LbLm5ucQEh3-Jo9KmduiGAnVvDRgwyWvEPbxtLdei0ZrKNiLm6BmyyN6HcK6GNS7S740b1-3npx25zPV1Zd_EDv-7-fdI3eW4JRu19p0n6yYcoNsbpeQmJ8t6BZ17aKuDr9B1neareI2yVmOyHc8ujQFxYUSdZmXjkoK8JJOK0DF1RTy5WqyoBq7ey9o5P_8sQArm1ILmlh9hwhKS-y-pBMIkKMJ3twsNH9HZUnt4HCPOjLcB-S4t3u00_eW-zh4OuYR9zjzreaxryOTWMAEzMapBA8dm0gnOO_DlSxUJrNEGpsxrpQvrU2SUCoVMGujh2S1rErzmFAptUoiGyllZMy1ryLLQFxZmKrYyiDokLfN_xR6SXKOe22MRZPsgFiFE2uHvG6HntfMHjcN2nJK0Y6Qk1NsheOJOMk_iPTTMO-x-FCcdMirRmsECB9nXWRpqvlUIF8R4vDA75BHtTq1TwuTFMmP4MrnWr_aK8j6XSdgYsn69FWM52JqxPmVcq6wrACXGzABrtjAQWVCQcYsmAFH7Ye60JEGmThF-_tXit393J08-fehL8l6_2hwIA728o9PyW3AkUndF_mMrM4mc_McsNpMvXAm-Qs8wDut |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGJgEvXDYu5WoQmnhJlcSJncDTNFa2wSJUmFYhJMt2bFHWJVXTinW_ht_CL-PYubChISFeokhxovj4XL5jH39G6EWSM5YGEkbAMOJFYai9VNDco1KB_UkBMdwmigcZ3T2M9kfxaAW9bvfC1PwQ3YSbtQznr62BT3Nzzsj1t6IPwSpgV9BaRCFMWkQ0_M0dlVB3QrHlU_OSgI4aWiFbxtO9eiEYrVm5nl6GNDsa0YsI1oWgwU30pf35uvLkuL-Yy746-4PX8T97dwvdaKAp3qp16TZa0cU62tgqIC0_WeJN7IpF3Sz8Orq23R4Ut4FOMot7J-MznWO7TaKe5MXjAgO4xFUJmLisIFsuZ0usbG3vKSb-zx9LsLEKG9DD8jvET1zY2ks8g_A4ntmX223mr7AosDkY7mFHhXsHHQ52Pm3ves0pDp6KGGEeo75RLPIV0bEBREBNlAjwz5EmKrarPkyKXKYijYU2KWVS-sKYOA6FlAE1htxFq0VZ6PsIC6FkTAyRUouIKV8SQ0FcaZjIyIgg6KGX7XBy1VCc25M2JrxNdUCs3Im1h553Tac1r8dljTadTnQtxOzYFsKxmB9lb3nycZQNaDTkRz30rFUaDsK3ay6i0OWi4patyKLwwO-he7U2dV8L48RSH8GTz7V6dU8s53edfvGG8-krnyx4pfn03GQuNzQHhxtQDo5Yw0WmXEK-zKkGN-2HKldEgUycnv29l3xnP3M3D_696VN09cObAX-_l717iK4DiIzroshHaHU-W-jHANTm8okzyF9mNTpc |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Normalized+activation+in+the+somatosensory+cortex+30%C2%A0years+following+nerve+repair+in+children%3A+an+fMRI+study&rft.jtitle=The+European+journal+of+neuroscience&rft.au=Chemnitz%2C+Anette&rft.au=Weibull%2C+Andreas&rft.au=Ros%C3%A9n%2C+Birgitta&rft.au=Andersson%2C+Gert&rft.date=2015-08-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0953-816X&rft.eissn=1460-9568&rft.volume=42&rft.issue=4&rft.spage=2022&rft.epage=2027&rft_id=info:doi/10.1111%2Fejn.12917&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_WNG_8SXNF64R_W |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0953-816X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0953-816X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0953-816X&client=summon |