B-Cell Stimulatory Cytokines and Markers of Immune Activation Are Elevated Several Years Prior to the Diagnosis of Systemic AIDS–Associated Non-Hodgkin B-Cell Lymphoma
Background: The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL). Methods: Serum levels of B...
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| Published in | Cancer epidemiology, biomarkers & prevention Vol. 20; no. 7; pp. 1303 - 1314 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia, PA
American Association for Cancer Research
01.07.2011
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1055-9965 1538-7755 1538-7755 |
| DOI | 10.1158/1055-9965.EPI-11-0037 |
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| Abstract | Background: The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL).
Methods: Serum levels of B-cell activation–associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), sCD27, sCD30, C-reactive protein (CRP), and immunoglobulin E were determined in 179 NHL cases and HIV+ controls in the Multicenter AIDS Cohort Study, collected at up to 3 time points per subject, 0 to 5 years prior to AIDS-NHL diagnosis.
Results: Serum IL6, IL10, CRP, sCD23, sCD27, and sCD30 levels were all significantly elevated in the AIDS-NHL group, when compared with HIV+ controls or with AIDS controls, after adjusting for CD4 T-cell number. Elevated serum levels of B-cell activation–associated molecules were seen to be associated with the development of systemic [non-CNS (central nervous system)] NHL, but not with the development of primary CNS lymphoma.
Conclusions: Levels of certain B-cell stimulatory cytokines and molecules associated with immune activation are elevated for several years preceding the diagnosis of systemic AIDS-NHL. This observation is consistent with the hypothesis that chronic B-cell activation contributes to the development of these hematologic malignancies.
Impact: Marked differences in serum levels of several molecules are seen for several years prediagnosis in those who eventually develop AIDS-NHL. Some of these molecules may serve as candidate biomarkers and provide valuable information to better define the etiology of NHL. Cancer Epidemiol Biomarkers Prev; 20(7); 1303–14. ©2011 AACR. |
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| AbstractList | BACKGROUND: The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL). METHODS: Serum levels of B-cell activation-associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), sCD27, sCD30, C-reactive protein (CRP), and immunoglobulin E were determined in 179 NHL cases and HIV+ controls in the Multicenter AIDS Cohort Study, collected at up to 3 time points per subject, 0 to 5 years prior to AIDS-NHL diagnosis. RESULTS: Serum IL6, IL10, CRP, sCD23, sCD27, and sCD30 levels were all significantly elevated in the AIDS-NHL group, when compared with HIV+ controls or with AIDS controls, after adjusting for CD4 T-cell number. Elevated serum levels of B-cell activation-associated molecules were seen to be associated with the development of systemic [non-CNS (central nervous system)] NHL, but not with the development of primary CNS lymphoma. CONCLUSIONS: Levels of certain B-cell stimulatory cytokines and molecules associated with immune activation are elevated for several years preceding the diagnosis of systemic AIDS-NHL. This observation is consistent with the hypothesis that chronic B-cell activation contributes to the development of these hematologic malignancies. IMPACT: Marked differences in serum levels of several molecules are seen for several years prediagnosis in those who eventually develop AIDS-NHL. Some of these molecules may serve as candidate biomarkers and provide valuable information to better define the etiology of NHL. Cancer Epidemiol Biomarkers Prev; 20(7); 1303-14. [copy ]2011 AACR. The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL).BACKGROUNDThe risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL).Serum levels of B-cell activation-associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), sCD27, sCD30, C-reactive protein (CRP), and immunoglobulin E were determined in 179 NHL cases and HIV+ controls in the Multicenter AIDS Cohort Study, collected at up to 3 time points per subject, 0 to 5 years prior to AIDS-NHL diagnosis.METHODSSerum levels of B-cell activation-associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), sCD27, sCD30, C-reactive protein (CRP), and immunoglobulin E were determined in 179 NHL cases and HIV+ controls in the Multicenter AIDS Cohort Study, collected at up to 3 time points per subject, 0 to 5 years prior to AIDS-NHL diagnosis.Serum IL6, IL10, CRP, sCD23, sCD27, and sCD30 levels were all significantly elevated in the AIDS-NHL group, when compared with HIV+ controls or with AIDS controls, after adjusting for CD4 T-cell number. Elevated serum levels of B-cell activation-associated molecules were seen to be associated with the development of systemic [non-CNS (central nervous system)] NHL, but not with the development of primary CNS lymphoma.RESULTSSerum IL6, IL10, CRP, sCD23, sCD27, and sCD30 levels were all significantly elevated in the AIDS-NHL group, when compared with HIV+ controls or with AIDS controls, after adjusting for CD4 T-cell number. Elevated serum levels of B-cell activation-associated molecules were seen to be associated with the development of systemic [non-CNS (central nervous system)] NHL, but not with the development of primary CNS lymphoma.Levels of certain B-cell stimulatory cytokines and molecules associated with immune activation are elevated for several years preceding the diagnosis of systemic AIDS-NHL. This observation is consistent with the hypothesis that chronic B-cell activation contributes to the development of these hematologic malignancies.CONCLUSIONSLevels of certain B-cell stimulatory cytokines and molecules associated with immune activation are elevated for several years preceding the diagnosis of systemic AIDS-NHL. This observation is consistent with the hypothesis that chronic B-cell activation contributes to the development of these hematologic malignancies.Marked differences in serum levels of several molecules are seen for several years prediagnosis in those who eventually develop AIDS-NHL. Some of these molecules may serve as candidate biomarkers and provide valuable information to better define the etiology of NHL.IMPACTMarked differences in serum levels of several molecules are seen for several years prediagnosis in those who eventually develop AIDS-NHL. Some of these molecules may serve as candidate biomarkers and provide valuable information to better define the etiology of NHL. The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL). Serum levels of B-cell activation-associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), sCD27, sCD30, C-reactive protein (CRP), and immunoglobulin E were determined in 179 NHL cases and HIV+ controls in the Multicenter AIDS Cohort Study, collected at up to 3 time points per subject, 0 to 5 years prior to AIDS-NHL diagnosis. Serum IL6, IL10, CRP, sCD23, sCD27, and sCD30 levels were all significantly elevated in the AIDS-NHL group, when compared with HIV+ controls or with AIDS controls, after adjusting for CD4 T-cell number. Elevated serum levels of B-cell activation-associated molecules were seen to be associated with the development of systemic [non-CNS (central nervous system)] NHL, but not with the development of primary CNS lymphoma. Levels of certain B-cell stimulatory cytokines and molecules associated with immune activation are elevated for several years preceding the diagnosis of systemic AIDS-NHL. This observation is consistent with the hypothesis that chronic B-cell activation contributes to the development of these hematologic malignancies. Marked differences in serum levels of several molecules are seen for several years prediagnosis in those who eventually develop AIDS-NHL. Some of these molecules may serve as candidate biomarkers and provide valuable information to better define the etiology of NHL. Background: The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels of molecules associated with B-cell activation precede the diagnosis of AIDS-associated NHL (AIDS-NHL). Methods: Serum levels of B-cell activation–associated molecules, interleukin (IL)6, IL10, soluble CD23 (sCD23), sCD27, sCD30, C-reactive protein (CRP), and immunoglobulin E were determined in 179 NHL cases and HIV+ controls in the Multicenter AIDS Cohort Study, collected at up to 3 time points per subject, 0 to 5 years prior to AIDS-NHL diagnosis. Results: Serum IL6, IL10, CRP, sCD23, sCD27, and sCD30 levels were all significantly elevated in the AIDS-NHL group, when compared with HIV+ controls or with AIDS controls, after adjusting for CD4 T-cell number. Elevated serum levels of B-cell activation–associated molecules were seen to be associated with the development of systemic [non-CNS (central nervous system)] NHL, but not with the development of primary CNS lymphoma. Conclusions: Levels of certain B-cell stimulatory cytokines and molecules associated with immune activation are elevated for several years preceding the diagnosis of systemic AIDS-NHL. This observation is consistent with the hypothesis that chronic B-cell activation contributes to the development of these hematologic malignancies. Impact: Marked differences in serum levels of several molecules are seen for several years prediagnosis in those who eventually develop AIDS-NHL. Some of these molecules may serve as candidate biomarkers and provide valuable information to better define the etiology of NHL. Cancer Epidemiol Biomarkers Prev; 20(7); 1303–14. ©2011 AACR. |
| Author | Kaslow, Richard A. Martinez-Maza, Otoniel Hussain, Shehnaz K. Rinaldo, Charles R. Detels, Roger Variakojis, Daina Breen, Elizabeth Crabb Magpantay, Larry Ambinder, Richard F. Rabkin, Charles S. Bream, Jay H. Jacobson, Lisa P. |
| AuthorAffiliation | 7 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 1 Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 4 Departments of Obstetrics & Gynecology and Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 5 Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 9 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 3 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 8 Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 6 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 10 Departments of Epidemiology, Medicine, Microbiology and Genetics, University of Alabama at Birmingham, Birmingham, AL 11 Department of Pathology, Northwestern University Feinberg School of Medicine, Ch |
| AuthorAffiliation_xml | – name: 6 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD – name: 10 Departments of Epidemiology, Medicine, Microbiology and Genetics, University of Alabama at Birmingham, Birmingham, AL – name: 9 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD – name: 4 Departments of Obstetrics & Gynecology and Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA – name: 2 UCLA AIDS Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA – name: 1 Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA – name: 5 Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA – name: 7 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD – name: 8 Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD – name: 3 Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA – name: 11 Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL – name: 12 University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA |
| Author_xml | – sequence: 1 givenname: Elizabeth Crabb surname: Breen fullname: Breen, Elizabeth Crabb – sequence: 2 givenname: Shehnaz K. surname: Hussain fullname: Hussain, Shehnaz K. – sequence: 3 givenname: Larry surname: Magpantay fullname: Magpantay, Larry – sequence: 4 givenname: Lisa P. surname: Jacobson fullname: Jacobson, Lisa P. – sequence: 5 givenname: Roger surname: Detels fullname: Detels, Roger – sequence: 6 givenname: Charles S. surname: Rabkin fullname: Rabkin, Charles S. – sequence: 7 givenname: Richard A. surname: Kaslow fullname: Kaslow, Richard A. – sequence: 8 givenname: Daina surname: Variakojis fullname: Variakojis, Daina – sequence: 9 givenname: Jay H. surname: Bream fullname: Bream, Jay H. – sequence: 10 givenname: Charles R. surname: Rinaldo fullname: Rinaldo, Charles R. – sequence: 11 givenname: Richard F. surname: Ambinder fullname: Ambinder, Richard F. – sequence: 12 givenname: Otoniel surname: Martinez-Maza fullname: Martinez-Maza, Otoniel |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24350127$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21527584$$D View this record in MEDLINE/PubMed |
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| Keywords | Immunopathology Immunostimulation Cytokine Biological marker Biological indicator AIDS Malignant hemopathy B-Lymphocyte Systemic Non Hodgkin lymphoma Immune deficiency Infection Cancerology Lymphoproliferative syndrome Viral disease β Cell Diagnosis Disseminated Cancer |
| Language | English |
| License | CC BY 4.0 2011 AACR |
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| PublicationDate | 2011-07-01 |
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| PublicationPlace | Philadelphia, PA |
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| PublicationTitle | Cancer epidemiology, biomarkers & prevention |
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| PublicationYear | 2011 |
| Publisher | American Association for Cancer Research |
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| Snippet | Background: The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated... The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated serum levels... BACKGROUND: The risk of developing non-Hodgkin lymphoma (NHL) is greatly increased in HIV infection. The aim of this study was to determine whether elevated... |
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| SubjectTerms | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - immunology Adult B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological and medical sciences Biomarkers, Tumor - blood Biomarkers, Tumor - immunology Case-Control Studies Cytokines - blood Cytokines - immunology Human viral diseases Humans Infectious diseases Lymphocyte Activation - immunology Lymphoma, AIDS-Related - blood Lymphoma, AIDS-Related - complications Lymphoma, AIDS-Related - immunology Lymphoma, B-Cell - blood Lymphoma, B-Cell - complications Lymphoma, B-Cell - immunology Male Medical sciences Middle Aged Tumors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult |
| Title | B-Cell Stimulatory Cytokines and Markers of Immune Activation Are Elevated Several Years Prior to the Diagnosis of Systemic AIDS–Associated Non-Hodgkin B-Cell Lymphoma |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/21527584 https://www.proquest.com/docview/875724314 https://www.proquest.com/docview/904484144 https://pubmed.ncbi.nlm.nih.gov/PMC3132317 |
| Volume | 20 |
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