Guidelines for performing Mendelian randomization investigations
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ni...
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| Published in | Wellcome open research Vol. 4; p. 186 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Wellcome Trust Limited
28.04.2020
F1000 Research Limited Wellcome |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2398-502X 2398-502X |
| DOI | 10.12688/wellcomeopenres.15555.2 |
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| Abstract | This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months. |
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| AbstractList | This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months. This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months. |
| Author | Glymour, M. Maria Holmes, Michael V. Davey Smith, George Dudbridge, Frank Hartwig, Fernando P. Burgess, Stephen Relton, Caroline L. Davies, Neil M. Minelli, Cosetta Theodoratou, Evropi Gill, Dipender |
| Author_xml | – sequence: 1 givenname: Stephen orcidid: 0000-0001-5365-8760 surname: Burgess fullname: Burgess, Stephen – sequence: 2 givenname: George orcidid: 0000-0002-1407-8314 surname: Davey Smith fullname: Davey Smith, George – sequence: 3 givenname: Neil M. orcidid: 0000-0002-2460-0508 surname: Davies fullname: Davies, Neil M. – sequence: 4 givenname: Frank surname: Dudbridge fullname: Dudbridge, Frank – sequence: 5 givenname: Dipender orcidid: 0000-0001-7312-7078 surname: Gill fullname: Gill, Dipender – sequence: 6 givenname: M. Maria surname: Glymour fullname: Glymour, M. Maria – sequence: 7 givenname: Fernando P. orcidid: 0000-0003-3729-0710 surname: Hartwig fullname: Hartwig, Fernando P. – sequence: 8 givenname: Michael V. orcidid: 0000-0001-6617-0879 surname: Holmes fullname: Holmes, Michael V. – sequence: 9 givenname: Cosetta orcidid: 0000-0001-9166-3958 surname: Minelli fullname: Minelli, Cosetta – sequence: 10 givenname: Caroline L. surname: Relton fullname: Relton, Caroline L. – sequence: 11 givenname: Evropi orcidid: 0000-0001-5887-9132 surname: Theodoratou fullname: Theodoratou, Evropi |
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| Title | Guidelines for performing Mendelian randomization investigations |
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