Myocardial ischaemia in patients with peripheral arterial disease

Summary Aim:  To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group. Methods:  Ninety‐nine male patients with PAD and 94 age‐ and sex‐matched control subjects without PAD or i...

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Published inClinical physiology and functional imaging Vol. 27; no. 1; pp. 30 - 35
Main Authors Svensson, Per, De Faire, Ulf, Niklasson, U., Östergren, Jan
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.2007
Blackwell Science
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ISSN1475-0961
1475-097X
DOI10.1111/j.1475-097X.2007.00710.x

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Abstract Summary Aim:  To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group. Methods:  Ninety‐nine male patients with PAD and 94 age‐ and sex‐matched control subjects without PAD or ischaemic heart disease performed a exercise treadmill test, dipyridamole Tc‐99m sestamibi myocardial perfusion SPECT (MPS) (43 controls) and 48‐h ambulatory ECG (AECG)‐monitoring (43 controls). Results:  Thirteen of 99 patients had irreversible and 24 of 99 had reversible perfusion defects in MPS in comparison with 0 of 43 and six of 43 of control subjects respectively (P<0·01). Thirteen of 84 evaluable patients experienced a total of 36 episodes of ST‐depression in AECG in comparison with two episodes in two of 42 control subjects (P = 0·07). Out of 13 patients with ST‐depression episodes only three had reversible ischaemia in MPS. Conclusion:  Most PAD patients with episodes of ST‐segment depression have no reversible ischaemia as assessed with dipyridamole‐stress MPS. Episodes of ST‐segment depression may reflect types of myocardial ischaemia that are different from those detected by MPS.
AbstractList To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group. Ninety-nine male patients with PAD and 94 age- and sex-matched control subjects without PAD or ischaemic heart disease performed a exercise treadmill test, dipyridamole Tc-99m sestamibi myocardial perfusion SPECT (MPS) (43 controls) and 48-h ambulatory ECG (AECG)-monitoring (43 controls). Thirteen of 99 patients had irreversible and 24 of 99 had reversible perfusion defects in MPS in comparison with 0 of 43 and six of 43 of control subjects respectively (P<0.01). Thirteen of 84 evaluable patients experienced a total of 36 episodes of ST-depression in AECG in comparison with two episodes in two of 42 control subjects (P = 0.07). Out of 13 patients with ST-depression episodes only three had reversible ischaemia in MPS. Most PAD patients with episodes of ST-segment depression have no reversible ischaemia as assessed with dipyridamole-stress MPS. Episodes of ST-segment depression may reflect types of myocardial ischaemia that are different from those detected by MPS.
Aim:  To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group. Methods:  Ninety‐nine male patients with PAD and 94 age‐ and sex‐matched control subjects without PAD or ischaemic heart disease performed a exercise treadmill test, dipyridamole Tc‐99m sestamibi myocardial perfusion SPECT (MPS) (43 controls) and 48‐h ambulatory ECG (AECG)‐monitoring (43 controls). Results:  Thirteen of 99 patients had irreversible and 24 of 99 had reversible perfusion defects in MPS in comparison with 0 of 43 and six of 43 of control subjects respectively ( P <0·01). Thirteen of 84 evaluable patients experienced a total of 36 episodes of ST‐depression in AECG in comparison with two episodes in two of 42 control subjects ( P  = 0·07). Out of 13 patients with ST‐depression episodes only three had reversible ischaemia in MPS. Conclusion:  Most PAD patients with episodes of ST‐segment depression have no reversible ischaemia as assessed with dipyridamole‐stress MPS. Episodes of ST‐segment depression may reflect types of myocardial ischaemia that are different from those detected by MPS.
Summary Aim:  To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group. Methods:  Ninety‐nine male patients with PAD and 94 age‐ and sex‐matched control subjects without PAD or ischaemic heart disease performed a exercise treadmill test, dipyridamole Tc‐99m sestamibi myocardial perfusion SPECT (MPS) (43 controls) and 48‐h ambulatory ECG (AECG)‐monitoring (43 controls). Results:  Thirteen of 99 patients had irreversible and 24 of 99 had reversible perfusion defects in MPS in comparison with 0 of 43 and six of 43 of control subjects respectively (P<0·01). Thirteen of 84 evaluable patients experienced a total of 36 episodes of ST‐depression in AECG in comparison with two episodes in two of 42 control subjects (P = 0·07). Out of 13 patients with ST‐depression episodes only three had reversible ischaemia in MPS. Conclusion:  Most PAD patients with episodes of ST‐segment depression have no reversible ischaemia as assessed with dipyridamole‐stress MPS. Episodes of ST‐segment depression may reflect types of myocardial ischaemia that are different from those detected by MPS.
To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group.AIMTo study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a matched control group.Ninety-nine male patients with PAD and 94 age- and sex-matched control subjects without PAD or ischaemic heart disease performed a exercise treadmill test, dipyridamole Tc-99m sestamibi myocardial perfusion SPECT (MPS) (43 controls) and 48-h ambulatory ECG (AECG)-monitoring (43 controls).METHODSNinety-nine male patients with PAD and 94 age- and sex-matched control subjects without PAD or ischaemic heart disease performed a exercise treadmill test, dipyridamole Tc-99m sestamibi myocardial perfusion SPECT (MPS) (43 controls) and 48-h ambulatory ECG (AECG)-monitoring (43 controls).Thirteen of 99 patients had irreversible and 24 of 99 had reversible perfusion defects in MPS in comparison with 0 of 43 and six of 43 of control subjects respectively (P<0.01). Thirteen of 84 evaluable patients experienced a total of 36 episodes of ST-depression in AECG in comparison with two episodes in two of 42 control subjects (P = 0.07). Out of 13 patients with ST-depression episodes only three had reversible ischaemia in MPS.RESULTSThirteen of 99 patients had irreversible and 24 of 99 had reversible perfusion defects in MPS in comparison with 0 of 43 and six of 43 of control subjects respectively (P<0.01). Thirteen of 84 evaluable patients experienced a total of 36 episodes of ST-depression in AECG in comparison with two episodes in two of 42 control subjects (P = 0.07). Out of 13 patients with ST-depression episodes only three had reversible ischaemia in MPS.Most PAD patients with episodes of ST-segment depression have no reversible ischaemia as assessed with dipyridamole-stress MPS. Episodes of ST-segment depression may reflect types of myocardial ischaemia that are different from those detected by MPS.CONCLUSIONMost PAD patients with episodes of ST-segment depression have no reversible ischaemia as assessed with dipyridamole-stress MPS. Episodes of ST-segment depression may reflect types of myocardial ischaemia that are different from those detected by MPS.
Author Niklasson, U.
De Faire, Ulf
Svensson, Per
Östergren, Jan
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Issue 1
Keywords Physical exercise
Human
Pathophysiology
Cardiovascular disease
Myocardial ischemia
Coronary heart disease
Myocardial disease
peripheral vascular disease
Arterial disease
Vascular disease
ischaemic heart disease/pathophysiology
Vertebrata
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electrocardiography ambulatory
Imaging
exercise testing and exercise physiology
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Snippet Summary Aim:  To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in...
Aim:  To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison...
To study the relation between myocardial ischemia assessed with different techniques in patients with peripheral arterial disease (PAD) in comparison with a...
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SubjectTerms Aged
Aged, 80 and over
Biological and medical sciences
Electrocardiography - methods
electrocardiography ambulatory
Exercise Test
exercise testing and exercise physiology
Female
Fundamental and applied biological sciences. Psychology
general clinical cardiology
Humans
imaging/nuclear cardiology
ischaemic heart disease/pathophysiology
Male
Middle Aged
Myocardial Ischemia - complications
Myocardial Ischemia - diagnosis
peripheral vascular disease
Peripheral Vascular Diseases - complications
Peripheral Vascular Diseases - diagnosis
Risk Assessment - methods
Risk Factors
Tomography, Emission-Computed, Single-Photon - methods
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Title Myocardial ischaemia in patients with peripheral arterial disease
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