Electronic Cigarettes: Their Constituents and Potential Links to Asthma
Purpose of Review Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-e...
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| Published in | Current allergy and asthma reports Vol. 17; no. 11; p. 79 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.11.2017
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1529-7322 1534-6315 1534-6315 |
| DOI | 10.1007/s11882-017-0747-5 |
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| Abstract | Purpose of Review
Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig aerosols, such as propylene glycol, vegetable glycerin, nicotine, and flavorings, and discuss their relevance in the context of asthma.
Recent Findings
Recent survey data indicate that adolescents with asthma had a higher prevalence of current e-cig use (12.4%) compared to their non-asthmatics peers (10.2%) and conveyed positive beliefs about tobacco products, especially e-cigs. Similarly, a study conducted among high school students from Ontario, Canada, indicated a greater likelihood of e-cig use in asthmatics as compared to their non-asthmatic peers. Availability of different flavorings is often cited as the main reason among youth/adolescents for trying e-cigs or switching from cigarettes to e-cigs. Occupational inhalation of some common food-safe flavoring agents is reported to cause occupational asthma and worsen asthmatic symptoms. Moreover, workplace inhalation exposures to the flavoring agent diacetyl have caused irreversible obstructive airway disease in healthy workers. Additionally, recent studies report that thermal decomposition of propylene glycol (PG) and vegetable glycerin (VG), the base constituents of e-liquids, produces reactive carbonyls, including acrolein, formaldehyde, and acetaldehyde, which have known respiratory toxicities. Furthermore, recent nicotine studies in rodents reveal that prenatal nicotine exposures lead to epigenetic reprogramming in the offspring, abnormal lung development, and multigenerational transmission of asthmatic-like symptoms.
Summary
Comparisons of the toxicity and health effects of e-cigs and conventional cigarettes often focus on toxicants known to be present in cigarette smoke (CS) (i.e., formaldehyde, nitrosamines, etc.), as well as smoking-associated clinical endpoints, such as cancer, bronchitis, and chronic obstructive pulmonary disease (COPD). However, this approach disregards potential toxicity of components unique to flavored e-cigs, such as PG, VG, and the many different flavoring chemicals, which likely induce respiratory effects not usually observed in cigarette smokers. |
|---|---|
| AbstractList | Purpose of Review
Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig aerosols, such as propylene glycol, vegetable glycerin, nicotine, and flavorings, and discuss their relevance in the context of asthma.
Recent Findings
Recent survey data indicate that adolescents with asthma had a higher prevalence of current e-cig use (12.4%) compared to their non-asthmatics peers (10.2%) and conveyed positive beliefs about tobacco products, especially e-cigs. Similarly, a study conducted among high school students from Ontario, Canada, indicated a greater likelihood of e-cig use in asthmatics as compared to their non-asthmatic peers. Availability of different flavorings is often cited as the main reason among youth/adolescents for trying e-cigs or switching from cigarettes to e-cigs. Occupational inhalation of some common food-safe flavoring agents is reported to cause occupational asthma and worsen asthmatic symptoms. Moreover, workplace inhalation exposures to the flavoring agent diacetyl have caused irreversible obstructive airway disease in healthy workers. Additionally, recent studies report that thermal decomposition of propylene glycol (PG) and vegetable glycerin (VG), the base constituents of e-liquids, produces reactive carbonyls, including acrolein, formaldehyde, and acetaldehyde, which have known respiratory toxicities. Furthermore, recent nicotine studies in rodents reveal that prenatal nicotine exposures lead to epigenetic reprogramming in the offspring, abnormal lung development, and multigenerational transmission of asthmatic-like symptoms.
Summary
Comparisons of the toxicity and health effects of e-cigs and conventional cigarettes often focus on toxicants known to be present in cigarette smoke (CS) (i.e., formaldehyde, nitrosamines, etc.), as well as smoking-associated clinical endpoints, such as cancer, bronchitis, and chronic obstructive pulmonary disease (COPD). However, this approach disregards potential toxicity of components unique to flavored e-cigs, such as PG, VG, and the many different flavoring chemicals, which likely induce respiratory effects not usually observed in cigarette smokers. Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig aerosols, such as propylene glycol, vegetable glycerin, nicotine, and flavorings, and discuss their relevance in the context of asthma.PURPOSE OF REVIEWVaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig aerosols, such as propylene glycol, vegetable glycerin, nicotine, and flavorings, and discuss their relevance in the context of asthma.Recent survey data indicate that adolescents with asthma had a higher prevalence of current e-cig use (12.4%) compared to their non-asthmatics peers (10.2%) and conveyed positive beliefs about tobacco products, especially e-cigs. Similarly, a study conducted among high school students from Ontario, Canada, indicated a greater likelihood of e-cig use in asthmatics as compared to their non-asthmatic peers. Availability of different flavorings is often cited as the main reason among youth/adolescents for trying e-cigs or switching from cigarettes to e-cigs. Occupational inhalation of some common food-safe flavoring agents is reported to cause occupational asthma and worsen asthmatic symptoms. Moreover, workplace inhalation exposures to the flavoring agent diacetyl have caused irreversible obstructive airway disease in healthy workers. Additionally, recent studies report that thermal decomposition of propylene glycol (PG) and vegetable glycerin (VG), the base constituents of e-liquids, produces reactive carbonyls, including acrolein, formaldehyde, and acetaldehyde, which have known respiratory toxicities. Furthermore, recent nicotine studies in rodents reveal that prenatal nicotine exposures lead to epigenetic reprogramming in the offspring, abnormal lung development, and multigenerational transmission of asthmatic-like symptoms. Comparisons of the toxicity and health effects of e-cigs and conventional cigarettes often focus on toxicants known to be present in cigarette smoke (CS) (i.e., formaldehyde, nitrosamines, etc.), as well as smoking-associated clinical endpoints, such as cancer, bronchitis, and chronic obstructive pulmonary disease (COPD). However, this approach disregards potential toxicity of components unique to flavored e-cigs, such as PG, VG, and the many different flavoring chemicals, which likely induce respiratory effects not usually observed in cigarette smokers.RECENT FINDINGSRecent survey data indicate that adolescents with asthma had a higher prevalence of current e-cig use (12.4%) compared to their non-asthmatics peers (10.2%) and conveyed positive beliefs about tobacco products, especially e-cigs. Similarly, a study conducted among high school students from Ontario, Canada, indicated a greater likelihood of e-cig use in asthmatics as compared to their non-asthmatic peers. Availability of different flavorings is often cited as the main reason among youth/adolescents for trying e-cigs or switching from cigarettes to e-cigs. Occupational inhalation of some common food-safe flavoring agents is reported to cause occupational asthma and worsen asthmatic symptoms. Moreover, workplace inhalation exposures to the flavoring agent diacetyl have caused irreversible obstructive airway disease in healthy workers. Additionally, recent studies report that thermal decomposition of propylene glycol (PG) and vegetable glycerin (VG), the base constituents of e-liquids, produces reactive carbonyls, including acrolein, formaldehyde, and acetaldehyde, which have known respiratory toxicities. Furthermore, recent nicotine studies in rodents reveal that prenatal nicotine exposures lead to epigenetic reprogramming in the offspring, abnormal lung development, and multigenerational transmission of asthmatic-like symptoms. Comparisons of the toxicity and health effects of e-cigs and conventional cigarettes often focus on toxicants known to be present in cigarette smoke (CS) (i.e., formaldehyde, nitrosamines, etc.), as well as smoking-associated clinical endpoints, such as cancer, bronchitis, and chronic obstructive pulmonary disease (COPD). However, this approach disregards potential toxicity of components unique to flavored e-cigs, such as PG, VG, and the many different flavoring chemicals, which likely induce respiratory effects not usually observed in cigarette smokers. Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig aerosols, such as propylene glycol, vegetable glycerin, nicotine, and flavorings, and discuss their relevance in the context of asthma. Recent survey data indicate that adolescents with asthma had a higher prevalence of current e-cig use (12.4%) compared to their non-asthmatics peers (10.2%) and conveyed positive beliefs about tobacco products, especially e-cigs. Similarly, a study conducted among high school students from Ontario, Canada, indicated a greater likelihood of e-cig use in asthmatics as compared to their non-asthmatic peers. Availability of different flavorings is often cited as the main reason among youth/adolescents for trying e-cigs or switching from cigarettes to e-cigs. Occupational inhalation of some common food-safe flavoring agents is reported to cause occupational asthma and worsen asthmatic symptoms. Moreover, workplace inhalation exposures to the flavoring agent diacetyl have caused irreversible obstructive airway disease in healthy workers. Additionally, recent studies report that thermal decomposition of propylene glycol (PG) and vegetable glycerin (VG), the base constituents of e-liquids, produces reactive carbonyls, including acrolein, formaldehyde, and acetaldehyde, which have known respiratory toxicities. Furthermore, recent nicotine studies in rodents reveal that prenatal nicotine exposures lead to epigenetic reprogramming in the offspring, abnormal lung development, and multigenerational transmission of asthmatic-like symptoms. Comparisons of the toxicity and health effects of e-cigs and conventional cigarettes often focus on toxicants known to be present in cigarette smoke (CS) (i.e., formaldehyde, nitrosamines, etc.), as well as smoking-associated clinical endpoints, such as cancer, bronchitis, and chronic obstructive pulmonary disease (COPD). However, this approach disregards potential toxicity of components unique to flavored e-cigs, such as PG, VG, and the many different flavoring chemicals, which likely induce respiratory effects not usually observed in cigarette smokers. Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco cigarettes, little is known regarding the health effects of their short- or long-term use, especially in individuals with pre-existing respiratory diseases such as asthma. Flavored e-cig liquids (e-liquids) and e-cig aerosols contain airway irritants and toxicants that have been implicated in the pathogenesis and worsening of lung diseases. In this review, we will summarize existing data on potential health effects of components present in e-cig aerosols, such as propylene glycol, vegetable glycerin, nicotine, and flavorings, and discuss their relevance in the context of asthma. Recent survey data indicate that adolescents with asthma had a higher prevalence of current e-cig use (12.4%) compared to their non-asthmatics peers (10.2%) and conveyed positive beliefs about tobacco products, especially e-cigs. Similarly, a study conducted among high school students from Ontario, Canada, indicated a greater likelihood of e-cig use in asthmatics as compared to their non-asthmatic peers. Availability of different flavorings is often cited as the main reason among youth/adolescents for trying e-cigs or switching from cigarettes to e-cigs. Occupational inhalation of some common food-safe flavoring agents is reported to cause occupational asthma and worsen asthmatic symptoms. Moreover, workplace inhalation exposures to the flavoring agent diacetyl have caused irreversible obstructive airway disease in healthy workers. Additionally, recent studies report that thermal decomposition of propylene glycol (PG) and vegetable glycerin (VG), the base constituents of e-liquids, produces reactive carbonyls, including acrolein, formaldehyde, and acetaldehyde, which have known respiratory toxicities. Furthermore, recent nicotine studies in rodents reveal that prenatal nicotine exposures lead to epigenetic reprogramming in the offspring, abnormal lung development, and multigenerational transmission of asthmatic-like symptoms. Comparisons of the toxicity and health effects of e-cigs and conventional cigarettes often focus on toxicants known to be present in cigarette smoke (CS) (i.e., formaldehyde, nitrosamines, etc.), as well as smoking-associated clinical endpoints, such as cancer, bronchitis, and chronic obstructive pulmonary disease (COPD). However, this approach disregards potential toxicity of components unique to flavored e-cigs, such as PG, VG, and the many different flavoring chemicals, which likely induce respiratory effects not usually observed in cigarette smokers. |
| ArticleNumber | 79 |
| Author | Clapp, Phillip W. Jaspers, Ilona |
| AuthorAffiliation | 1 Curriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, NC USA 2 Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA 3 Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA |
| AuthorAffiliation_xml | – name: 3 Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA – name: 2 Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA – name: 1 Curriculum in Toxicology, School of Medicine, University of North Carolina, Chapel Hill, NC USA |
| Author_xml | – sequence: 1 givenname: Phillip W. surname: Clapp fullname: Clapp, Phillip W. organization: Curriculum in Toxicology, School of Medicine, University of North Carolina, Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina – sequence: 2 givenname: Ilona surname: Jaspers fullname: Jaspers, Ilona email: Ilona_jaspers@med.unc.edu organization: Curriculum in Toxicology, School of Medicine, University of North Carolina, Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina, Department of Pediatrics, University of North Carolina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28983782$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1523/JNEUROSCI.5369-07.2008 10.1016/j.ejphar.2011.04.027 10.1016/j.intimp.2014.07.029 10.1016/j.amepre.2016.03.010 10.1001/archderm.1960.03730040103018 10.1136/tobaccocontrol-2014-051670 10.1016/j.ejphar.2005.12.063 10.1016/j.jaci.2012.04.002 10.1038/nature05544 10.1016/j.pupt.2008.09.005 10.1126/science.287.5458.1604 10.1007/s00408-007-9068-0 10.1136/thoraxjnl-2015-207895 10.1016/j.neulet.2004.03.016 10.1111/j.0105-1873.2004.00301.x 10.1096/fasebj.7.11.8370474 10.1002/ajim.20151 10.1016/0091-6749(92)90478-K 10.1073/pnas.0609598103 10.1007/s10753-010-9228-x 10.1016/j.neuroscience.2012.02.040 10.1096/fj.11-188383 10.1136/bmj.j3262 10.1016/j.cell.2009.09.028 10.1093/ntr/ntu078 10.3390/ijerph13050465 10.1111/j.1398-9995.2007.01525.x 10.1016/j.rmed.2016.09.013 10.1007/978-3-540-69248-5_2 10.1136/tobaccocontrol-2012-050860 10.12659/MSM.896557 10.1016/0165-1218(95)00037-2 10.1177/1559325817691159 10.3390/ijerph110504965 10.2174/1877381801002030071 10.1016/j.cell.2006.02.023 10.1074/jbc.C110.159491 10.1007/BF01899077 10.1128/CDLI.11.3.563-568.2004 10.1016/j.neuroscience.2013.12.047 10.1016/S0893-133X(97)00040-7 10.1080/10915810600716612 10.1080/15298669191365126 10.1172/JCI34192 10.1016/j.intimp.2013.02.010 10.1016/S0165-5728(97)00231-2 10.1002/ejp.840 10.1183/09031936.04.00039004 10.3109/08037059609062111 10.1093/ntr/ntu176 10.1371/journal.pone.0169811 10.1136/tobaccocontrol-2016-053174 10.1152/physiol.00026.2008 10.1186/s12890-015-0106-z 10.1001/archpedi.162.5.477 10.1186/s12931-017-0518-9 10.1126/stke.2722005re3 10.1016/j.annepidem.2016.10.004 10.1073/pnas.0900591106 10.1111/j.1600-0536.2008.01486.x 10.1016/j.pupt.2010.12.003 10.1016/S8756-3282(01)00427-6 10.1007/s00018-010-0525-1 10.1136/tobaccocontrol-2014-052175 10.1152/japplphysiol.01144.2012 10.1111/j.1600-0536.1999.tb06021.x 10.1152/ajplung.00234.2014 10.18001/TRS.3.1.9 10.1152/ajplung.00064.2017 10.1186/s12916-015-0355-y 10.1124/jpet.302.3.935 10.1111/j.1398-9995.2010.02329.x 10.1111/j.1600-0536.1999.tb06189.x 10.1177/1741826711411738 10.1097/DER.0000000000000126 10.1186/1741-7015-10-129 10.1016/j.anai.2015.10.012 10.1371/journal.pone.0151022 10.1152/ajplung.00452.2016 10.1136/thoraxjnl-2011-200391 10.1038/ncomms13202 10.1289/ehp.118-a131b 10.1289/ehp.02110s4505 10.1136/tobaccocontrol-2016-053224 10.1016/j.coph.2009.02.002 10.2105/AJPH.84.4.543 10.1056/NEJMoa020300 10.1016/j.amepre.2009.10.029 10.1021/acs.est.6b01741 10.1001/jama.2014.14830 10.1016/S0306-4530(97)00076-0 10.1161/01.RES.9.3.631 10.1542/peds.2016-2513 10.1016/j.rmed.2017.02.004 10.1038/nn1692 10.1016/j.ypmed.2014.06.014 10.1152/ajplung.00078.2013 10.4049/jimmunol.180.11.7655 10.1164/rccm.200611-1620OC 10.2340/00015555-0782 10.1021/cn500094a 10.1016/j.cellimm.2004.07.007 10.1007/978-1-4615-5347-2_31 10.1124/jpet.116.239384 10.1111/dar.12309 10.1016/S0741-5214(99)70329-0 10.1093/ntr/ntu156 10.2500/aap.2015.36.3828 10.1016/j.jadohealth.2015.03.018 10.3109/08958378.2012.758197 10.1016/j.pmedr.2016.11.001 10.1152/ajplung.00396.2012 10.1016/j.ijheh.2016.01.004 10.1016/j.bbadis.2007.01.013 10.1016/j.toxicon.2004.01.017 |
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| References | RogerioAPAndradeELCalixtoJBC-fibers, but not the transient potential receptor vanilloid 1 (TRPV1), play a role in experimental allergic airway inflammationEur J Pharmacol20116621–355621:CAS:528:DC%2BC3MXmvVejt7g%3D2153984010.1016/j.ejphar.2011.04.027 TierneyPAKarpinskiCDBrownJELuoWPankowJFFlavour chemicals in electronic cigarette fluidsTob Control201625e1e10e152587737710.1136/tobaccocontrol-2014-052175This study quantified flavoring chemicals in 30 popular e-cig liquids. Many of the e-liquids contained aldehyde flavoring agents that made up 1 to 4% of the total e-liquid volume. The authors conclude that concentrations of some flavor chemicals in e-cigs are sufficiently high for inhalation exposure by vaping to be of toxicological concern. Galle-TregerLSuzukiYPatelNSankaranarayananIAronJLMaaziHNicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivityNat Commun20167132021:CAS:528:DC%2BC28XhslSlsbnK27752043507185110.1038/ncomms13202 CobbCOHendricksPSEissenbergTElectronic cigarettes and nicotine dependence: evolving products, evolving problemsBMC Med20151311925998379444060210.1186/s12916-015-0355-y KreissKGomaaAKullmanGFedanKSimoesEJEnrightPLClinical bronchiolitis obliterans in workers at a microwave-popcorn plantN Engl J Med200234753303381215147010.1056/NEJMoa020300 GundavarapuSWilderJAMishraNCRir-Sima-AhJLangleyRJSinghSPRole of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivoJ Allergy Clin Immunol201213037707801:CAS:528:DC%2BC38XntlSrtLY%3D22578901341977210.1016/j.jaci.2012.04.002e11 BessacBFJordtSEBreathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex controlPhysiology (Bethesda)2008233603701:CAS:528:DC%2BD1MXpvFKmtA%3D%3D10.1152/physiol.00026.2008 McNeill A, Brose L, Calder R, Hitchman S, Hajek P, McRobbie H. E-cigarettes: an evidence update. Public Health England. 2015;3. A government report by Public Health England (PHE), an agency of England’s Department of Health, which estimates that e-cigs are 95% less harmful to your health than normal cigarettes and supports the use of e-cigs as effective tobacco cessation and reduction aids. TakemuraMQuarcooDNiimiADinhQTGeppettiPFischerAIs TRPV1 a useful target in respiratory diseases?Pulm Pharmacol Ther20082168338391:CAS:528:DC%2BD1cXhsVCmsb%2FK1899235610.1016/j.pupt.2008.09.005 QuirceSFernandez-NietoMdel PozoVSastreBSastreJOccupational asthma and rhinitis caused by eugenol in a hairdresserAllergy20086311371381:STN:280:DC%2BD2sjhsFyjtg%3D%3D17711554 Cantero-RecasensGGonzalezJRFandosCDuran-TauleriaESmitLAKauffmannFLoss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthmaJ Biol Chem20102853627532275351:CAS:528:DC%2BC3cXhtVOnsL7N20639579293461910.1074/jbc.C110.159491 Benowitz NL, Hukkanen J, Jacob III P. Nicotine chemistry, metabolism, kinetics and biomarkers. Nicotine psychopharmacology. Springer; 2009. p. 29–60. GarrettBEDubeSTrosclairACaraballoRPechacekTCigarette smoking-United States, 1965–2008MMWR Surveill Summ201160109113 LauriolaMMDe BitontoASenaPAllergic contact dermatitis due to cinnamon oil in galenic vaginal suppositoriesActa Derm Venereol20109021871882016930610.2340/00015555-0782 DoolittleDJWinegarRLeeCKCaldwellWSHayesAWDonald deBethizyJThe genotoxic potential of nicotine and its major metabolitesMutat Res Genet Toxicol19953443–4951021:CAS:528:DyaK2MXpsV2rs70%3D10.1016/0165-1218(95)00037-2 BerridgeMJLippPBootmanMDSignal transduction. The calcium entry pas de deuxScience20002875458160416051:CAS:528:DC%2BD3cXhs1OrtL8%3D1073342910.1126/science.287.5458.1604 KosmiderLSobczakAFikMKnysakJZacieraMKurekJCarbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltageNicotine Tob Res201416101319132624832759483802810.1093/ntr/ntu078 PrietoLGutierrezVCerveraALinanaJAirway obstruction induced by inhaled acetaldehyde in asthma: repeatability relationship to adenosine 5′-monophosphate responsivenessJ Investig Allergol Clin Immunol200212291981:CAS:528:DC%2BD38XnvVOnt7s%3D12371536 CarlsonLAOröLThe effect of nicotinic acid on the plasma free fatty acids demonstration of a metabolic type of sympathicolysisJ Intern Med196217266416451:CAS:528:DyaF3sXlsFKisg%3D%3D PolosaRMorjariaJBCaponnettoPCarusoMCampagnaDAmaradioMDPersisting long term benefits of smoking abstinence and reduction in asthmatic smokers who have switched to electronic cigarettesDiscov Med2016211149910827011045 ZhuSHZhuangYLWongSCumminsSETedeschiGJE-cigarette use and associated changes in population smoking cessation: evidence from US current population surveysBMJ2017358j326228747333552604610.1136/bmj.j3262This study used survey data from the largest representative sample of e-cig users among the US population to show that that e-cig use is not only associated with a higher smoking cessation rate at the individual user level but also at the population level. PolosaRMorjariaJCaponnettoPCarusoMStranoSBattagliaEEffect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversalInt J Environ Res Public Health20141154965497724814944405387910.3390/ijerph110504965A retrospective study which identifies improvements in asthma control, airway hyper-responsiveness, and pulmonary function in asthmatic smokers who quit or dramatically reduced their tobacco consumption by switching to e-cigs. FerrariMZanasiANardiEMorselli LabateAMCerianaPBalestrinoAShort-term effects of a nicotine-free e-cigarette compared to a traditional cigarette in smokers and non-smokersBMC Pulm Med20151512026459355460392310.1186/s12890-015-0106-z1:CAS:528:DC%2BC28Xos1Kkt7s%3D WangPChenWLiaoJMatsuoTItoKFowlesJA device-independent evaluation of carbonyl emissions from heated electronic cigarette solventsPLoS One2017121e016981128076380522672710.1371/journal.pone.0169811Quantitation of toxic volatile carbonyl compounds produced when vaping propylene glycol and glycerin under precisely controlled temperatures in the absence of nicotine and flavor additives. LiuJSakuraiRRehanVKPPAR-gamma agonist rosiglitazone reverses perinatal nicotine exposure-induced asthma in rat offspringAm J Physiol Lung Cell Mol Physiol.20153088L788L7961:CAS:528:DC%2BC2MXot12rs70%3D25659902439887110.1152/ajplung.00234.2014 UragodaCGAsthma and other symptoms in cinnamon workersBr J Ind Med19844122242271:STN:280:DyaL2c3gtlCitw%3D%3D62329421009288 Amrock SM, Zakhar J, Zhou S, Weitzman M. Perception of e-cigarette harm and its correlation with use among US adolescents. Nicotine Tob Res. 2015;17(3):330–6. https://doi.org/10.1093/ntr/ntu156. BencherifMLippielloPMLucasRMarreroMBAlpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseasesCell Mol Life Sci20116869319491:CAS:528:DC%2BC3MXit1Klsrk%3D2095365810.1007/s00018-010-0525-1 JangTYParkCSKimKSHeoMJKimYHBenzaldehyde suppresses murine allergic asthma and rhinitisInt Immunopharmacol20142224444501:CAS:528:DC%2BC2cXht1ylu7jJ2510744110.1016/j.intimp.2014.07.029 LarsenKGEJFBoakAHamiltonHAMannREIrvingHMLooking beyond cigarettes: are Ontario adolescents with asthma less likely to smoke e-cigarettes, marijuana, waterpipes or tobacco cigarettes?Respir Med201612010152781780510.1016/j.rmed.2016.09.013This study used the 2013 Ontario Student Drug Use and Health Survey data (n = 6,159 high school students) to determine whether asthmatic students in Ontario smoke cigarettes, waterpipes, marijuana, or e-cig more or less than those without asthma. Students with asthma have higher odds of using e-cigs but not cigarettes, waterpipes, or marijuana, when compared to their non-asthmatic peers. CourtneyRThe health consequences of smoking—50 years of progress: a report of the surgeon general, 2014 US Department of Health and Human Services Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 20141081 pp. Online (grey literature): http://www/. surgeongeneral. gov/library/reports/50-years-of-progressDrug Alcohol Rev201534669469510.1111/dar.12309 FedeleDABarnettTEDekevichDGibson-YoungLMMartinasekMJaggerMAPrevalence of and beliefs about electronic cigarettes and hookah among high school students with asthmaAnn Epidemiol201626128658692783965710.1016/j.annepidem.2016.10.004This study used 2014 Florida Youth Tobacco Survey data (n = 32,921) to assess current cigarette, hookah, and e-cig use among high school students with and without asthma. Adolescents with asthma had a higher prevalence of current hookah and e-cig use, reported positive beliefs about tobacco products, and were more likely to live with individuals who used cigarettes, hookah, and e-cig compared with their peers. BesaratiniaATommasiSElectronic cigarettes: the road aheadPrev Med20146665672495209510.1016/j.ypmed.2014.06.014 HopkinsDPRaziSLeeksKDPriya KalraGChattopadhyaySKSolerRESmokefree policies to reduce tobacco use: a systematic reviewAm J Prev Med2010382 SupplS275S2892011761210.1016/j.amepre.2009.10.029 RehanVKLiuJNaeemETianJSakuraiRKwongKPerinatal nicotine exposure induces asthma in second generation offspringBMC Med2012101291:CAS:528:DC%2BC3sXjsFyrurY%3D23106849356873710.1186/1741-7015-10-129 Zhong J, Cao S, Gong W, Fei F, Wang M. Electronic cigarettes use and intention to cigarette smoking among never-smoking adolescents and young adults: a meta-analysis. Int J Environ Res Public Health. 2016;13(5):pii: E465. https://doi.org/10.3390/ijerph13050465. YildizDNicotine, its metabolism and an overview of its biological effectsToxicon20044366196321:CAS:528:DC%2BD2cXjtlyhs70%3D1510988310.1016/j.toxicon.2004.01.017 WalkerLMPrestonMRMagnayJLThomasPBEl HajAJNicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ cultureBone20012866036081:CAS:528:DC%2BD3MXks1Olsbc%3D1142564810.1016/S8756-3282(01)004 LY Lee (747_CR104) 2009; 9 S Wright (747_CR40) 1993; 7 M Takemura (747_CR103) 2008; 21 MP Lopez-Saez (747_CR75) 2015; 25 J Mabley (747_CR50) 2011; 34 M Bencherif (747_CR56) 2011; 68 J Plevkova (747_CR96) 2013; 115 BF Bessac (747_CR120) 2008; 118 A Kershbaum (747_CR37) 1969; 25 G Cantero-Recasens (747_CR106) 2010; 285 M Inoue (747_CR126) 2012; 210 R Rehman (747_CR108) 2013; 15 AI Basbaum (747_CR121) 2009; 139 EY Chen (747_CR58) 2014; 307 BE Garrett (747_CR3) 2011; 60 DJ Doolittle (747_CR44) 1995; 344 747_CR130 I Annesi-Maesano (747_CR91) 2012; 67 S Gundavarapu (747_CR59) 2012; 130 PT Symanowicz (747_CR115) 2004; 362 L Ackermann (747_CR80) 2009; 60 ML Sopori (747_CR54) 1998; 437 F Facchinetti (747_CR112) 2010; 2 A Besaratinia (747_CR8) 2014; 66 A Hinman (747_CR116) 2006; 103 DK Eaton (747_CR4) 2012; 61 K Kreiss (747_CR70) 2002; 347 JH Cho (747_CR23) 2016; 11 AP Rogerio (747_CR109) 2011; 662 ML Sopori (747_CR53) 1998; 23 FG van Rooy (747_CR71) 2007; 176 GT Yocum (747_CR110) 2017; 312 CL Chen (747_CR107) 2015; 36 AB Kern (747_CR77) 1960; 81 CO Cobb (747_CR64) 2015; 13 SW Wu (747_CR124) 2017; 362 DN Willis (747_CR97) 2011; 25 BW Spurlock (747_CR93) 1990; 323 S Varughese (747_CR27) 2005; 47 A Kershbaum (747_CR36) 1961; 9 K Choi (747_CR21) 2016; 51 P Geppetti (747_CR101) 2006; 533 K Larsen (747_CR22) 2016; 120 H Xu (747_CR125) 2006; 9 H Dai (747_CR65) 2016; 138 BF Bessac (747_CR114) 2008; 23 R Courtney (747_CR2) 2015; 34 A Vandersall (747_CR78) 2015; 26 747_CR34 P Omvik (747_CR39) 1996; 5 J Liu (747_CR46) 2015; 308 S Quirce (747_CR76) 2008; 63 L Kosmider (747_CR12) 2014; 16 R Kalra (747_CR52) 2002; 302 SH Zhu (747_CR16) 2017; 358 VK Rehan (747_CR47) 2013; 305 DA Fedele (747_CR20) 2016; 26 T Kaimoto (747_CR128) 2016; 20 NL Benowitz (747_CR48) 2013; 22 L Galle-Treger (747_CR49) 2016; 7 GD Leikauf (747_CR89) 1992; 49 SM Brooks (747_CR111) 2008; 186 747_CR9 LA Carlson (747_CR38) 1962; 172 S Laham (747_CR86) 1991; 52 L Prieto (747_CR32) 2002; 12 747_CR7 P Wang (747_CR28) 2017; 12 MJ Berridge (747_CR99) 2000; 287 747_CR88 T Tillett (747_CR30) 2010; 118 R Polosa (747_CR17) 2014; 11 MB Harrell (747_CR62) 2017; 5 JL Barrington-Trimis (747_CR72) 2014; 312 H Yang (747_CR113) 2016; 22 C Montell (747_CR100) 2005; 2005 LS Premkumar (747_CR123) 2014; 5 SH Zhu (747_CR61) 2014; 23 RZ Behar (747_CR68) 2016; 25 747_CR15 R Kalra (747_CR51) 2004; 11 M Paiva (747_CR95) 2010; 65 ME Boulay (747_CR24) 2017; 18 L Kosmider (747_CR85) 2016; 71 LM Walker (747_CR41) 2001; 28 NC Mishra (747_CR57) 2008; 180 747_CR10 M Sleiman (747_CR13) 2016; 50 747_CR14 G Chung (747_CR127) 2014; 261 A D’alessandro (747_CR35) 2012; 19 MM Lauriola (747_CR79) 2010; 90 RA Silverman (747_CR129) 2017; 125 AA Padon (747_CR67) 2017; 3 Y Yao (747_CR29) 2015; 8 747_CR1 ML Sopori (747_CR55) 1998; 83 R Golden (747_CR31) 2017; 15 M Ferrari (747_CR25) 2015; 15 DM Bautista (747_CR119) 2006; 124 AI Caceres (747_CR122) 2009; 106 KE Farsalinos (747_CR73) 2015; 17 JK Pepper (747_CR63) 2016; 25 DP Hopkins (747_CR5) 2010; 38 747_CR66 747_CR69 CG Uragoda (747_CR84) 1984; 41 M Nisell (747_CR42) 1997; 17 V De Benito (747_CR83) 1999; 40 LY Lee (747_CR105) 2011; 24 D Whitley (747_CR43) 1999; 29 TY Jang (747_CR92) 2014; 22 D Yildiz (747_CR33) 2004; 43 PA Tierney (747_CR98) 2016; 25 Y Jia (747_CR102) 2007; 1772 M Siegel (747_CR6) 2008; 162 K Hartmann (747_CR81) 2004; 50 A Andersen (747_CR87) 2006; 25 DA Andersson (747_CR118) 2008; 28 R Polosa (747_CR19) 2016; 116 747_CR74 J Sanchez-Perez (747_CR82) 1999; 41 J Subiza (747_CR94) 1992; 90 R Polosa (747_CR18) 2016; 21 AD Flouris (747_CR26) 2013; 25 VK Rehan (747_CR45) 2012; 10 LJ Macpherson (747_CR117) 2007; 445 O Geiss (747_CR11) 2016; 219 GD Leikauf (747_CR90) 2002; 110 S Razani-Boroujerdi (747_CR60) 2004; 230 |
| References_xml | – reference: Benowitz NL, Hukkanen J, Jacob III P. Nicotine chemistry, metabolism, kinetics and biomarkers. Nicotine psychopharmacology. Springer; 2009. p. 29–60. – reference: UragodaCGAsthma and other symptoms in cinnamon workersBr J Ind Med19844122242271:STN:280:DyaL2c3gtlCitw%3D%3D62329421009288 – reference: LeeLYNiDHayesDJrLinRLTRPV1 as a cough sensor and its temperature-sensitive propertiesPulm Pharmacol Ther20112432802851:CAS:528:DC%2BC3MXmtFSmtrw%3D2121532110.1016/j.pupt.2010.12.003 – reference: LahamSBroxupBRobinetMPotvinMSchraderKSubacute inhalation toxicity of benzaldehyde in the Sprague-Dawley ratAm Ind Hyg Assoc J199152125035101:CAS:528:DyaK3sXks1GhsLc%3D178142910.1080/15298669191365126 – reference: ChenCLLiHXingXHGuanHSZhangJHZhaoJWEffect of TRPV1 gene mutation on bronchial asthma in children before and after treatmentAllergy Asthma Proc2015362e29e362571523610.2500/aap.2015.36.3828 – reference: LeikaufGDHazardous air pollutants and asthmaEnviron Health Perspect2002110Suppl 45055261:CAS:528:DC%2BD38XntVGrs74%3D12194881124120010.1289/ehp.02110s4505 – reference: CarlsonLAOröLThe effect of nicotinic acid on the plasma free fatty acids demonstration of a metabolic type of sympathicolysisJ Intern Med196217266416451:CAS:528:DyaF3sXlsFKisg%3D%3D – reference: PrietoLGutierrezVCerveraALinanaJAirway obstruction induced by inhaled acetaldehyde in asthma: repeatability relationship to adenosine 5′-monophosphate responsivenessJ Investig Allergol Clin Immunol200212291981:CAS:528:DC%2BD38XnvVOnt7s%3D12371536 – reference: YildizDNicotine, its metabolism and an overview of its biological effectsToxicon20044366196321:CAS:528:DC%2BD2cXjtlyhs70%3D1510988310.1016/j.toxicon.2004.01.017 – reference: WhitleyDGoldbergSPJordanWDHeat shock proteins: a review of the molecular chaperonesJ Vasc Surg19992947487511:STN:280:DyaK1M3ht1Wgsw%3D%3D1019451110.1016/S0741-5214(99)70329-0 – reference: DaiHHaoJFlavored electronic cigarette use and smoking among youthPediatrics2016138e201625132794071810.1542/peds.2016-2513 – reference: DoolittleDJWinegarRLeeCKCaldwellWSHayesAWDonald deBethizyJThe genotoxic potential of nicotine and its major metabolitesMutat Res Genet Toxicol19953443–4951021:CAS:528:DyaK2MXpsV2rs70%3D10.1016/0165-1218(95)00037-2 – reference: PepperJKRibislKMBrewerNTAdolescents’ interest in trying flavoured e-cigarettesTob Control201625Suppl 2ii62iii61:STN:280:DC%2BC2svgsl2ltQ%3D%3D2763376210.1136/tobaccocontrol-2016-053174 – reference: BencherifMLippielloPMLucasRMarreroMBAlpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseasesCell Mol Life Sci20116869319491:CAS:528:DC%2BC3MXit1Klsrk%3D2095365810.1007/s00018-010-0525-1 – reference: KershbaumABelletSDicksteinERFeinberglJEffect of cigarette smoking and nicotine on serum free fatty acids based on a study in the human subject and the experimental animalCirc Res196196316381:CAS:528:DyaF2cXktlGmur8%3D1375268710.1161/01.RES.9.3.631 – reference: GundavarapuSWilderJAMishraNCRir-Sima-AhJLangleyRJSinghSPRole of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivoJ Allergy Clin Immunol201213037707801:CAS:528:DC%2BC38XntlSrtLY%3D22578901341977210.1016/j.jaci.2012.04.002e11 – reference: VandersallAKattaREyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamonDermatitis20152641892617248910.1097/DER.0000000000000126 – reference: MontellCThe TRP superfamily of cation channelsSci STKE20052005272re315728426 – reference: EatonDKKannLKinchenSShanklinSFlintKHHawkinsJYouth risk behavior surveillance—United States, 2011Morb Mortal Wkly Rep Surveill Summ20126141162 – reference: De BenitoVAlzagaROccupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffeeContact Dermatitis199940316510073451 – reference: GeppettiPMaterazziSNicolettiPThe transient receptor potential vanilloid 1: role in airway inflammation and diseaseEur J Pharmacol20065331–32072141:CAS:528:DC%2BD28XitVKgsro%3D1646444910.1016/j.ejphar.2005.12.063 – reference: KershbaumAOsadaHPappajohnDJBelletSEffect of nicotine on the mobilization of free fatty acids from adipose tissue in vitroExperientia19692521281:CAS:528:DyaF1MXms1Gqtw%3D%3D578607810.1007/BF01899077 – reference: LiuJSakuraiRRehanVKPPAR-gamma agonist rosiglitazone reverses perinatal nicotine exposure-induced asthma in rat offspringAm J Physiol Lung Cell Mol Physiol.20153088L788L7961:CAS:528:DC%2BC2MXot12rs70%3D25659902439887110.1152/ajplung.00234.2014 – reference: XuHDellingMJunJCClaphamDEOregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channelsNat Neurosci2006956286351:CAS:528:DC%2BD28XjvFaqs70%3D1661733810.1038/nn1692 – reference: Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J. 2004;24(5):822–33. https://doi.org/10.1183/09031936.04.00039004. – reference: BesaratiniaATommasiSElectronic cigarettes: the road aheadPrev Med20146665672495209510.1016/j.ypmed.2014.06.014 – reference: YaoYLiangWZhuLDuanYJinYHeLRelationship between the concentration of formaldehyde in the air and asthma in children: a meta-analysisInt J Clin Exp Med201586835883621:CAS:528:DC%2BC28XhsVers77J263094884538175 – reference: Galle-TregerLSuzukiYPatelNSankaranarayananIAronJLMaaziHNicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivityNat Commun20167132021:CAS:528:DC%2BC28XhslSlsbnK27752043507185110.1038/ncomms13202 – reference: AndersenAFinal report on the safety assessment of benzaldehydeInt J Toxicol200625Suppl 111271:CAS:528:DC%2BD28Xnt1GiurY%3D16835129 – reference: SleimanMLogueJMMontesinosVNRussellMLLitterMIGundelLAEmissions from electronic cigarettes: key parameters affecting the release of harmful chemicalsEnviron Sci Technol20165017964496511:CAS:528:DC%2BC28Xht1eitL7O2746187010.1021/acs.est.6b01741This study quantified potentially toxic compounds in e-cig aerosol emissions and identified key parameters affecting toxic compound generation, including heating coil configuration and applied voltage. – reference: Zhong J, Cao S, Gong W, Fei F, Wang M. Electronic cigarettes use and intention to cigarette smoking among never-smoking adolescents and young adults: a meta-analysis. Int J Environ Res Public Health. 2016;13(5):pii: E465. https://doi.org/10.3390/ijerph13050465. – reference: Amrock SM, Zakhar J, Zhou S, Weitzman M. Perception of e-cigarette harm and its correlation with use among US adolescents. Nicotine Tob Res. 2015;17(3):330–6. https://doi.org/10.1093/ntr/ntu156. – reference: Razani-BoroujerdiSSinghSPKnallCHahnFFPena-PhilippidesJCKalraRChronic nicotine inhibits inflammation and promotes influenza infectionCell Immunol20042301191:CAS:528:DC%2BD2cXpslWntrc%3D1554171310.1016/j.cellimm.2004.07.007 – reference: SoporiMLKozakWSavageSMGengYSoszynskiDKlugerMJEffect of nicotine on the immune system: possible regulation of immune responses by central and peripheral mechanismsPsychoneuroendocrinology19982321892041:CAS:528:DyaK1cXjslWiu7w%3D962139810.1016/S0306-4530(97)00076-0 – reference: RehanVKLiuJSakuraiRTordayJSPerinatal nicotine-induced transgenerational asthmaAm J Physiol Lung Cell Mol Physiol.20133057L501L5071:CAS:528:DC%2BC3sXhslejur3I23911437379876210.1152/ajplung.00078.2013 – reference: SymanowiczPTGianutsosGMorrisJBLack of role for the vanilloid receptor in response to several inspired irritant air pollutants in the C57Bl/6J mouseNeurosci Lett200436221501531:CAS:528:DC%2BD2cXktlCqsbg%3D1519377410.1016/j.neulet.2004.03.016 – reference: PremkumarLSTransient receptor potential channels as targets for phytochemicalsACS Chem Neurosci2014511111711301:CAS:528:DC%2BC2cXps1Kmt7o%3D24926802424025510.1021/cn500094a – reference: TakemuraMQuarcooDNiimiADinhQTGeppettiPFischerAIs TRPV1 a useful target in respiratory diseases?Pulm Pharmacol Ther20082168338391:CAS:528:DC%2BD1cXhsVCmsb%2FK1899235610.1016/j.pupt.2008.09.005 – reference: BessacBFJordtSEBreathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex controlPhysiology (Bethesda)2008233603701:CAS:528:DC%2BD1MXpvFKmtA%3D%3D10.1152/physiol.00026.2008 – reference: FacchinettiFPatacchiniRThe rising role of TRPA1 in asthmaOpen Drug Discov J20102171801:CAS:528:DC%2BC3cXhtVens7vL10.2174/1877381801002030071 – reference: LeeLYGuQRole of TRPV1 in inflammation-induced airway hypersensitivityCurr Opin Pharmacol2009932432491:CAS:528:DC%2BD1MXms1Ohu7o%3D19269247270409510.1016/j.coph.2009.02.002 – reference: FarsalinosKEKistlerKAGillmanGVoudrisVEvaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxinsNicotine Tob Res20151721681741:CAS:528:DC%2BC28XhvFaqtrrF2518008010.1093/ntr/ntu176This study found that diacetyl and acetyl propionyl, known respiratory toxicants, were present in a large proportion of sweet-flavored e-cig liquids. The authors conclude that the use of many of the products evaluated would result in exposures that exceed NIOSH-defined safety levels. – reference: KernABContact dermatitis from cinnamonArch Dermatol1960815996001:STN:280:DyaF3c7mtFansw%3D%3D1440860510.1001/archderm.1960.03730040103018 – reference: WrightSZhongJZhengHLarrickJNicotine inhibition of apoptosis suggests a role in tumor promotionFASEB J1993711104510511:CAS:528:DyaK3sXms1Cms70%3D8370474 – reference: KalraRSinghSPPena-PhilippidesJCLangleyRJRazani-BoroujerdiSSoporiMLImmunosuppressive and anti-inflammatory effects of nicotine administered by patch in an animal modelClin Diagn Lab Immunol20041135635681:CAS:528:DC%2BD2cXkvFKqs74%3D15138183404586 – reference: SoporiMLKozakWImmunomodulatory effects of cigarette smokeJ Neuroimmunol1998831–21481561:CAS:528:DyaK1cXitlSru7k%3D961068310.1016/S0165-5728(97)00231-2 – reference: RogerioAPAndradeELCalixtoJBC-fibers, but not the transient potential receptor vanilloid 1 (TRPV1), play a role in experimental allergic airway inflammationEur J Pharmacol20116621–355621:CAS:528:DC%2BC3MXmvVejt7g%3D2153984010.1016/j.ejphar.2011.04.027 – reference: YocumGTChenJChoiCHTownsendEAZhangYXuDRole of transient receptor potential vanilloid 1 in the modulation of airway smooth muscle tone and calcium handlingAm J Physiol Lung Cell Mol Physiol20173126L812LL212833681010.1152/ajplung.00064.2017 – reference: PlevkovaJKollarikMPoliacekIBrozmanovaMSurdenikovaLTatarMThe role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of mentholJ Appl Physiol (1985)201311522682741:CAS:528:DC%2BC3sXhtlWksbfN10.1152/japplphysiol.01144.2012 – reference: BoulayMEHenryCBosseYBouletLPMorissetteMCAcute effects of nicotine-free and flavour-free electronic cigarette use on lung functions in healthy and asthmatic individualsRespir Res20171813328183298530144610.1186/s12931-017-0518-9A crossover, placebo-controlled study investigating the effects of a 1-h acute vaping session of nicotine- and flavor-free e-liquid on the pulmonary functions and respiratory mechanics of healthy and asthmatic individuals. Acute exposure to propylene glycol and glycerin aerosol in a controlled environment does not significantly impact pulmonary function or symptoms in both healthy and asthmatic subjects. – reference: SoporiMLKozakWSavageSMGengYKlugerMJNicotine-induced modulation of T cell function. Implications for inflammation and infectionAdv Exp Med Biol19984372792891:CAS:528:DyaK1cXmvFGksrc%3D966628110.1007/978-1-4615-5347-2_31 – reference: ChenEYSunAChenCSMintzAJChinWCNicotine alters mucin rheological propertiesAm J Physiol Lung Cell Mol Physiol.20143072L149L1571:CAS:528:DC%2BC2cXht1ygtr%2FP24838753410179510.1152/ajplung.00396.2012 – reference: VarugheseSTeschkeKBrauerMChowYvan NettenCKennedySMEffects of theatrical smokes and fogs on respiratory health in the entertainment industryAm J Ind Med20054754114181582807310.1002/ajim.20151 – reference: NisellMNomikosGGCherguiKGrillnerPSvenssonTHChronic nicotine enhances basal and nicotine-induced Fos immunoreactivity preferentially in the medial prefrontal cortex of the ratNeuropsychopharmacology19971731511611:CAS:528:DyaK2sXls1Oru7k%3D927248210.1016/S0893-133X(97)00040-7 – reference: SilvermanRAHasegawaKEganDJStifflerKASullivanAFCamargoCAMulticenter study of cigarette smoking among adults with asthma exacerbations in the emergency department, 2011–2012Respir Med201712589912821410610.1016/j.rmed.2017.02.004 – reference: FerrariMZanasiANardiEMorselli LabateAMCerianaPBalestrinoAShort-term effects of a nicotine-free e-cigarette compared to a traditional cigarette in smokers and non-smokersBMC Pulm Med20151512026459355460392310.1186/s12890-015-0106-z1:CAS:528:DC%2BC28Xos1Kkt7s%3D – reference: GoldenRHolmSIndoor air quality and asthma: has unrecognized exposure to acrolein confounded results of previous studies?Dose Response2017151155932581769115928250718531880110.1177/1559325817691159 – reference: LarsenKGEJFBoakAHamiltonHAMannREIrvingHMLooking beyond cigarettes: are Ontario adolescents with asthma less likely to smoke e-cigarettes, marijuana, waterpipes or tobacco cigarettes?Respir Med201612010152781780510.1016/j.rmed.2016.09.013This study used the 2013 Ontario Student Drug Use and Health Survey data (n = 6,159 high school students) to determine whether asthmatic students in Ontario smoke cigarettes, waterpipes, marijuana, or e-cig more or less than those without asthma. Students with asthma have higher odds of using e-cigs but not cigarettes, waterpipes, or marijuana, when compared to their non-asthmatic peers. – reference: KaimotoTHatakeyamaYTakahashiKImagawaTTominagaMOhtaTInvolvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limoneneEur J Pain2016207115511651:CAS:528:DC%2BC28XhtFSis7zP2703050910.1002/ejp.840 – reference: PolosaRMorjariaJBCaponnettoPCarusoMCampagnaDAmaradioMDPersisting long term benefits of smoking abstinence and reduction in asthmatic smokers who have switched to electronic cigarettesDiscov Med2016211149910827011045 – reference: AnderssonDAGentryCMossSBevanSTransient receptor potential A1 is a sensory receptor for multiple products of oxidative stressJ Neurosci20082810248524941:CAS:528:DC%2BD1cXjt1Ghu7Y%3D18322093270920610.1523/JNEUROSCI.5369-07.2008 – reference: van RooyFGRooyackersJMProkopMHoubaRSmitLAHeederikDJBronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavoringsAm J Respir Crit Care Med200717654985041754101510.1164/rccm.200611-1620OC1:CAS:528:DC%2BD2sXhtFSgtLjI – reference: MableyJGordonSPacherPNicotine exerts an anti-inflammatory effect in a murine model of acute lung injuryInflammation20113442312371:CAS:528:DC%2BC3MXosVWjtbk%3D20625922300851110.1007/s10753-010-9228-x – reference: KosmiderLSobczakAProkopowiczAKurekJZacieraMKnysakJCherry-flavoured electronic cigarettes expose users to the inhalation irritant, benzaldehydeThorax201671437637726822067493761610.1136/thoraxjnl-2015-207895This study measured benzaldehyde, a known respiratory irritant, in aerosol generated from flavored e-cigs purchased online. Benzaldehyde was detected in 108 out of 145 products. – reference: MacphersonLJDubinAEEvansMJMarrFSchultzPGCravattBFNoxious compounds activate TRPA1 ion channels through covalent modification of cysteinesNature200744571275415451:CAS:528:DC%2BD2sXhtFWhur0%3D1723776210.1038/nature05544 – reference: RehanVKLiuJNaeemETianJSakuraiRKwongKPerinatal nicotine exposure induces asthma in second generation offspringBMC Med2012101291:CAS:528:DC%2BC3sXjsFyrurY%3D23106849356873710.1186/1741-7015-10-129 – reference: BessacBFSivulaMvon HehnCAEscaleraJCohnLJordtSETRPA1 is a major oxidant sensor in murine airway sensory neuronsJ Clin Invest20081185189919101:CAS:528:DC%2BD1cXlsF2nur0%3D18398506228979610.1172/JCI34192 – reference: PolosaRCampagnaDSandsMFCounseling patients with asthma and allergy about electronic cigarettes: an evidence-based approachAnn Allergy Asthma Immunol201611621061112652225310.1016/j.anai.2015.10.012 – reference: Lopez-SaezMPCarrilloPHuertasAJFernandez-NietoMLopezJDOccupational asthma and dermatitis induced by eugenol in a cleanerJ Investig Allergol Clin Immunol201525164651:STN:280:DC%2BC2MjmvVyrsg%3D%3D25898700 – reference: YangHLiSTransient receptor potential ankyrin 1 (TRPA1) channel and neurogenic inflammation in pathogenesis of asthmaMed Sci Monit2016222917292327539812500316410.12659/MSM.896557This review discusses how activation of TRPA1 expressed in C-fiber nociceptors promotes neurogenic inflammation in asthma. – reference: PolosaRMorjariaJCaponnettoPCarusoMStranoSBattagliaEEffect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversalInt J Environ Res Public Health20141154965497724814944405387910.3390/ijerph110504965A retrospective study which identifies improvements in asthma control, airway hyper-responsiveness, and pulmonary function in asthmatic smokers who quit or dramatically reduced their tobacco consumption by switching to e-cigs. – reference: RehmanRBhatYAPandaLMabalirajanUTRPV1 inhibition attenuates IL-13 mediated asthma features in mice by reducing airway epithelial injuryInt Immunopharmacol20131535976051:CAS:528:DC%2BC3sXks1Sgt74%3D2345370210.1016/j.intimp.2013.02.010 – reference: HartmannKHunzelmannNAllergic contact dermatitis from cinnamon as an odour-neutralizing agent in shoe insolesContact Dermatitis20045042532541518638610.1111/j.0105-1873.2004.00301.x – reference: WillisDNLiuBHaMAJordtSEMorrisJBMenthol attenuates respiratory irritation responses to multiple cigarette smoke irritantsFASEB J20112512443444441:CAS:528:DC%2BC3MXhs1Wlt7jJ21903934323662810.1096/fj.11-188383 – reference: HopkinsDPRaziSLeeksKDPriya KalraGChattopadhyaySKSolerRESmokefree policies to reduce tobacco use: a systematic reviewAm J Prev Med2010382 SupplS275S2892011761210.1016/j.amepre.2009.10.029 – reference: Barrington-TrimisJLSametJMMcConnellRFlavorings in electronic cigarettes: an unrecognized respiratory health hazard?JAMA201431223249324941:CAS:528:DC%2BC2MXit1Onsrw%3D25383564436101110.1001/jama.2014.14830 – reference: KosmiderLSobczakAFikMKnysakJZacieraMKurekJCarbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltageNicotine Tob Res201416101319132624832759483802810.1093/ntr/ntu078 – reference: Alert N. Preventing Lung Disease in Workers Who Use or Make Flavorings. NIOSH Publication No. 2004-110. 2003. – reference: BrooksSMIrritant-induced chronic cough: irritant-induced TRPpathyLung2008186Suppl 1S88S931:CAS:528:DC%2BD1cXksFKjsL4%3D1823996110.1007/s00408-007-9068-0 – reference: CaceresAIBrackmannMEliaMDBessacBFdel CaminoDD’AmoursMA sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthmaProc Natl Acad Sci U S A200910622909991041:CAS:528:DC%2BD1MXntlyrsbc%3D19458046268449810.1073/pnas.0900591106 – reference: PaivaMPiedadeSGasparAToothpaste-induced anaphylaxis caused by mint (Mentha) allergyAllergy2010659120112021:STN:280:DC%2BC3cjks1ehsw%3D%3D20148803 – reference: •• McNeill A, Brose L, Calder R, Hitchman S, Hajek P, McRobbie H. E-cigarettes: an evidence update. Public Health England. 2015;3. A government report by Public Health England (PHE), an agency of England’s Department of Health, which estimates that e-cigs are 95% less harmful to your health than normal cigarettes and supports the use of e-cigs as effective tobacco cessation and reduction aids. – reference: BeharRZLuoWLinSCWangYValleJPankowJFDistribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosolsTob Control201625Suppl 2ii94ii10227633763550384310.1136/tobaccocontrol-2016-053224 – reference: KalraRSinghSPKrackoDMattaSGSharpBMSoporiMLChronic self-administration of nicotine in rats impairs T cell responsivenessJ Pharmacol Exp Ther200230239359391:CAS:528:DC%2BD38XmsF2hsLs%3D1218364910.1124/jpet.302.3.935 – reference: CobbCOHendricksPSEissenbergTElectronic cigarettes and nicotine dependence: evolving products, evolving problemsBMC Med20151311925998379444060210.1186/s12916-015-0355-y – reference: OmvikPHow smoking affects blood pressureBlood Press19965271771:STN:280:DyaK2s%2Fhtlamug%3D%3D916244710.3109/08037059609062111 – reference: LeikaufGDMechanisms of aldehyde-induced bronchial reactivity: role of airway epitheliumRes Rep Health Eff Inst199249135 – reference: SpurlockBWDaileyTMShortness of (fresh) breath--toothpaste-induced bronchospasmN Engl J Med199032326184518461:STN:280:DyaK3M%2FmtFymug%3D%3D2247130 – reference: WalkerLMPrestonMRMagnayJLThomasPBEl HajAJNicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ cultureBone20012866036081:CAS:528:DC%2BD3MXks1Olsbc%3D1142564810.1016/S8756-3282(01)00427-6 – reference: FlourisADChortiMSPoulianitiKPJamurtasAZKostikasKTzatzarakisMNAcute impact of active and passive electronic cigarette smoking on serum cotinine and lung functionInhal Toxicol2013252911011:CAS:528:DC%2BC3sXhs1ahs78%3D2336304110.3109/08958378.2012.758197 – reference: Organization WH. WHO global report on mortality attributable to tobacco. 2012. – reference: WangPChenWLiaoJMatsuoTItoKFowlesJA device-independent evaluation of carbonyl emissions from heated electronic cigarette solventsPLoS One2017121e016981128076380522672710.1371/journal.pone.0169811Quantitation of toxic volatile carbonyl compounds produced when vaping propylene glycol and glycerin under precisely controlled temperatures in the absence of nicotine and flavor additives. – reference: WuSWFowlerDKShafferFJLindbergJEMPetersJHEthyl vanillin activates TRPA1J Pharmacol Exp Ther201736233683771:CAS:528:DC%2BC2sXhs1CmtbbL2862012010.1124/jpet.116.239384This study provides evidence that ethyl vanillin, a common e-cig flavoring agent, is a potent activator of TRPA1. – reference: Anand V, McGinty KL, O’Brien K, Guenthner G, Hahn E, Martin CA. E-cigarette use and beliefs among urban public high school students in North Carolina. J Adolesc Health. 2015;57(1):46–51. https://doi.org/10.1016/j.jadohealth.2015.03.018. – reference: AckermannLAalto-KorteKJolankiRAlankoKOccupational allergic contact dermatitis from cinnamon including one case from airborne exposureContact Dermatitis200960296991920738010.1111/j.1600-0536.2008.01486.x – reference: CourtneyRThe health consequences of smoking—50 years of progress: a report of the surgeon general, 2014 US Department of Health and Human Services Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 20141081 pp. Online (grey literature): http://www/. surgeongeneral. gov/library/reports/50-years-of-progressDrug Alcohol Rev201534669469510.1111/dar.12309 – reference: SubizaJSubizaJLValdiviesoREscribanoPMGarciaRJerezMToothpaste flavor-induced asthmaJ Allergy Clin Immunol1992906 Pt 1100410061:STN:280:DyaK3s%2FpsVCltQ%3D%3D146019010.1016/0091-6749(92)90478-K – reference: D’alessandroABoeckelmannIHammwhönerMGoetteANicotine, cigarette smoking and cardiac arrhythmia: an overviewEur J Prev Cardiol20121932973052277908510.1177/1741826711411738 – reference: LauriolaMMDe BitontoASenaPAllergic contact dermatitis due to cinnamon oil in galenic vaginal suppositoriesActa Derm Venereol20109021871882016930610.2340/00015555-0782 – reference: JiaYLeeLYRole of TRPV receptors in respiratory diseasesBiochim Biophys Acta2007177289159271:CAS:528:DC%2BD2sXosFOjtLc%3D1734694510.1016/j.bbadis.2007.01.013 – reference: Zezima K. Cigarettes without smoke or regulation. New York Times. 2009;1. – reference: ChoJHPaikSYAssociation between electronic cigarette use and asthma among high school students in South KoreaPLoS One2016113e015102226942764477891610.1371/journal.pone.01510221:CAS:528:DC%2BC28XhsFGlu73EThis cross-sectional study investigated the association between e-cig use and asthma in 35,904 high school students. The authors report that e-cig users have an increased association with asthma and are more likely to have had days absent from school due to severe asthma symptoms. – reference: Sanchez-PerezJGarcia-DiezAOccupational allergic contact dermatitis from eugenol, oil of cinnamon and oil of cloves in a physiotherapistContact Dermatitis19994163463471:STN:280:DC%2BD3c%2FotlGisw%3D%3D1061722110.1111/j.1600-0536.1999.tb06189.x – reference: Cantero-RecasensGGonzalezJRFandosCDuran-TauleriaESmitLAKauffmannFLoss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthmaJ Biol Chem20102853627532275351:CAS:528:DC%2BC3cXhtVOnsL7N20639579293461910.1074/jbc.C110.159491 – reference: MishraNCRir-Sima-AhJLangleyRJSinghSPPena-PhilippidesJCKogaTNicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergensJ Immunol200818011765576631:CAS:528:DC%2BD1cXmtVams7Y%3D18490768261413110.4049/jimmunol.180.11.7655 – reference: ZhuSHSunJYBonnevieECumminsSEGamstAYinLFour hundred and sixty brands of e-cigarettes and counting: implications for product regulationTob Control201423Suppl 3iii3iii924935895407867310.1136/tobaccocontrol-2014-051670 – reference: InoueMFujitaTGotoMKumamotoEPresynaptic enhancement by eugenol of spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons is mediated by transient receptor potential A1 channelsNeuroscience20122104034151:CAS:528:DC%2BC38XntlahurY%3D2242623810.1016/j.neuroscience.2012.02.040 – reference: ZhuSHZhuangYLWongSCumminsSETedeschiGJE-cigarette use and associated changes in population smoking cessation: evidence from US current population surveysBMJ2017358j326228747333552604610.1136/bmj.j3262This study used survey data from the largest representative sample of e-cig users among the US population to show that that e-cig use is not only associated with a higher smoking cessation rate at the individual user level but also at the population level. – reference: FedeleDABarnettTEDekevichDGibson-YoungLMMartinasekMJaggerMAPrevalence of and beliefs about electronic cigarettes and hookah among high school students with asthmaAnn Epidemiol201626128658692783965710.1016/j.annepidem.2016.10.004This study used 2014 Florida Youth Tobacco Survey data (n = 32,921) to assess current cigarette, hookah, and e-cig use among high school students with and without asthma. Adolescents with asthma had a higher prevalence of current hookah and e-cig use, reported positive beliefs about tobacco products, and were more likely to live with individuals who used cigarettes, hookah, and e-cig compared with their peers. – reference: Elders MJ, Perry CL, Eriksen MP, Giovino GA. The report of the Surgeon General: preventing tobacco use among young people. Am J Public Health. 1994;84(4):543–7. – reference: JangTYParkCSKimKSHeoMJKimYHBenzaldehyde suppresses murine allergic asthma and rhinitisInt Immunopharmacol20142224444501:CAS:528:DC%2BC2cXht1ylu7jJ2510744110.1016/j.intimp.2014.07.029 – reference: HarrellMBWeaverSRLoukasACreamerMMartiCNJacksonCDFlavored e-cigarette use: characterizing youth, young adult, and adult usersPrev Med Rep2017533401:STN:280:DC%2BC2sjhtlSjtA%3D%3D2789604110.1016/j.pmedr.2016.11.001 – reference: BautistaDMJordtSENikaiTTsurudaPRReadAJPobleteJTRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agentsCell20061246126912821:CAS:528:DC%2BD28Xjt1Khs70%3D1656401610.1016/j.cell.2006.02.023 – reference: KreissKGomaaAKullmanGFedanKSimoesEJEnrightPLClinical bronchiolitis obliterans in workers at a microwave-popcorn plantN Engl J Med200234753303381215147010.1056/NEJMoa020300 – reference: QuirceSFernandez-NietoMdel PozoVSastreBSastreJOccupational asthma and rhinitis caused by eugenol in a hairdresserAllergy20086311371381:STN:280:DC%2BD2sjhsFyjtg%3D%3D17711554 – reference: Leikauf GD. 12 formaldehyde and other aldehydes. Environmental toxicants: human exposures and their health effects. 2000:409. – reference: HinmanAChuangHHBautistaDMJuliusDTRP channel activation by reversible covalent modificationProc Natl Acad Sci U S A20061035119564195681:CAS:528:DC%2BD2sXhsVGksg%3D%3D17164327174826510.1073/pnas.0609598103 – reference: GeissOBianchiIBarrero-MorenoJCorrelation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapoursInt J Hyg Environ Health201621932682771:CAS:528:DC%2BC28Xhs1Kktr8%3D2684741010.1016/j.ijheh.2016.01.004 – reference: SiegelMAlbersABChengDMHamiltonWLBienerLLocal restaurant smoking regulations and the adolescent smoking initiation process: results of a multilevel contextual analysis among Massachusetts youthArch Pediatr Adolesc Med2008162547748318458195294820410.1001/archpedi.162.5.477 – reference: Annesi-MaesanoIHulinMLavaudFRaherisonCKopferschmittCde BlayFPoor air quality in classrooms related to asthma and rhinitis in primary schoolchildren of the French 6 Cities StudyThorax201267868268822436169340275810.1136/thoraxjnl-2011-200391 – reference: BasbaumAIBautistaDMScherrerGJuliusDCellular and molecular mechanisms of painCell200913922672841:CAS:528:DC%2BD1MXhsFWht7zI19837031285264310.1016/j.cell.2009.09.028 – reference: TierneyPAKarpinskiCDBrownJELuoWPankowJFFlavour chemicals in electronic cigarette fluidsTob Control201625e1e10e152587737710.1136/tobaccocontrol-2014-052175This study quantified flavoring chemicals in 30 popular e-cig liquids. Many of the e-liquids contained aldehyde flavoring agents that made up 1 to 4% of the total e-liquid volume. The authors conclude that concentrations of some flavor chemicals in e-cigs are sufficiently high for inhalation exposure by vaping to be of toxicological concern. – reference: ChungGImSTKimYHJungSJRhyuMROhSBActivation of transient receptor potential ankyrin 1 by eugenolNeuroscience20142611531601:CAS:528:DC%2BC2cXitleltbk%3D2438422610.1016/j.neuroscience.2013.12.047 – reference: GarrettBEDubeSTrosclairACaraballoRPechacekTCigarette smoking-United States, 1965–2008MMWR Surveill Summ201160109113 – reference: PadonAAMaloneyEKCappellaJNYouth-targeted e-cigarette marketing in the USTob Regul Sci201731951012808354510.18001/TRS.3.1.9 – reference: BerridgeMJLippPBootmanMDSignal transduction. The calcium entry pas de deuxScience20002875458160416051:CAS:528:DC%2BD3cXhs1OrtL8%3D1073342910.1126/science.287.5458.1604 – reference: TillettTFormaldehyde exposure among children: a potential building block of asthmaEnviron Health Perspect20101183A 1312019405810.1289/ehp.118-a131b – reference: ChoiKBernatDE-cigarette use among Florida youth with and without asthmaAm J Prev Med201651444645327085691503012010.1016/j.amepre.2016.03.010A study which used the 2012 Florida Youth Tobacco Survey data (n = 36,085) to assess the prevalence of e-cig use among asthmatic youth and examine the associations between e-cig use, susceptibility to cigarette smoking, and asthma attack. The authors conclude that e-cig use is more common among asthmatic youth and is associated with increased susceptibility to cigarette smoking. – reference: Clapp PW, Pawlak EA, Lackey JT, Keating JE, Reeber SL, Glish GL, et al. Flavored e-cigarette liquids and cinnamaldehyde impair respiratory innate immune cell function. Am J Physiol Lung Cell Mol Physiol. 2017; https://doi.org/10.1152/ajplung.00452.2016. – reference: BenowitzNLHenningfieldJEReducing the nicotine content to make cigarettes less addictiveTob Control201322suppl 1i14ii723591498363298310.1136/tobaccocontrol-2012-050860 – volume: 28 start-page: 2485 issue: 10 year: 2008 ident: 747_CR118 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5369-07.2008 – volume: 662 start-page: 55 issue: 1–3 year: 2011 ident: 747_CR109 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2011.04.027 – volume: 22 start-page: 444 issue: 2 year: 2014 ident: 747_CR92 publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2014.07.029 – volume: 51 start-page: 446 issue: 4 year: 2016 ident: 747_CR21 publication-title: Am J Prev Med doi: 10.1016/j.amepre.2016.03.010 – volume: 81 start-page: 599 year: 1960 ident: 747_CR77 publication-title: Arch Dermatol doi: 10.1001/archderm.1960.03730040103018 – volume: 23 start-page: iii3 issue: Suppl 3 year: 2014 ident: 747_CR61 publication-title: Tob Control doi: 10.1136/tobaccocontrol-2014-051670 – volume: 533 start-page: 207 issue: 1–3 year: 2006 ident: 747_CR101 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2005.12.063 – volume: 130 start-page: 770 issue: 3 year: 2012 ident: 747_CR59 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2012.04.002 – volume: 445 start-page: 541 issue: 7127 year: 2007 ident: 747_CR117 publication-title: Nature doi: 10.1038/nature05544 – volume: 21 start-page: 833 issue: 6 year: 2008 ident: 747_CR103 publication-title: Pulm Pharmacol Ther doi: 10.1016/j.pupt.2008.09.005 – volume: 287 start-page: 1604 issue: 5458 year: 2000 ident: 747_CR99 publication-title: Science doi: 10.1126/science.287.5458.1604 – volume: 323 start-page: 1845 issue: 26 year: 1990 ident: 747_CR93 publication-title: N Engl J Med – volume: 186 start-page: S88 issue: Suppl 1 year: 2008 ident: 747_CR111 publication-title: Lung doi: 10.1007/s00408-007-9068-0 – volume: 71 start-page: 376 issue: 4 year: 2016 ident: 747_CR85 publication-title: Thorax doi: 10.1136/thoraxjnl-2015-207895 – ident: 747_CR15 – volume: 362 start-page: 150 issue: 2 year: 2004 ident: 747_CR115 publication-title: Neurosci Lett doi: 10.1016/j.neulet.2004.03.016 – volume: 50 start-page: 253 issue: 4 year: 2004 ident: 747_CR81 publication-title: Contact Dermatitis doi: 10.1111/j.0105-1873.2004.00301.x – volume: 7 start-page: 1045 issue: 11 year: 1993 ident: 747_CR40 publication-title: FASEB J doi: 10.1096/fasebj.7.11.8370474 – volume: 47 start-page: 411 issue: 5 year: 2005 ident: 747_CR27 publication-title: Am J Ind Med doi: 10.1002/ajim.20151 – volume: 90 start-page: 1004 issue: 6 Pt 1 year: 1992 ident: 747_CR94 publication-title: J Allergy Clin Immunol doi: 10.1016/0091-6749(92)90478-K – ident: 747_CR1 – volume: 103 start-page: 19564 issue: 51 year: 2006 ident: 747_CR116 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0609598103 – volume: 21 start-page: 99 issue: 114 year: 2016 ident: 747_CR18 publication-title: Discov Med – volume: 34 start-page: 231 issue: 4 year: 2011 ident: 747_CR50 publication-title: Inflammation doi: 10.1007/s10753-010-9228-x – volume: 210 start-page: 403 year: 2012 ident: 747_CR126 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.02.040 – volume: 25 start-page: 4434 issue: 12 year: 2011 ident: 747_CR97 publication-title: FASEB J doi: 10.1096/fj.11-188383 – volume: 358 start-page: j3262 year: 2017 ident: 747_CR16 publication-title: BMJ doi: 10.1136/bmj.j3262 – volume: 139 start-page: 267 issue: 2 year: 2009 ident: 747_CR121 publication-title: Cell doi: 10.1016/j.cell.2009.09.028 – volume: 16 start-page: 1319 issue: 10 year: 2014 ident: 747_CR12 publication-title: Nicotine Tob Res doi: 10.1093/ntr/ntu078 – ident: 747_CR66 doi: 10.3390/ijerph13050465 – volume: 63 start-page: 137 issue: 1 year: 2008 ident: 747_CR76 publication-title: Allergy doi: 10.1111/j.1398-9995.2007.01525.x – volume: 120 start-page: 10 year: 2016 ident: 747_CR22 publication-title: Respir Med doi: 10.1016/j.rmed.2016.09.013 – ident: 747_CR34 doi: 10.1007/978-3-540-69248-5_2 – volume: 22 start-page: i14 issue: suppl 1 year: 2013 ident: 747_CR48 publication-title: Tob Control doi: 10.1136/tobaccocontrol-2012-050860 – volume: 22 start-page: 2917 year: 2016 ident: 747_CR113 publication-title: Med Sci Monit doi: 10.12659/MSM.896557 – volume: 344 start-page: 95 issue: 3–4 year: 1995 ident: 747_CR44 publication-title: Mutat Res Genet Toxicol doi: 10.1016/0165-1218(95)00037-2 – volume: 15 start-page: 155932581769115 issue: 1 year: 2017 ident: 747_CR31 publication-title: Dose Response doi: 10.1177/1559325817691159 – volume: 11 start-page: 4965 issue: 5 year: 2014 ident: 747_CR17 publication-title: Int J Environ Res Public Health doi: 10.3390/ijerph110504965 – volume: 2 start-page: 71 issue: 1 year: 2010 ident: 747_CR112 publication-title: Open Drug Discov J doi: 10.2174/1877381801002030071 – volume: 124 start-page: 1269 issue: 6 year: 2006 ident: 747_CR119 publication-title: Cell doi: 10.1016/j.cell.2006.02.023 – volume: 285 start-page: 27532 issue: 36 year: 2010 ident: 747_CR106 publication-title: J Biol Chem doi: 10.1074/jbc.C110.159491 – volume: 25 start-page: 128 issue: 2 year: 1969 ident: 747_CR37 publication-title: Experientia doi: 10.1007/BF01899077 – volume: 11 start-page: 563 issue: 3 year: 2004 ident: 747_CR51 publication-title: Clin Diagn Lab Immunol doi: 10.1128/CDLI.11.3.563-568.2004 – volume: 49 start-page: 1 year: 1992 ident: 747_CR89 publication-title: Res Rep Health Eff Inst – volume: 261 start-page: 153 year: 2014 ident: 747_CR127 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2013.12.047 – volume: 17 start-page: 151 issue: 3 year: 1997 ident: 747_CR42 publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(97)00040-7 – volume: 25 start-page: 11 issue: Suppl 1 year: 2006 ident: 747_CR87 publication-title: Int J Toxicol doi: 10.1080/10915810600716612 – volume: 52 start-page: 503 issue: 12 year: 1991 ident: 747_CR86 publication-title: Am Ind Hyg Assoc J doi: 10.1080/15298669191365126 – volume: 118 start-page: 1899 issue: 5 year: 2008 ident: 747_CR120 publication-title: J Clin Invest doi: 10.1172/JCI34192 – volume: 15 start-page: 597 issue: 3 year: 2013 ident: 747_CR108 publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2013.02.010 – volume: 83 start-page: 148 issue: 1–2 year: 1998 ident: 747_CR55 publication-title: J Neuroimmunol doi: 10.1016/S0165-5728(97)00231-2 – volume: 8 start-page: 8358 issue: 6 year: 2015 ident: 747_CR29 publication-title: Int J Clin Exp Med – volume: 41 start-page: 224 issue: 2 year: 1984 ident: 747_CR84 publication-title: Br J Ind Med – volume: 20 start-page: 1155 issue: 7 year: 2016 ident: 747_CR128 publication-title: Eur J Pain doi: 10.1002/ejp.840 – ident: 747_CR130 doi: 10.1183/09031936.04.00039004 – volume: 5 start-page: 71 issue: 2 year: 1996 ident: 747_CR39 publication-title: Blood Press doi: 10.3109/08037059609062111 – volume: 17 start-page: 168 issue: 2 year: 2015 ident: 747_CR73 publication-title: Nicotine Tob Res doi: 10.1093/ntr/ntu176 – volume: 12 start-page: e0169811 issue: 1 year: 2017 ident: 747_CR28 publication-title: PLoS One doi: 10.1371/journal.pone.0169811 – volume: 25 start-page: ii62 issue: Suppl 2 year: 2016 ident: 747_CR63 publication-title: Tob Control doi: 10.1136/tobaccocontrol-2016-053174 – volume: 23 start-page: 360 year: 2008 ident: 747_CR114 publication-title: Physiology (Bethesda) doi: 10.1152/physiol.00026.2008 – volume: 15 start-page: 120 year: 2015 ident: 747_CR25 publication-title: BMC Pulm Med doi: 10.1186/s12890-015-0106-z – volume: 60 start-page: 109 year: 2011 ident: 747_CR3 publication-title: MMWR Surveill Summ – volume: 162 start-page: 477 issue: 5 year: 2008 ident: 747_CR6 publication-title: Arch Pediatr Adolesc Med doi: 10.1001/archpedi.162.5.477 – volume: 18 start-page: 33 issue: 1 year: 2017 ident: 747_CR24 publication-title: Respir Res doi: 10.1186/s12931-017-0518-9 – volume: 2005 start-page: re3 issue: 272 year: 2005 ident: 747_CR100 publication-title: Sci STKE doi: 10.1126/stke.2722005re3 – volume: 26 start-page: 865 issue: 12 year: 2016 ident: 747_CR20 publication-title: Ann Epidemiol doi: 10.1016/j.annepidem.2016.10.004 – volume: 106 start-page: 9099 issue: 22 year: 2009 ident: 747_CR122 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0900591106 – volume: 60 start-page: 96 issue: 2 year: 2009 ident: 747_CR80 publication-title: Contact Dermatitis doi: 10.1111/j.1600-0536.2008.01486.x – volume: 24 start-page: 280 issue: 3 year: 2011 ident: 747_CR105 publication-title: Pulm Pharmacol Ther doi: 10.1016/j.pupt.2010.12.003 – ident: 747_CR88 – volume: 28 start-page: 603 issue: 6 year: 2001 ident: 747_CR41 publication-title: Bone doi: 10.1016/S8756-3282(01)00427-6 – volume: 68 start-page: 931 issue: 6 year: 2011 ident: 747_CR56 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-010-0525-1 – volume: 25 start-page: e10 issue: e1 year: 2016 ident: 747_CR98 publication-title: Tob Control doi: 10.1136/tobaccocontrol-2014-052175 – volume: 115 start-page: 268 issue: 2 year: 2013 ident: 747_CR96 publication-title: J Appl Physiol (1985) doi: 10.1152/japplphysiol.01144.2012 – volume: 40 start-page: 165 issue: 3 year: 1999 ident: 747_CR83 publication-title: Contact Dermatitis doi: 10.1111/j.1600-0536.1999.tb06021.x – volume: 308 start-page: L788 issue: 8 year: 2015 ident: 747_CR46 publication-title: Am J Physiol Lung Cell Mol Physiol. doi: 10.1152/ajplung.00234.2014 – volume: 3 start-page: 95 issue: 1 year: 2017 ident: 747_CR67 publication-title: Tob Regul Sci doi: 10.18001/TRS.3.1.9 – volume: 312 start-page: L812 issue: 6 year: 2017 ident: 747_CR110 publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00064.2017 – volume: 13 start-page: 119 year: 2015 ident: 747_CR64 publication-title: BMC Med doi: 10.1186/s12916-015-0355-y – volume: 302 start-page: 935 issue: 3 year: 2002 ident: 747_CR52 publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.302.3.935 – volume: 65 start-page: 1201 issue: 9 year: 2010 ident: 747_CR95 publication-title: Allergy doi: 10.1111/j.1398-9995.2010.02329.x – volume: 41 start-page: 346 issue: 6 year: 1999 ident: 747_CR82 publication-title: Contact Dermatitis doi: 10.1111/j.1600-0536.1999.tb06189.x – volume: 19 start-page: 297 issue: 3 year: 2012 ident: 747_CR35 publication-title: Eur J Prev Cardiol doi: 10.1177/1741826711411738 – ident: 747_CR74 – volume: 26 start-page: 189 issue: 4 year: 2015 ident: 747_CR78 publication-title: Dermatitis doi: 10.1097/DER.0000000000000126 – volume: 10 start-page: 129 year: 2012 ident: 747_CR45 publication-title: BMC Med doi: 10.1186/1741-7015-10-129 – volume: 116 start-page: 106 issue: 2 year: 2016 ident: 747_CR19 publication-title: Ann Allergy Asthma Immunol doi: 10.1016/j.anai.2015.10.012 – volume: 11 start-page: e0151022 issue: 3 year: 2016 ident: 747_CR23 publication-title: PLoS One doi: 10.1371/journal.pone.0151022 – ident: 747_CR69 doi: 10.1152/ajplung.00452.2016 – volume: 67 start-page: 682 issue: 8 year: 2012 ident: 747_CR91 publication-title: Thorax doi: 10.1136/thoraxjnl-2011-200391 – volume: 7 start-page: 13202 year: 2016 ident: 747_CR49 publication-title: Nat Commun doi: 10.1038/ncomms13202 – ident: 747_CR14 – volume: 118 start-page: A 131 issue: 3 year: 2010 ident: 747_CR30 publication-title: Environ Health Perspect doi: 10.1289/ehp.118-a131b – volume: 110 start-page: 505 issue: Suppl 4 year: 2002 ident: 747_CR90 publication-title: Environ Health Perspect doi: 10.1289/ehp.02110s4505 – volume: 25 start-page: ii94 issue: Suppl 2 year: 2016 ident: 747_CR68 publication-title: Tob Control doi: 10.1136/tobaccocontrol-2016-053224 – volume: 9 start-page: 243 issue: 3 year: 2009 ident: 747_CR104 publication-title: Curr Opin Pharmacol doi: 10.1016/j.coph.2009.02.002 – ident: 747_CR7 doi: 10.2105/AJPH.84.4.543 – volume: 347 start-page: 330 issue: 5 year: 2002 ident: 747_CR70 publication-title: N Engl J Med doi: 10.1056/NEJMoa020300 – volume: 61 start-page: 1 issue: 4 year: 2012 ident: 747_CR4 publication-title: Morb Mortal Wkly Rep Surveill Summ – volume: 38 start-page: S275 issue: 2 Suppl year: 2010 ident: 747_CR5 publication-title: Am J Prev Med doi: 10.1016/j.amepre.2009.10.029 – volume: 50 start-page: 9644 issue: 17 year: 2016 ident: 747_CR13 publication-title: Environ Sci Technol doi: 10.1021/acs.est.6b01741 – volume: 172 start-page: 641 issue: 6 year: 1962 ident: 747_CR38 publication-title: J Intern Med – volume: 312 start-page: 2493 issue: 23 year: 2014 ident: 747_CR72 publication-title: JAMA doi: 10.1001/jama.2014.14830 – volume: 23 start-page: 189 issue: 2 year: 1998 ident: 747_CR53 publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(97)00076-0 – volume: 9 start-page: 631 year: 1961 ident: 747_CR36 publication-title: Circ Res doi: 10.1161/01.RES.9.3.631 – volume: 138 start-page: e20162513 year: 2016 ident: 747_CR65 publication-title: Pediatrics doi: 10.1542/peds.2016-2513 – volume: 125 start-page: 89 year: 2017 ident: 747_CR129 publication-title: Respir Med doi: 10.1016/j.rmed.2017.02.004 – volume: 9 start-page: 628 issue: 5 year: 2006 ident: 747_CR125 publication-title: Nat Neurosci doi: 10.1038/nn1692 – volume: 66 start-page: 65 year: 2014 ident: 747_CR8 publication-title: Prev Med doi: 10.1016/j.ypmed.2014.06.014 – volume: 305 start-page: L501 issue: 7 year: 2013 ident: 747_CR47 publication-title: Am J Physiol Lung Cell Mol Physiol. doi: 10.1152/ajplung.00078.2013 – volume: 180 start-page: 7655 issue: 11 year: 2008 ident: 747_CR57 publication-title: J Immunol doi: 10.4049/jimmunol.180.11.7655 – volume: 176 start-page: 498 issue: 5 year: 2007 ident: 747_CR71 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200611-1620OC – volume: 90 start-page: 187 issue: 2 year: 2010 ident: 747_CR79 publication-title: Acta Derm Venereol doi: 10.2340/00015555-0782 – volume: 5 start-page: 1117 issue: 11 year: 2014 ident: 747_CR123 publication-title: ACS Chem Neurosci doi: 10.1021/cn500094a – volume: 230 start-page: 1 issue: 1 year: 2004 ident: 747_CR60 publication-title: Cell Immunol doi: 10.1016/j.cellimm.2004.07.007 – volume: 12 start-page: 91 issue: 2 year: 2002 ident: 747_CR32 publication-title: J Investig Allergol Clin Immunol – volume: 437 start-page: 279 year: 1998 ident: 747_CR54 publication-title: Adv Exp Med Biol doi: 10.1007/978-1-4615-5347-2_31 – volume: 362 start-page: 368 issue: 3 year: 2017 ident: 747_CR124 publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.116.239384 – volume: 34 start-page: 694 issue: 6 year: 2015 ident: 747_CR2 publication-title: Drug Alcohol Rev doi: 10.1111/dar.12309 – volume: 29 start-page: 748 issue: 4 year: 1999 ident: 747_CR43 publication-title: J Vasc Surg doi: 10.1016/S0741-5214(99)70329-0 – ident: 747_CR10 doi: 10.1093/ntr/ntu156 – volume: 36 start-page: e29 issue: 2 year: 2015 ident: 747_CR107 publication-title: Allergy Asthma Proc doi: 10.2500/aap.2015.36.3828 – ident: 747_CR9 doi: 10.1016/j.jadohealth.2015.03.018 – volume: 25 start-page: 91 issue: 2 year: 2013 ident: 747_CR26 publication-title: Inhal Toxicol doi: 10.3109/08958378.2012.758197 – volume: 5 start-page: 33 year: 2017 ident: 747_CR62 publication-title: Prev Med Rep doi: 10.1016/j.pmedr.2016.11.001 – volume: 25 start-page: 64 issue: 1 year: 2015 ident: 747_CR75 publication-title: J Investig Allergol Clin Immunol – volume: 307 start-page: L149 issue: 2 year: 2014 ident: 747_CR58 publication-title: Am J Physiol Lung Cell Mol Physiol. doi: 10.1152/ajplung.00396.2012 – volume: 219 start-page: 268 issue: 3 year: 2016 ident: 747_CR11 publication-title: Int J Hyg Environ Health doi: 10.1016/j.ijheh.2016.01.004 – volume: 1772 start-page: 915 issue: 8 year: 2007 ident: 747_CR102 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2007.01.013 – volume: 43 start-page: 619 issue: 6 year: 2004 ident: 747_CR33 publication-title: 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Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer... Vaping is gaining popularity in the USA, particularly among teens and young adults. While e-cigs are commonly represented as safer alternatives to tobacco... |
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| SubjectTerms | Allergies and the Environment (M Hernandez Allergology Animals Asthma Asthma - etiology Chronic obstructive pulmonary disease Electronic cigarettes Electronic Nicotine Delivery Systems Flavoring Agents - toxicity Flavors Health risk assessment Humans Lung - drug effects Lung - immunology Lung - metabolism Medicine Medicine & Public Health Nicotine Section Editor Smoking - adverse effects Teenagers Topical Collection on Allergies and the Environment Transient Receptor Potential Channels - metabolism |
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| Title | Electronic Cigarettes: Their Constituents and Potential Links to Asthma |
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