Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite - Kadirvelraj, Renuka; Yang, Jeong-Yeh; Sanders, Justin H.; Liu, Lin; Ramiah, Annapoorani; Prabhakar, Pradeep Kumar; Boons, Geert-Jan; Wood, Zachary A.; Moremen, Kelley W. (Proceedings of the National Academy of Sciences - PNAS, 2018)
Keywords: Architecture; BASIC BIOLOGICAL SCIENCES; Biological Sciences; Biosynthesis; Catalysis; Catalytic converters; Cells; Chain branching; Chemical synthesis; Convergence; convergent evolution; Coordination compounds; exosite; Glycan; Glycoproteins; Glycoside hydrolase; glycosyltranferase; Golgi apparatus; Humans; Hydrolase; Mammalian cells; Mannosidase; Modular structures; Monosaccharides; N-Acetylglucosaminyltransferases - chemistry; N-Acetylglucosaminyltransferases - metabolism; N-Acetylglucosinyldiphosphodolichol N-acetylglucosaminyltransferase; N-glycan processing; Oligosaccharides; Polysaccharides; Protein Domains; Protein Folding; Recognition; substrate recognition; Substrates; Sugar; Trimming; Uridine Diphosphate N-Acetylglucosamine - chemistry; Uridine Diphosphate N-Acetylglucosamine - metabolism; glycosyltranferase; N-glycan processing; substrate recognition; convergent evolution; exosite