Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth - Yan, Huaming; Konstorum, Anna; Lowengrub, John S. (Bulletin of mathematical biology, 2018)
Keywords: Animals; Bone morphogenetic proteins; Brain cancer; Cancer; Cell Biology; Cell Death; Cell Differentiation; Cell Lineage; Cell Self Renewal; Colon; Colon cancer; Colonic Neoplasms - pathology; Colorectal cancer; Computer Simulation; Control theory; Feedback; Feedback loops; Feedback, Physiological; Fingers; Hepatocyte growth factor; Humans; Imaging, Three-Dimensional; Invasiveness; Life Sciences; Low concentrations; Mathematical and Computational Biology; Mathematical Concepts; Mathematical models; Mathematics; Mathematics and Statistics; Models, Biological; Negative feedback; Neoplastic Stem Cells - pathology; Organoids; Organoids - pathology; Promoters; Proteins; Spatio-Temporal Analysis; Special Issue : Mathematical Oncology; Stem cells; Three dimensional models; Tumors; Wnt protein; Feedback regulation; Mathematical modeling; Cancer stem cells; Cancer therapies; Brain tumors