Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence

This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was...

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Published inEuropean journal of obstetrics & gynecology and reproductive biology Vol. 184; pp. 117 - 124
Main Authors Zhao, Linjie, Yang, Huiliang, Xuan, Yu, Luo, Zhongyue, Lin, Qiao, Zhao, Jitong, Ren, Ning, Zhou, Shengtao, Zhao, Xia
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.01.2015
Subjects
Animals
Computational Biology
Disease Models, Animal
Dysmenorrhea
Dysmenorrhea - etiology
Dysmenorrhea - genetics
Dysmenorrhea - metabolism
Dysmenorrhea - pathology
Endometriosis
Endometriosis - complications
Endometriosis - genetics
Endometriosis - metabolism
Endometriosis - pathology
Endometrium - metabolism
Endometrium - pathology
Female
FGFR1
Gene Expression Profiling
Humans
Mice
Mice, Nude
Obstetrics and Gynecology
Receptor, Fibroblast Growth Factor, Type 1 - genetics
Receptor, Fibroblast Growth Factor, Type 1 - metabolism
Recurrence
Recurrence
Endometriosis
Dysmenorrhea
FGFR1
Online AccessGet full text
ISSN0301-2115
1872-7654
1872-7654
DOI10.1016/j.ejogrb.2014.11.013

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Abstract This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo. FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients (P<0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo. FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity (P<0.05) and recurrence in endometriosis patients (P<0.05). FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.
AbstractList This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence.OBJECTIVE(S)This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence.We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo.STUDY DESIGNWe utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo.FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients (P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo. FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity (P < 0.05) and recurrence in endometriosis patients (P < 0.05).RESULTSFGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients (P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo. FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity (P < 0.05) and recurrence in endometriosis patients (P < 0.05).FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.CONCLUSION(S)FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.
This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo. FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients (P<0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo. FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity (P<0.05) and recurrence in endometriosis patients (P<0.05). FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.
Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence. Study design We utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo. Results FGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients ( P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo . FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity ( P < 0.05) and recurrence in endometriosis patients ( P < 0.05). Conclusion(s) FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.
Author Yang, Huiliang
Xuan, Yu
Lin, Qiao
Zhao, Linjie
Zhao, Xia
Luo, Zhongyue
Zhao, Jitong
Ren, Ning
Zhou, Shengtao
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  surname: Ren
  fullname: Ren, Ning
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  email: taotaovip2005@163.com
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Keywords Recurrence
Endometriosis
Dysmenorrhea
FGFR1
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Snippet This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea...
Abstract Objective(s) This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its...
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SubjectTerms Animals
Computational Biology
Disease Models, Animal
Dysmenorrhea
Dysmenorrhea - etiology
Dysmenorrhea - genetics
Dysmenorrhea - metabolism
Dysmenorrhea - pathology
Endometriosis
Endometriosis - complications
Endometriosis - genetics
Endometriosis - metabolism
Endometriosis - pathology
Endometrium - metabolism
Endometrium - pathology
Female
FGFR1
Gene Expression Profiling
Humans
Mice
Mice, Nude
Obstetrics and Gynecology
Receptor, Fibroblast Growth Factor, Type 1 - genetics
Receptor, Fibroblast Growth Factor, Type 1 - metabolism
Recurrence
Title Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence
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https://dx.doi.org/10.1016/j.ejogrb.2014.11.013
https://www.ncbi.nlm.nih.gov/pubmed/25500535
https://www.proquest.com/docview/1642608330
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