β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline - Hammond, Tyler C.; Xing, Xin; Wang, Chris; Ma, David; Nho, Kwangsik; Crane, Paul K.; Elahi, Fanny; Ziegler, David A.; Liang, Gongbo; Cheng, Qiang; Yanckello, Lucille M.; Jacobs, Nathan; et al. (Communications biology, 2020)
Keywords: 59/57; 59/78; 631/378/116/2396; 692/53/2423; Aged; Algorithms; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Biomarkers; Biomarkers - metabolism; Biomedical and Life Sciences; Brain - diagnostic imaging; Brain - metabolism; Brain - pathology; Clinical trials; Dementia; Dementia disorders; Disease Progression; Female; Glucose; Glucose - metabolism; Humans; Learning algorithms; Life Sciences; Machine learning; Magnetic Resonance Imaging; Male; Medical imaging; Mental Status and Dementia Tests; Neurodegeneration; Neurodegenerative diseases; Neuroimaging; Positron-Emission Tomography; Tau protein; tau Proteins - metabolism; β-Amyloid