Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells

• Published in: European heart journal Vol. 30; no. 5; pp. 584 - 593
• Main Authors: Stellos, Konstantinos, Bigalke, Boris, Langer, Harald, Geisler, Tobias, Schad, Annika, Kögel, Andreas, Pfaff, Florian, Stakos, Dimitrios, Seizer, Peter, Müller, Iris, Htun, Patrick, Lindemann, Stephan, Gawaz, Meinrad
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2009; Oxford Publishing Limited (England)
• Subjects: Acute coronary syndrome; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - physiopathology; Aged; Aged, 80 and over; Antigens, CD34 - blood; Biological and medical sciences; Biomarkers - blood; Blood Platelets - metabolism; Cardiology. Vascular system; Cell Count; Chemokine CXCL12 - blood; Coronary heart disease; Female; Heart; Hematopoietic Stem Cells - metabolism; Humans; Male; Medical sciences; Middle Aged; Myocarditis. Cardiomyopathies; Platelet Activation; Platelets; Progenitor cells; SDF-1; Stroke Volume; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - physiopathology; SDF-1; Platelets; Acute coronary syndrome; Progenitor cells; Human; Cardiovascular disease; Gene expression; Coronary heart disease; Myocardial disease; Stromal cell derived factor 1; Platelet; Number; Circulatory system; Cardiology; CXC chemokine; Progenitor cell
• ISSN: 0195-668X; 1522-9645; 1522-9645
• DOI: 10.1093/eurheartj/ehn566

Aims Previous experimental studies have suggested that platelet stromal-cell-derived factor-1 (SDF-1) regulates mobilization and recruitment of haematopoietic progenitor cells supporting revascularization in mice. However, there are no clinical data available regarding platelet-bound SDF-1 in patients with acute coronary syndrome (ACS). The objective of this study was to evaluate the platelet-surface expression of SDF-1 in patients with ACS. Methods and results Patients with ACS (n = 418) showed a significantly enhanced SDF-1 expression on admission compared with those with stable angina pectoris (SAP, n = 486) [SAP (mean fluorescence intensity (MFI) ± SD): 13.48 ± 5.27; ACS: 18.45 ± 12.85; P < 0.001) independent of cardiovascular risk factors and medication. Enhanced platelet-bound SDF-1 expression was found in patients with reduced left ventricular ejection fraction (LVEF <55%) in comparison to patients with normal LVEF (P = 0.005). Platelet-bound SDF-1 expression positively correlated with the degree of platelet activation [CD62P: r = 0.325; glycoprotein VI (GPVI): r = 0.277; PAC-1: r = 0.501; P < 0.001 for all] and showed a significant, but slight association with plasma levels of SDF-1 (r = 0.084; P = 0.045). In a subgroup of patients with coronary artery disease, platelet-bound SDF-1, but not other platelet activation markers, significantly correlated with the number of circulating CD34+ progenitor cells (r = 0.252; P = 0.002) or CD34+/CD133+ endothelial progenitor cells (r = 0.352; P = 0.008). Conclusion Platelet-bound SDF-1 may play an important role in peripheral homing of circulating progenitor cells thus in tissue regeneration.