Rational design of a SOCS1-edited tumor-infiltrating lymphocyte therapy using CRISPR/Cas9 screens - Schlabach, Michael R.; Lin, Sharon; Collester, Zachary R.; Wrocklage, Christopher; Shenker, Sol; Calnan, Conor; Xu, Tianlei; Gannon, Hugh S.; Williams, Leila J.; Thompson, Frank; Dunbar, Paul R.; LaMothe, Robert A.; et al. (The Journal of clinical investigation, 2023)
Keywords: Animal models; Antitumor activity; Biomedical research; CD8 antigen; Cell culture; Cells; CRISPR; Cytokines; Genes; Immunological memory; Immunology; Lymphocytes; Lymphocytes T; Melanoma; Memory cells; Metastasis; Progenitor cells; Solid tumors; Therapeutics; Tumors; Immunology; Cancer immunotherapy; Gene therapy; T cells; Therapeutics