Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming - Wu, Shaofa; Luo, Xiaolin; Chen, Yang; Wang, Zelan; Liu, Xi; Sun, Ning; Zhao, Junyong; Luo, Wenjian; Zhang, Jiawen; Tong, Xiaoyong; Huang, Lan; Liu, Chuan; et al. (Redox biology, 2024)
Keywords: Animals; Benzhydryl Compounds - pharmacology; Core Binding Factor Alpha 1 Subunit - genetics; Core Binding Factor Alpha 1 Subunit - metabolism; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Disease Models, Animal; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; Endoplasmic reticulum stress; Endoplasmic Reticulum Stress - drug effects; Female; Glucosides - pharmacology; Humans; Male; Mice; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Osteogenesis - drug effects; Rats; Runx2; Sodium-glucose cotransporter 2 inhibitors; Sodium-Glucose Transporter 2 Inhibitors - pharmacology; Thioredoxin domain containing 5; Thioredoxins - genetics; Thioredoxins - metabolism; Vascular calcification; Vascular Calcification - drug therapy; Vascular Calcification - etiology; Vascular Calcification - metabolism; Vascular Calcification - pathology; Vascular calcification; Thioredoxin domain containing 5; Sodium-glucose cotransporter 2 inhibitors; Runx2; Endoplasmic reticulum stress