Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Key Points Notable heterogeneity exists in the neuropathological substrates that underlie dementia in the setting of Parkinson's disease dementia (PDD). Nevertheless, the presumptive caudal-to-rostral spread of Lewy body and neurite pathology from the lower brainstem to telencephalic regions, w...
Saved in:
| Published in | Nature reviews. Neuroscience Vol. 14; no. 9; pp. 626 - 636 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.09.2013
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1471-003X 1471-0048 1471-0048 |
| DOI | 10.1038/nrn3549 |
Cover
| Abstract | Key Points
Notable heterogeneity exists in the neuropathological substrates that underlie dementia in the setting of Parkinson's disease dementia (PDD). Nevertheless, the presumptive caudal-to-rostral spread of Lewy body and neurite pathology from the lower brainstem to telencephalic regions, which culminates in a heavy burden of this α-synuclein (α-syn) pathology in limbic and neocortical structures, is the most characteristic pathological finding in most PDD cases.
Up to 50% of patients with PDD can have sufficient amyloid-β (Aβ) plaque and tau neurofibrillary tangle (NFT) pathology for the diagnosis of a second neurodegenerative dementia — that is, Alzheimer's disease (AD) — and this co-morbid pathology is more common in PDD than PD.
Tau NFT and Aβ plaque pathology may act synergistically with Lewy body and neurite pathology to confer a worse prognosis and a higher burden of cortical Lewy body and neurite pathology in PDD.
Clinical phenotypes of PD may help to identify neuropathological subtypes of PD that exhibit differing propensities for developing dementia. For example, non-tremor-dominant or postural gait instability PD phenotypes may often be associated with greater Aβ plaque pathology and shorter times to dementia in patients with PDD than in patients with PD exhibiting less co-morbid AD neuropathology and a tremor-dominant phenotype.
Genetic variations may contribute to the heterogeneity in the neuropathology and the time-of-onset of dementia in PD. For example, the apolipoprotein E (
APOE
) ε4 genotype may increase both Lewy body and neurite pathology and AD neuropathology and result in an increased risk of dementia in PD. Moreover, heterozygous mutations in β-glucocerebrosidase (
GBA
) may increase the severity of Lewy body and neurite patholgy in 'pure' synucleinopathies.
Further biomarker and detailed clinicopathological correlation studies of prospective patients will help to further elucidate the inter-relationships of AD and α-syn pathology in PD and the development of dementia in patients with PD. These discoveries will be crucial in the development of meaningful disease-modifying therapies for PDD.
Many cases of Parkinson's disease (PD) are characterized by not only deficits in movement but also cognitive dysfunction, which can develop into dementia. Here, Irwin
et al
. review the complex connections between the neuropathological aetiologies that underlie the cognitive deficits associated with PD.
Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in PD. In addition, up to 50% of patients with PDD also develop sufficient numbers of amyloid-β plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease, and these pathologies may act synergistically with α-syn pathology to confer a worse prognosis. An understanding of the relationships between these three distinct pathologies and their resultant clinical phenotypes is crucial for the development of effective disease-modifying treatments for PD and PDD. |
|---|---|
| AbstractList | Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in PD. In addition, up to 50% of patients with PDD also develop sufficient numbers of amyloid-β plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease, and these pathologies may act synergistically with α-syn pathology to confer a worse prognosis. An understanding of the relationships between these three distinct pathologies and their resultant clinical phenotypes is crucial for the development of effective disease-modifying treatments for PD and PDD. Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in PD. In addition, up to 50% of patients with PDD also develop sufficient amyloid-β plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease (AD), and these pathologies may act synergistically with α-syn pathology to confer a worse prognosis. Understanding the relationships between these three distinct pathologies and their resultant clinical phenotypes are crucial to the development of effective disease-modifying treatments for PD and PDD. Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in PD. In addition, up to 50% of patients with PDD also develop sufficient numbers of amyloid-β plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease, and these pathologies may act synergistically with α-syn pathology to confer a worse prognosis. An understanding of the relationships between these three distinct pathologies and their resultant clinical phenotypes is crucial for the development of effective disease-modifying treatments for PD and PDD.Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in PD. In addition, up to 50% of patients with PDD also develop sufficient numbers of amyloid-β plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease, and these pathologies may act synergistically with α-syn pathology to confer a worse prognosis. An understanding of the relationships between these three distinct pathologies and their resultant clinical phenotypes is crucial for the development of effective disease-modifying treatments for PD and PDD. Key Points Notable heterogeneity exists in the neuropathological substrates that underlie dementia in the setting of Parkinson's disease dementia (PDD). Nevertheless, the presumptive caudal-to-rostral spread of Lewy body and neurite pathology from the lower brainstem to telencephalic regions, which culminates in a heavy burden of this α-synuclein (α-syn) pathology in limbic and neocortical structures, is the most characteristic pathological finding in most PDD cases. Up to 50% of patients with PDD can have sufficient amyloid-β (Aβ) plaque and tau neurofibrillary tangle (NFT) pathology for the diagnosis of a second neurodegenerative dementia — that is, Alzheimer's disease (AD) — and this co-morbid pathology is more common in PDD than PD. Tau NFT and Aβ plaque pathology may act synergistically with Lewy body and neurite pathology to confer a worse prognosis and a higher burden of cortical Lewy body and neurite pathology in PDD. Clinical phenotypes of PD may help to identify neuropathological subtypes of PD that exhibit differing propensities for developing dementia. For example, non-tremor-dominant or postural gait instability PD phenotypes may often be associated with greater Aβ plaque pathology and shorter times to dementia in patients with PDD than in patients with PD exhibiting less co-morbid AD neuropathology and a tremor-dominant phenotype. Genetic variations may contribute to the heterogeneity in the neuropathology and the time-of-onset of dementia in PD. For example, the apolipoprotein E ( APOE ) ε4 genotype may increase both Lewy body and neurite pathology and AD neuropathology and result in an increased risk of dementia in PD. Moreover, heterozygous mutations in β-glucocerebrosidase ( GBA ) may increase the severity of Lewy body and neurite patholgy in 'pure' synucleinopathies. Further biomarker and detailed clinicopathological correlation studies of prospective patients will help to further elucidate the inter-relationships of AD and α-syn pathology in PD and the development of dementia in patients with PD. These discoveries will be crucial in the development of meaningful disease-modifying therapies for PDD. Many cases of Parkinson's disease (PD) are characterized by not only deficits in movement but also cognitive dysfunction, which can develop into dementia. Here, Irwin et al . review the complex connections between the neuropathological aetiologies that underlie the cognitive deficits associated with PD. Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in PD. In addition, up to 50% of patients with PDD also develop sufficient numbers of amyloid-β plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease, and these pathologies may act synergistically with α-syn pathology to confer a worse prognosis. An understanding of the relationships between these three distinct pathologies and their resultant clinical phenotypes is crucial for the development of effective disease-modifying treatments for PD and PDD. |
| Audience | Academic |
| Author | Lee, Virginia M.-Y. Trojanowski, John Q. Irwin, David J. |
| AuthorAffiliation | 2 Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6021, USA 1 Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer's Disease Core Center, Institute on Aging, Philadelphia, PA 19104-6021, USA |
| AuthorAffiliation_xml | – name: 2 Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6021, USA – name: 1 Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Alzheimer's Disease Core Center, Institute on Aging, Philadelphia, PA 19104-6021, USA |
| Author_xml | – sequence: 1 givenname: David J. surname: Irwin fullname: Irwin, David J. organization: Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer's Disease Core Center, Institute on Aging, University of Pennsylvania Perelman School of Medicine, HUP, Department of Neurology, University of Pennsylvania Perelman School of Medicine – sequence: 2 givenname: Virginia M.-Y. surname: Lee fullname: Lee, Virginia M.-Y. organization: Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer's Disease Core Center, Institute on Aging, University of Pennsylvania Perelman School of Medicine, HUP – sequence: 3 givenname: John Q. surname: Trojanowski fullname: Trojanowski, John Q. email: trojanow@mail.med.upenn.edu organization: Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Alzheimer's Disease Core Center, Institute on Aging, University of Pennsylvania Perelman School of Medicine, HUP |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23900411$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkttqFTEUhoO02JP4BhLwol50ak6TmfFCKMUeoKAXFfQqZDJrpqmZZJvMFPZj6YP0mcxm7xZrJRcJyZef_19r7aEtHzwg9JqSY0p4_d5Hz0vRvEC7VFS0IETUW49n_m0H7aV0SwiVtJIv0Q7jTUYo3UXfv-j4w_oU_GHCnU2gE-AORvCT1R-wCf4O4gDeAA49vv9VpKWfjQPrj_CkZ6x9h_W4dMF2xf1vvNDTTXBhsJAO0HavXYJXm30ffT37dH16UVx9Pr88PbkqjJDNVPSSdGVlQDRcUt6yFipGSN2WnDDGpC5r3rTMcC0ayUwPlaBlyzpOSN9S2Wq-jz6udRdzO0JnsvOonVpEO-q4VEFb9fTF2xs1hDslCK0YL7PAu41ADD9nSJMabTLgnPYQ5qSoYLISdd3QjL5do4N2oKzvQ1Y0K1ydcJGdCSlJpo7_Q-WV62pzRaG3-f7Jhzd_R3j0_tCmDBRrwMSQUoReGTvpyYZVIusUJWo1BmozBpk__Id_kHxObsKnTPgBoroNc_S5Yc_QP93iwC0 |
| CitedBy_id | crossref_primary_10_3390_biom12020329 crossref_primary_10_1002_acn3_51988 crossref_primary_10_1002_mds_27075 crossref_primary_10_1007_s12035_024_04119_2 crossref_primary_10_1007_s00401_020_02227_6 crossref_primary_10_1111_nan_12829 crossref_primary_10_1007_s13139_024_00842_9 crossref_primary_10_3390_ijms21093301 crossref_primary_10_1093_jnen_nlx002 crossref_primary_10_1016_S1875_5364_22_60145_6 crossref_primary_10_3389_fnins_2015_00059 crossref_primary_10_1016_j_nbd_2016_12_021 crossref_primary_10_3389_fnins_2024_1453499 crossref_primary_10_3390_ijms25031672 crossref_primary_10_1016_j_pneurobio_2018_09_007 crossref_primary_10_1534_genetics_115_179457 crossref_primary_10_1016_j_parkreldis_2021_09_008 crossref_primary_10_1021_acs_nanolett_1c00058 crossref_primary_10_15324_kjcls_2022_54_4_249 crossref_primary_10_1002_mds_29367 crossref_primary_10_1016_j_pneurobio_2020_101822 crossref_primary_10_3390_bioengineering7040162 crossref_primary_10_1111_bpa_12505 crossref_primary_10_1002_pro_4360 crossref_primary_10_1002_brb3_2112 crossref_primary_10_1021_acschemneuro_3c00464 crossref_primary_10_1212_WNL_0000000000003285 crossref_primary_10_1016_j_tjpad_2024_100040 crossref_primary_10_1016_j_chembiol_2019_07_007 crossref_primary_10_3390_antiox11010008 crossref_primary_10_1080_23279095_2020_1786832 crossref_primary_10_3389_fnagi_2023_1132907 crossref_primary_10_3389_fnins_2021_647783 crossref_primary_10_1093_brain_awu193 crossref_primary_10_1007_s00415_024_12525_8 crossref_primary_10_1371_journal_pone_0257372 crossref_primary_10_3389_fonc_2023_1116061 crossref_primary_10_1038_s41589_020_00708_z crossref_primary_10_1038_nrneurol_2017_27 crossref_primary_10_3988_jcn_2016_12_2_172 crossref_primary_10_1038_s41598_021_82037_2 crossref_primary_10_1177_1073858418778747 crossref_primary_10_1002_mds_29273 crossref_primary_10_1007_s13311_021_01067_w crossref_primary_10_1002_bit_28569 crossref_primary_10_1016_j_jalz_2019_02_002 crossref_primary_10_1111_ncn3_12444 crossref_primary_10_1038_s41531_022_00330_x crossref_primary_10_17116_jnevro202012005150 crossref_primary_10_1038_pr_2018_42 crossref_primary_10_1155_2022_7165387 crossref_primary_10_1371_journal_pone_0295981 crossref_primary_10_1016_j_parkreldis_2014_09_003 crossref_primary_10_1073_pnas_1524807113 crossref_primary_10_1016_j_ecoenv_2023_115550 crossref_primary_10_1073_pnas_1402215111 crossref_primary_10_1186_s40478_018_0550_0 crossref_primary_10_1021_acs_biochem_9b00655 crossref_primary_10_3390_molecules27061776 crossref_primary_10_1007_s12640_024_00705_3 crossref_primary_10_1016_j_arr_2021_101359 crossref_primary_10_1080_14656566_2018_1519548 crossref_primary_10_1007_s11910_018_0898_3 crossref_primary_10_1016_j_parkreldis_2023_105804 crossref_primary_10_1016_j_neubiorev_2019_05_016 crossref_primary_10_1021_acschemneuro_0c00523 crossref_primary_10_1523_JNEUROSCI_4658_15_2016 crossref_primary_10_1016_S1474_4422_16_30291_5 crossref_primary_10_1093_brain_awy211 crossref_primary_10_3390_ijms22126185 crossref_primary_10_1016_j_ejphar_2016_08_011 crossref_primary_10_1021_acsomega_9b03671 crossref_primary_10_1016_j_exger_2021_111376 crossref_primary_10_1093_brain_awv189 crossref_primary_10_1126_sciadv_abq6495 crossref_primary_10_3233_JAD_190323 crossref_primary_10_3389_fneur_2020_00137 crossref_primary_10_1002_hbm_23499 crossref_primary_10_1186_s12974_023_02770_5 crossref_primary_10_1007_s00234_020_02378_z crossref_primary_10_1016_j_neuropharm_2016_02_006 crossref_primary_10_1093_braincomms_fcae178 crossref_primary_10_1016_j_neulet_2023_137219 crossref_primary_10_1016_j_molliq_2022_118761 crossref_primary_10_1016_j_molmed_2019_05_006 crossref_primary_10_1039_D0FO03301D crossref_primary_10_1080_00207454_2018_1486837 crossref_primary_10_1016_j_parkreldis_2021_01_004 crossref_primary_10_1371_journal_pbio_3001578 crossref_primary_10_1016_j_talanta_2022_123838 crossref_primary_10_1007_s12035_021_02596_3 crossref_primary_10_1515_revneuro_2024_0090 crossref_primary_10_1016_j_bionps_2021_100041 crossref_primary_10_1016_j_neulet_2016_04_014 crossref_primary_10_1016_j_exger_2024_112497 crossref_primary_10_3233_JPD_230129 crossref_primary_10_1080_14656566_2020_1828350 crossref_primary_10_1093_brain_aww340 crossref_primary_10_1002_ana_25707 crossref_primary_10_1016_j_arr_2022_101764 crossref_primary_10_1016_j_parkreldis_2021_01_002 crossref_primary_10_1038_s41598_024_54800_8 crossref_primary_10_1194_jlr_R075481 crossref_primary_10_1016_j_neuron_2019_10_010 crossref_primary_10_1038_s41467_024_54945_0 crossref_primary_10_1007_s40142_018_0133_1 crossref_primary_10_3390_md13116665 crossref_primary_10_1371_journal_pone_0166415 crossref_primary_10_3390_jcm8101601 crossref_primary_10_1016_j_crphys_2022_100097 crossref_primary_10_3389_fimmu_2024_1426656 crossref_primary_10_1016_j_abb_2022_109120 crossref_primary_10_1016_j_jns_2016_09_028 crossref_primary_10_1038_srep37630 crossref_primary_10_3389_fnmol_2019_00312 crossref_primary_10_3389_fphar_2024_1478964 crossref_primary_10_1016_j_arr_2023_101931 crossref_primary_10_1186_s12920_014_0060_2 crossref_primary_10_3389_fnins_2019_00868 crossref_primary_10_1186_s40035_019_0172_x crossref_primary_10_1016_j_arr_2024_102289 crossref_primary_10_3390_brainsci13081196 crossref_primary_10_1371_journal_pone_0090659 crossref_primary_10_1016_j_psc_2015_02_002 crossref_primary_10_1186_s13024_023_00651_2 crossref_primary_10_3233_JAD_210114 crossref_primary_10_1007_s00401_016_1552_2 crossref_primary_10_1016_j_neuron_2018_06_003 crossref_primary_10_1002_agt2_711 crossref_primary_10_1111_ejn_12504 crossref_primary_10_1186_s13024_021_00428_5 crossref_primary_10_1016_j_jalz_2014_06_016 crossref_primary_10_1186_s40478_019_0687_5 crossref_primary_10_3390_biom11050744 crossref_primary_10_1097_WAD_0000000000000546 crossref_primary_10_1007_s00259_020_05133_x crossref_primary_10_1096_fj_202100787R crossref_primary_10_1001_jamanetworkopen_2019_13383 crossref_primary_10_1007_s00702_017_1821_9 crossref_primary_10_3390_biomedicines11071996 crossref_primary_10_1002_mds_30031 crossref_primary_10_1016_j_gene_2016_11_022 crossref_primary_10_1038_s41440_022_01032_w crossref_primary_10_1016_j_disamonth_2022_101441 crossref_primary_10_29328_journal_jnnd_1001052 crossref_primary_10_1021_acschemneuro_2c00655 crossref_primary_10_1016_S1474_4422_16_00060_0 crossref_primary_10_1021_acsami_0c22270 crossref_primary_10_1111_ene_12894 crossref_primary_10_1111_ncn3_12599 crossref_primary_10_1016_j_jalz_2014_06_009 crossref_primary_10_1038_s41598_019_55830_3 crossref_primary_10_3390_ijms20030696 crossref_primary_10_1002_ctd2_150 crossref_primary_10_1002_alz_12765 crossref_primary_10_3233_JAD_201548 crossref_primary_10_5607_en_2014_23_4_352 crossref_primary_10_1016_j_expneurol_2015_04_019 crossref_primary_10_3389_fnins_2022_892374 crossref_primary_10_3390_cells9020357 crossref_primary_10_1016_j_parkreldis_2019_03_023 crossref_primary_10_1016_j_celrep_2017_09_064 crossref_primary_10_1038_s41598_023_35229_x crossref_primary_10_1186_s13024_021_00501_z crossref_primary_10_1002_adma_202404576 crossref_primary_10_3390_molecules24071350 crossref_primary_10_1016_j_dadm_2019_04_008 crossref_primary_10_1002_mds_27907 crossref_primary_10_1080_07391102_2023_2293258 crossref_primary_10_3233_JAD_180133 crossref_primary_10_1002_tcr_202400053 crossref_primary_10_3389_fnagi_2021_707165 crossref_primary_10_1021_acschemneuro_1c00441 crossref_primary_10_1002_pro_4093 crossref_primary_10_1007_s13346_025_01799_8 crossref_primary_10_3233_JPD_240002 crossref_primary_10_1523_JNEUROSCI_0344_18_2018 crossref_primary_10_1021_acscentsci_8b00230 crossref_primary_10_1038_s41583_023_00720_x crossref_primary_10_1136_postgradmedj_2015_133247 crossref_primary_10_3389_fnins_2021_660379 crossref_primary_10_1002_mds_30098 crossref_primary_10_3233_JAD_180390 crossref_primary_10_1517_17460441_2016_1107041 crossref_primary_10_1080_19336896_2015_1020277 crossref_primary_10_14802_jmd_16017 crossref_primary_10_1021_acs_biochem_5b00087 crossref_primary_10_4103_1673_5374_390970 crossref_primary_10_1007_s13311_021_01161_z crossref_primary_10_1371_journal_pone_0166861 crossref_primary_10_1016_j_bmc_2022_117131 crossref_primary_10_1016_j_jocn_2018_10_029 crossref_primary_10_3390_ijms23031089 crossref_primary_10_1038_s41598_024_72538_1 crossref_primary_10_1007_s13760_023_02251_9 crossref_primary_10_1016_j_parkreldis_2015_02_010 crossref_primary_10_1038_s41598_022_05627_8 crossref_primary_10_1186_s40035_018_0129_5 crossref_primary_10_1021_ic4031377 crossref_primary_10_1016_j_phrs_2019_104336 crossref_primary_10_1126_science_abm6131 crossref_primary_10_1016_j_biopsych_2017_12_018 crossref_primary_10_1586_14737175_2015_1038244 crossref_primary_10_1038_s41398_017_0049_7 crossref_primary_10_1016_j_nbd_2015_07_016 crossref_primary_10_1016_j_trci_2018_06_006 crossref_primary_10_1016_j_neuropharm_2017_09_023 crossref_primary_10_3390_ijms25168935 crossref_primary_10_1016_j_expneurol_2024_115007 crossref_primary_10_1016_j_bbrc_2016_08_052 crossref_primary_10_3928_00485713_20200206_01 crossref_primary_10_1016_j_jneuroim_2017_12_003 crossref_primary_10_1038_cddis_2014_175 crossref_primary_10_58558_jcd_2024_3_1_12 crossref_primary_10_1074_jbc_RA119_012284 crossref_primary_10_1016_j_freeradbiomed_2019_06_007 crossref_primary_10_1242_dev_104786 crossref_primary_10_1109_ACCESS_2023_3268523 crossref_primary_10_1091_mbc_e14_06_1099 crossref_primary_10_15252_embj_201899871 crossref_primary_10_1111_cbdd_13067 crossref_primary_10_3233_JAD_150610 crossref_primary_10_1124_jpet_124_002199 crossref_primary_10_1017_cjn_2015_49 crossref_primary_10_1093_braincomms_fcab180 crossref_primary_10_1016_j_bpc_2020_106507 crossref_primary_10_1371_journal_pone_0143852 crossref_primary_10_1371_journal_pone_0143854 crossref_primary_10_2217_bmm_2021_0092 crossref_primary_10_1016_j_ymthe_2017_08_004 crossref_primary_10_1016_j_neuro_2021_12_004 crossref_primary_10_3233_JPD_160932 crossref_primary_10_3390_brainsci14080787 crossref_primary_10_3389_fnins_2025_1515374 crossref_primary_10_3389_fneur_2022_945523 crossref_primary_10_1073_pnas_1918617117 crossref_primary_10_3389_fnagi_2022_974414 crossref_primary_10_1016_j_bej_2021_108292 crossref_primary_10_1016_S0140_6736_15_00462_6 crossref_primary_10_1016_j_bmc_2017_10_010 crossref_primary_10_1016_j_bbrc_2021_08_049 crossref_primary_10_1016_j_parkreldis_2022_05_024 crossref_primary_10_1212_WNL_0000000000201404 crossref_primary_10_1371_journal_pone_0106883 crossref_primary_10_3390_jcm9010257 crossref_primary_10_1039_D4SC00024B crossref_primary_10_3390_ijms22073430 crossref_primary_10_1016_j_bbapap_2014_12_010 crossref_primary_10_3390_ijms23116058 crossref_primary_10_2196_12870 crossref_primary_10_1586_14737175_2015_1077703 crossref_primary_10_1016_j_parkreldis_2020_01_009 crossref_primary_10_1155_2021_6147434 crossref_primary_10_1371_journal_pone_0173240 crossref_primary_10_1371_journal_pone_0153989 crossref_primary_10_3233_JPD_202288 crossref_primary_10_29413_ABS_2023_8_6_14 crossref_primary_10_1007_s40005_021_00521_3 crossref_primary_10_1039_D2CB00194B crossref_primary_10_1007_s11307_023_01814_9 crossref_primary_10_1016_j_nbd_2018_11_015 crossref_primary_10_1007_s11065_015_9307_8 crossref_primary_10_1016_j_parkreldis_2018_07_015 crossref_primary_10_1016_j_neuron_2024_10_015 crossref_primary_10_1021_acschemneuro_2c00473 crossref_primary_10_3389_fnagi_2021_743754 crossref_primary_10_1002_acn3_285 crossref_primary_10_1016_j_cell_2020_06_039 crossref_primary_10_1177_17562864221150329 crossref_primary_10_1371_journal_pone_0162696 crossref_primary_10_31083_j_jin2206172 crossref_primary_10_1136_jnnp_2016_314411 crossref_primary_10_1017_S1355617717000017 crossref_primary_10_1016_j_jmb_2022_167713 crossref_primary_10_11569_wcjd_v32_i12_878 crossref_primary_10_3390_molecules25040977 crossref_primary_10_3390_ph16121714 crossref_primary_10_1016_j_bbr_2022_114035 crossref_primary_10_3233_JAD_200838 crossref_primary_10_1016_S1474_4422_17_30042_X crossref_primary_10_1002_jmr_2686 crossref_primary_10_1021_acschemneuro_0c00381 crossref_primary_10_1016_j_ebiom_2024_105079 crossref_primary_10_1016_j_bj_2018_03_004 crossref_primary_10_1002_mds_26961 crossref_primary_10_1016_j_exger_2018_11_020 crossref_primary_10_3389_fcogn_2024_1369538 crossref_primary_10_1007_s12017_015_8349_7 crossref_primary_10_3390_brainsci14070674 crossref_primary_10_1038_s41392_022_01078_9 crossref_primary_10_3143_geriatrics_58_341 crossref_primary_10_3390_ijms21134718 crossref_primary_10_3390_life11111239 crossref_primary_10_3389_fnins_2020_00857 crossref_primary_10_1016_j_nicl_2016_12_025 crossref_primary_10_1016_j_lfs_2020_118159 crossref_primary_10_4103_1673_5374_306066 crossref_primary_10_1021_acschemneuro_1c00144 crossref_primary_10_1371_journal_pone_0163781 crossref_primary_10_1007_s00702_022_02498_1 crossref_primary_10_1038_npjparkd_2015_27 crossref_primary_10_18632_aging_202335 crossref_primary_10_1186_s12929_018_0428_2 crossref_primary_10_3389_fnagi_2023_1170663 crossref_primary_10_1016_j_nbd_2023_106337 crossref_primary_10_1021_acs_biochem_9b00215 crossref_primary_10_1007_s11010_019_03592_x crossref_primary_10_1002_pro_4025 crossref_primary_10_1155_2014_454696 crossref_primary_10_1016_j_ejphar_2025_177419 crossref_primary_10_1111_ane_13517 crossref_primary_10_1002_mds_27717 crossref_primary_10_1073_pnas_1417883112 crossref_primary_10_1016_j_ccr_2022_214978 crossref_primary_10_1002_acn3_299 crossref_primary_10_1038_mp_2016_242 crossref_primary_10_1016_j_bcp_2023_115923 crossref_primary_10_1016_j_jns_2016_06_009 crossref_primary_10_1016_j_vibspec_2015_07_004 crossref_primary_10_1186_s12974_016_0606_7 crossref_primary_10_1016_j_expneurol_2021_113833 crossref_primary_10_1016_j_nbd_2021_105512 crossref_primary_10_1038_srep29523 crossref_primary_10_1007_s10571_022_01282_9 crossref_primary_10_1016_j_neuropharm_2021_108618 crossref_primary_10_3390_ijms25105307 crossref_primary_10_1186_s12916_018_1016_8 crossref_primary_10_1016_j_jamda_2023_10_002 crossref_primary_10_4049_jimmunol_1801506 crossref_primary_10_1016_j_nlm_2025_108036 crossref_primary_10_1002_mds_27867 crossref_primary_10_1038_s41467_021_25060_1 crossref_primary_10_1186_s13195_014_0077_y crossref_primary_10_1186_s40478_021_01288_2 crossref_primary_10_1073_pnas_1512876113 crossref_primary_10_1111_jnc_13234 crossref_primary_10_1038_lsa_2017_29 crossref_primary_10_1519_SSC_0000000000000887 crossref_primary_10_3389_fncel_2017_00388 crossref_primary_10_1021_acs_jpclett_4c02827 crossref_primary_10_1016_j_celrep_2020_108050 crossref_primary_10_1016_j_ijbiomac_2024_134417 crossref_primary_10_1159_000507757 crossref_primary_10_3390_ijms22115768 crossref_primary_10_1136_jnnp_2016_314857 crossref_primary_10_1016_j_ncl_2017_01_004 crossref_primary_10_1038_cddis_2014_307 crossref_primary_10_1007_s00702_019_02028_6 crossref_primary_10_1002_mds_27738 crossref_primary_10_1136_jnnp_2016_313775 crossref_primary_10_1373_jalm_2019_029876 crossref_primary_10_3389_fnsyn_2020_00026 crossref_primary_10_1039_D3CS01065A crossref_primary_10_1002_alz_14122 crossref_primary_10_1016_j_crneur_2022_100065 crossref_primary_10_1111_jnc_14698 crossref_primary_10_1016_j_phrs_2024_107101 crossref_primary_10_3389_fneur_2021_748096 crossref_primary_10_1002_ange_201712286 crossref_primary_10_2967_jnumed_115_156067 crossref_primary_10_1007_s00702_022_02522_4 crossref_primary_10_1016_j_jmb_2021_166953 crossref_primary_10_1111_ejn_13476 crossref_primary_10_1021_acs_nanolett_8b02372 crossref_primary_10_1111_bpa_12182 crossref_primary_10_3389_fimmu_2020_571083 crossref_primary_10_1186_s13195_020_00684_5 crossref_primary_10_1016_j_pneurobio_2016_10_001 crossref_primary_10_3389_fendo_2024_1406455 crossref_primary_10_1038_s41531_019_0084_6 crossref_primary_10_3389_fnins_2018_00230 crossref_primary_10_1007_s00401_015_1392_5 crossref_primary_10_1002_mdc3_14305 crossref_primary_10_1007_s00702_023_02660_3 crossref_primary_10_1016_S1474_4422_15_00182_9 crossref_primary_10_1126_sciadv_abl8809 crossref_primary_10_1136_bmjno_2021_000168 crossref_primary_10_1186_s40035_020_00213_2 crossref_primary_10_3389_fnagi_2022_892493 crossref_primary_10_1002_anie_201712286 crossref_primary_10_1186_s12974_020_02065_z crossref_primary_10_23736_S0393_3660_24_05620_1 crossref_primary_10_1016_j_nbd_2023_106011 crossref_primary_10_1038_s41598_023_37644_6 crossref_primary_10_11622_smedj_2021182 crossref_primary_10_3390_ijms221910698 crossref_primary_10_1155_2014_181325 crossref_primary_10_1002_mds_27518 crossref_primary_10_1021_acsnano_4c15808 crossref_primary_10_1073_pnas_1616119114 crossref_primary_10_1007_s11011_020_00665_5 crossref_primary_10_1016_j_parkreldis_2015_09_034 crossref_primary_10_3389_fnagi_2022_938117 crossref_primary_10_1002_alz_14584 crossref_primary_10_1016_j_preteyeres_2025_101335 crossref_primary_10_1016_j_jare_2022_10_013 crossref_primary_10_1038_s41598_018_20320_5 crossref_primary_10_1002_mds_26422 crossref_primary_10_3389_fnagi_2024_1369733 crossref_primary_10_1038_cdd_2014_179 crossref_primary_10_1002_ana_25392 crossref_primary_10_1016_j_jbc_2025_108351 crossref_primary_10_3389_fnins_2019_01399 crossref_primary_10_1016_j_jmb_2025_169048 crossref_primary_10_1186_s40478_018_0624_z crossref_primary_10_3390_ijms25010498 crossref_primary_10_1016_j_bbadis_2021_166203 crossref_primary_10_1186_s12951_016_0198_5 crossref_primary_10_3233_JPD_202323 crossref_primary_10_7759_cureus_44353 crossref_primary_10_1002_asia_201600236 crossref_primary_10_3389_fneur_2017_00653 crossref_primary_10_1016_j_chempr_2017_09_011 crossref_primary_10_3390_metabo12020187 crossref_primary_10_1016_j_praneu_2014_01_010 crossref_primary_10_3233_JPD_150762 crossref_primary_10_3389_fnagi_2021_751897 crossref_primary_10_1002_anie_201809716 crossref_primary_10_1016_j_jbc_2022_102498 crossref_primary_10_1080_0889311X_2023_2208518 crossref_primary_10_3389_fnmol_2015_00001 crossref_primary_10_1002_cphc_201800678 crossref_primary_10_1016_j_freeradbiomed_2019_05_033 crossref_primary_10_1002_acn3_52089 crossref_primary_10_1016_j_biopha_2020_110145 crossref_primary_10_1007_s00018_016_2351_6 crossref_primary_10_1177_0891988717711451 crossref_primary_10_1021_acschemneuro_1c00530 crossref_primary_10_1002_dvdy_24599 crossref_primary_10_1016_j_neucli_2020_05_001 crossref_primary_10_1016_j_parkreldis_2022_07_023 crossref_primary_10_1093_sleep_zsae251 crossref_primary_10_1093_brain_awae203 crossref_primary_10_3389_fcell_2024_1469751 crossref_primary_10_1002_ange_201809716 crossref_primary_10_1007_s12035_016_0214_7 crossref_primary_10_1016_j_ijleo_2020_164703 crossref_primary_10_1016_j_parkreldis_2016_02_013 crossref_primary_10_3233_JPD_181484 crossref_primary_10_1016_j_nbd_2019_104708 crossref_primary_10_1038_s41531_022_00316_9 crossref_primary_10_32604_cmc_2023_032341 crossref_primary_10_1093_hmg_ddu544 crossref_primary_10_1007_s12035_023_03372_1 crossref_primary_10_1016_j_arr_2024_102639 crossref_primary_10_3233_JAD_220976 crossref_primary_10_1016_j_parkreldis_2023_105316 crossref_primary_10_1166_mex_2023_2502 crossref_primary_10_1093_brain_awad227 crossref_primary_10_1093_brain_awac258 crossref_primary_10_1016_j_ibmb_2019_05_010 crossref_primary_10_1016_j_parkreldis_2022_105273 crossref_primary_10_1136_jnnp_2015_312690 crossref_primary_10_1039_C8CP07211F crossref_primary_10_3233_JPD_202221 crossref_primary_10_1002_ana_27006 crossref_primary_10_3389_fmolb_2023_1153839 crossref_primary_10_1016_j_jns_2018_08_009 crossref_primary_10_1039_D4NR04624B crossref_primary_10_1016_j_bbamem_2018_02_013 crossref_primary_10_1016_j_neurobiolaging_2014_12_016 crossref_primary_10_3389_fnagi_2021_660843 crossref_primary_10_5316_wjn_v4_i4_23 crossref_primary_10_1016_j_neuron_2014_10_031 crossref_primary_10_3389_fnins_2022_1049118 crossref_primary_10_3389_fnins_2024_1439443 crossref_primary_10_3390_ijms17020189 crossref_primary_10_1016_j_parkreldis_2014_08_023 crossref_primary_10_31083_j_fbl2810255 crossref_primary_10_1016_j_neulet_2019_134316 crossref_primary_10_1186_s13195_014_0073_2 crossref_primary_10_3389_fneur_2023_1145939 crossref_primary_10_1021_acsami_5b06219 crossref_primary_10_1021_cn5001827 crossref_primary_10_1016_j_nicl_2023_103475 crossref_primary_10_1039_C7RA08030A crossref_primary_10_1186_1750_1326_9_43 crossref_primary_10_3389_fnhum_2023_1284416 crossref_primary_10_1111_cns_70082 crossref_primary_10_1002_mds_28522 crossref_primary_10_1002_mds_28643 crossref_primary_10_1016_j_lfs_2016_06_027 crossref_primary_10_1002_ana_26209 crossref_primary_10_1186_s13024_021_00486_9 crossref_primary_10_1016_j_bbapap_2023_140950 crossref_primary_10_1016_j_jchemneu_2021_101922 crossref_primary_10_1186_s10020_021_00301_7 crossref_primary_10_1186_s40035_023_00378_6 crossref_primary_10_1007_s10548_018_0675_2 crossref_primary_10_1111_ejn_13056 crossref_primary_10_1007_s40142_019_0158_0 crossref_primary_10_1007_s40263_020_00736_2 crossref_primary_10_1111_ene_70022 crossref_primary_10_1007_s12035_022_03042_8 crossref_primary_10_1038_s41593_018_0235_9 crossref_primary_10_1002_mdc3_12425 crossref_primary_10_1093_brain_awad289 crossref_primary_10_1016_j_neubiorev_2024_105677 crossref_primary_10_1016_j_trac_2025_118173 crossref_primary_10_1186_s40478_024_01803_1 crossref_primary_10_1016_S1353_8020_13_70026_9 crossref_primary_10_1038_s41374_019_0196_y crossref_primary_10_18632_oncotarget_23538 crossref_primary_10_3390_biomedicines11102863 crossref_primary_10_1016_S0140_6736_14_61393_3 crossref_primary_10_1007_s40263_018_0601_x crossref_primary_10_3233_JAD_190851 crossref_primary_10_1371_journal_pone_0147319 crossref_primary_10_1038_ncomms8025 crossref_primary_10_1007_s00213_018_4870_3 crossref_primary_10_1186_s40478_019_0679_5 crossref_primary_10_1002_mds_26128 crossref_primary_10_4103_NRR_NRR_D_23_01677 crossref_primary_10_1038_nrneurol_2014_226 crossref_primary_10_1016_j_arr_2019_01_005 crossref_primary_10_1016_j_neubiorev_2016_08_003 crossref_primary_10_3390_molecules26072058 crossref_primary_10_1007_s00109_023_02407_3 crossref_primary_10_1007_s13311_020_00994_4 crossref_primary_10_1111_nan_12554 crossref_primary_10_1136_jnnp_2017_316385 crossref_primary_10_3390_ijms24076301 crossref_primary_10_1002_mds_29511 crossref_primary_10_1212_WNL_0000000000011852 crossref_primary_10_7554_eLife_49298 crossref_primary_10_1021_jacs_3c03212 crossref_primary_10_3390_ijms18010227 crossref_primary_10_1186_2051_5960_1_79 crossref_primary_10_1007_s00401_019_02032_w crossref_primary_10_1186_s12859_021_04446_4 crossref_primary_10_3233_JAD_201187 crossref_primary_10_1016_j_brainres_2022_148054 crossref_primary_10_1007_s13311_014_0313_y crossref_primary_10_1039_C7CS00372B crossref_primary_10_3390_life13071523 crossref_primary_10_1111_ejn_15493 crossref_primary_10_3389_fneur_2018_00560 crossref_primary_10_1126_scitranslmed_aay3069 crossref_primary_10_1176_appi_focus_15105 crossref_primary_10_3390_ijms25063554 crossref_primary_10_1016_j_parkreldis_2018_05_022 crossref_primary_10_1016_j_jocn_2016_10_013 crossref_primary_10_1093_brain_awad265 crossref_primary_10_3389_fnins_2018_00073 crossref_primary_10_1128_jvi_00418_24 crossref_primary_10_1016_j_csbj_2022_08_060 crossref_primary_10_3389_fnmol_2014_00076 crossref_primary_10_1371_journal_pone_0262464 crossref_primary_10_1212_WNL_0000000000005166 crossref_primary_10_1038_nrneurol_2017_96 crossref_primary_10_1096_fj_202200235R crossref_primary_10_1212_WNL_0000000000005161 crossref_primary_10_1007_s00439_021_02345_5 crossref_primary_10_1038_s41467_021_26433_2 crossref_primary_10_1038_s41467_022_28797_5 crossref_primary_10_1093_jnen_nlx099 crossref_primary_10_3390_cells9030591 crossref_primary_10_1038_s41593_019_0530_0 crossref_primary_10_1111_nan_12577 crossref_primary_10_1093_intbio_zyad012 crossref_primary_10_3389_fnins_2020_00265 crossref_primary_10_1016_j_neuint_2014_06_014 crossref_primary_10_1002_mds_27593 crossref_primary_10_1038_s41531_023_00578_x crossref_primary_10_1016_j_cbi_2024_111224 crossref_primary_10_1016_j_chemphys_2014_10_015 crossref_primary_10_1111_cns_14208 crossref_primary_10_3389_fnsys_2021_777706 crossref_primary_10_3390_molecules26082195 crossref_primary_10_1007_s00401_017_1707_9 crossref_primary_10_1016_j_immuni_2024_09_014 crossref_primary_10_1038_s41583_020_00416_6 crossref_primary_10_3389_fneur_2021_749047 crossref_primary_10_1007_s00359_016_1108_x crossref_primary_10_1038_srep15164 crossref_primary_10_3389_fnhum_2016_00693 crossref_primary_10_1016_j_carbon_2025_120152 crossref_primary_10_3389_fendo_2018_00608 crossref_primary_10_1039_D4AN00634H crossref_primary_10_3389_fneur_2023_1239653 crossref_primary_10_3389_fnagi_2021_623977 crossref_primary_10_1016_j_neulet_2021_135709 crossref_primary_10_3389_fneur_2019_00391 crossref_primary_10_3390_biomedicines10092261 crossref_primary_10_1007_s12031_016_0809_5 crossref_primary_10_1038_tp_2016_186 crossref_primary_10_1038_cddiscovery_2017_53 crossref_primary_10_1016_j_jphs_2014_11_011 crossref_primary_10_3390_biom5020282 crossref_primary_10_1016_j_baga_2018_06_001 crossref_primary_10_1016_j_bcp_2018_12_007 crossref_primary_10_3389_fnmol_2019_00158 crossref_primary_10_5607_en_2014_23_4_292 crossref_primary_10_1016_j_foodchem_2015_12_026 crossref_primary_10_1007_s13273_020_00104_7 crossref_primary_10_1016_j_neurobiolaging_2024_02_004 crossref_primary_10_1084_jem_20192193 crossref_primary_10_1038_s41531_023_00531_y crossref_primary_10_1007_s11910_017_0779_1 crossref_primary_10_3389_fneur_2015_00071 crossref_primary_10_3390_ijms241713199 crossref_primary_10_1016_j_brainresbull_2018_10_003 crossref_primary_10_4155_bio_2016_0166 crossref_primary_10_3390_ph14040383 crossref_primary_10_1186_s13041_022_00964_1 crossref_primary_10_1016_j_pharmthera_2018_09_010 crossref_primary_10_1016_j_cortex_2018_11_021 crossref_primary_10_3389_fnagi_2023_1189809 crossref_primary_10_1186_s13195_020_00610_9 crossref_primary_10_3390_cells9122581 crossref_primary_10_1039_C4SM01845A crossref_primary_10_1016_j_nbd_2017_07_018 crossref_primary_10_1371_journal_pone_0123444 crossref_primary_10_3390_ijms21020590 crossref_primary_10_1038_s41598_021_94345_8 crossref_primary_10_1021_jm5017544 crossref_primary_10_1016_j_bbapap_2022_140885 crossref_primary_10_1021_acs_jmedchem_5b00789 crossref_primary_10_1007_s00702_019_01996_z crossref_primary_10_1016_j_obmed_2023_100500 crossref_primary_10_3389_fnmol_2021_711396 crossref_primary_10_1038_srep28420 crossref_primary_10_1371_journal_pone_0298816 crossref_primary_10_1242_dmm_039396 crossref_primary_10_14348_molcells_2016_0050 crossref_primary_10_1002_mds_28370 crossref_primary_10_1016_j_ajhg_2020_06_002 crossref_primary_10_1016_j_envres_2015_06_009 crossref_primary_10_3390_ph18030328 crossref_primary_10_1007_s00401_019_02087_9 crossref_primary_10_1038_s41467_025_56099_z crossref_primary_10_1002_acn3_52144 crossref_primary_10_1128_mBio_02095_18 crossref_primary_10_1021_acsphotonics_9b01125 crossref_primary_10_26599_BSA_2022_9050012 crossref_primary_10_1002_hsr2_2019 crossref_primary_10_1186_s13024_023_00600_z crossref_primary_10_1016_j_drudis_2016_01_013 crossref_primary_10_1016_j_bbr_2022_113887 crossref_primary_10_1111_nan_12659 crossref_primary_10_1002_acn3_51183 crossref_primary_10_3390_biom10091323 crossref_primary_10_1002_agt2_333 |
| Cites_doi | 10.1056/NEJM198509193131205 10.1016/S0002-9440(10)65722-7 10.1002/ana.410130304 10.1002/ana.21157 10.1038/nm1746 10.1212/WNL.0b013e31827b915c 10.1002/ana.20321 10.1016/j.neuron.2006.09.026 10.1212/WNL.0b013e318278fe32 10.1002/mds.21507 10.1212/WNL.40.10.1529 10.1038/nrneurol.2012.242 10.1016/j.expneurol.2008.06.004 10.1038/3311 10.1001/archneurol.2009.54 10.1523/JNEUROSCI.0618-11.2011 10.1056/NEJMoa0901281 10.1002/mds.23884 10.1111/j.1750-3639.2007.00117.x 10.1007/s00401-008-0347-5 10.1007/s00401-009-0538-8 10.1136/jnnp.2009.199950 10.1073/pnas.211412398 10.1212/WNL.54.10.1916 10.1212/01.WNL.0000065889.42856.F2 10.3233/JAD-2006-9S347 10.1097/WAD.0b013e31819c5ef4 10.1007/s00702-010-0462-z 10.1093/jnen/61.5.413 10.1001/archneur.1993.00540020018011 10.1159/000107703 10.1093/brain/awp234 10.1084/jem.20112457 10.1126/science.1082324 10.1093/brain/awq008 10.1126/science.6801762 10.1212/01.wnl.0000256715.13907.d3 10.1016/j.neuron.2011.08.033 10.1016/j.biocel.2008.01.017 10.1212/01.wnl.0000249130.63615.cc 10.1001/archneur.60.3.387 10.1001/archneur.59.1.102 10.1093/brain/awr031 10.1001/archneur.55.7.969 10.1001/jamaneurol.2013.600 10.1007/s12035-012-8280-y 10.1002/mds.22369 10.1002/mds.21956 10.1001/archneurol.2012.1608 10.1016/j.tins.2004.01.007 10.1093/brain/awp044 10.1002/ana.22311 10.1002/mds.10274 10.1016/S1474-4422(12)70152-7 10.1093/brain/awr277 10.1007/978-3-211-73574-9_12 10.1073/pnas.0908005106 10.1111/j.1750-3639.2000.tb00269.x 10.1002/ana.410350504 10.1002/mds.24893 10.1002/mds.23287 10.1001/jamaneurol.2013.1925 10.1038/42166 10.1093/jnen/64.2.156 10.1007/s00401-007-0261-2 10.1002/mds.25213 10.1002/mds.25282 10.1038/nrn3406 10.1212/01.wnl.0000180516.69442.95 10.1007/s00401-002-0563-3 10.1007/s00401-011-0910-3 10.1093/brain/awq059 10.1016/S0896-6273(02)00682-7 10.1093/brain/awp245 10.1212/WNL.0b013e31827b1a07 10.1002/ana.22271 10.1097/WAD.0b013e318199d833 10.1007/s00415-006-0234-8 10.1016/S0079-6123(10)84004-X 10.1038/nm1747 10.1016/j.neurobiolaging.2011.06.022 10.1126/science.1227157 10.1097/NEN.0b013e31816362aa 10.1007/s00401-008-0406-y 10.1002/mds.24946 10.1212/WNL.55.4.539 10.1007/s00401-007-0336-0 10.1212/01.WNL.0000165987.89198.65 10.1212/WNL.0b013e3182735e9a 10.1007/s00401-008-0346-6 10.1016/j.jalz.2011.03.003 10.1016/S1353-8020(08)70005-1 10.1016/j.parkreldis.2010.10.003 10.1002/mds.23116 10.1007/s004019900168 10.1136/jnnp.74.7.852 10.1007/s00702-004-0138-7 10.1002/ana.10279 10.1007/s00702-011-0641-6 10.1007/s00415-009-0119-8 10.1212/WNL.0b013e3181f39a78 10.1073/pnas.0903691106 10.1007/s007020200027 10.1038/cdd.2011.53 10.1002/ana.21192 10.1002/mds.22594 10.1002/ana.10219 10.1007/s004010050824 10.1093/jnen/62.6.644 10.1002/mds.23073 10.1016/j.expneurol.2009.09.016 10.1016/j.neulet.2010.10.015 10.1016/j.pharmthera.2013.01.013 10.1126/science.1090278 10.1212/WNL.0b013e3182698d4a 10.1007/s00415-009-5324-y 10.1002/mds.25373 10.1002/mds.870130605 10.1002/mds.20897 10.1212/01.WNL.0000158422.41380.82 10.1093/hmg/8.4.711 10.1002/mds.22637 10.1002/ana.23659 10.1001/archneurol.2009.221 10.1016/j.bandl.2011.08.007 10.1007/s00401-008-0345-7 10.1523/JNEUROSCI.0490-10.2010 10.1126/science.276.5321.2045 10.1016/j.pneurobio.2011.09.005 10.1212/WNL.0b013e3181fd613b 10.1016/j.parkreldis.2012.04.028 10.1002/mds.24962 10.1136/jnnp.48.5.413 10.1007/s00401-008-0344-8 10.1212/01.wnl.0000242630.52203.8f 10.1001/jamaneurol.2013.1933 10.1007/s00415-012-6648-6 10.1002/mds.10280 10.1093/brain/awt037 10.1007/s00401-006-0088-2 10.1212/WNL.53.9.1974 10.2967/jnumed.111.089946 10.1111/j.1440-1789.2003.00530.x 10.1016/S0197-4580(02)00065-9 10.1007/s00401-011-0852-9 10.1016/j.neurobiolaging.2004.10.006 10.1007/s004010100390 10.1007/s00401-003-0705-2 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2013 COPYRIGHT 2013 Nature Publishing Group |
| Copyright_xml | – notice: Springer Nature Limited 2013 – notice: COPYRIGHT 2013 Nature Publishing Group |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1038/nrn3549 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1471-0048 |
| EndPage | 636 |
| ExternalDocumentID | PMC4017235 A344154660 23900411 10_1038_nrn3549 |
| Genre | Journal Article Review Research Support, N.I.H., Extramural |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: T32 AG000255 – fundername: NIA NIH HHS grantid: P30 AG010124 – fundername: NINDS NIH HHS grantid: P50 NS053488 – fundername: NINDS NIH HHS grantid: P50 NS53488 – fundername: NIA NIH HHS grantid: P30 AG10124 – fundername: NIA NIH HHS grantid: P01 AG017586 – fundername: NIA NIH HHS grantid: AG17586 – fundername: NIA NIH HHS grantid: T32‑AG000255 |
| GroupedDBID | --- .55 0R~ 123 29M 36B 39C 3V. 4.4 53G 70F 7RV 7X7 88E 8AO 8FI 8FJ 8R4 8R5 AAEEF AARCD AAWYQ AAYZH AAZLF ABAWZ ABDBF ABIVO ABJNI ABLJU ABNNU ABUWG ACGFS ACIWK ACPRK ACRPL ACUHS ADBBV ADNMO AENEX AFBBN AFKRA AFSHS AGAYW AGGDT AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKEYQ BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBS EE. EJD EMB EMK EMOBN EPL EPS ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR INH INR IPY ITC L-9 M1P M2M M7P N9A NAPCQ NNMJJ O9- ODYON P2P PQQKQ PROAC PSQYO PSYQQ Q2X RIG RNR RNT RNTTT SHXYY SIXXV SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP WOW X7M ~8M AAYXX ACSTC AETEA AFANA ALPWD ATHPR CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NFIDA NPM PMFND 7X8 PJZUB PPXIY PQGLB PUEGO 5PM |
| ID | FETCH-LOGICAL-c469t-f60d57ce493613b2be72008b5302226a5839b2c3a4962cfe7415b2d300fb16ba3 |
| ISSN | 1471-003X 1471-0048 |
| IngestDate | Thu Aug 21 18:11:49 EDT 2025 Fri Sep 05 07:53:34 EDT 2025 Tue Jun 17 21:11:37 EDT 2025 Tue Jun 10 20:40:00 EDT 2025 Thu Apr 03 06:55:41 EDT 2025 Tue Jul 01 00:42:00 EDT 2025 Thu Apr 24 23:07:16 EDT 2025 Fri Feb 21 02:38:39 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c469t-f60d57ce493613b2be72008b5302226a5839b2c3a4962cfe7415b2d300fb16ba3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/4017235 |
| PMID | 23900411 |
| PQID | 1426748891 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4017235 proquest_miscellaneous_1426748891 gale_infotracmisc_A344154660 gale_infotracacademiconefile_A344154660 pubmed_primary_23900411 crossref_citationtrail_10_1038_nrn3549 crossref_primary_10_1038_nrn3549 springer_journals_10_1038_nrn3549 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-09-01 |
| PublicationDateYYYYMMDD | 2013-09-01 |
| PublicationDate_xml | – month: 09 year: 2013 text: 2013-09-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature reviews. Neuroscience |
| PublicationTitleAbbrev | Nat Rev Neurosci |
| PublicationTitleAlternate | Nat Rev Neurosci |
| PublicationYear | 2013 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Singleton (CR27) 2003; 302 Jellinger (CR82) 2007; 72 Neumann (CR116) 2009; 132 Conway, Harper, Lansbury (CR28) 1998; 4 Williams-Gray (CR121) 2009; 256 Perry (CR79) 1985; 48 Petrou (CR143) 2012; 79 Selikhova (CR106) 2009; 132 Chen-Plotkin (CR128) 2011; 69 Hall (CR131) 2012; 69 Harding, Halliday (CR74) 2001; 102 Jellinger, Attems (CR73) 2008; 115 Alves (CR109) 2012; 85 Halliday, Song, Harding (CR99) 2011; 118 Lee (CR59) 2008; 40 Alves (CR132) 2010; 81 Valera, Masliah (CR150) 2013; 138 Kraybill (CR104) 2005; 64 Lee, Giasson, Trojanowski (CR91) 2004; 27 Levy (CR22) 2000; 55 Sperling (CR151) 2011; 7 Tsuboi, Uchikado, Dickson (CR72) 2007; 13 Richard, Papka, Rubio, Kurlan (CR97) 2002; 17 Pellecchia (CR129) 2012; 260 Magen, Chesselet (CR32) 2010; 184 Apaydin, Ahlskog, Parisi, Boeve, Dickson (CR69) 2002; 59 Lippa (CR14) 2007; 68 Svenningsson, Westman, Ballard, Aarsland (CR113) 2012; 11 Ward, Gibb (CR153) 1990; 53 McKeith (CR16) 2006; 9 Braak (CR46) 2006; 70 Wakabayashi (CR122) 1998; 95 Goedert, Spillantini, Del Tredici, Braak (CR1) 2012; 9 Müller (CR111) 2012; 28 Lashley (CR87) 2008; 115 Grossman (CR13) 2012; 120 Emre (CR5) 2007; 22 Siderowf (CR123) 2010; 75 Lo (CR11) 2009; 66 Hughes, Daniel, Blankson, Lees (CR85) 1993; 50 Prikrylova Vranova (CR108) 2010; 117 Duda, Giasson, Mabon, Lee, Trojanowski (CR68) 2002; 52 Jellinger (CR36) 2004; 111 Iseki (CR49) 2004; 24 Hurtig (CR67) 2000; 54 Weintraub (CR17) 2008; 64 Steiner, Angot, Brundin (CR63) 2011; 18 Duda (CR90) 2002; 104 Mougenot (CR61) 2012; 33 Mollenhauer (CR135) 2008; 213 Bohnen (CR144) 2011; 52 Poulopoulos, Levy, Alcalay (CR26) 2012; 27 Del Tredici, Rub, De Vos, Bohl, Braak (CR34) 2002; 61 Rolinski, Fox, Maidment, McShane (CR147) 2012; 3 Litvan (CR12) 2012; 27 Nakashima-Yasuda (CR95) 2007; 114 Merdes (CR100) 2003; 60 Mattila, Rinne, Helenius, Dickson, Roytta (CR76) 2000; 100 Halliday, Hely, Reid, Morris (CR6) 2008; 115 Olanow, Brundin (CR64) 2013; 28 Ballard (CR78) 2006; 67 Tsuang (CR115) 2012; 79 Shi (CR139) 2011; 69 Levy (CR24) 2002; 17 Hong (CR138) 2010; 133 Kotzbauer (CR84) 2012; 69 Muslimovic, Post, Speelman, Schmand (CR9) 2005; 65 van Rooden (CR105) 2010; 25 Compta (CR71) 2011; 134 Wang (CR136) 2012; 4 Parkkinen (CR45) 2011; 1 Beach (CR38) 2009; 117 Polymeropoulos (CR25) 1997; 276 Li (CR52) 2008; 14 Aarsland, Andersen, Larsen, Lolk, Kragh-Sorensen (CR3) 2003; 60 Levy (CR7) 2002; 51 Kordower, Chu, Hauser, Olanow, Freeman (CR54) 2008; 23 Mikolaenko (CR39) 2005; 64 Gomperts (CR142) 2013; 80 Kordower, Chu, Hauser, Freeman, Olanow (CR53) 2008; 14 Sidransky (CR114) 2009; 361 Compta (CR140) 2012; 18 Hely, Reid, Adena, Halliday, Morris (CR2) 2008; 23 Brown, Gajdusek, Gibbs, Asher (CR157) 1985; 313 Spillantini (CR29) 1997; 388 Jellinger (CR51) 2008; 116 Irwin (CR66) 2013; 70 Parkkinen, Pirttila, Alafuzoff (CR37) 2008; 115 Dickson (CR41) 2008; 115 Goris (CR126) 2007; 62 Hamilton (CR47) 2000; 10 Leverenz (CR50) 2008; 18 Williams-Gray (CR8) 2009; 132 Jellinger, Seppi, Wenning, Poewe (CR83) 2002; 109 CR110 Milber (CR44) 2012; 79 Halliday, Holton, Revesz, Dickson (CR112) 2011; 122 Saito (CR42) 2003; 62 Nelson (CR103) 2010; 257 Weintraub, Papay, Siderowf (CR18) 2013; 80 Clinton, Blurton-Jones, Myczek, Trojanowski, LaFerla (CR89) 2010; 30 Pletnikova (CR77) 2005; 26 Aarsland (CR20) 2007; 254 Galvin, Pollack, Morris (CR15) 2006; 67 Sabbagh (CR94) 2009; 23 Beyer (CR145) 2013; 28 Lashuel, Overk, Oueslati, Masliah (CR149) 2013; 14 Kempster, O'Sullivan, Holton, Revesz, Lees (CR4) 2010; 133 Kalaitzakis, Graeber, Gentleman, Pearce (CR81) 2008; 67 Braak, Rub, Jansen Steur, Del Tredici, de Vos (CR21) 2005; 64 Verghese, Crystal, Dickson, Lipton (CR101) 1999; 53 Litvan (CR102) 1998; 55 Rosenthal (CR10) 2010; 25 Morley (CR119) 2012; 27 Giasson (CR30) 2002; 34 Jankovic (CR23) 1990; 40 Dickson, Uchikado, Fujishiro, Tsuboi (CR35) 2010; 25 Weintraub (CR141) 2011; 135 Jellinger, Attems (CR98) 2006; 112 Brown (CR156) 1994; 35 Kovari (CR75) 2003; 106 Nalls (CR117) 2013; 70 Masliah (CR88) 2001; 98 Luk (CR57) 2012; 209 Parkkinen, Kauppinen, Pirttila, Autere, Alafuzoff (CR40) 2005; 57 Braak (CR33) 2003; 24 Lim (CR31) 2011; 31 Alves, Larsen, Emre, Wentzel-Larsen, Aarsland (CR107) 2006; 21 Zabetian (CR125) 2007; 62 Desplats (CR60) 2009; 106 Compta (CR130) 2009; 24 Tsuang (CR120) 2013; 70 Wakabayashi (CR43) 2013; 47 Jellinger, Wenning, Seppi (CR93) 2007; 4 Kordower, Brundin (CR155) 2009; 220 Volpicelli-Daley (CR56) 2011; 72 Masuda-Suzukake (CR62) 2013; 136 Irwin (CR70) 2012; 72 Montine (CR133) 2010; 25 Giasson (CR92) 2003; 300 Leverenz (CR134) 2011; 17 Sabbagh (CR86) 2009; 23 Baker (CR124) 1999; 8 Compta (CR127) 2011; 487 Montine (CR152) 2012; 123 Colosimo, Hughes, Kilford, Lees (CR96) 2003; 74 Luk (CR58) 2012; 338 Schrag, Ben-Shlomo, Brown, Marsden, Quinn (CR19) 1998; 13 Seppi (CR148) 2011; 26 Luk (CR55) 2009; 106 Marek (CR146) 2011; 95 Prusiner (CR154) 1982; 216 Clark (CR118) 2009; 66 Tokuda (CR137) 2010; 75 Whitehouse, Hedreen, White, Price (CR80) 1983; 13 Lee, Trojanowski (CR65) 2006; 52 Lippa (CR48) 1998; 153 MH Polymeropoulos (BFnrn3549_CR25) 1997; 276 JB Leverenz (BFnrn3549_CR50) 2008; 18 K Wakabayashi (BFnrn3549_CR43) 2013; 47 JH Kordower (BFnrn3549_CR53) 2008; 14 ML Müller (BFnrn3549_CR111) 2012; 28 KA Jellinger (BFnrn3549_CR51) 2008; 116 DJ Irwin (BFnrn3549_CR66) 2013; 70 PT Kotzbauer (BFnrn3549_CR84) 2012; 69 TJ Montine (BFnrn3549_CR152) 2012; 123 TJ Montine (BFnrn3549_CR133) 2010; 25 DW Dickson (BFnrn3549_CR41) 2008; 115 PT Nelson (BFnrn3549_CR103) 2010; 257 CP Zabetian (BFnrn3549_CR125) 2007; 62 KC Luk (BFnrn3549_CR58) 2012; 338 E Kovari (BFnrn3549_CR75) 2003; 106 J Neumann (BFnrn3549_CR116) 2009; 132 AJ Hughes (BFnrn3549_CR85) 1993; 50 DJ Irwin (BFnrn3549_CR70) 2012; 72 Y Saito (BFnrn3549_CR42) 2003; 62 JH Kordower (BFnrn3549_CR155) 2009; 220 JE Duda (BFnrn3549_CR68) 2002; 52 PM Mattila (BFnrn3549_CR76) 2000; 100 E Iseki (BFnrn3549_CR49) 2004; 24 A Siderowf (BFnrn3549_CR123) 2010; 75 E Masliah (BFnrn3549_CR88) 2001; 98 VM Lee (BFnrn3549_CR91) 2004; 27 J Verghese (BFnrn3549_CR101) 1999; 53 K Seppi (BFnrn3549_CR148) 2011; 26 G Levy (BFnrn3549_CR24) 2002; 17 SN Gomperts (BFnrn3549_CR142) 2013; 80 Y Lim (BFnrn3549_CR31) 2011; 31 T Lashley (BFnrn3549_CR87) 2008; 115 M Emre (BFnrn3549_CR5) 2007; 22 KA Conway (BFnrn3549_CR28) 1998; 4 CH Williams-Gray (BFnrn3549_CR8) 2009; 132 NI Bohnen (BFnrn3549_CR144) 2011; 52 P Brown (BFnrn3549_CR156) 1994; 35 JH Kordower (BFnrn3549_CR54) 2008; 23 MG Spillantini (BFnrn3549_CR29) 1997; 388 M Masuda-Suzukake (BFnrn3549_CR62) 2013; 136 P Brown (BFnrn3549_CR157) 1985; 313 MN Sabbagh (BFnrn3549_CR94) 2009; 23 Y Compta (BFnrn3549_CR140) 2012; 18 E Valera (BFnrn3549_CR150) 2013; 138 CD Ward (BFnrn3549_CR153) 1990; 53 M Baker (BFnrn3549_CR124) 1999; 8 M Rolinski (BFnrn3549_CR147) 2012; 3 PJ Whitehouse (BFnrn3549_CR80) 1983; 13 KC Luk (BFnrn3549_CR57) 2012; 209 Y Wang (BFnrn3549_CR136) 2012; 4 ME Kalaitzakis (BFnrn3549_CR81) 2008; 67 GM Halliday (BFnrn3549_CR112) 2011; 122 KC Luk (BFnrn3549_CR55) 2009; 106 D Aarsland (BFnrn3549_CR3) 2003; 60 IG McKeith (BFnrn3549_CR16) 2006; 9 H Apaydin (BFnrn3549_CR69) 2002; 59 TG Beach (BFnrn3549_CR38) 2009; 117 HI Hurtig (BFnrn3549_CR67) 2000; 54 JE Duda (BFnrn3549_CR90) 2002; 104 D Tsuang (BFnrn3549_CR115) 2012; 79 I Mikolaenko (BFnrn3549_CR39) 2005; 64 AJ Harding (BFnrn3549_CR74) 2001; 102 Y Compta (BFnrn3549_CR130) 2009; 24 A Schrag (BFnrn3549_CR19) 1998; 13 JA Steiner (BFnrn3549_CR63) 2011; 18 I Litvan (BFnrn3549_CR102) 1998; 55 M Poulopoulos (BFnrn3549_CR26) 2012; 27 JY Li (BFnrn3549_CR52) 2008; 14 D Weintraub (BFnrn3549_CR141) 2011; 135 KA Jellinger (BFnrn3549_CR82) 2007; 72 SB Prusiner (BFnrn3549_CR154) 1982; 216 I Litvan (BFnrn3549_CR12) 2012; 27 CH Williams-Gray (BFnrn3549_CR121) 2009; 256 GM Halliday (BFnrn3549_CR99) 2011; 118 AR Merdes (BFnrn3549_CR100) 2003; 60 S Hall (BFnrn3549_CR131) 2012; 69 M Goedert (BFnrn3549_CR1) 2012; 9 L Parkkinen (BFnrn3549_CR40) 2005; 57 H Prikrylova Vranova (BFnrn3549_CR108) 2010; 117 HA Lashuel (BFnrn3549_CR149) 2013; 14 MA Hely (BFnrn3549_CR2) 2008; 23 G Alves (BFnrn3549_CR107) 2006; 21 A Goris (BFnrn3549_CR126) 2007; 62 H Braak (BFnrn3549_CR33) 2003; 24 PA Kempster (BFnrn3549_CR4) 2010; 133 E Sidransky (BFnrn3549_CR114) 2009; 361 SM van Rooden (BFnrn3549_CR105) 2010; 25 RY Lo (BFnrn3549_CR11) 2009; 66 I Magen (BFnrn3549_CR32) 2010; 184 MT Pellecchia (BFnrn3549_CR129) 2012; 260 EK Perry (BFnrn3549_CR79) 1985; 48 D Muslimovic (BFnrn3549_CR9) 2005; 65 J Jankovic (BFnrn3549_CR23) 1990; 40 P Desplats (BFnrn3549_CR60) 2009; 106 MA Nalls (BFnrn3549_CR117) 2013; 70 KA Jellinger (BFnrn3549_CR93) 2007; 4 Y Tsuboi (BFnrn3549_CR72) 2007; 13 G Alves (BFnrn3549_CR132) 2010; 81 C Ballard (BFnrn3549_CR78) 2006; 67 Z Hong (BFnrn3549_CR138) 2010; 133 AL Mougenot (BFnrn3549_CR61) 2012; 33 AB Singleton (BFnrn3549_CR27) 2003; 302 G Alves (BFnrn3549_CR109) 2012; 85 B Mollenhauer (BFnrn3549_CR135) 2008; 213 LK Clinton (BFnrn3549_CR89) 2010; 30 E Rosenthal (BFnrn3549_CR10) 2010; 25 JM Milber (BFnrn3549_CR44) 2012; 79 CF Lippa (BFnrn3549_CR14) 2007; 68 DW Dickson (BFnrn3549_CR35) 2010; 25 G Halliday (BFnrn3549_CR6) 2008; 115 KA Jellinger (BFnrn3549_CR73) 2008; 115 T Tokuda (BFnrn3549_CR137) 2010; 75 C Colosimo (BFnrn3549_CR96) 2003; 74 LN Clark (BFnrn3549_CR118) 2009; 66 JE Galvin (BFnrn3549_CR15) 2006; 67 D Weintraub (BFnrn3549_CR17) 2008; 64 H Braak (BFnrn3549_CR21) 2005; 64 H Braak (BFnrn3549_CR46) 2006; 70 BI Giasson (BFnrn3549_CR92) 2003; 300 K Marek (BFnrn3549_CR146) 2011; 95 G Levy (BFnrn3549_CR22) 2000; 55 HJ Lee (BFnrn3549_CR59) 2008; 40 KA Jellinger (BFnrn3549_CR83) 2002; 109 M Shi (BFnrn3549_CR139) 2011; 69 CW Olanow (BFnrn3549_CR64) 2013; 28 JF Morley (BFnrn3549_CR119) 2012; 27 JB Leverenz (BFnrn3549_CR134) 2011; 17 IH Richard (BFnrn3549_CR97) 2002; 17 G Levy (BFnrn3549_CR7) 2002; 51 Y Compta (BFnrn3549_CR127) 2011; 487 K Wakabayashi (BFnrn3549_CR122) 1998; 95 M Grossman (BFnrn3549_CR13) 2012; 120 D Weintraub (BFnrn3549_CR18) 2013; 80 CF Lippa (BFnrn3549_CR48) 1998; 153 RL Hamilton (BFnrn3549_CR47) 2000; 10 KA Jellinger (BFnrn3549_CR98) 2006; 112 LA Volpicelli-Daley (BFnrn3549_CR56) 2011; 72 L Parkkinen (BFnrn3549_CR45) 2011; 1 D Aarsland (BFnrn3549_CR20) 2007; 254 BI Giasson (BFnrn3549_CR30) 2002; 34 H Nakashima-Yasuda (BFnrn3549_CR95) 2007; 114 M Selikhova (BFnrn3549_CR106) 2009; 132 M Petrou (BFnrn3549_CR143) 2012; 79 O Pletnikova (BFnrn3549_CR77) 2005; 26 BFnrn3549_CR110 K Del Tredici (BFnrn3549_CR34) 2002; 61 VM Lee (BFnrn3549_CR65) 2006; 52 P Svenningsson (BFnrn3549_CR113) 2012; 11 ML Kraybill (BFnrn3549_CR104) 2005; 64 RA Sperling (BFnrn3549_CR151) 2011; 7 L Parkkinen (BFnrn3549_CR37) 2008; 115 MN Sabbagh (BFnrn3549_CR86) 2009; 23 KA Jellinger (BFnrn3549_CR36) 2004; 111 AS Chen-Plotkin (BFnrn3549_CR128) 2011; 69 D Tsuang (BFnrn3549_CR120) 2013; 70 MK Beyer (BFnrn3549_CR145) 2013; 28 Y Compta (BFnrn3549_CR71) 2011; 134 22825369 - Arch Neurol. 2012 Oct;69(10):1326-31 19127573 - Ann Neurol. 2008 Dec;64 Suppl 2:S93-100 19433657 - Arch Neurol. 2009 May;66(5):578-83 19812474 - Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):295-7 12498954 - Neurobiol Aging. 2003 Mar-Apr;24(2):197-211 11956955 - J Neural Transm (Vienna). 2002 Mar;109(3):329-39 18592254 - Acta Neuropathol. 2008 Jul;116(1):1-16 9827611 - Mov Disord. 1998 Nov;13(6):885-94 22508839 - J Exp Med. 2012 May 7;209(5):975-86 18264713 - Acta Neuropathol. 2008 Apr;115(4):437-44 2239463 - Adv Neurol. 1990;53:245-9 23243071 - Neurology. 2013 Jan 1;80(1):85-91 18625222 - Exp Neurol. 2008 Oct;213(2):315-25 23296128 - Neurology. 2013 Jan 8;80(2):176-80 17934326 - Neurodegener Dis. 2007;4(6):428-30 21596773 - Brain. 2011 May;134(Pt 5):1493-505 9809558 - Nat Med. 1998 Nov;4(11):1318-20 18291704 - Int J Biochem Cell Biol. 2008;40(9):1835-49 15562510 - Ann Neurol. 2005 Jan;57(1):82-91 12714745 - Science. 2003 Apr 25;300(5619):636-40 19006193 - Mov Disord. 2008 Dec 15;23(16):2303-6 20720189 - Neurology. 2010 Sep 21;75(12):1055-61 18241240 - Brain Pathol. 2008 Apr;18(2):220-4 6801762 - Science. 1982 Apr 9;216(4542):136-44 19399512 - Acta Neuropathol. 2009 Jun;117(6):613-34 20951764 - Neurosci Lett. 2011 Jan 7;487(2):169-73 22275317 - Mov Disord. 2012 Mar;27(3):349-56 12112078 - Ann Neurol. 2002 Jun;51(6):722-9 12633150 - Arch Neurol. 2003 Mar;60(3):387-92 10953188 - Neurology. 2000 Aug 22;55(4):539-44 18267239 - Parkinsonism Relat Disord. 2007;13 Suppl 3:S221-4 18273624 - Acta Neuropathol. 2008 Apr;115(4):427-36 20157014 - Brain. 2010 Mar;133(Pt 3):713-26 11603811 - Acta Neuropathol. 2001 Oct;102(4):355-63 15480835 - J Neural Transm (Vienna). 2004 Oct;111(10-11):1219-35 6847136 - Ann Neurol. 1983 Mar;13(3):243-8 15751230 - J Neuropathol Exp Neurol. 2005 Feb;64(2):156-62 15068176 - Neuropathology. 2004 Mar;24(1):72-8 22108576 - Brain. 2012 Jan;135(Pt 1):170-80 12030260 - J Neuropathol Exp Neurol. 2002 May;61(5):413-26 2215943 - Neurology. 1990 Oct;40(10):1529-34 16914880 - J Alzheimers Dis. 2006;9(3 Suppl):417-23 23408705 - Mov Disord. 2013 Mar;28(3):302-10 21479514 - J Neural Transm (Vienna). 2011 May;118(5):713-9 18391963 - Nat Med. 2008 May;14(5):501-3 20818673 - Mov Disord. 2010 Nov 15;25(15):2682-5 23239424 - Mov Disord. 2013 Mar;28(3):296-301 22021174 - Mov Disord. 2011 Oct;26 Suppl 3:S42-80 17683088 - Ann Neurol. 2007 Aug;62(2):145-53 17982882 - J Neural Transm Suppl. 2007;(72):91-104 22933741 - Neurology. 2012 Sep 11;79(11):1161-7 16247051 - Neurology. 2005 Oct 25;65(8):1239-45 22911513 - J Neurol. 2013 Feb;260(2):438-44 9678315 - Arch Neurol. 1998 Jul;55(7):969-78 20962290 - Neurology. 2010 Nov 16;75(20):1766-72 10822429 - Neurology. 2000 May 23;54(10):1916-21 22925882 - Arch Neurol. 2012 Nov;69(11):1445-52 9278044 - Nature. 1997 Aug 28;388(6645):839-40 8179297 - Ann Neurol. 1994 May;35(5):513-29 19651612 - Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5 22344688 - Sci Transl Med. 2012 Feb 15;4(121):121ra20 12210791 - Ann Neurol. 2002 Aug;52(2):205-10 17159096 - Neurology. 2006 Dec 12;67(11):1931-4 11790237 - Arch Neurol. 2002 Jan;59(1):102-12 12810766 - J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):852-6 20310053 - Mov Disord. 2010 Jul 15;25(9):1170-6 22814541 - Lancet Neurol. 2012 Aug;11(8):697-707 15851731 - Neurology. 2005 Apr 26;64(8):1404-10 21982369 - Neuron. 2011 Oct 6;72(1):57-71 23588557 - JAMA Neurol. 2013 Jun;70(6):727-35 23939308 - J Parkinsons Dis. 2011;1(3):277-86 19846850 - N Engl J Med. 2009 Oct 22;361(17):1651-61 16637023 - Mov Disord. 2006 Aug;21(8):1123-30 22344634 - Mov Disord. 2012 Apr;27(4):512-8 18185940 - Acta Neuropathol. 2008 Apr;115(4):417-25 9600590 - Acta Neuropathol. 1998 May;95(5):450-4 23254192 - Nat Rev Neurosci. 2013 Jan;14(1):38-48 20187227 - Mov Disord. 2010;25 Suppl 1:S78-82 18297293 - Acta Neuropathol. 2008 Apr;115(4):399-407 22595621 - Parkinsonism Relat Disord. 2012 Sep;18(8):941-7 19308307 - J Neurol. 2009 Mar;256(3):493-8 21520231 - Ann Neurol. 2011 Apr;69(4):655-63 12070658 - Acta Neuropathol. 2002 Jul;104(1):7-11 12465052 - Mov Disord. 2002 Nov;17(6):1161-5 23979011 - JAMA Neurol. 2013 Oct;70(10):1277-87 19892735 - Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20051-6 21400565 - Ann Neurol. 2011 Mar;69(3):570-80 21813214 - Neurobiol Aging. 2012 Sep;33(9):2225-8 21734300 - J Neurosci. 2011 Jul 6;31(27):10076-87 10965798 - Acta Neuropathol. 2000 Sep;100(3):285-90 19901166 - Arch Neurol. 2009 Nov;66(11):1353-8 23380910 - JAMA Neurol. 2013 Apr;70(4):462-8 21720849 - Acta Neuropathol. 2011 Aug;122(2):187-204 14593171 - Science. 2003 Oct 31;302(5646):841 21566660 - Cell Death Differ. 2011 Sep;18(9):1425-33 10599768 - Neurology. 1999 Dec 10;53(9):1974-82 12687392 - Acta Neuropathol. 2003 Jul;106(1):83-8 23117496 - J Neurol Neurosurg Psychiatry. 2013 May;84(5):537-43 10072441 - Hum Mol Genet. 1999 Apr;8(4):711-5 22451330 - Mov Disord. 2012 Jun;27(7):831-42 12771246 - Neurology. 2003 May 27;60(10):1586-90 17353469 - Neurology. 2007 Mar 13;68(11):812-9 15036877 - Trends Neurosci. 2004 Mar;27(3):129-34 23161999 - Science. 2012 Nov 16;338(6109):949-53 17514749 - Ann Neurol. 2007 Aug;62(2):137-44 20535823 - Mov Disord. 2010 Jun 15;25(8):969-78 12465060 - Mov Disord. 2002 Nov;17(6):1221-6 17508138 - J Neurol. 2007 Jan;254(1):38-45 18391962 - Nat Med. 2008 May;14(5):504-6 20730548 - J Neural Transm (Vienna). 2010 Oct;117(10):1177-81 18219254 - J Neuropathol Exp Neurol. 2008 Feb;67(2):155-61 23384597 - Pharmacol Ther. 2013 Jun;138(3):311-22 23390095 - Mov Disord. 2013 Jan;28(1):31-40 20371510 - Brain. 2010 Jun;133(Pt 6):1755-62 21044858 - Parkinsonism Relat Disord. 2011 Jan;17(1):61-4 19812464 - Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):229-33 23152586 - Neurology. 2012 Dec 11;79(24):2307-14 20887870 - Prog Brain Res. 2010;184:53-87 11572944 - Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12245-50 20547614 - J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1080-6 18231798 - Acta Neuropathol. 2008 Apr;115(4):409-15 19812213 - Brain. 2009 Nov;132(Pt 11):2958-69 19795154 - J Neurol. 2010 Mar;257(3):359-66 22101365 - Acta Neuropathol. 2012 Jan;123(1):1-11 20505094 - J Neurosci. 2010 May 26;30(21):7281-9 17542011 - Mov Disord. 2007 Sep 15;22(12):1689-707; quiz 1837 9811326 - Am J Pathol. 1998 Nov;153(5):1365-70 23037886 - Ann Neurol. 2012 Oct;72(4):587-98 21930184 - Prog Neurobiol. 2011 Dec;95(4):629-35 12062037 - Neuron. 2002 May 16;34(4):521-33 16804711 - Acta Neuropathol. 2006 Sep;112(3):253-60 21514248 - Alzheimers Dement. 2011 May;7(3):280-92 12834109 - J Neuropathol Exp Neurol. 2003 Jun;62(6):644-54 23183883 - Nat Rev Neurol. 2013 Jan;9(1):13-24 21571793 - J Nucl Med. 2011 Jun;52(6):848-55 3998751 - J Neurol Neurosurg Psychiatry. 1985 May;48(5):413-21 23035075 - Neurology. 2012 Nov 6;79(19):1944-50 10885656 - Brain Pathol. 2000 Jul;10(3):378-84 21962945 - Brain Lang. 2012 Jan;120(1):52-60 17017514 - J Neural Transm Suppl. 2006;(70):89-97 19759203 - Brain. 2009 Nov;132(Pt 11):2947-57 3929089 - N Engl J Med. 1985 Sep 19;313(12):728-31 17015225 - Neuron. 2006 Oct 5;52(1):33-8 23407718 - JAMA Neurol. 2013 Feb;70(2):223-8 23466394 - Brain. 2013 Apr;136(Pt 4):1128-38 22622968 - Mol Neurobiol. 2013 Apr;47(2):495-508 17101891 - Neurology. 2006 Nov 14;67(9):1605-11 19795497 - Mov Disord. 2009 Nov 15;24(15):2203-10 8431132 - Arch Neurol. 1993 Feb;50(2):140-8 15917102 - Neurobiol Aging. 2005 Aug-Sep;26(8):1183-92 17653732 - Acta Neuropathol. 2007 Sep;114(3):221-9 22419314 - Cochrane Database Syst Rev. 2012;3:CD006504 19286695 - Brain. 2009 Jul;132(Pt 7):1783-94 9197268 - Science. 1997 Jun 27;276(5321):2045-7 18307261 - Mov Disord. 2008 Apr 30;23(6):837-44 19786018 - Exp Neurol. 2009 Dec;220(2):224-5 15985574 - Neurology. 2005 Jun 28;64(12):2069-73 |
| References_xml | – volume: 313 start-page: 728 year: 1985 end-page: 731 ident: CR157 article-title: Potential epidemic of Creutzfeldt–Jakob disease from human growth hormone therapy publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198509193131205 – volume: 153 start-page: 1365 year: 1998 end-page: 1370 ident: CR48 article-title: Lewy bodies contain altered α-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)65722-7 – volume: 13 start-page: 243 year: 1983 end-page: 248 ident: CR80 article-title: Basal forebrain neurons in the dementia of Parkinson disease publication-title: Ann. Neurol. doi: 10.1002/ana.410130304 – volume: 62 start-page: 137 year: 2007 end-page: 144 ident: CR125 article-title: Association analysis of H1 haplotype and subhaplotypes in Parkinson's disease publication-title: Ann. Neurol. doi: 10.1002/ana.21157 – volume: 14 start-page: 501 year: 2008 end-page: 503 ident: CR52 article-title: Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation publication-title: Nature Med. doi: 10.1038/nm1746 – volume: 80 start-page: 176 year: 2013 end-page: 180 ident: CR18 article-title: Screening for impulse control symptoms in patients with Parkinson disease: a case-control study publication-title: Neurology doi: 10.1212/WNL.0b013e31827b915c – volume: 57 start-page: 82 year: 2005 end-page: 91 ident: CR40 article-title: α-synuclein pathology does not predict extrapyramidal symptoms or dementia publication-title: Ann. Neurol. doi: 10.1002/ana.20321 – volume: 52 start-page: 33 year: 2006 end-page: 38 ident: CR65 article-title: Mechanisms of Parkinson's disease linked to pathological α-synuclein: new targets for drug discovery publication-title: Neuron doi: 10.1016/j.neuron.2006.09.026 – volume: 79 start-page: 2307 year: 2012 end-page: 2314 ident: CR44 article-title: Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease publication-title: Neurology doi: 10.1212/WNL.0b013e318278fe32 – volume: 22 start-page: 1689 year: 2007 end-page: 1707 ident: CR5 article-title: Clinical diagnostic criteria for dementia associated with Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.21507 – volume: 85 start-page: 537 year: 2012 end-page: 543 ident: CR109 article-title: Cerebrospinal fluid amyloid-β and phenotypic heterogeneity in Parkinson's disease publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 40 start-page: 1529 year: 1990 end-page: 1534 ident: CR23 article-title: Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group publication-title: Neurology doi: 10.1212/WNL.40.10.1529 – volume: 9 start-page: 13 year: 2012 end-page: 24 ident: CR1 article-title: 100 years of Lewy pathology publication-title: Nature Rev. Neurol. doi: 10.1038/nrneurol.2012.242 – volume: 213 start-page: 315 year: 2008 end-page: 325 ident: CR135 article-title: Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2008.06.004 – volume: 4 start-page: 1318 year: 1998 end-page: 1320 ident: CR28 article-title: Accelerated fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease publication-title: Nature Med. doi: 10.1038/3311 – volume: 66 start-page: 578 year: 2009 end-page: 583 ident: CR118 article-title: Association of glucocerebrosidase mutations with dementia with lewy bodies publication-title: Arch. Neurol. doi: 10.1001/archneurol.2009.54 – volume: 31 start-page: 10076 year: 2011 end-page: 10087 ident: CR31 article-title: α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0618-11.2011 – volume: 361 start-page: 1651 year: 2009 end-page: 1661 ident: CR114 article-title: Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0901281 – volume: 26 start-page: 42 issue: Suppl. 3 year: 2011 end-page: 80 ident: CR148 article-title: The movement disorder society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.23884 – volume: 18 start-page: 220 year: 2008 end-page: 224 ident: CR50 article-title: Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient publication-title: Brain Pathol. doi: 10.1111/j.1750-3639.2007.00117.x – volume: 115 start-page: 427 year: 2008 end-page: 436 ident: CR73 article-title: Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0347-5 – volume: 117 start-page: 613 year: 2009 end-page: 634 ident: CR38 article-title: Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction publication-title: Acta Neuropathol. doi: 10.1007/s00401-009-0538-8 – volume: 81 start-page: 1080 year: 2010 end-page: 1086 ident: CR132 article-title: CSF amyloid-β and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.2009.199950 – volume: 98 start-page: 12245 year: 2001 end-page: 12250 ident: CR88 article-title: β-amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.211412398 – volume: 54 start-page: 1916 year: 2000 end-page: 1921 ident: CR67 article-title: Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease publication-title: Neurology doi: 10.1212/WNL.54.10.1916 – volume: 60 start-page: 1586 year: 2003 end-page: 1590 ident: CR100 article-title: Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies publication-title: Neurology doi: 10.1212/01.WNL.0000065889.42856.F2 – volume: 9 start-page: 417 year: 2006 end-page: 423 ident: CR16 article-title: Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-2006-9S347 – volume: 23 start-page: 295 year: 2009 end-page: 297 ident: CR86 article-title: Parkinson disease with dementia: comparing patients with and without Alzheimer pathology publication-title: Alzheimer Dis. Assoc. Disord. doi: 10.1097/WAD.0b013e31819c5ef4 – volume: 117 start-page: 1177 year: 2010 end-page: 1181 ident: CR108 article-title: CSF markers of neurodegeneration in Parkinson's disease publication-title: J. Neural Transm. doi: 10.1007/s00702-010-0462-z – volume: 61 start-page: 413 year: 2002 end-page: 426 ident: CR34 article-title: Where does parkinson disease pathology begin in the brain? publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/61.5.413 – volume: 50 start-page: 140 year: 1993 end-page: 148 ident: CR85 article-title: A clinicopathologic study of 100 cases of Parkinson's disease publication-title: Arch. Neurol. doi: 10.1001/archneur.1993.00540020018011 – volume: 4 start-page: 428 year: 2007 end-page: 430 ident: CR93 article-title: Predictors of survival in dementia with lewy bodies and Parkinson dementia publication-title: Neurodegener. Dis. doi: 10.1159/000107703 – volume: 132 start-page: 2947 year: 2009 end-page: 2957 ident: CR106 article-title: A clinico-pathological study of subtypes in Parkinson's disease publication-title: Brain doi: 10.1093/brain/awp234 – volume: 209 start-page: 975 year: 2012 end-page: 986 ident: CR57 article-title: Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice publication-title: J. Exp. Med. doi: 10.1084/jem.20112457 – volume: 300 start-page: 636 year: 2003 end-page: 640 ident: CR92 article-title: Initiation and synergistic fibrillization of tau and α-synuclein publication-title: Science doi: 10.1126/science.1082324 – volume: 133 start-page: 713 year: 2010 end-page: 726 ident: CR138 article-title: DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease publication-title: Brain doi: 10.1093/brain/awq008 – volume: 216 start-page: 136 year: 1982 end-page: 144 ident: CR154 article-title: Novel proteinaceous infectious particles cause scrapie publication-title: Science doi: 10.1126/science.6801762 – volume: 68 start-page: 812 year: 2007 end-page: 819 ident: CR14 article-title: DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers publication-title: Neurology doi: 10.1212/01.wnl.0000256715.13907.d3 – volume: 72 start-page: 57 year: 2011 end-page: 71 ident: CR56 article-title: Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death publication-title: Neuron doi: 10.1016/j.neuron.2011.08.033 – volume: 40 start-page: 1835 year: 2008 end-page: 1849 ident: CR59 article-title: Assembly-dependent endocytosis and clearance of extracellular α-synuclein publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2008.01.017 – volume: 67 start-page: 1931 year: 2006 end-page: 1934 ident: CR78 article-title: Differences in neuropathologic characteristics across the Lewy body dementia spectrum publication-title: Neurology doi: 10.1212/01.wnl.0000249130.63615.cc – volume: 60 start-page: 387 year: 2003 end-page: 392 ident: CR3 article-title: Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study publication-title: Arch. Neurol. doi: 10.1001/archneur.60.3.387 – volume: 59 start-page: 102 year: 2002 end-page: 112 ident: CR69 article-title: Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response publication-title: Arch. Neurol. doi: 10.1001/archneur.59.1.102 – volume: 134 start-page: 1493 year: 2011 end-page: 1505 ident: CR71 article-title: Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important? publication-title: Brain. doi: 10.1093/brain/awr031 – volume: 55 start-page: 969 year: 1998 end-page: 978 ident: CR102 article-title: Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study publication-title: Arch. Neurol. doi: 10.1001/archneur.55.7.969 – volume: 70 start-page: 223 year: 2013 end-page: 228 ident: CR120 article-title: ε4 increases risk for dementia in pure synucleinopathies publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.600 – volume: 47 start-page: 495 year: 2013 end-page: 508 ident: CR43 article-title: The Lewy body in Parkinson's disease and related neurodegenerative disorders publication-title: Mol. Neurobiol. doi: 10.1007/s12035-012-8280-y – volume: 23 start-page: 2303 year: 2008 end-page: 2306 ident: CR54 article-title: Transplanted dopaminergic neurons develop PD pathologic changes: a second case report publication-title: Mov. Disord. doi: 10.1002/mds.22369 – volume: 23 start-page: 837 year: 2008 end-page: 844 ident: CR2 article-title: The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years publication-title: Mov. Disord. doi: 10.1002/mds.21956 – volume: 69 start-page: 1326 year: 2012 end-page: 1331 ident: CR84 article-title: Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia publication-title: Arch. Neurol. doi: 10.1001/archneurol.2012.1608 – volume: 27 start-page: 129 year: 2004 end-page: 134 ident: CR91 article-title: More than just two peas in a pod: common amyloidogenic properties of tau and α-synuclein in neurodegenerative diseases publication-title: Trends Neurosci. doi: 10.1016/j.tins.2004.01.007 – volume: 132 start-page: 1783 year: 2009 end-page: 1794 ident: CR116 article-title: Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease publication-title: Brain doi: 10.1093/brain/awp044 – volume: 69 start-page: 570 year: 2011 end-page: 580 ident: CR139 article-title: Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression publication-title: Ann. Neurol. doi: 10.1002/ana.22311 – volume: 17 start-page: 1161 year: 2002 end-page: 1165 ident: CR97 article-title: Parkinson's disease and dementia with Lewy bodies: one disease or two? publication-title: Mov. Disord. doi: 10.1002/mds.10274 – volume: 11 start-page: 697 year: 2012 end-page: 707 ident: CR113 article-title: Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(12)70152-7 – volume: 135 start-page: 170 year: 2011 end-page: 180 ident: CR141 article-title: Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease publication-title: Brain doi: 10.1093/brain/awr277 – volume: 72 start-page: 91 year: 2007 end-page: 104 ident: CR82 article-title: Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study publication-title: J. Neural. Transm. Suppl. doi: 10.1007/978-3-211-73574-9_12 – volume: 106 start-page: 20051 year: 2009 end-page: 20056 ident: CR55 article-title: Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0908005106 – volume: 70 start-page: 89 year: 2006 end-page: 97 ident: CR46 article-title: Pathology associated with sporadic Parkinson's disease — where does it end? publication-title: J. Neural Transm. Suppl. – volume: 10 start-page: 378 year: 2000 end-page: 384 ident: CR47 article-title: Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using α-synuclein immunohistochemistry publication-title: Brain Pathol. doi: 10.1111/j.1750-3639.2000.tb00269.x – volume: 1 start-page: 277 year: 2011 end-page: 286 ident: CR45 article-title: Disentangling the relationship between Lewy bodies and nigral neuronal loss in Parkinson's disease publication-title: J. Park Dis. – volume: 35 start-page: 513 year: 1994 end-page: 529 ident: CR156 article-title: Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease publication-title: Ann. Neurol. doi: 10.1002/ana.410350504 – volume: 27 start-page: 349 year: 2012 end-page: 356 ident: CR12 article-title: Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines publication-title: Mov. Disord. doi: 10.1002/mds.24893 – volume: 25 start-page: 2682 year: 2010 end-page: 2685 ident: CR133 article-title: CSF Aβ and tau in Parkinson's disease with cognitive impairment publication-title: Mov. Disord. doi: 10.1002/mds.23287 – volume: 70 start-page: 727 year: 2013 end-page: 735 ident: CR117 article-title: A multicenter study of glucocerebrosidase mutations in dementia with lewy bodies publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.1925 – volume: 3 start-page: CD006504 year: 2012 ident: CR147 article-title: Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease publication-title: Cochrane Database Syst. Rev. – volume: 53 start-page: 245 year: 1990 end-page: 249 ident: CR153 article-title: Research diagnostic criteria for Parkinson's disease publication-title: Adv. Neurol. – volume: 388 start-page: 839 year: 1997 end-page: 840 ident: CR29 article-title: α-Synuclein in Lewy bodies publication-title: Nature doi: 10.1038/42166 – volume: 64 start-page: 156 year: 2005 end-page: 162 ident: CR39 article-title: α-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA) publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/64.2.156 – volume: 114 start-page: 221 year: 2007 end-page: 229 ident: CR95 article-title: Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases publication-title: Acta Neuropathol. doi: 10.1007/s00401-007-0261-2 – volume: 28 start-page: 296 year: 2012 end-page: 301 ident: CR111 article-title: β-amyloid and postural instability and gait difficulty in Parkinson's disease at risk for dementia publication-title: Mov. Disord. doi: 10.1002/mds.25213 – volume: 28 start-page: 302 year: 2013 end-page: 310 ident: CR145 article-title: Cerebrospinal fluid Aβ levels correlate with structural brain changes in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.25282 – volume: 14 start-page: 38 year: 2013 end-page: 48 ident: CR149 article-title: The many faces of α-synuclein: from structure and toxicity to therapeutic target publication-title: Nature Rev. Neurosci. doi: 10.1038/nrn3406 – volume: 65 start-page: 1239 year: 2005 end-page: 1245 ident: CR9 article-title: Cognitive profile of patients with newly diagnosed Parkinson disease publication-title: Neurology doi: 10.1212/01.wnl.0000180516.69442.95 – volume: 104 start-page: 7 year: 2002 end-page: 11 ident: CR90 article-title: Concurrence of α-synuclein and tau brain pathology in the Contursi kindred publication-title: Acta Neuropathol. doi: 10.1007/s00401-002-0563-3 – volume: 123 start-page: 1 year: 2012 end-page: 11 ident: CR152 article-title: National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach publication-title: Acta Neuropathol. doi: 10.1007/s00401-011-0910-3 – volume: 133 start-page: 1755 year: 2010 end-page: 1762 ident: CR4 article-title: Relationships between age and late progression of Parkinson's disease: a clinico-pathological study publication-title: Brain doi: 10.1093/brain/awq059 – volume: 34 start-page: 521 year: 2002 end-page: 533 ident: CR30 article-title: Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein publication-title: Neuron doi: 10.1016/S0896-6273(02)00682-7 – volume: 132 start-page: 2958 year: 2009 end-page: 2969 ident: CR8 article-title: The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort publication-title: Brain doi: 10.1093/brain/awp245 – volume: 80 start-page: 85 year: 2013 end-page: 91 ident: CR142 article-title: Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia publication-title: Neurology doi: 10.1212/WNL.0b013e31827b1a07 – volume: 4 start-page: 121ra20 year: 2012 ident: CR136 article-title: Phosphorylated α-synuclein in Parkinson's disease publication-title: Sci. Transl. Med. – volume: 69 start-page: 655 year: 2011 end-page: 663 ident: CR128 article-title: Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease publication-title: Ann. Neurol. doi: 10.1002/ana.22271 – volume: 23 start-page: 229 year: 2009 end-page: 233 ident: CR94 article-title: Correlation of clinical features with argyrophilic grains at autopsy publication-title: Alzheimer Dis. Assoc. Disord. doi: 10.1097/WAD.0b013e318199d833 – volume: 254 start-page: 38 year: 2007 end-page: 45 ident: CR20 article-title: The effect of age of onset of PD on risk of dementia publication-title: J. Neurol. doi: 10.1007/s00415-006-0234-8 – volume: 184 start-page: 53 year: 2010 end-page: 87 ident: CR32 article-title: Genetic mouse models of Parkinson's disease: the state of the art publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(10)84004-X – volume: 14 start-page: 504 year: 2008 end-page: 506 ident: CR53 article-title: Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease publication-title: Nature Med. doi: 10.1038/nm1747 – volume: 33 start-page: 2225 year: 2012 end-page: 2228 ident: CR61 article-title: Prion-like acceleration of a synucleinopathy in a transgenic mouse model publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2011.06.022 – volume: 338 start-page: 949 year: 2012 end-page: 953 ident: CR58 article-title: Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice publication-title: Science doi: 10.1126/science.1227157 – volume: 67 start-page: 155 year: 2008 end-page: 161 ident: CR81 article-title: Striatal β-amyloid deposition in Parkinson disease with dementia publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1097/NEN.0b013e31816362aa – volume: 116 start-page: 1 year: 2008 end-page: 16 ident: CR51 article-title: A critical reappraisal of current staging of Lewy-related pathology in human brain publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0406-y – volume: 27 start-page: 512 year: 2012 end-page: 518 ident: CR119 article-title: Genetic influences on cognitive decline in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.24946 – volume: 55 start-page: 539 year: 2000 end-page: 544 ident: CR22 article-title: Motor impairment in PD: relationship to incident dementia and age publication-title: Neurology doi: 10.1212/WNL.55.4.539 – volume: 115 start-page: 417 year: 2008 end-page: 425 ident: CR87 article-title: Cortical α-synuclein load is associated with amyloid-β plaque burden in a subset of Parkinson's disease patients publication-title: Acta Neuropathol. doi: 10.1007/s00401-007-0336-0 – volume: 64 start-page: 2069 year: 2005 end-page: 2073 ident: CR104 article-title: Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both publication-title: Neurology doi: 10.1212/01.WNL.0000165987.89198.65 – volume: 79 start-page: 1944 year: 2012 end-page: 1950 ident: CR115 article-title: mutations increase risk for Lewy body disease with and without Alzheimer disease pathology publication-title: Neurology doi: 10.1212/WNL.0b013e3182735e9a – volume: 115 start-page: 399 year: 2008 end-page: 407 ident: CR37 article-title: Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0346-6 – volume: 7 start-page: 280 year: 2011 end-page: 292 ident: CR151 article-title: Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2011.03.003 – volume: 13 start-page: 221 issue: Suppl. 3 year: 2007 end-page: 224 ident: CR72 article-title: Neuropathology of Parkinson's disease dementia and dementia with Lewy bodies with reference to striatal pathology publication-title: Parkinsonism Relat. Disord. doi: 10.1016/S1353-8020(08)70005-1 – volume: 17 start-page: 61 year: 2011 end-page: 64 ident: CR134 article-title: Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2010.10.003 – volume: 25 start-page: 969 year: 2010 end-page: 978 ident: CR105 article-title: The identification of Parkinson's disease subtypes using cluster analysis: a systematic review publication-title: Mov. Disord. doi: 10.1002/mds.23116 – volume: 100 start-page: 285 year: 2000 end-page: 290 ident: CR76 article-title: α-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease publication-title: Acta Neuropathol. doi: 10.1007/s004019900168 – volume: 74 start-page: 852 year: 2003 end-page: 856 ident: CR96 article-title: Lewy body cortical involvement may not always predict dementia in Parkinson's disease publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.74.7.852 – volume: 111 start-page: 1219 year: 2004 end-page: 1235 ident: CR36 article-title: Lewy body-related α-synucleinopathy in the aged human brain publication-title: J. Neural Transm. doi: 10.1007/s00702-004-0138-7 – volume: 52 start-page: 205 year: 2002 end-page: 210 ident: CR68 article-title: Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases publication-title: Ann. Neurol. doi: 10.1002/ana.10279 – volume: 118 start-page: 713 year: 2011 end-page: 719 ident: CR99 article-title: Striatal β-amyloid in dementia with Lewy bodies but not Parkinson's disease publication-title: J. Neural Transm. doi: 10.1007/s00702-011-0641-6 – volume: 256 start-page: 493 year: 2009 end-page: 498 ident: CR121 article-title: Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease publication-title: J. Neurol. doi: 10.1007/s00415-009-0119-8 – volume: 75 start-page: 1055 year: 2010 end-page: 1061 ident: CR123 article-title: CSF amyloid β predicts cognitive decline in Parkinson disease publication-title: Neurology doi: 10.1212/WNL.0b013e3181f39a78 – volume: 106 start-page: 13010 year: 2009 end-page: 13015 ident: CR60 article-title: Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0903691106 – volume: 109 start-page: 329 year: 2002 end-page: 339 ident: CR83 article-title: Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease publication-title: J. Neural Transm. doi: 10.1007/s007020200027 – volume: 18 start-page: 1425 year: 2011 end-page: 1433 ident: CR63 article-title: A deadly spread: cellular mechanisms of α-synuclein transfer publication-title: Cell Death Differ. doi: 10.1038/cdd.2011.53 – volume: 62 start-page: 145 year: 2007 end-page: 153 ident: CR126 article-title: Tau and α-synuclein in susceptibility to, and dementia in, Parkinson's disease publication-title: Ann. Neurol. doi: 10.1002/ana.21192 – volume: 24 start-page: 2203 year: 2009 end-page: 2210 ident: CR130 article-title: Cerebrospinal tau, phospho-tau, and β-amyloid and neuropsychological functions in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.22594 – volume: 51 start-page: 722 year: 2002 end-page: 729 ident: CR7 article-title: Combined effect of age and severity on the risk of dementia in Parkinson's disease publication-title: Ann. Neurol. doi: 10.1002/ana.10219 – volume: 95 start-page: 450 year: 1998 end-page: 454 ident: CR122 article-title: Apolipoprotein E ε4 allele and progression of cortical Lewy body pathology in Parkinson's disease publication-title: Acta Neuropathol. doi: 10.1007/s004010050824 – volume: 62 start-page: 644 year: 2003 end-page: 654 ident: CR42 article-title: Accumulation of phosphorylated α-synuclein in aging human brain publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/62.6.644 – volume: 25 start-page: 1170 year: 2010 end-page: 1176 ident: CR10 article-title: Association between cognition and function in patients with Parkinson disease with and without dementia publication-title: Mov. Disord. doi: 10.1002/mds.23073 – volume: 106 start-page: 83 year: 2003 end-page: 88 ident: CR75 article-title: Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease publication-title: Acta Neuropathol. – volume: 220 start-page: 224 year: 2009 end-page: 225 ident: CR155 article-title: Propagation of host disease to grafted neurons: accumulating evidence publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2009.09.016 – volume: 487 start-page: 169 year: 2011 end-page: 173 ident: CR127 article-title: High cerebrospinal tau levels are associated with the rs242557 gene variant and low cerebrospinal β-amyloid in Parkinson disease publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2010.10.015 – volume: 64 start-page: 93 issue: Suppl. 2 year: 2008 end-page: 100 ident: CR17 article-title: Dopamine and impulse control disorders in Parkinson's disease publication-title: Ann. Neurol. – volume: 138 start-page: 311 year: 2013 end-page: 322 ident: CR150 article-title: Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2013.01.013 – volume: 302 start-page: 841 year: 2003 ident: CR27 article-title: α-synuclein locus triplication causes Parkinson's disease publication-title: Science doi: 10.1126/science.1090278 – volume: 79 start-page: 1161 year: 2012 end-page: 1167 ident: CR143 article-title: Aβ-amyloid deposition in patients with Parkinson disease at risk for development of dementia publication-title: Neurology doi: 10.1212/WNL.0b013e3182698d4a – volume: 257 start-page: 359 year: 2010 end-page: 366 ident: CR103 article-title: Low sensitivity in clinical diagnoses of dementia with Lewy bodies publication-title: J. Neurol. doi: 10.1007/s00415-009-5324-y – volume: 28 start-page: 31 year: 2013 end-page: 40 ident: CR64 article-title: Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? publication-title: Mov. Disord. doi: 10.1002/mds.25373 – volume: 13 start-page: 885 year: 1998 end-page: 894 ident: CR19 article-title: Young-onset Parkinson's disease revisited — clinical features, natural history, and mortality publication-title: Mov. Disord. doi: 10.1002/mds.870130605 – volume: 21 start-page: 1123 year: 2006 end-page: 1130 ident: CR107 article-title: Changes in motor subtype and risk for incident dementia in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.20897 – volume: 64 start-page: 1404 year: 2005 end-page: 1410 ident: CR21 article-title: Cognitive status correlates with neuropathologic stage in Parkinson disease publication-title: Neurology doi: 10.1212/01.WNL.0000158422.41380.82 – volume: 8 start-page: 711 year: 1999 end-page: 715 ident: CR124 article-title: Association of an extended haplotype in the tau gene with progressive supranuclear palsy publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/8.4.711 – volume: 25 start-page: 78 issue: Suppl. 1 year: 2010 end-page: 82 ident: CR35 article-title: Evidence in favor of Braak staging of Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.22637 – volume: 72 start-page: 587 year: 2012 end-page: 598 ident: CR70 article-title: Neuropathologic substrates of Parkinson disease dementia publication-title: Ann. Neurol. doi: 10.1002/ana.23659 – volume: 66 start-page: 1353 year: 2009 end-page: 1358 ident: CR11 article-title: Clinical features in early Parkinson disease and survival publication-title: Arch. Neurol. doi: 10.1001/archneurol.2009.221 – volume: 120 start-page: 52 year: 2012 end-page: 60 ident: CR13 article-title: Difficulty processing temporary syntactic ambiguities in Lewy body spectrum disorder publication-title: Brain Lang. doi: 10.1016/j.bandl.2011.08.007 – volume: 115 start-page: 437 year: 2008 end-page: 444 ident: CR41 article-title: Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0345-7 – volume: 30 start-page: 7281 year: 2010 end-page: 7289 ident: CR89 article-title: Synergistic interactions between Aβ, tau, and α-synuclein: acceleration of neuropathology and cognitive decline publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0490-10.2010 – volume: 276 start-page: 2045 year: 1997 end-page: 2047 ident: CR25 article-title: Mutation in the α-synuclein gene identified in families with Parkinson's disease publication-title: Science doi: 10.1126/science.276.5321.2045 – volume: 95 start-page: 629 year: 2011 end-page: 635 ident: CR146 article-title: The Parkinson Progression Marker Initiative (PPMI) publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2011.09.005 – volume: 75 start-page: 1766 year: 2010 end-page: 1772 ident: CR137 article-title: Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease publication-title: Neurology doi: 10.1212/WNL.0b013e3181fd613b – volume: 18 start-page: 941 year: 2012 end-page: 947 ident: CR140 article-title: Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson's disease and related dementia publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2012.04.028 – volume: 27 start-page: 831 year: 2012 end-page: 842 ident: CR26 article-title: The neuropathology of genetic Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.24962 – volume: 48 start-page: 413 year: 1985 end-page: 421 ident: CR79 article-title: Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.48.5.413 – volume: 115 start-page: 409 year: 2008 end-page: 415 ident: CR6 article-title: The progression of pathology in longitudinally followed patients with Parkinson's disease publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0344-8 – volume: 67 start-page: 1605 year: 2006 end-page: 1611 ident: CR15 article-title: Clinical phenotype of Parkinson disease dementia publication-title: Neurology doi: 10.1212/01.wnl.0000242630.52203.8f – volume: 70 start-page: 462 year: 2013 end-page: 468 ident: CR66 article-title: Evaluation of potential infectivity of Alzheimer's and Parkinson's disease proteins in recipients of cadaver-derived human growth hormone publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.1933 – volume: 260 start-page: 438 year: 2012 end-page: 444 ident: CR129 article-title: Serum epidermal growth factor predicts cognitive functions in early, drug-naive Parkinson's disease patients publication-title: J. Neurol. doi: 10.1007/s00415-012-6648-6 – volume: 17 start-page: 1221 year: 2002 end-page: 1226 ident: CR24 article-title: Memory and executive function impairment predict dementia in Parkinson's disease publication-title: Mov. Disord. doi: 10.1002/mds.10280 – volume: 136 start-page: 1128 year: 2013 end-page: 1138 ident: CR62 article-title: Prion-like spreading of pathological α-synuclein in brain publication-title: Brain doi: 10.1093/brain/awt037 – volume: 112 start-page: 253 year: 2006 end-page: 260 ident: CR98 article-title: Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? publication-title: Acta Neuropathol. doi: 10.1007/s00401-006-0088-2 – volume: 53 start-page: 1974 year: 1999 end-page: 1982 ident: CR101 article-title: Validity of clinical criteria for the diagnosis of dementia with Lewy bodies publication-title: Neurology doi: 10.1212/WNL.53.9.1974 – volume: 52 start-page: 848 year: 2011 end-page: 855 ident: CR144 article-title: Cerebral glucose metabolic features of Parkinson disease and incident dementia: longitudinal study publication-title: J. Nucl. Med. doi: 10.2967/jnumed.111.089946 – volume: 24 start-page: 72 year: 2004 end-page: 78 ident: CR49 article-title: Dementia with Lewy bodies: reclassification of pathological subtypes and boundary with Parkinson's disease or Alzheimer's disease publication-title: Neuropathology doi: 10.1111/j.1440-1789.2003.00530.x – volume: 69 start-page: 1445 year: 2012 end-page: 1452 ident: CR131 article-title: Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders publication-title: JAMA Neurol. – volume: 102 start-page: 355 year: 2001 end-page: 363 ident: CR74 article-title: Cortical Lewy body pathology in the diagnosis of dementia publication-title: Acta Neuropathol. – ident: CR110 – volume: 24 start-page: 197 year: 2003 end-page: 211 ident: CR33 article-title: Staging of brain pathology related to sporadic Parkinson's disease publication-title: Neurobiol. Aging doi: 10.1016/S0197-4580(02)00065-9 – volume: 122 start-page: 187 year: 2011 end-page: 204 ident: CR112 article-title: Neuropathology underlying clinical variability in patients with synucleinopathies publication-title: Acta Neuropathol. doi: 10.1007/s00401-011-0852-9 – volume: 26 start-page: 1183 year: 2005 end-page: 1192 ident: CR77 article-title: Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2004.10.006 – volume: 30 start-page: 7281 year: 2010 ident: BFnrn3549_CR89 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0490-10.2010 – volume: 28 start-page: 31 year: 2013 ident: BFnrn3549_CR64 publication-title: Mov. Disord. doi: 10.1002/mds.25373 – volume: 123 start-page: 1 year: 2012 ident: BFnrn3549_CR152 publication-title: Acta Neuropathol. doi: 10.1007/s00401-011-0910-3 – volume: 54 start-page: 1916 year: 2000 ident: BFnrn3549_CR67 publication-title: Neurology doi: 10.1212/WNL.54.10.1916 – volume: 104 start-page: 7 year: 2002 ident: BFnrn3549_CR90 publication-title: Acta Neuropathol. doi: 10.1007/s00401-002-0563-3 – volume: 23 start-page: 837 year: 2008 ident: BFnrn3549_CR2 publication-title: Mov. Disord. doi: 10.1002/mds.21956 – volume: 257 start-page: 359 year: 2010 ident: BFnrn3549_CR103 publication-title: J. Neurol. doi: 10.1007/s00415-009-5324-y – volume: 115 start-page: 409 year: 2008 ident: BFnrn3549_CR6 publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0344-8 – volume: 27 start-page: 512 year: 2012 ident: BFnrn3549_CR119 publication-title: Mov. Disord. doi: 10.1002/mds.24946 – volume: 313 start-page: 728 year: 1985 ident: BFnrn3549_CR157 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198509193131205 – volume: 300 start-page: 636 year: 2003 ident: BFnrn3549_CR92 publication-title: Science doi: 10.1126/science.1082324 – ident: BFnrn3549_CR110 – volume: 70 start-page: 727 year: 2013 ident: BFnrn3549_CR117 publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.1925 – volume: 79 start-page: 1944 year: 2012 ident: BFnrn3549_CR115 publication-title: Neurology doi: 10.1212/WNL.0b013e3182735e9a – volume: 55 start-page: 539 year: 2000 ident: BFnrn3549_CR22 publication-title: Neurology doi: 10.1212/WNL.55.4.539 – volume: 132 start-page: 1783 year: 2009 ident: BFnrn3549_CR116 publication-title: Brain doi: 10.1093/brain/awp044 – volume: 75 start-page: 1766 year: 2010 ident: BFnrn3549_CR137 publication-title: Neurology doi: 10.1212/WNL.0b013e3181fd613b – volume: 7 start-page: 280 year: 2011 ident: BFnrn3549_CR151 publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2011.03.003 – volume: 31 start-page: 10076 year: 2011 ident: BFnrn3549_CR31 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0618-11.2011 – volume: 72 start-page: 57 year: 2011 ident: BFnrn3549_CR56 publication-title: Neuron doi: 10.1016/j.neuron.2011.08.033 – volume: 40 start-page: 1529 year: 1990 ident: BFnrn3549_CR23 publication-title: Neurology doi: 10.1212/WNL.40.10.1529 – volume: 388 start-page: 839 year: 1997 ident: BFnrn3549_CR29 publication-title: Nature doi: 10.1038/42166 – volume: 25 start-page: 1170 year: 2010 ident: BFnrn3549_CR10 publication-title: Mov. Disord. doi: 10.1002/mds.23073 – volume: 23 start-page: 229 year: 2009 ident: BFnrn3549_CR94 publication-title: Alzheimer Dis. Assoc. Disord. doi: 10.1097/WAD.0b013e318199d833 – volume: 213 start-page: 315 year: 2008 ident: BFnrn3549_CR135 publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2008.06.004 – volume: 109 start-page: 329 year: 2002 ident: BFnrn3549_CR83 publication-title: J. Neural Transm. doi: 10.1007/s007020200027 – volume: 64 start-page: 2069 year: 2005 ident: BFnrn3549_CR104 publication-title: Neurology doi: 10.1212/01.WNL.0000165987.89198.65 – volume: 10 start-page: 378 year: 2000 ident: BFnrn3549_CR47 publication-title: Brain Pathol. doi: 10.1111/j.1750-3639.2000.tb00269.x – volume: 17 start-page: 61 year: 2011 ident: BFnrn3549_CR134 publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2010.10.003 – volume: 111 start-page: 1219 year: 2004 ident: BFnrn3549_CR36 publication-title: J. Neural Transm. doi: 10.1007/s00702-004-0138-7 – volume: 122 start-page: 187 year: 2011 ident: BFnrn3549_CR112 publication-title: Acta Neuropathol. doi: 10.1007/s00401-011-0852-9 – volume: 14 start-page: 501 year: 2008 ident: BFnrn3549_CR52 publication-title: Nature Med. doi: 10.1038/nm1746 – volume: 67 start-page: 1931 year: 2006 ident: BFnrn3549_CR78 publication-title: Neurology doi: 10.1212/01.wnl.0000249130.63615.cc – volume: 74 start-page: 852 year: 2003 ident: BFnrn3549_CR96 publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.74.7.852 – volume: 13 start-page: 221 issue: Suppl. 3 year: 2007 ident: BFnrn3549_CR72 publication-title: Parkinsonism Relat. Disord. doi: 10.1016/S1353-8020(08)70005-1 – volume: 53 start-page: 1974 year: 1999 ident: BFnrn3549_CR101 publication-title: Neurology doi: 10.1212/WNL.53.9.1974 – volume: 17 start-page: 1221 year: 2002 ident: BFnrn3549_CR24 publication-title: Mov. Disord. doi: 10.1002/mds.10280 – volume: 338 start-page: 949 year: 2012 ident: BFnrn3549_CR58 publication-title: Science doi: 10.1126/science.1227157 – volume: 17 start-page: 1161 year: 2002 ident: BFnrn3549_CR97 publication-title: Mov. Disord. doi: 10.1002/mds.10274 – volume: 95 start-page: 450 year: 1998 ident: BFnrn3549_CR122 publication-title: Acta Neuropathol. doi: 10.1007/s004010050824 – volume: 133 start-page: 713 year: 2010 ident: BFnrn3549_CR138 publication-title: Brain doi: 10.1093/brain/awq008 – volume: 112 start-page: 253 year: 2006 ident: BFnrn3549_CR98 publication-title: Acta Neuropathol. doi: 10.1007/s00401-006-0088-2 – volume: 18 start-page: 220 year: 2008 ident: BFnrn3549_CR50 publication-title: Brain Pathol. doi: 10.1111/j.1750-3639.2007.00117.x – volume: 116 start-page: 1 year: 2008 ident: BFnrn3549_CR51 publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0406-y – volume: 487 start-page: 169 year: 2011 ident: BFnrn3549_CR127 publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2010.10.015 – volume: 51 start-page: 722 year: 2002 ident: BFnrn3549_CR7 publication-title: Ann. Neurol. doi: 10.1002/ana.10219 – volume: 14 start-page: 504 year: 2008 ident: BFnrn3549_CR53 publication-title: Nature Med. doi: 10.1038/nm1747 – volume: 114 start-page: 221 year: 2007 ident: BFnrn3549_CR95 publication-title: Acta Neuropathol. doi: 10.1007/s00401-007-0261-2 – volume: 138 start-page: 311 year: 2013 ident: BFnrn3549_CR150 publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2013.01.013 – volume: 260 start-page: 438 year: 2012 ident: BFnrn3549_CR129 publication-title: J. Neurol. doi: 10.1007/s00415-012-6648-6 – volume: 35 start-page: 513 year: 1994 ident: BFnrn3549_CR156 publication-title: Ann. Neurol. doi: 10.1002/ana.410350504 – volume: 70 start-page: 462 year: 2013 ident: BFnrn3549_CR66 publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.1933 – volume: 220 start-page: 224 year: 2009 ident: BFnrn3549_CR155 publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2009.09.016 – volume: 34 start-page: 521 year: 2002 ident: BFnrn3549_CR30 publication-title: Neuron doi: 10.1016/S0896-6273(02)00682-7 – volume: 115 start-page: 399 year: 2008 ident: BFnrn3549_CR37 publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0346-6 – volume: 57 start-page: 82 year: 2005 ident: BFnrn3549_CR40 publication-title: Ann. Neurol. doi: 10.1002/ana.20321 – volume: 115 start-page: 427 year: 2008 ident: BFnrn3549_CR73 publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0347-5 – volume: 25 start-page: 78 issue: Suppl. 1 year: 2010 ident: BFnrn3549_CR35 publication-title: Mov. Disord. doi: 10.1002/mds.22637 – volume: 59 start-page: 102 year: 2002 ident: BFnrn3549_CR69 publication-title: Arch. Neurol. doi: 10.1001/archneur.59.1.102 – volume: 53 start-page: 245 year: 1990 ident: BFnrn3549_CR153 publication-title: Adv. Neurol. – volume: 50 start-page: 140 year: 1993 ident: BFnrn3549_CR85 publication-title: Arch. Neurol. doi: 10.1001/archneur.1993.00540020018011 – volume: 24 start-page: 72 year: 2004 ident: BFnrn3549_CR49 publication-title: Neuropathology doi: 10.1111/j.1440-1789.2003.00530.x – volume: 72 start-page: 91 year: 2007 ident: BFnrn3549_CR82 publication-title: J. Neural. Transm. Suppl. doi: 10.1007/978-3-211-73574-9_12 – volume: 132 start-page: 2947 year: 2009 ident: BFnrn3549_CR106 publication-title: Brain doi: 10.1093/brain/awp234 – volume: 65 start-page: 1239 year: 2005 ident: BFnrn3549_CR9 publication-title: Neurology doi: 10.1212/01.wnl.0000180516.69442.95 – volume: 61 start-page: 413 year: 2002 ident: BFnrn3549_CR34 publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/61.5.413 – volume: 1 start-page: 277 year: 2011 ident: BFnrn3549_CR45 publication-title: J. Park Dis. – volume: 27 start-page: 129 year: 2004 ident: BFnrn3549_CR91 publication-title: Trends Neurosci. doi: 10.1016/j.tins.2004.01.007 – volume: 75 start-page: 1055 year: 2010 ident: BFnrn3549_CR123 publication-title: Neurology doi: 10.1212/WNL.0b013e3181f39a78 – volume: 24 start-page: 2203 year: 2009 ident: BFnrn3549_CR130 publication-title: Mov. Disord. doi: 10.1002/mds.22594 – volume: 302 start-page: 841 year: 2003 ident: BFnrn3549_CR27 publication-title: Science doi: 10.1126/science.1090278 – volume: 11 start-page: 697 year: 2012 ident: BFnrn3549_CR113 publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(12)70152-7 – volume: 209 start-page: 975 year: 2012 ident: BFnrn3549_CR57 publication-title: J. Exp. Med. doi: 10.1084/jem.20112457 – volume: 4 start-page: 428 year: 2007 ident: BFnrn3549_CR93 publication-title: Neurodegener. Dis. doi: 10.1159/000107703 – volume: 117 start-page: 1177 year: 2010 ident: BFnrn3549_CR108 publication-title: J. Neural Transm. doi: 10.1007/s00702-010-0462-z – volume: 85 start-page: 537 year: 2012 ident: BFnrn3549_CR109 publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 70 start-page: 89 year: 2006 ident: BFnrn3549_CR46 publication-title: J. Neural Transm. Suppl. – volume: 135 start-page: 170 year: 2011 ident: BFnrn3549_CR141 publication-title: Brain doi: 10.1093/brain/awr277 – volume: 64 start-page: 93 issue: Suppl. 2 year: 2008 ident: BFnrn3549_CR17 publication-title: Ann. Neurol. – volume: 117 start-page: 613 year: 2009 ident: BFnrn3549_CR38 publication-title: Acta Neuropathol. doi: 10.1007/s00401-009-0538-8 – volume: 106 start-page: 20051 year: 2009 ident: BFnrn3549_CR55 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0908005106 – volume: 52 start-page: 848 year: 2011 ident: BFnrn3549_CR144 publication-title: J. Nucl. Med. doi: 10.2967/jnumed.111.089946 – volume: 9 start-page: 417 year: 2006 ident: BFnrn3549_CR16 publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-2006-9S347 – volume: 62 start-page: 145 year: 2007 ident: BFnrn3549_CR126 publication-title: Ann. Neurol. doi: 10.1002/ana.21192 – volume: 69 start-page: 1445 year: 2012 ident: BFnrn3549_CR131 publication-title: JAMA Neurol. – volume: 25 start-page: 2682 year: 2010 ident: BFnrn3549_CR133 publication-title: Mov. Disord. doi: 10.1002/mds.23287 – volume: 254 start-page: 38 year: 2007 ident: BFnrn3549_CR20 publication-title: J. Neurol. doi: 10.1007/s00415-006-0234-8 – volume: 69 start-page: 1326 year: 2012 ident: BFnrn3549_CR84 publication-title: Arch. Neurol. doi: 10.1001/archneurol.2012.1608 – volume: 14 start-page: 38 year: 2013 ident: BFnrn3549_CR149 publication-title: Nature Rev. Neurosci. doi: 10.1038/nrn3406 – volume: 55 start-page: 969 year: 1998 ident: BFnrn3549_CR102 publication-title: Arch. Neurol. doi: 10.1001/archneur.55.7.969 – volume: 26 start-page: 42 issue: Suppl. 3 year: 2011 ident: BFnrn3549_CR148 publication-title: Mov. Disord. doi: 10.1002/mds.23884 – volume: 48 start-page: 413 year: 1985 ident: BFnrn3549_CR79 publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.48.5.413 – volume: 72 start-page: 587 year: 2012 ident: BFnrn3549_CR70 publication-title: Ann. Neurol. doi: 10.1002/ana.23659 – volume: 67 start-page: 1605 year: 2006 ident: BFnrn3549_CR15 publication-title: Neurology doi: 10.1212/01.wnl.0000242630.52203.8f – volume: 153 start-page: 1365 year: 1998 ident: BFnrn3549_CR48 publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)65722-7 – volume: 102 start-page: 355 year: 2001 ident: BFnrn3549_CR74 publication-title: Acta Neuropathol. doi: 10.1007/s004010100390 – volume: 18 start-page: 1425 year: 2011 ident: BFnrn3549_CR63 publication-title: Cell Death Differ. doi: 10.1038/cdd.2011.53 – volume: 60 start-page: 1586 year: 2003 ident: BFnrn3549_CR100 publication-title: Neurology doi: 10.1212/01.WNL.0000065889.42856.F2 – volume: 66 start-page: 578 year: 2009 ident: BFnrn3549_CR118 publication-title: Arch. Neurol. doi: 10.1001/archneurol.2009.54 – volume: 4 start-page: 121ra20 year: 2012 ident: BFnrn3549_CR136 publication-title: Sci. Transl. Med. – volume: 68 start-page: 812 year: 2007 ident: BFnrn3549_CR14 publication-title: Neurology doi: 10.1212/01.wnl.0000256715.13907.d3 – volume: 361 start-page: 1651 year: 2009 ident: BFnrn3549_CR114 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0901281 – volume: 67 start-page: 155 year: 2008 ident: BFnrn3549_CR81 publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1097/NEN.0b013e31816362aa – volume: 28 start-page: 302 year: 2013 ident: BFnrn3549_CR145 publication-title: Mov. Disord. doi: 10.1002/mds.25282 – volume: 134 start-page: 1493 year: 2011 ident: BFnrn3549_CR71 publication-title: Brain. doi: 10.1093/brain/awr031 – volume: 118 start-page: 713 year: 2011 ident: BFnrn3549_CR99 publication-title: J. Neural Transm. doi: 10.1007/s00702-011-0641-6 – volume: 66 start-page: 1353 year: 2009 ident: BFnrn3549_CR11 publication-title: Arch. Neurol. doi: 10.1001/archneurol.2009.221 – volume: 120 start-page: 52 year: 2012 ident: BFnrn3549_CR13 publication-title: Brain Lang. doi: 10.1016/j.bandl.2011.08.007 – volume: 64 start-page: 1404 year: 2005 ident: BFnrn3549_CR21 publication-title: Neurology doi: 10.1212/01.WNL.0000158422.41380.82 – volume: 24 start-page: 197 year: 2003 ident: BFnrn3549_CR33 publication-title: Neurobiol. Aging doi: 10.1016/S0197-4580(02)00065-9 – volume: 23 start-page: 295 year: 2009 ident: BFnrn3549_CR86 publication-title: Alzheimer Dis. Assoc. Disord. doi: 10.1097/WAD.0b013e31819c5ef4 – volume: 13 start-page: 885 year: 1998 ident: BFnrn3549_CR19 publication-title: Mov. Disord. doi: 10.1002/mds.870130605 – volume: 276 start-page: 2045 year: 1997 ident: BFnrn3549_CR25 publication-title: Science doi: 10.1126/science.276.5321.2045 – volume: 27 start-page: 831 year: 2012 ident: BFnrn3549_CR26 publication-title: Mov. Disord. doi: 10.1002/mds.24962 – volume: 23 start-page: 2303 year: 2008 ident: BFnrn3549_CR54 publication-title: Mov. Disord. doi: 10.1002/mds.22369 – volume: 216 start-page: 136 year: 1982 ident: BFnrn3549_CR154 publication-title: Science doi: 10.1126/science.6801762 – volume: 115 start-page: 437 year: 2008 ident: BFnrn3549_CR41 publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0345-7 – volume: 98 start-page: 12245 year: 2001 ident: BFnrn3549_CR88 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.211412398 – volume: 22 start-page: 1689 year: 2007 ident: BFnrn3549_CR5 publication-title: Mov. Disord. doi: 10.1002/mds.21507 – volume: 27 start-page: 349 year: 2012 ident: BFnrn3549_CR12 publication-title: Mov. Disord. doi: 10.1002/mds.24893 – volume: 256 start-page: 493 year: 2009 ident: BFnrn3549_CR121 publication-title: J. Neurol. doi: 10.1007/s00415-009-0119-8 – volume: 100 start-page: 285 year: 2000 ident: BFnrn3549_CR76 publication-title: Acta Neuropathol. doi: 10.1007/s004019900168 – volume: 136 start-page: 1128 year: 2013 ident: BFnrn3549_CR62 publication-title: Brain doi: 10.1093/brain/awt037 – volume: 132 start-page: 2958 year: 2009 ident: BFnrn3549_CR8 publication-title: Brain doi: 10.1093/brain/awp245 – volume: 47 start-page: 495 year: 2013 ident: BFnrn3549_CR43 publication-title: Mol. Neurobiol. doi: 10.1007/s12035-012-8280-y – volume: 106 start-page: 83 year: 2003 ident: BFnrn3549_CR75 publication-title: Acta Neuropathol. doi: 10.1007/s00401-003-0705-2 – volume: 106 start-page: 13010 year: 2009 ident: BFnrn3549_CR60 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0903691106 – volume: 26 start-page: 1183 year: 2005 ident: BFnrn3549_CR77 publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2004.10.006 – volume: 69 start-page: 655 year: 2011 ident: BFnrn3549_CR128 publication-title: Ann. Neurol. doi: 10.1002/ana.22271 – volume: 81 start-page: 1080 year: 2010 ident: BFnrn3549_CR132 publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.2009.199950 – volume: 4 start-page: 1318 year: 1998 ident: BFnrn3549_CR28 publication-title: Nature Med. doi: 10.1038/3311 – volume: 40 start-page: 1835 year: 2008 ident: BFnrn3549_CR59 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2008.01.017 – volume: 95 start-page: 629 year: 2011 ident: BFnrn3549_CR146 publication-title: Prog. Neurobiol. doi: 10.1016/j.pneurobio.2011.09.005 – volume: 79 start-page: 1161 year: 2012 ident: BFnrn3549_CR143 publication-title: Neurology doi: 10.1212/WNL.0b013e3182698d4a – volume: 8 start-page: 711 year: 1999 ident: BFnrn3549_CR124 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/8.4.711 – volume: 13 start-page: 243 year: 1983 ident: BFnrn3549_CR80 publication-title: Ann. Neurol. doi: 10.1002/ana.410130304 – volume: 33 start-page: 2225 year: 2012 ident: BFnrn3549_CR61 publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2011.06.022 – volume: 115 start-page: 417 year: 2008 ident: BFnrn3549_CR87 publication-title: Acta Neuropathol. doi: 10.1007/s00401-007-0336-0 – volume: 18 start-page: 941 year: 2012 ident: BFnrn3549_CR140 publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2012.04.028 – volume: 9 start-page: 13 year: 2012 ident: BFnrn3549_CR1 publication-title: Nature Rev. Neurol. doi: 10.1038/nrneurol.2012.242 – volume: 133 start-page: 1755 year: 2010 ident: BFnrn3549_CR4 publication-title: Brain doi: 10.1093/brain/awq059 – volume: 60 start-page: 387 year: 2003 ident: BFnrn3549_CR3 publication-title: Arch. Neurol. doi: 10.1001/archneur.60.3.387 – volume: 69 start-page: 570 year: 2011 ident: BFnrn3549_CR139 publication-title: Ann. Neurol. doi: 10.1002/ana.22311 – volume: 25 start-page: 969 year: 2010 ident: BFnrn3549_CR105 publication-title: Mov. Disord. doi: 10.1002/mds.23116 – volume: 64 start-page: 156 year: 2005 ident: BFnrn3549_CR39 publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/64.2.156 – volume: 52 start-page: 33 year: 2006 ident: BFnrn3549_CR65 publication-title: Neuron doi: 10.1016/j.neuron.2006.09.026 – volume: 80 start-page: 176 year: 2013 ident: BFnrn3549_CR18 publication-title: Neurology doi: 10.1212/WNL.0b013e31827b915c – volume: 62 start-page: 644 year: 2003 ident: BFnrn3549_CR42 publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/62.6.644 – volume: 21 start-page: 1123 year: 2006 ident: BFnrn3549_CR107 publication-title: Mov. Disord. doi: 10.1002/mds.20897 – volume: 62 start-page: 137 year: 2007 ident: BFnrn3549_CR125 publication-title: Ann. Neurol. doi: 10.1002/ana.21157 – volume: 79 start-page: 2307 year: 2012 ident: BFnrn3549_CR44 publication-title: Neurology doi: 10.1212/WNL.0b013e318278fe32 – volume: 3 start-page: CD006504 year: 2012 ident: BFnrn3549_CR147 publication-title: Cochrane Database Syst. Rev. – volume: 80 start-page: 85 year: 2013 ident: BFnrn3549_CR142 publication-title: Neurology doi: 10.1212/WNL.0b013e31827b1a07 – volume: 28 start-page: 296 year: 2012 ident: BFnrn3549_CR111 publication-title: Mov. Disord. doi: 10.1002/mds.25213 – volume: 184 start-page: 53 year: 2010 ident: BFnrn3549_CR32 publication-title: Prog. Brain Res. doi: 10.1016/S0079-6123(10)84004-X – volume: 52 start-page: 205 year: 2002 ident: BFnrn3549_CR68 publication-title: Ann. Neurol. doi: 10.1002/ana.10279 – volume: 70 start-page: 223 year: 2013 ident: BFnrn3549_CR120 publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2013.600 – reference: 20371510 - Brain. 2010 Jun;133(Pt 6):1755-62 – reference: 23117496 - J Neurol Neurosurg Psychiatry. 2013 May;84(5):537-43 – reference: 21514248 - Alzheimers Dement. 2011 May;7(3):280-92 – reference: 15851731 - Neurology. 2005 Apr 26;64(8):1404-10 – reference: 23037886 - Ann Neurol. 2012 Oct;72(4):587-98 – reference: 21400565 - Ann Neurol. 2011 Mar;69(3):570-80 – reference: 18592254 - Acta Neuropathol. 2008 Jul;116(1):1-16 – reference: 23161999 - Science. 2012 Nov 16;338(6109):949-53 – reference: 12771246 - Neurology. 2003 May 27;60(10):1586-90 – reference: 22814541 - Lancet Neurol. 2012 Aug;11(8):697-707 – reference: 22595621 - Parkinsonism Relat Disord. 2012 Sep;18(8):941-7 – reference: 15751230 - J Neuropathol Exp Neurol. 2005 Feb;64(2):156-62 – reference: 17101891 - Neurology. 2006 Nov 14;67(9):1605-11 – reference: 21813214 - Neurobiol Aging. 2012 Sep;33(9):2225-8 – reference: 22933741 - Neurology. 2012 Sep 11;79(11):1161-7 – reference: 18291704 - Int J Biochem Cell Biol. 2008;40(9):1835-49 – reference: 2215943 - Neurology. 1990 Oct;40(10):1529-34 – reference: 15562510 - Ann Neurol. 2005 Jan;57(1):82-91 – reference: 22451330 - Mov Disord. 2012 Jun;27(7):831-42 – reference: 22825369 - Arch Neurol. 2012 Oct;69(10):1326-31 – reference: 15480835 - J Neural Transm (Vienna). 2004 Oct;111(10-11):1219-35 – reference: 8179297 - Ann Neurol. 1994 May;35(5):513-29 – reference: 21982369 - Neuron. 2011 Oct 6;72(1):57-71 – reference: 15917102 - Neurobiol Aging. 2005 Aug-Sep;26(8):1183-92 – reference: 19308307 - J Neurol. 2009 Mar;256(3):493-8 – reference: 22275317 - Mov Disord. 2012 Mar;27(3):349-56 – reference: 18273624 - Acta Neuropathol. 2008 Apr;115(4):427-36 – reference: 23939308 - J Parkinsons Dis. 2011;1(3):277-86 – reference: 10072441 - Hum Mol Genet. 1999 Apr;8(4):711-5 – reference: 11603811 - Acta Neuropathol. 2001 Oct;102(4):355-63 – reference: 10953188 - Neurology. 2000 Aug 22;55(4):539-44 – reference: 20887870 - Prog Brain Res. 2010;184:53-87 – reference: 19286695 - Brain. 2009 Jul;132(Pt 7):1783-94 – reference: 18231798 - Acta Neuropathol. 2008 Apr;115(4):409-15 – reference: 17934326 - Neurodegener Dis. 2007;4(6):428-30 – reference: 19006193 - Mov Disord. 2008 Dec 15;23(16):2303-6 – reference: 9827611 - Mov Disord. 1998 Nov;13(6):885-94 – reference: 20547614 - J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1080-6 – reference: 9278044 - Nature. 1997 Aug 28;388(6645):839-40 – reference: 22925882 - Arch Neurol. 2012 Nov;69(11):1445-52 – reference: 9809558 - Nat Med. 1998 Nov;4(11):1318-20 – reference: 23152586 - Neurology. 2012 Dec 11;79(24):2307-14 – reference: 21930184 - Prog Neurobiol. 2011 Dec;95(4):629-35 – reference: 6847136 - Ann Neurol. 1983 Mar;13(3):243-8 – reference: 12687392 - Acta Neuropathol. 2003 Jul;106(1):83-8 – reference: 3998751 - J Neurol Neurosurg Psychiatry. 1985 May;48(5):413-21 – reference: 22344634 - Mov Disord. 2012 Apr;27(4):512-8 – reference: 21734300 - J Neurosci. 2011 Jul 6;31(27):10076-87 – reference: 18267239 - Parkinsonism Relat Disord. 2007;13 Suppl 3:S221-4 – reference: 18219254 - J Neuropathol Exp Neurol. 2008 Feb;67(2):155-61 – reference: 3929089 - N Engl J Med. 1985 Sep 19;313(12):728-31 – reference: 8431132 - Arch Neurol. 1993 Feb;50(2):140-8 – reference: 12633150 - Arch Neurol. 2003 Mar;60(3):387-92 – reference: 19759203 - Brain. 2009 Nov;132(Pt 11):2947-57 – reference: 23380910 - JAMA Neurol. 2013 Apr;70(4):462-8 – reference: 22419314 - Cochrane Database Syst Rev. 2012;3:CD006504 – reference: 23407718 - JAMA Neurol. 2013 Feb;70(2):223-8 – reference: 12714745 - Science. 2003 Apr 25;300(5619):636-40 – reference: 6801762 - Science. 1982 Apr 9;216(4542):136-44 – reference: 16637023 - Mov Disord. 2006 Aug;21(8):1123-30 – reference: 17982882 - J Neural Transm Suppl. 2007;(72):91-104 – reference: 21044858 - Parkinsonism Relat Disord. 2011 Jan;17(1):61-4 – reference: 12030260 - J Neuropathol Exp Neurol. 2002 May;61(5):413-26 – reference: 12210791 - Ann Neurol. 2002 Aug;52(2):205-10 – reference: 23243071 - Neurology. 2013 Jan 1;80(1):85-91 – reference: 17653732 - Acta Neuropathol. 2007 Sep;114(3):221-9 – reference: 9600590 - Acta Neuropathol. 1998 May;95(5):450-4 – reference: 17514749 - Ann Neurol. 2007 Aug;62(2):137-44 – reference: 18307261 - Mov Disord. 2008 Apr 30;23(6):837-44 – reference: 10599768 - Neurology. 1999 Dec 10;53(9):1974-82 – reference: 20187227 - Mov Disord. 2010;25 Suppl 1:S78-82 – reference: 17508138 - J Neurol. 2007 Jan;254(1):38-45 – reference: 20720189 - Neurology. 2010 Sep 21;75(12):1055-61 – reference: 19651612 - Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5 – reference: 17015225 - Neuron. 2006 Oct 5;52(1):33-8 – reference: 23588557 - JAMA Neurol. 2013 Jun;70(6):727-35 – reference: 12498954 - Neurobiol Aging. 2003 Mar-Apr;24(2):197-211 – reference: 11790237 - Arch Neurol. 2002 Jan;59(1):102-12 – reference: 12070658 - Acta Neuropathol. 2002 Jul;104(1):7-11 – reference: 17353469 - Neurology. 2007 Mar 13;68(11):812-9 – reference: 19892735 - Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20051-6 – reference: 22508839 - J Exp Med. 2012 May 7;209(5):975-86 – reference: 18391963 - Nat Med. 2008 May;14(5):501-3 – reference: 9811326 - Am J Pathol. 1998 Nov;153(5):1365-70 – reference: 12834109 - J Neuropathol Exp Neurol. 2003 Jun;62(6):644-54 – reference: 19433657 - Arch Neurol. 2009 May;66(5):578-83 – reference: 15068176 - Neuropathology. 2004 Mar;24(1):72-8 – reference: 18264713 - Acta Neuropathol. 2008 Apr;115(4):437-44 – reference: 21571793 - J Nucl Med. 2011 Jun;52(6):848-55 – reference: 10885656 - Brain Pathol. 2000 Jul;10(3):378-84 – reference: 18297293 - Acta Neuropathol. 2008 Apr;115(4):399-407 – reference: 10965798 - Acta Neuropathol. 2000 Sep;100(3):285-90 – reference: 19846850 - N Engl J Med. 2009 Oct 22;361(17):1651-61 – reference: 21520231 - Ann Neurol. 2011 Apr;69(4):655-63 – reference: 17017514 - J Neural Transm Suppl. 2006;(70):89-97 – reference: 23254192 - Nat Rev Neurosci. 2013 Jan;14(1):38-48 – reference: 19786018 - Exp Neurol. 2009 Dec;220(2):224-5 – reference: 19127573 - Ann Neurol. 2008 Dec;64 Suppl 2:S93-100 – reference: 20730548 - J Neural Transm (Vienna). 2010 Oct;117(10):1177-81 – reference: 19795154 - J Neurol. 2010 Mar;257(3):359-66 – reference: 19795497 - Mov Disord. 2009 Nov 15;24(15):2203-10 – reference: 20818673 - Mov Disord. 2010 Nov 15;25(15):2682-5 – reference: 12112078 - Ann Neurol. 2002 Jun;51(6):722-9 – reference: 15985574 - Neurology. 2005 Jun 28;64(12):2069-73 – reference: 23035075 - Neurology. 2012 Nov 6;79(19):1944-50 – reference: 23296128 - Neurology. 2013 Jan 8;80(2):176-80 – reference: 21596773 - Brain. 2011 May;134(Pt 5):1493-505 – reference: 12062037 - Neuron. 2002 May 16;34(4):521-33 – reference: 20505094 - J Neurosci. 2010 May 26;30(21):7281-9 – reference: 20157014 - Brain. 2010 Mar;133(Pt 3):713-26 – reference: 21479514 - J Neural Transm (Vienna). 2011 May;118(5):713-9 – reference: 20951764 - Neurosci Lett. 2011 Jan 7;487(2):169-73 – reference: 22021174 - Mov Disord. 2011 Oct;26 Suppl 3:S42-80 – reference: 23979011 - JAMA Neurol. 2013 Oct;70(10):1277-87 – reference: 23183883 - Nat Rev Neurol. 2013 Jan;9(1):13-24 – reference: 22344688 - Sci Transl Med. 2012 Feb 15;4(121):121ra20 – reference: 11572944 - Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12245-50 – reference: 12465060 - Mov Disord. 2002 Nov;17(6):1221-6 – reference: 22622968 - Mol Neurobiol. 2013 Apr;47(2):495-508 – reference: 17683088 - Ann Neurol. 2007 Aug;62(2):145-53 – reference: 22108576 - Brain. 2012 Jan;135(Pt 1):170-80 – reference: 20962290 - Neurology. 2010 Nov 16;75(20):1766-72 – reference: 19812464 - Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):229-33 – reference: 19901166 - Arch Neurol. 2009 Nov;66(11):1353-8 – reference: 21566660 - Cell Death Differ. 2011 Sep;18(9):1425-33 – reference: 23384597 - Pharmacol Ther. 2013 Jun;138(3):311-22 – reference: 10822429 - Neurology. 2000 May 23;54(10):1916-21 – reference: 17542011 - Mov Disord. 2007 Sep 15;22(12):1689-707; quiz 1837 – reference: 21720849 - Acta Neuropathol. 2011 Aug;122(2):187-204 – reference: 18241240 - Brain Pathol. 2008 Apr;18(2):220-4 – reference: 9678315 - Arch Neurol. 1998 Jul;55(7):969-78 – reference: 12810766 - J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):852-6 – reference: 2239463 - Adv Neurol. 1990;53:245-9 – reference: 14593171 - Science. 2003 Oct 31;302(5646):841 – reference: 22911513 - J Neurol. 2013 Feb;260(2):438-44 – reference: 11956955 - J Neural Transm (Vienna). 2002 Mar;109(3):329-39 – reference: 18625222 - Exp Neurol. 2008 Oct;213(2):315-25 – reference: 19812213 - Brain. 2009 Nov;132(Pt 11):2958-69 – reference: 9197268 - Science. 1997 Jun 27;276(5321):2045-7 – reference: 15036877 - Trends Neurosci. 2004 Mar;27(3):129-34 – reference: 23408705 - Mov Disord. 2013 Mar;28(3):302-10 – reference: 19812474 - Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):295-7 – reference: 23390095 - Mov Disord. 2013 Jan;28(1):31-40 – reference: 23466394 - Brain. 2013 Apr;136(Pt 4):1128-38 – reference: 20310053 - Mov Disord. 2010 Jul 15;25(9):1170-6 – reference: 16914880 - J Alzheimers Dis. 2006;9(3 Suppl):417-23 – reference: 16804711 - Acta Neuropathol. 2006 Sep;112(3):253-60 – reference: 21962945 - Brain Lang. 2012 Jan;120(1):52-60 – reference: 23239424 - Mov Disord. 2013 Mar;28(3):296-301 – reference: 17159096 - Neurology. 2006 Dec 12;67(11):1931-4 – reference: 12465052 - Mov Disord. 2002 Nov;17(6):1161-5 – reference: 19399512 - Acta Neuropathol. 2009 Jun;117(6):613-34 – reference: 16247051 - Neurology. 2005 Oct 25;65(8):1239-45 – reference: 22101365 - Acta Neuropathol. 2012 Jan;123(1):1-11 – reference: 18185940 - Acta Neuropathol. 2008 Apr;115(4):417-25 – reference: 18391962 - Nat Med. 2008 May;14(5):504-6 – reference: 20535823 - Mov Disord. 2010 Jun 15;25(8):969-78 |
| SSID | ssj0016176 |
| Score | 2.6192927 |
| SecondaryResourceType | review_article |
| Snippet | Key Points
Notable heterogeneity exists in the neuropathological substrates that underlie dementia in the setting of Parkinson's disease dementia (PDD).... Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein... |
| SourceID | pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 626 |
| SubjectTerms | 631/378/1689/364 692/698/1688/1366/64 692/699/375/365/1283 692/699/375/365/1718 alpha-Synuclein - physiology Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - physiology Amyloid beta-protein Animal Genetics and Genomics Behavioral Sciences Biological Techniques Biomedicine Brain - pathology Brain - physiology Development and progression Diagnosis Genetic aspects Humans Neurobiology Neurons - pathology Neurons - physiology Neurosciences Parkinson Disease - pathology Parkinson Disease - physiopathology Physiological aspects review-article Risk factors tau Proteins - physiology |
| Title | Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies |
| URI | https://link.springer.com/article/10.1038/nrn3549 https://www.ncbi.nlm.nih.gov/pubmed/23900411 https://www.proquest.com/docview/1426748891 https://pubmed.ncbi.nlm.nih.gov/PMC4017235 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1471-0048 dateEnd: 20151231 omitProxy: true ssIdentifier: ssj0016176 issn: 1471-003X databaseCode: ABDBF dateStart: 20001001 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1471-0048 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0016176 issn: 1471-003X databaseCode: BENPR dateStart: 20001001 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1471-0048 dateEnd: 20171231 omitProxy: true ssIdentifier: ssj0016176 issn: 1471-003X databaseCode: 7X7 dateStart: 20001001 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLVYJyFeEN8UxmQkxh5GutZ2nIa3dnQaSK0Adag8RbGTQKeRoqYVgn8FP2S_iXtj56ubEPCSVrGVurknN8f2vecS8iwWkeq7LnMSxVxMyYkcJUXkxMDOVSTg8crTx8YTeXIq3szcWRXKm2eXrFRH_7gyr-R_rArnwK6YJfsPli0vCifgO9gXjmBhOP6VjTFl2WZveVmx13IQ5St-87zoTh5UvjSCm0AL945Ge8Oek31PUcbYyAeswrVRbP0Cc_d55OR9GAquGsdogwwtgZ3kQqA24yXrHEwqPcwSIq9RVbgMmK82nmzQz4f58tMck8HGHack0tPl4ixMF99sGe08oOddfUkCy0P49SUJO5Ir19GMl4U3ogPuZNZww6IGN7_mU6VJqb_k642ye7pMuWtUTzeEswcc54pCyu4W2WaelKxFtgfDV8PjcpsJ6JtJP7PjMVnVeOVDe90GXdl8addYy2ZE7ca2es5WprfITTvNoAODmdvkWpzeIdfHNpDiLvlYQmc_oxY4tADOS1qDDV0k9OJnBZkXFABDATC0AMzFL1oDyz1yejyaHp04tsqGo4X0V04iu5Hr6Vj4HKidYir2MCZGYTkp4OahCxRaMc1D4UumkxgpqGIR73YT1ZMq5PdJK12k8UNCpQ6TSHlCxTETUvGwxyItE2CkXLmh0m3yvLiZgbYS9FgJ5TzIQyF4P7B3vU1o2fGrUV253GUfrREgJOAaOrTpJDASVDQLKuu3yU6jJ_hP3Wh-WtgzwCYMOkzjxTqDWTHDUjx9v9cmD4x9y9Ew7qNUHbR4DcuXHVC2vdmSzj_n8u0Cl124C79bYCSwPiXb_JOP_jz0x-RG9fjtkNZquY6fAEdeqV2y5c28XYt3-ByOJm_f_waAdMPU |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Parkinson%27s+disease+dementia%3A+convergence+of+%CE%B1-synuclein%2C+tau+and+amyloid-%CE%B2+pathologies&rft.jtitle=Nature+reviews.+Neuroscience&rft.au=Irwin%2C+David+J&rft.au=Lee%2C+Virginia+M.-Y&rft.au=Trojanowski%2C+John+Q&rft.date=2013-09-01&rft.pub=Nature+Publishing+Group&rft.issn=1471-003X&rft.volume=14&rft.issue=9&rft.spage=626&rft_id=info:doi/10.1038%2Fnrn3549&rft.externalDocID=A344154660 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-003X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-003X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-003X&client=summon |