Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft - Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr; Borgos, Sven Even; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; et al. (Journal of controlled release, 2019)
Keywords: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - blood; Antineoplastic Agents - pharmacokinetics; Biodistribution; blood; Breast cancer; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Cabazitaxel; Cell Line, Tumor; cell lines; Cell Survival - drug effects; Cell toxicity; Clinical medical disciplines: 750; Cyanoacrylates - administration & dosage; Cyanoacrylates - pharmacokinetics; cytotoxicity; drugs; encapsulation; Female; fluorescent substances; Humans; image analysis; immunohistochemistry; Klinisk medisinske fag: 750; Macrophage infiltration; macrophages; mass spectrometry; Medical disciplines: 700; Medisinske Fag: 700; mice; Mice, Nude; nanoparticles; Nanoparticles - administration & dosage; neoplasm cells; Oncology: 762; Onkologi: 762; patients; Poly(alkyl cyanoacrylate) nanoparticles; remission; Taxoids - administration & dosage; Taxoids - blood; Taxoids - pharmacokinetics; therapeutics; Tissue Distribution; Treatment Outcome; VDP; PDX; EPR; MS; Macrophage infiltration; Cell toxicity; PACA; Breast cancer; PEBCA; Biodistribution; Cabazitaxel; AUC; LOQ; Poly(alkyl cyanoacrylate) nanoparticles; i.v; LNs; NPs; PEG; PDI; TAMs; PBCA; LC; POCA; CBZ