The effects of ambient particulate matter air pollution on platelets and hemostasis

• Published in: Frontiers in public health Vol. 12; p. 1410406
• Main Authors: Hantrakool, Sasinee, Sriwichai, Maitree, Shaengkhamnang, Banphot, Leetrakool, Nipapan, Niprapan, Piangrawee, Kawichai, Sawaeng, Wannakul, Sitapak, Panyasit, Noppamas, Tuntivate, Pakinee, Wongtagan, Ornkamon, Natesirinilkul, Rungrote, Koonyosying, Pimpisid, Phinyo, Phichayut, Punnachet, Teerachat, Hantrakun, Nonthakorn, Piriyakhuntorn, Pokpong, Rattanathammethee, Thanawat, Chai-Adisaksopha, Chatree, Rattarittamrong, Ekarat, Tantiworawit, Adisak, Norasetthada, Lalita, Srichairatanakool, Somdet
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.07.2024
• Subjects: Adult; Air Pollutants - adverse effects; Air Pollution - adverse effects; Blood Coagulation Tests; Blood Platelets - drug effects; coagulation; Environmental Exposure - adverse effects; hemostasis; Hemostasis - drug effects; Humans; Male; Middle Aged; particulate matter; Particulate Matter - adverse effects; Platelet Count; platelet function; Prospective Studies; Public Health; Seasons; Thailand; von Willebrand factor; von Willebrand Factor - analysis; von Willebrand Factor - metabolism; Thailand; particulate matter; hemostasis; platelet function; coagulation; von Willebrand factor
• ISSN: 2296-2565; 2296-2565
• DOI: 10.3389/fpubh.2024.1410406

Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with the balance of hemostatic system remain unclear. This study investigates PM-mediated hemostatic changes in individuals across unique seasonal variations of ambient pollution. This prospective study was conducted between February and July 2020 during alterations in ambient pollution in Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times in total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWF), platelet count, and platelet functions, were evaluated. A mixed-effects model was used to analyze the impact of high PM2.5 and PM10 on hemostatic parameters. Thirty male subjects with mean age of 38.9 ± 8.2 years, were included. High levels of PM2.5 and PM10 were significantly associated with PT shortening, with no such effect observed in aPTT. PM2.5 and PM10 values also positively correlated with vWF function, while vWF antigen levels remained unchanged. Soluble P-selectin showed a strong positive association with PM2.5 and PM10 levels. Platelet function analysis revealed no correlation with PM values. Short-term exposure to elevated PM2.5 and PM10 concentrations was linked to shortened PT and enhanced vWF function in healthy individuals. Exploring the impact of these changes on clinically relevant thrombosis is crucial. Additional studies on the pathogenesis of pollution-related thrombosis are warranted for maintaining good health.