Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects - Ren, Rendong; Azuma, Yosuke; Ojima, Takao; Hashimoto, Takashi; Mizuno, Masashi; Nishitani, Yosuke; Yoshida, Masaru; Azuma, Takeshi; Kanazawa, Kazuki (British journal of nutrition, 2013)
Keywords: 6-Ketoprostaglandin F1 alpha - genetics; 6-Ketoprostaglandin F1 alpha - metabolism; Adult; Algae; Anticoagulants - chemistry; Anticoagulants - pharmacology; Biological and medical sciences; Blood; Blood Coagulation - drug effects; blood serum; Caco-2 Cells; coculture; Coculture Techniques; detection limit; Diet; Eicosanoids - metabolism; feces; Feeding. Feeding behavior; Female; fucoidan; Fundamental and applied biological sciences. Psychology; hematologic tests; Human and Clinical Nutrition; human cell lines; Humans; Hydrogen Peroxide; ingredients; intestinal mucosa; Japan; Laminaria - chemistry; Laminaria japonica; lutein; Male; messenger RNA; mice; monoclonal antibodies; NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); Nutrition; platelet aggregation; Platelet Aggregation - physiology; Polysaccharides - chemistry; Polysaccharides - pharmacology; Preventive medicine; prostacyclin; Saccharina japonica; secretion; Stress, Mechanical; Thromboembolism; Thrombosis; Thromboxane B2 - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; volunteers; Young Adult; Japan; F-fucoidan; Prostacyclin; Hydrogen peroxide; Thromboxane A2; Anti-thrombosis; Human; Nutrition; Prostaglandin I2; Hydrogen; Algae; Arachidonic acid derivatives; Cardiovascular disease; Thrombosis; Vascular disease; Aggregation; Heterokontophyta; Laminaria; Eicosanoid; Production; Thromboxane A; Peroxides; Phaeophyceae