Advances in the knowledge and therapeutics of schizophrenia, major depression disorder, and bipolar disorder from human brain organoid research
Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that recapitulates early developmental stages of nervous tissue differentiation. Technical progress in culture methodol...
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| Published in | Frontiers in psychiatry Vol. 14; p. 1178494 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
12.07.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-0640 1664-0640 |
| DOI | 10.3389/fpsyt.2023.1178494 |
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| Abstract | Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed “brain organoids” are now employed as an
in vitro
assay that recapitulates early developmental stages of nervous tissue differentiation. Technical progress in culture methodology enabled the generation of regionally specialized organoids with structural and neurochemical characters of distinct encephalic regions. The technical process of organoid elaboration is undergoing progressively implementation, but current robustness of the assay has attracted the attention of psychiatric research to substitute/complement animal experimentation for analyzing the pathophysiology of psychiatric disorders. Numerous morphological, structural, molecular and functional insights of psychiatric disorders have been uncovered by comparing brain organoids made with iPSCs obtained from control healthy subjects and psychiatric patients. Brain organoids were also employed for analyzing the response to conventional treatments, to search for new drugs, and to anticipate the therapeutic response of individual patients in a personalized manner. In this review, we gather data obtained by studying cerebral organoids made from iPSCs of patients of the three most frequent serious psychiatric disorders: schizophrenia, major depression disorder, and bipolar disorder. Among the data obtained in these studies, we emphasize: (i) that the origin of these pathologies takes place in the stages of embryonic development; (ii) the existence of shared molecular pathogenic aspects among patients of the three distinct disorders; (iii) the occurrence of molecular differences between patients bearing the same disorder, and (iv) that functional alterations can be activated or aggravated by environmental signals in patients bearing genetic risk for these disorders. |
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| AbstractList | Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed “brain organoids” are now employed as an
in vitro
assay that recapitulates early developmental stages of nervous tissue differentiation. Technical progress in culture methodology enabled the generation of regionally specialized organoids with structural and neurochemical characters of distinct encephalic regions. The technical process of organoid elaboration is undergoing progressively implementation, but current robustness of the assay has attracted the attention of psychiatric research to substitute/complement animal experimentation for analyzing the pathophysiology of psychiatric disorders. Numerous morphological, structural, molecular and functional insights of psychiatric disorders have been uncovered by comparing brain organoids made with iPSCs obtained from control healthy subjects and psychiatric patients. Brain organoids were also employed for analyzing the response to conventional treatments, to search for new drugs, and to anticipate the therapeutic response of individual patients in a personalized manner. In this review, we gather data obtained by studying cerebral organoids made from iPSCs of patients of the three most frequent serious psychiatric disorders: schizophrenia, major depression disorder, and bipolar disorder. Among the data obtained in these studies, we emphasize: (i) that the origin of these pathologies takes place in the stages of embryonic development; (ii) the existence of shared molecular pathogenic aspects among patients of the three distinct disorders; (iii) the occurrence of molecular differences between patients bearing the same disorder, and (iv) that functional alterations can be activated or aggravated by environmental signals in patients bearing genetic risk for these disorders. Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed "brain organoids" are now employed as an assay that recapitulates early developmental stages of nervous tissue differentiation. Technical progress in culture methodology enabled the generation of regionally specialized organoids with structural and neurochemical characters of distinct encephalic regions. The technical process of organoid elaboration is undergoing progressively implementation, but current robustness of the assay has attracted the attention of psychiatric research to substitute/complement animal experimentation for analyzing the pathophysiology of psychiatric disorders. Numerous morphological, structural, molecular and functional insights of psychiatric disorders have been uncovered by comparing brain organoids made with iPSCs obtained from control healthy subjects and psychiatric patients. Brain organoids were also employed for analyzing the response to conventional treatments, to search for new drugs, and to anticipate the therapeutic response of individual patients in a personalized manner. In this review, we gather data obtained by studying cerebral organoids made from iPSCs of patients of the three most frequent serious psychiatric disorders: schizophrenia, major depression disorder, and bipolar disorder. Among the data obtained in these studies, we emphasize: (i) that the origin of these pathologies takes place in the stages of embryonic development; (ii) the existence of shared molecular pathogenic aspects among patients of the three distinct disorders; (iii) the occurrence of molecular differences between patients bearing the same disorder, and (iv) that functional alterations can be activated or aggravated by environmental signals in patients bearing genetic risk for these disorders. Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that recapitulates early developmental stages of nervous tissue differentiation. Technical progress in culture methodology enabled the generation of regionally specialized organoids with structural and neurochemical characters of distinct encephalic regions. The technical process of organoid elaboration is undergoing progressively implementation, but current robustness of the assay has attracted the attention of psychiatric research to substitute/complement animal experimentation for analyzing the pathophysiology of psychiatric disorders. Numerous morphological, structural, molecular and functional insights of psychiatric disorders have been uncovered by comparing brain organoids made with iPSCs obtained from control healthy subjects and psychiatric patients. Brain organoids were also employed for analyzing the response to conventional treatments, to search for new drugs, and to anticipate the therapeutic response of individual patients in a personalized manner. In this review, we gather data obtained by studying cerebral organoids made from iPSCs of patients of the three most frequent serious psychiatric disorders: schizophrenia, major depression disorder, and bipolar disorder. Among the data obtained in these studies, we emphasize: (i) that the origin of these pathologies takes place in the stages of embryonic development; (ii) the existence of shared molecular pathogenic aspects among patients of the three distinct disorders; (iii) the occurrence of molecular differences between patients bearing the same disorder, and (iv) that functional alterations can be activated or aggravated by environmental signals in patients bearing genetic risk for these disorders. Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed "brain organoids" are now employed as an in vitro assay that recapitulates early developmental stages of nervous tissue differentiation. Technical progress in culture methodology enabled the generation of regionally specialized organoids with structural and neurochemical characters of distinct encephalic regions. The technical process of organoid elaboration is undergoing progressively implementation, but current robustness of the assay has attracted the attention of psychiatric research to substitute/complement animal experimentation for analyzing the pathophysiology of psychiatric disorders. Numerous morphological, structural, molecular and functional insights of psychiatric disorders have been uncovered by comparing brain organoids made with iPSCs obtained from control healthy subjects and psychiatric patients. Brain organoids were also employed for analyzing the response to conventional treatments, to search for new drugs, and to anticipate the therapeutic response of individual patients in a personalized manner. In this review, we gather data obtained by studying cerebral organoids made from iPSCs of patients of the three most frequent serious psychiatric disorders: schizophrenia, major depression disorder, and bipolar disorder. Among the data obtained in these studies, we emphasize: (i) that the origin of these pathologies takes place in the stages of embryonic development; (ii) the existence of shared molecular pathogenic aspects among patients of the three distinct disorders; (iii) the occurrence of molecular differences between patients bearing the same disorder, and (iv) that functional alterations can be activated or aggravated by environmental signals in patients bearing genetic risk for these disorders.Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed "brain organoids" are now employed as an in vitro assay that recapitulates early developmental stages of nervous tissue differentiation. Technical progress in culture methodology enabled the generation of regionally specialized organoids with structural and neurochemical characters of distinct encephalic regions. The technical process of organoid elaboration is undergoing progressively implementation, but current robustness of the assay has attracted the attention of psychiatric research to substitute/complement animal experimentation for analyzing the pathophysiology of psychiatric disorders. Numerous morphological, structural, molecular and functional insights of psychiatric disorders have been uncovered by comparing brain organoids made with iPSCs obtained from control healthy subjects and psychiatric patients. Brain organoids were also employed for analyzing the response to conventional treatments, to search for new drugs, and to anticipate the therapeutic response of individual patients in a personalized manner. In this review, we gather data obtained by studying cerebral organoids made from iPSCs of patients of the three most frequent serious psychiatric disorders: schizophrenia, major depression disorder, and bipolar disorder. Among the data obtained in these studies, we emphasize: (i) that the origin of these pathologies takes place in the stages of embryonic development; (ii) the existence of shared molecular pathogenic aspects among patients of the three distinct disorders; (iii) the occurrence of molecular differences between patients bearing the same disorder, and (iv) that functional alterations can be activated or aggravated by environmental signals in patients bearing genetic risk for these disorders. |
| Author | Villanueva, Rosa |
| AuthorAffiliation | Departamento de Psiquiatría y Salud Mental, Hospital Universitario La Paz , La Paz, Madrid , Spain |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37502814$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/tp.2014.12 10.1097/WNR.0000000000001131 10.1038/s41380-022-01856-5 10.1016/j.actbio.2022.12.011 10.1038/nature.2011.9415 10.1007/s00221-011-2933-3 10.1016/j.stemcr.2021.02.004 10.1038/s41380-019-0377-5 10.1016/j.bbi.2023.02.007 10.1016/j.neuron.2012.05.034 10.1093/schbul/sbx077 10.3390/ijms23115968 10.1016/j.isci.2022.105898 10.1016/j.schres.2022.11.001 10.1016/j.stem.2023.01.004 10.1038/mp.2014.176 10.1038/s42003-023-04547-1 10.1155/2013/873278 10.1016/j.biopsych.2022.12.015 10.1126/science.aal3231 10.1038/mp.2016.260 10.1016/j.semcdb.2022.09.007 10.1007/s12035-012-8277-6 10.1038/mp.2017.66 10.3389/fncel.2020.00025 10.1016/j.cell.2006.07.024 10.3389/fcell.2023.1083175 10.1038/s41398-017-0054-x 10.1155/2021/6338722 10.1038/s41380-022-01806-1 10.1038/s41380-021-01316-6 10.1016/j.reprotox.2023.108358 10.1017/S0963180123000038 10.1038/s41586-022-05277-w 10.1038/s41380-019-0363-y 10.1016/j.medj.2021.08.005 10.1038/mp.2015.7 10.1371/journal.pone.0142693 10.1016/j.stem.2019.09.002 10.1152/physiol.00036.2016 10.1038/mp.2017.241 10.1016/j.cell.2016.09.027 10.1038/mp.2014.22 10.3389/fncel 10.1016/j.stem.2022.11.002 10.1016/j.neuron.2014.03.002 10.1039/d3lc00124e 10.1038/s41380-019-0634-7 10.1126/sciadv.aaz9499 10.1186/s13578-022-00928-x 10.1038/s41380-023-01944-0 10.1016/j.stem.2020.02.002 10.1038/s41398-021-01319-5 10.1016/j.celrep.2014.12.051 10.3389/fnmol.2022.1023765 10.1073/pnas.2109395119 10.3389/fsci.2023.1017235 10.1038/mp.2013.67 10.1177/0706743718771833 10.1038/s41576-022-00466-9 10.1007/s40473-014-0013-2 10.3389/fncel.2020.607399 10.3389/fsci.2023.1148873 10.1038/nature09915 10.1111/joa.12257 10.3389/fnins.2020.00538 10.1038/s41380-022-01708-2 10.1038/s41380-020-0844-z 10.1073/pnas.1612906114 10.1016/j.schres.2022.06.027 10.1016/j.neuron.2014.02.033 10.1016/j.bios.2023.115271 10.1002/cphy.c180025 10.1073/pnas.051611498 10.5045/br.2015.50.4.194 10.1016/j.jad.2021.06.075 10.1038/s41586-022-04434-5 10.1002/wps.20631 10.1016/j.schres.2016.12.012 10.3390/jpm12081340 10.1038/nature12517 10.1016/j.xpro.2022.101860 10.1016/j.stem.2016.07.005 10.1002/bies.201600127 10.1242/dev.162214 10.1038/s42003-022-03963-z 10.1007/s12272-020-01260-z 10.1038/nature22330 10.1038/d41586-021-02628-x 10.3389/fncel.2022.1039957 10.1038/s41588-018-0151-7 10.2174/1566524015666150303003028 10.1073/pnas.1700111114 10.3390/cells7090140 10.1037/ccp0000482 |
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| Keywords | induced pluripotent stem cells brain organoids modeling psychiatric disorders tridimensional neural cultures transdiagnostic psychiatry organ-on-chip |
| Language | English |
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| References | Goo (ref68) 2023; 28 Robicsek (ref55) 2013; 18 Dixon (ref12) 2023; 28 Tabata (ref8) 2012; 216 Magliaro (ref23) 2023; 1 Nascimento (ref54) 2022; 12 Konopka (ref5) 2012; 75 Brennand (ref62) 2015; 20 Chen (ref88) 2014; 4 Avior (ref53) 2021; 11 Takahashi (ref25) 2006; 126 Villanueva (ref74) 2013; 2013 Kim (ref42) 2023 Collo (ref82) 2018; 29 Nagel (ref69) 2018; 50 Villanueva (ref14) 2017; 45 Vadodaria (ref79) 2019; 24 Zhang (ref43) 2017; 114 Osete (ref85) 2023 Birey (ref21) 2017; 545 Couch (ref96) 2023; 110 Bao (ref50) 2021; 2021 Stachowiak (ref66) 2017; 7 Smirnova (ref24) 2023; 1 Duval (ref13) 2017; 32 Bose (ref40) 2021; 2 Kim (ref87) 2015; 10 Logan (ref16) 2019; 9 Schmidt (ref22) 2021; 597 Nei (ref10) 2001; 98 Winkelman (ref44) 2023; 9 Bavamian (ref92) 2015; 20 Flint (ref75) 2014; 81 Zang (ref94) 2022; 15 Abdullah (ref26) 2012; 45 Fries (ref77) 2023; 28 Qian (ref37) 2020; 26 Muguruma (ref34) 2015; 10 Park (ref27) 2015; 50 Benson (ref73) 2020; 14 Robicsek (ref63) 2018; 44 Ingber (ref41) 2022; 23 Brennand (ref56) 2011; 473 Vadodaria (ref76) 2016; 38 Jgamadze (ref48) 2023; 30 Revah (ref49) 2022; 610 Parr (ref30) 2017; 22 Nam (ref17) 2020; 43 Notaras (ref71) 2022; 27 Tobe (ref93) 2017; 114 Saglam-Metiner (ref20) 2023; 6 Cavalleri (ref81) 2018; 23 Chen (ref52) 2019; 25 Matsui (ref7) 2020; 14 Jo (ref32) 2016; 19 Marinho (ref83) 2022; 144 Narla (ref65) 2017; 185 Chen (ref80) 2017; 356 Park (ref99) 2022; 5 Knight (ref46) 2015; 227 Gordovez (ref86) 2020; 25 Choudhary (ref64) 2022 Zhong (ref84) 2020; 14 Dalgleish (ref98) 2020; 88 Ogura (ref35) 2018; 145 Page (ref58) 2022; 119 Bassil (ref51) 2023; 17 Fusar-Poli (ref97) 2019; 18 Madison (ref89) 2015; 20 Mayhew (ref29) 2022; 4 Cervetto (ref15) 2023; 117 Eura (ref33) 2020; 14 Goldrick (ref19) 2023; 11 Monteduro (ref45) 2023; 231 Hunsberger (ref91) 2013; 5 Gao (ref60) 2015; 15 Białoń (ref3) 2022; 23 Howland (ref4) 2019; 64 Alich (ref39) 2023; 16 Trubetskoy (ref9) 2022; 604 Lee (ref57) 2022; 246 Brennand (ref67) 2011; 473 Forrest (ref2) 2014; 1 Sawada (ref59) 2020; 25 Li (ref70) 2021; 294 La Manno (ref6) 2016; 167 Stern (ref90) 2018; 23 Ahmad (ref61) 2018; 7 Xue (ref36) 2022; 26 Hashimoto-Torii (ref72) 2014; 82 Walsh (ref38) 2023 Velasco (ref47) 2022; 29 Vadodaria (ref95) 2021; 16 Yan (ref18) 2023; 157 Vadodaria (ref78) 2019; 24 Lancaster (ref28) 2013; 501 Zhang (ref31) 2023; 93 Callaway (ref1) 2011 Alciati (ref11) 2022; 12 |
| References_xml | – volume: 4 start-page: e375 year: 2014 ident: ref88 article-title: Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients publication-title: Transl Psychiatry doi: 10.1038/tp.2014.12 – volume: 5 start-page: 450 year: 2013 ident: ref91 article-title: Mood stabilizer-regulated MiRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions publication-title: Am J Transl Res – volume: 29 start-page: 1425 year: 2018 ident: ref82 article-title: (2R,6R)-hydroxynorketamine promotes dendrite outgrowth in human inducible pluripotent stem cell-derived neurons through AMPA receptor with timing and exposure compatible with ketamine infusion pharmacokinetics in humans publication-title: Neuroreport doi: 10.1097/WNR.0000000000001131 – volume: 28 start-page: 856 year: 2023 ident: ref68 article-title: Schizophrenia-associated mitotic arrest deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex publication-title: Mol Psychiatry doi: 10.1038/s41380-022-01856-5 – volume: 157 start-page: 252 year: 2023 ident: ref18 article-title: Three-dimensional highly porous hydrogel scaffold for neural circuit dissection and modulation publication-title: Acta Biomater doi: 10.1016/j.actbio.2022.12.011 – year: 2011 ident: ref1 article-title: Rat models on the rise in autism research publication-title: Nature doi: 10.1038/nature.2011.9415 – volume: 216 start-page: 161 year: 2012 ident: ref8 article-title: Cytoarchitecture of mouse and human subventricular zone in developing cerebral neocortex publication-title: Exp Brain Res doi: 10.1007/s00221-011-2933-3 – volume: 16 start-page: 825 year: 2021 ident: ref95 article-title: Altered neuronal support and inflammatory response in bipolar disorder patient-derived astrocytes publication-title: Stem Cell Rep doi: 10.1016/j.stemcr.2021.02.004 – volume: 24 start-page: 808 year: 2019 ident: ref79 article-title: Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons publication-title: Mol Psychiatry doi: 10.1038/s41380-019-0377-5 – volume: 110 start-page: 43 year: 2023 ident: ref96 article-title: Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2023.02.007 – volume: 75 start-page: 601 year: 2012 ident: ref5 article-title: Human-specific transcriptional networks in the brain publication-title: Neuron doi: 10.1016/j.neuron.2012.05.034 – volume: 44 start-page: 432 year: 2018 ident: ref63 article-title: Isolated mitochondria transfer improves neuronal differentiation of schizophrenia-derived induced pluripotent stem cells and rescues deficits in a rat model of the disorder publication-title: Schizophr Bull doi: 10.1093/schbul/sbx077 – volume: 23 start-page: 5968 year: 2022 ident: ref3 article-title: Advantages and Limitations of Animal Schizophrenia Models publication-title: Int J Mol Sci doi: 10.3390/ijms23115968 – volume: 26 start-page: 105898 year: 2022 ident: ref36 article-title: Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing publication-title: iScience doi: 10.1016/j.isci.2022.105898 – start-page: S0920-9964(22)00406-6 year: 2022 ident: ref64 article-title: Current progress in understanding schizophrenia using genomics and pluripotent stem cells: a meta-analytical overview publication-title: Schizophr Res doi: 10.1016/j.schres.2022.11.001 – volume: 30 start-page: 137 year: 2023 ident: ref48 article-title: Structural and functional integration of human forebrain organoids with the injured adult rat visual system publication-title: Cell Stem Cell doi: 10.1016/j.stem.2023.01.004 – volume: 20 start-page: 573 year: 2015 ident: ref92 article-title: Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder publication-title: Mol Psychiatry doi: 10.1038/mp.2014.176 – volume: 6 start-page: 173 year: 2023 ident: ref20 article-title: Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids publication-title: Commun Biol doi: 10.1038/s42003-023-04547-1 – volume: 2013 start-page: 873278 year: 2013 ident: ref74 article-title: Neurobiology of major depressive disorder publication-title: Neural Plast doi: 10.1155/2013/873278 – volume: 93 start-page: 594 year: 2023 ident: ref31 article-title: Development and application of brain region-specific organoids for investigating psychiatric disorders publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2022.12.015 – volume: 356 start-page: 406 year: 2017 ident: ref80 article-title: Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice publication-title: Science doi: 10.1126/science.aal3231 – volume: 23 start-page: 1453 year: 2018 ident: ref90 article-title: Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium publication-title: Mol Psychiatry doi: 10.1038/mp.2016.260 – volume: 144 start-page: 67 year: 2022 ident: ref83 article-title: The impact of antidepressants on human neurodevelopment: brain organoids as experimental tools publication-title: Semin Cell Dev Biol doi: 10.1016/j.semcdb.2022.09.007 – volume: 45 start-page: 586 year: 2012 ident: ref26 article-title: The path from skin to brain: generation of functional neurons from fibroblasts publication-title: Mol Neurobiol doi: 10.1007/s12035-012-8277-6 – volume: 22 start-page: 808 year: 2017 ident: ref30 article-title: An update on stem cell biology and engineering for brain development publication-title: Mol Psychiatry doi: 10.1038/mp.2017.66 – volume: 14 start-page: 25 year: 2020 ident: ref84 article-title: Antidepressant paroxetine exerts developmental neurotoxicity in an iPSC-derived 3D human brain model Zhanj publication-title: Front Cell Neurosci doi: 10.3389/fncel.2020.00025 – volume: 126 start-page: 663 year: 2006 ident: ref25 article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors publication-title: Cells doi: 10.1016/j.cell.2006.07.024 – volume: 11 start-page: 1083175 year: 2023 ident: ref19 article-title: 3D multicellular systems in disease modelling: from organoids to organ-on-chip publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2023.1083175 – volume: 7 start-page: 6 year: 2017 ident: ref66 article-title: Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1 publication-title: Transl Psychiatry doi: 10.1038/s41398-017-0054-x – volume: 2021 start-page: 6338722 year: 2021 ident: ref50 article-title: Human cerebral organoid implantation alleviated the neurological deficits of traumatic brain injury in mice publication-title: Oxidative Med Cell Longev doi: 10.1155/2021/6338722 – volume: 28 start-page: 284 year: 2023 ident: ref77 article-title: Molecular pathways of major depressive disorder converge on the synapse publication-title: Mol Psychiatry doi: 10.1038/s41380-022-01806-1 – volume: 27 start-page: 1416 year: 2022 ident: ref71 article-title: Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids publication-title: Mol Psychiatry doi: 10.1038/s41380-021-01316-6 – volume: 117 start-page: 108358 year: 2023 ident: ref15 article-title: Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing publication-title: Reprod Toxicol doi: 10.1016/j.reprotox.2023.108358 – volume: 17 start-page: 1 year: 2023 ident: ref51 article-title: Ethical implications in making use of human cerebral organoids for investigating stress-related mechanisms and disorders publication-title: Camb Q Healthc Ethics doi: 10.1017/S0963180123000038 – volume: 610 start-page: 319 year: 2022 ident: ref49 article-title: Maturation and circuit integration of transplanted human cortical organoids publication-title: Nature doi: 10.1038/s41586-022-05277-w – volume: 24 start-page: 795 year: 2019 ident: ref78 article-title: Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons publication-title: Mol Psychiatry doi: 10.1038/s41380-019-0363-y – volume: 2 start-page: 1011 year: 2021 ident: ref40 article-title: Promises and challenges of organoid-guided precision medicine publication-title: Med doi: 10.1016/j.medj.2021.08.005 – volume: 20 start-page: 703 year: 2015 ident: ref89 article-title: Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities publication-title: Mol Psychiatry doi: 10.1038/mp.2015.7 – volume: 10 start-page: e0142693 year: 2015 ident: ref87 article-title: Transcriptomic analysis of induced pluripotent stem cells derived from patients with bipolar disorder from an old order Amish pedigree publication-title: PLoS One doi: 10.1371/journal.pone.0142693 – volume: 25 start-page: 462 year: 2019 ident: ref52 article-title: Transplantation of human brain organoids: revisiting the science and ethics of brain chimeras publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.09.002 – volume: 32 start-page: 266 year: 2017 ident: ref13 article-title: Modeling physiological events in 2D vs. 3D cell culture publication-title: Physiology doi: 10.1152/physiol.00036.2016 – volume: 23 start-page: 812 year: 2018 ident: ref81 article-title: Ketamine enhances structural plasticityin mouse mesencephalic and human IPSC-derived dopaminergic neurons via AMPAR-driven BDNF and MTOR signaling publication-title: Mol Psychiatry doi: 10.1038/mp.2017.241 – volume: 167 start-page: 566 year: 2016 ident: ref6 article-title: Molecular diversity of midbrain development in mouse, human, and stem cells publication-title: Cells doi: 10.1016/j.cell.2016.09.027 – volume: 20 start-page: 361 year: 2015 ident: ref62 article-title: Phenotypic differences in HiPSC NPCs derived from patients with schizophrenia publication-title: Mol Psychiatry doi: 10.1038/mp.2014.22 – volume: 14 start-page: 233 year: 2020 ident: ref73 article-title: Immune factor, TNFα, disrupts human brain organoid development similar to schizophrenia-schizophrenia increases developmental vulnerability to TNFα publication-title: Front Cell Neurosci doi: 10.3389/fncel – volume: 29 start-page: 1617 year: 2022 ident: ref47 article-title: Modeling brain disorders using transplanted organoids: beyond the short circuit publication-title: Cell Stem Cell doi: 10.1016/j.stem.2022.11.002 – volume: 82 start-page: 560 year: 2014 ident: ref72 article-title: Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders publication-title: Neuron doi: 10.1016/j.neuron.2014.03.002 – year: 2023 ident: ref42 article-title: Manufactured tissue-to-tissue barrier chip for modeling the human blood-brain barrier and regulation of cellular trafficking publication-title: Lab Chip doi: 10.1039/d3lc00124e – year: 2023 ident: ref38 – volume: 25 start-page: 544 year: 2020 ident: ref86 article-title: The genetics of bipolar disorder publication-title: Mol Psychiatry doi: 10.1038/s41380-019-0634-7 – volume: 9 start-page: eaaz9499 year: 2023 ident: ref44 article-title: Bioengineered perfused human brain microvascular networks enhance neural progenitor cell survival, neurogenesis, and maturation publication-title: Sci Adv doi: 10.1126/sciadv.aaz9499 – volume: 12 start-page: 189 year: 2022 ident: ref54 article-title: Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains publication-title: Cell Biosci doi: 10.1186/s13578-022-00928-x – year: 2023 ident: ref85 article-title: Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids publication-title: Mol Psychiatry doi: 10.1038/s41380-023-01944-0 – volume: 26 start-page: 766 year: 2020 ident: ref37 article-title: Sliced human cortical organoids for modeling distinct cortical layer formation publication-title: Cell Stem Cell doi: 10.1016/j.stem.2020.02.002 – volume: 11 start-page: 201 year: 2021 ident: ref53 article-title: Depression patient-derived cortical neurons reveal potential biomarkers for antidepressant response publication-title: Transl Psychiatry doi: 10.1038/s41398-021-01319-5 – volume: 10 start-page: 537 year: 2015 ident: ref34 article-title: Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells publication-title: Cell Rep doi: 10.1016/j.celrep.2014.12.051 – volume: 15 start-page: 1023765 year: 2022 ident: ref94 article-title: Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2022.1023765 – volume: 119 start-page: e2109395119 year: 2022 ident: ref58 article-title: Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.2109395119 – volume: 1 start-page: 1017235 year: 2023 ident: ref24 article-title: Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish publication-title: FrontSci doi: 10.3389/fsci.2023.1017235 – volume: 18 start-page: 1067 year: 2013 ident: ref55 article-title: Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients publication-title: Mol Psychiatry doi: 10.1038/mp.2013.67 – volume: 64 start-page: 3 year: 2019 ident: ref4 article-title: Practical aspects of animal models of psychiatric disorders publication-title: Can J Psychiatr doi: 10.1177/0706743718771833 – volume: 23 start-page: 467 year: 2022 ident: ref41 article-title: Human organs-on-chips for disease modelling, drug development and personalized medicine publication-title: Nat Rev Genet doi: 10.1038/s41576-022-00466-9 – volume: 1 start-page: 100 year: 2014 ident: ref2 article-title: Animal models of psychosis: current state and future directions publication-title: Curr Behav Neurosci Rep doi: 10.1007/s40473-014-0013-2 – volume: 14 start-page: 607399 year: 2020 ident: ref7 article-title: Challenges in modeling human neural circuit formation via brain organoid technology publication-title: Front Cell Neurosci doi: 10.3389/fncel.2020.607399 – volume: 1 start-page: 1148873 year: 2023 ident: ref23 article-title: To brain or not to brain publication-title: Front Sci doi: 10.3389/fsci.2023.1148873 – volume: 473 start-page: 221 year: 2011 ident: ref67 article-title: Modelling Schizophrenia Using Human Induced Pluripotent Stem Cells publication-title: Nature doi: 10.1038/nature09915 – volume: 227 start-page: 746 year: 2015 ident: ref46 article-title: Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro publication-title: J Anat doi: 10.1111/joa.12257 – volume: 14 start-page: 538 year: 2020 ident: ref33 article-title: Brainstem organoids from human pluripotent stem cells publication-title: Front Neurosci doi: 10.3389/fnins.2020.00538 – volume: 28 start-page: 83 year: 2023 ident: ref12 article-title: Advancing preclinical models of psychiatric disorders with human brain organoid cultures publication-title: Mol Psychiatry doi: 10.1038/s41380-022-01708-2 – volume: 25 start-page: 2695 year: 2020 ident: ref59 article-title: Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids publication-title: Mol Psychiatry doi: 10.1038/s41380-020-0844-z – volume: 114 start-page: E2293 year: 2017 ident: ref43 article-title: Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1612906114 – volume: 246 start-page: 225 year: 2022 ident: ref57 article-title: Impaired migration of autologous induced neural stem cells from patients with schizophrenia and implications for genetic risk for psychosis publication-title: Schizophr Res doi: 10.1016/j.schres.2022.06.027 – volume: 81 start-page: 1214 year: 2014 ident: ref75 article-title: The Genetics of Major Depression publication-title: Neuron doi: 10.1016/j.neuron.2014.02.033 – volume: 231 start-page: 115271 year: 2023 ident: ref45 article-title: Organs-on-chips technologies—a guide from disease models to opportunities for drug development publication-title: Biosens Bioelectron doi: 10.1016/j.bios.2023.115271 – volume: 9 start-page: 565 year: 2019 ident: ref16 article-title: Studying human neurological disorders using induced pluripotent stem cells: from 2D monolayer to 3D organoid and blood brain barrier models publication-title: Compr Physiol doi: 10.1002/cphy.c180025 – volume: 98 start-page: 2497 year: 2001 ident: ref10 article-title: Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organisms publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.051611498 – volume: 50 start-page: 194 year: 2015 ident: ref27 article-title: Hematopoietic stem cell expansion and generation: the ways to make a breakthrough publication-title: Blood Res doi: 10.5045/br.2015.50.4.194 – volume: 294 start-page: 33 year: 2021 ident: ref70 article-title: Comorbid major depression in first-episode drug-naïve patients with schizophrenia: analysis of the depression in schizophrenia in China (DISC) study publication-title: J Affect Disord doi: 10.1016/j.jad.2021.06.075 – volume: 604 start-page: 502 year: 2022 ident: ref9 article-title: Mapping genomic loci implicates genes and synaptic biology in schizophrenia publication-title: Nature doi: 10.1038/s41586-022-04434-5 – volume: 18 start-page: 192 year: 2019 ident: ref97 article-title: Transdiagnostic psychiatry: a systematic review publication-title: World Psychiatry doi: 10.1002/wps.20631 – volume: 185 start-page: 17 year: 2017 ident: ref65 article-title: Common developmental genome deprogramming in schizophrenia—role of integrative nuclear FGFR1 signaling (INFS) publication-title: Schizophr Res doi: 10.1016/j.schres.2016.12.012 – volume: 12 start-page: 1340 year: 2022 ident: ref11 article-title: Human-induced pluripotent stem cell technology: toward the future of personalized psychiatry publication-title: J Pers Med doi: 10.3390/jpm12081340 – volume: 501 start-page: 373 year: 2013 ident: ref28 article-title: Cerebral organoids model human brain development and microcephaly publication-title: Nature doi: 10.1038/nature12517 – volume: 4 start-page: 101860 year: 2022 ident: ref29 article-title: A review of protocols for brain organoids and applications for disease modeling publication-title: STAR Protoc doi: 10.1016/j.xpro.2022.101860 – volume: 19 start-page: 248 year: 2016 ident: ref32 article-title: Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons publication-title: Cell Stem Cell doi: 10.1016/j.stem.2016.07.005 – volume: 38 start-page: 1123 year: 2016 ident: ref76 article-title: Generating human serotonergic neurons in vitro: methodological advances publication-title: BioEssays doi: 10.1002/bies.201600127 – volume: 145 start-page: dev162214 year: 2018 ident: ref35 article-title: Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells publication-title: Development doi: 10.1242/dev.162214 – volume: 5 start-page: 1024 year: 2022 ident: ref99 article-title: Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology publication-title: Commun Biol doi: 10.1038/s42003-022-03963-z – volume: 43 start-page: 877 year: 2020 ident: ref17 article-title: In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid publication-title: Arch Pharm Res doi: 10.1007/s12272-020-01260-z – volume: 45 start-page: 303 year: 2017 ident: ref14 article-title: Application of stem cells to the knowledge and treatment of psychiatric diseases publication-title: Actas Esp Psiquiatr – volume: 545 start-page: 54 year: 2017 ident: ref21 article-title: Assembly of functionally integrated human forebrain spheroids publication-title: Nature doi: 10.1038/nature22330 – volume: 597 start-page: S22 year: 2021 ident: ref22 article-title: The rise of the assembloid publication-title: Nature doi: 10.1038/d41586-021-02628-x – volume: 16 start-page: 1039957 year: 2023 ident: ref39 article-title: Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings publication-title: Front Cell Neurosci doi: 10.3389/fncel.2022.1039957 – volume: 50 start-page: 920 year: 2018 ident: ref69 article-title: Meta-analysis of genome-wide association studies for neuroticism in 449, 484 individuals identifies novel genetic loci and pathways publication-title: Nat Genet doi: 10.1038/s41588-018-0151-7 – volume: 15 start-page: 146 year: 2015 ident: ref60 article-title: Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders publication-title: Curr Mol Med doi: 10.2174/1566524015666150303003028 – volume: 114 start-page: E4462 year: 2017 ident: ref93 article-title: Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1700111114 – volume: 7 start-page: 140 year: 2018 ident: ref61 article-title: Tracing early neurodevelopment in schizophrenia with induced pluripotent stem cells publication-title: Cells doi: 10.3390/cells7090140 – volume: 88 start-page: 179 year: 2020 ident: ref98 article-title: Transdiagnostic approaches to mental health problems: current status and future directions publication-title: J Consult Clin Psychol doi: 10.1037/ccp0000482 – volume: 473 start-page: 221 year: 2011 ident: ref56 article-title: Modelling schizophrenia using human induced pluripotent stem cells publication-title: Nature doi: 10.1038/nature09915 |
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| Snippet | Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed “brain organoids” are now employed... Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed to neural differentiation, termed "brain organoids" are now employed... |
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| SubjectTerms | brain organoids induced pluripotent stem cells modeling psychiatric disorders organ-on-chip Psychiatry transdiagnostic psychiatry tridimensional neural cultures |
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| Title | Advances in the knowledge and therapeutics of schizophrenia, major depression disorder, and bipolar disorder from human brain organoid research |
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