Nuclear Actin Is Required for Transcription during Drosophila Oogenesis
Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whether actin controls the transcription of only specific genes...
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| Published in | iScience Vol. 9; pp. 63 - 70 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier
30.11.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2589-0042 2589-0042 |
| DOI | 10.1016/j.isci.2018.10.010 |
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| Abstract | Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whether actin controls the transcription of only specific genes or has a global role in gene expression has remained elusive. Our genome-wide analysis reveals, for the first time, that actin interacts with essentially all transcribed genes in Drosophila ovaries. Actin co-occupies the majority of gene promoters together with Pol II, and on highly expressed genes, these two proteins also associate with gene bodies. Mechanistically, actin is required for Pol II recruitment to gene bodies, and manipulation of nuclear transport factors for actin leads to the decreased expression of eggshell genes. Collectively, these results uncover a global role for actin in transcription and demonstrate the in vivo importance of balanced nucleocytoplasmic shuttling of actin in the transcriptional control of a developmental process. |
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| AbstractList | Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whether actin controls the transcription of only specific genes or has a global role in gene expression has remained elusive. Our genome-wide analysis reveals, for the first time, that actin interacts with essentially all transcribed genes in Drosophila ovaries. Actin co-occupies the majority of gene promoters together with Pol II, and on highly expressed genes, these two proteins also associate with gene bodies. Mechanistically, actin is required for Pol II recruitment to gene bodies, and manipulation of nuclear transport factors for actin leads to the decreased expression of eggshell genes. Collectively, these results uncover a global role for actin in transcription and demonstrate the in vivo importance of balanced nucleocytoplasmic shuttling of actin in the transcriptional control of a developmental process. : Molecular Mechanism of Gene Regulation; Developmental Biology; Model Organism Subject Areas: Molecular Mechanism of Gene Regulation, Developmental Biology, Model Organism Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whether actin controls the transcription of only specific genes or has a global role in gene expression has remained elusive. Our genome-wide analysis reveals, for the first time, that actin interacts with essentially all transcribed genes in Drosophila ovaries. Actin co-occupies the majority of gene promoters together with Pol II, and on highly expressed genes, these two proteins also associate with gene bodies. Mechanistically, actin is required for Pol II recruitment to gene bodies, and manipulation of nuclear transport factors for actin leads to the decreased expression of eggshell genes. Collectively, these results uncover a global role for actin in transcription and demonstrate the in vivo importance of balanced nucleocytoplasmic shuttling of actin in the transcriptional control of a developmental process. • Genome-wide analysis shows actin on all transcribed genes • Actin binds with RNA polymerase II near transcription start sites of most genes • On highly expressed genes, actin is also found on the gene bodies • Nuclear transport of actin is required for transcription during fly development Molecular Mechanism of Gene Regulation; Developmental Biology; Model Organism Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whether actin controls the transcription of only specific genes or has a global role in gene expression has remained elusive. Our genome-wide analysis reveals, for the first time, that actin interacts with essentially all transcribed genes in Drosophila ovaries. Actin co-occupies the majority of gene promoters together with Pol II, and on highly expressed genes, these two proteins also associate with gene bodies. Mechanistically, actin is required for Pol II recruitment to gene bodies, and manipulation of nuclear transport factors for actin leads to the decreased expression of eggshell genes. Collectively, these results uncover a global role for actin in transcription and demonstrate the in vivo importance of balanced nucleocytoplasmic shuttling of actin in the transcriptional control of a developmental process. Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whether actin controls the transcription of only specific genes or has a global role in gene expression has remained elusive. Our genome-wide analysis reveals, for the first time, that actin interacts with essentially all transcribed genes in Drosophila ovaries. Actin co-occupies the majority of gene promoters together with Pol II, and on highly expressed genes, these two proteins also associate with gene bodies. Mechanistically, actin is required for Pol II recruitment to gene bodies, and manipulation of nuclear transport factors for actin leads to the decreased expression of eggshell genes. Collectively, these results uncover a global role for actin in transcription and demonstrate the in vivo importance of balanced nucleocytoplasmic shuttling of actin in the transcriptional control of a developmental process.Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whether actin controls the transcription of only specific genes or has a global role in gene expression has remained elusive. Our genome-wide analysis reveals, for the first time, that actin interacts with essentially all transcribed genes in Drosophila ovaries. Actin co-occupies the majority of gene promoters together with Pol II, and on highly expressed genes, these two proteins also associate with gene bodies. Mechanistically, actin is required for Pol II recruitment to gene bodies, and manipulation of nuclear transport factors for actin leads to the decreased expression of eggshell genes. Collectively, these results uncover a global role for actin in transcription and demonstrate the in vivo importance of balanced nucleocytoplasmic shuttling of actin in the transcriptional control of a developmental process. |
| Author | Vartiainen, Maria K. Dopie, Joseph Prajapati, Bina Sokolova, Maria Honkanen, Mikko Hietakangas, Ville Moore, Henna M. Poukkula, Minna Matos, Rita Cerejeira Meriläinen, Leena |
| AuthorAffiliation | 1 Cell and Molecular Biology Program, Institute of Biotechnology, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland 2 Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 9, 00014 Helsinki, Finland |
| AuthorAffiliation_xml | – name: 1 Cell and Molecular Biology Program, Institute of Biotechnology, University of Helsinki, Viikinkaari 5, 00014 Helsinki, Finland – name: 2 Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 9, 00014 Helsinki, Finland |
| Author_xml | – sequence: 1 givenname: Maria surname: Sokolova fullname: Sokolova, Maria – sequence: 2 givenname: Henna M. surname: Moore fullname: Moore, Henna M. – sequence: 3 givenname: Bina surname: Prajapati fullname: Prajapati, Bina – sequence: 4 givenname: Joseph surname: Dopie fullname: Dopie, Joseph – sequence: 5 givenname: Leena surname: Meriläinen fullname: Meriläinen, Leena – sequence: 6 givenname: Mikko surname: Honkanen fullname: Honkanen, Mikko – sequence: 7 givenname: Rita Cerejeira surname: Matos fullname: Matos, Rita Cerejeira – sequence: 8 givenname: Minna surname: Poukkula fullname: Poukkula, Minna – sequence: 9 givenname: Ville surname: Hietakangas fullname: Hietakangas, Ville – sequence: 10 givenname: Maria K. surname: Vartiainen fullname: Vartiainen, Maria K. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30384134$$D View this record in MEDLINE/PubMed |
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| Title | Nuclear Actin Is Required for Transcription during Drosophila Oogenesis |
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