Normative data stratified by age and education for a Spanish neuropsychological test battery: Results from the Colombian Alzheimer's prevention initiative registry

Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Anti...

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Published inApplied neuropsychology. Adult Vol. 28; no. 2; pp. 230 - 244
Main Authors Torres, Valeria L., Vila-Castelar, Clara, Bocanegra, Yamile, Baena, Ana, Guzmán-Vélez, Edmarie, Aguirre-Acevedo, Daniel C., Tirado, Victoria, Munoz, Claudia, Henao, Eliana, Moreno, Sonia, Giraldo, Margarita, Acosta, Natalia, Rios Romenets, Silvia, Langbaum, Jessica B., Cho, William, Reiman, Eric M., Tariot, Pierre N., Rosselli, Monica, Quiroz, Yakeel T., Lopera, Francisco
Format Journal Article
LanguageEnglish
Published United States Routledge 04.03.2021
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Online AccessGet full text
ISSN2327-9095
2327-9109
2327-9109
DOI10.1080/23279095.2019.1627357

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Abstract Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings.
AbstractList Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings.Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings.
Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings.
Author Vila-Castelar, Clara
Tariot, Pierre N.
Munoz, Claudia
Baena, Ana
Langbaum, Jessica B.
Lopera, Francisco
Aguirre-Acevedo, Daniel C.
Torres, Valeria L.
Guzmán-Vélez, Edmarie
Acosta, Natalia
Rios Romenets, Silvia
Cho, William
Henao, Eliana
Reiman, Eric M.
Quiroz, Yakeel T.
Tirado, Victoria
Giraldo, Margarita
Rosselli, Monica
Bocanegra, Yamile
Moreno, Sonia
AuthorAffiliation b Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA
c Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia
d Banner Alzheimer’s Institute, Phoenix, AZ, 85006, USA
e Genentech, South San Fransisco, CA, 94080, USA
f Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA
a Department of Psychology, Florida Atlantic University, Boca Raton, FL, 33431, USA
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Snippet Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed...
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SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Alzheimer Disease - diagnosis
Assessment
cognition
Colombia
Female
Humans
Male
Middle Aged
neuropsychological battery
Neuropsychological Tests
normative data
Reference Values
Registries
Retrospective Studies
Spanish
Young Adult
Title Normative data stratified by age and education for a Spanish neuropsychological test battery: Results from the Colombian Alzheimer's prevention initiative registry
URI https://www.tandfonline.com/doi/abs/10.1080/23279095.2019.1627357
https://www.ncbi.nlm.nih.gov/pubmed/31230490
https://www.proquest.com/docview/2246250077
https://pubmed.ncbi.nlm.nih.gov/PMC6926163
Volume 28
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