Normative data stratified by age and education for a Spanish neuropsychological test battery: Results from the Colombian Alzheimer's prevention initiative registry
Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Anti...
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Published in | Applied neuropsychology. Adult Vol. 28; no. 2; pp. 230 - 244 |
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Main Authors | , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Routledge
04.03.2021
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Subjects | |
Online Access | Get full text |
ISSN | 2327-9095 2327-9109 2327-9109 |
DOI | 10.1080/23279095.2019.1627357 |
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Abstract | Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings. |
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AbstractList | Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings.Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings. Neuropsychologists continue to face challenges when assessing Spanish-speaking individuals due to limited availability of normative data. We developed comprehensive normative data stratified by age and education for a Spanish neuropsychological test battery used by the Grupo de Neurociencias de Antioquia (Colombia) and the Colombian Alzheimer's Prevention Initiative Registry, which have followed large families at risk for autosomal-dominant Alzheimer's disease (ADAD) since the 1990s. Approximately 75% of these individuals are cognitively-unimpaired and are not genetically predisposed to develop ADAD. We conducted a retrospective study on neuropsychological evaluations from 2,673 cognitively unimpaired individuals (56% female), with ages ranging from 18 to 86 years and education from 1 to 25 years. Neuropsychological measures included the Consortium to Establish a Registry for Alzheimer's Disease-Colombia, and other multidomain Spanish tests. We examined associations between age, education, and sex with cognitive performance. Norms stratified by age and education are presented. Cognitive performance showed small associations with age and education and was unrelated to sex. We provided population-based norms for Spanish tests targeting multiple cognitive domains using a large Colombian sample. These normative data may be helpful for the neuropsychological characterization of Spanish speakers from Latin America in clinical and research settings. |
Author | Vila-Castelar, Clara Tariot, Pierre N. Munoz, Claudia Baena, Ana Langbaum, Jessica B. Lopera, Francisco Aguirre-Acevedo, Daniel C. Torres, Valeria L. Guzmán-Vélez, Edmarie Acosta, Natalia Rios Romenets, Silvia Cho, William Henao, Eliana Reiman, Eric M. Quiroz, Yakeel T. Tirado, Victoria Giraldo, Margarita Rosselli, Monica Bocanegra, Yamile Moreno, Sonia |
AuthorAffiliation | b Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA c Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia d Banner Alzheimer’s Institute, Phoenix, AZ, 85006, USA e Genentech, South San Fransisco, CA, 94080, USA f Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA a Department of Psychology, Florida Atlantic University, Boca Raton, FL, 33431, USA |
AuthorAffiliation_xml | – name: a Department of Psychology, Florida Atlantic University, Boca Raton, FL, 33431, USA – name: d Banner Alzheimer’s Institute, Phoenix, AZ, 85006, USA – name: f Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA – name: b Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA – name: c Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia – name: e Genentech, South San Fransisco, CA, 94080, USA |
Author_xml | – sequence: 1 givenname: Valeria L. surname: Torres fullname: Torres, Valeria L. organization: Department of Psychology, Florida Atlantic University – sequence: 2 givenname: Clara surname: Vila-Castelar fullname: Vila-Castelar, Clara organization: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School – sequence: 3 givenname: Yamile surname: Bocanegra fullname: Bocanegra, Yamile organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 4 givenname: Ana surname: Baena fullname: Baena, Ana organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 5 givenname: Edmarie surname: Guzmán-Vélez fullname: Guzmán-Vélez, Edmarie organization: Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School – sequence: 6 givenname: Daniel C. surname: Aguirre-Acevedo fullname: Aguirre-Acevedo, Daniel C. organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 7 givenname: Victoria surname: Tirado fullname: Tirado, Victoria organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 8 givenname: Claudia surname: Munoz fullname: Munoz, Claudia organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 9 givenname: Eliana surname: Henao fullname: Henao, Eliana organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 10 givenname: Sonia surname: Moreno fullname: Moreno, Sonia organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 11 givenname: Margarita surname: Giraldo fullname: Giraldo, Margarita organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 12 givenname: Natalia surname: Acosta fullname: Acosta, Natalia organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 13 givenname: Silvia surname: Rios Romenets fullname: Rios Romenets, Silvia organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia – sequence: 14 givenname: Jessica B. surname: Langbaum fullname: Langbaum, Jessica B. organization: Banner Alzheimer's Institute – sequence: 15 givenname: William surname: Cho fullname: Cho, William organization: Genentech – sequence: 16 givenname: Eric M. surname: Reiman fullname: Reiman, Eric M. organization: Banner Alzheimer's Institute – sequence: 17 givenname: Pierre N. surname: Tariot fullname: Tariot, Pierre N. organization: Banner Alzheimer's Institute – sequence: 18 givenname: Monica surname: Rosselli fullname: Rosselli, Monica organization: Department of Psychology, Florida Atlantic University – sequence: 19 givenname: Yakeel T. surname: Quiroz fullname: Quiroz, Yakeel T. organization: Department of Neurology, Massachusetts General Hospital, Harvard Medical School – sequence: 20 givenname: Francisco surname: Lopera fullname: Lopera, Francisco organization: Grupo de Neurociencias de Antioquia, Universidad de Antioquia |
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SubjectTerms | Adolescent Adult Aged Aged, 80 and over Alzheimer Disease - diagnosis Assessment cognition Colombia Female Humans Male Middle Aged neuropsychological battery Neuropsychological Tests normative data Reference Values Registries Retrospective Studies Spanish Young Adult |
Title | Normative data stratified by age and education for a Spanish neuropsychological test battery: Results from the Colombian Alzheimer's prevention initiative registry |
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