Brain-Derived Neurotrophic Factor and Alzheimer’s Disease: Physiopathology and Beyond

Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiat...

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Published in	Neuromolecular medicine Vol. 13; no. 4; pp. 217 - 222
Main Authors	Diniz, Breno Satler, Teixeira, Antonio Lucio
Format	Journal Article
Language	English
Published	New York Humana Press Inc 01.12.2011 Springer Nature B.V
Subjects	Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Alzheimer Disease - physiopathology Alzheimer's disease Animals Biomarkers Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Brain-Derived Neurotrophic Factor - cerebrospinal fluid Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - physiology Cell survival Central nervous system Cerebrospinal fluid Cognitive ability Disease Models, Animal Female Humans Internal Medicine Male Mental disorders Mice Neurodegenerative diseases Neurology Neurosciences Neurotrophins Plasticity (synaptic) Rats Review Paper Biomarker Alzheimer’s disease BDNF Mild cognitive impairment Physiopathology
Online Access	Get full text
ISSN	1535-1084 1559-1174 1559-1174
DOI	10.1007/s12017-011-8154-x

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Abstract	Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have reported altered levels of BDNF in the circulation, i.e. serum or plasma, of patients with Alzheimer’s disease (AD), and low BDNF levels in the CSF as predictor of future cognitive decline in healthy older subjects. Altered BDNF circulating levels have also been reported in other neurodegenerative and psychiatric disorders, hampering its use as a specific biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes.
AbstractList	Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have reported altered levels of BDNF in the circulation, i.e. serum or plasma, of patients with Alzheimer's disease (AD), and low BDNF levels in the CSF as predictor of future cognitive decline in healthy older subjects. Altered BDNF circulating levels have also been reported in other neurodegenerative and psychiatric disorders, hampering its use as a specific biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes.[PUBLICATION ABSTRACT] Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have reported altered levels of BDNF in the circulation, i.e. serum or plasma, of patients with Alzheimer’s disease (AD), and low BDNF levels in the CSF as predictor of future cognitive decline in healthy older subjects. Altered BDNF circulating levels have also been reported in other neurodegenerative and psychiatric disorders, hampering its use as a specific biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have reported altered levels of BDNF in the circulation, i.e. serum or plasma, of patients with Alzheimer's disease (AD), and low BDNF levels in the CSF as predictor of future cognitive decline in healthy older subjects. Altered BDNF circulating levels have also been reported in other neurodegenerative and psychiatric disorders, hampering its use as a specific biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes.Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target in the physiopathology of several neurological and psychiatric diseases. Recent studies have reported altered levels of BDNF in the circulation, i.e. serum or plasma, of patients with Alzheimer's disease (AD), and low BDNF levels in the CSF as predictor of future cognitive decline in healthy older subjects. Altered BDNF circulating levels have also been reported in other neurodegenerative and psychiatric disorders, hampering its use as a specific biomarker for AD. Therefore, BDNF seems to be an unspecific biomarker of neuropsychiatric disorders marked by neurodegenerative changes.
Author	Teixeira, Antonio Lucio Diniz, Breno Satler
Author_xml	– sequence: 1 givenname: Breno Satler surname: Diniz fullname: Diniz, Breno Satler email: brenosatler@usp.br organization: Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo – sequence: 2 givenname: Antonio Lucio surname: Teixeira fullname: Teixeira, Antonio Lucio organization: Group of Neuroimmunology, Laboratory of Immunopharmachology, Institute of Biological Sciences and School of Medicine, Federal University of Minas Gerais
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/21898045$$D View this record in MEDLINE/PubMed
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Snippet	Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in...
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SubjectTerms	Alzheimer Disease - blood Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Alzheimer Disease - physiopathology Alzheimer's disease Animals Biomarkers Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Brain-Derived Neurotrophic Factor - cerebrospinal fluid Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - physiology Cell survival Central nervous system Cerebrospinal fluid Cognitive ability Disease Models, Animal Female Humans Internal Medicine Male Mental disorders Mice Neurodegenerative diseases Neurology Neurosciences Neurotrophins Plasticity (synaptic) Rats Review Paper
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Title	Brain-Derived Neurotrophic Factor and Alzheimer’s Disease: Physiopathology and Beyond
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