Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence
As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adver...
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| Published in | Frontiers in endocrinology (Lausanne) Vol. 14; p. 1114463 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
20.02.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1664-2392 1664-2392 |
| DOI | 10.3389/fendo.2023.1114463 |
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| Abstract | As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca
2+
influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa. |
|---|---|
| AbstractList | As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca
2+
influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa. As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa. As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca2+ influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa.As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca2+ influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa. As emerging organic contaminants, per- and polyfluoroalkyl substances (PFASs) have aroused worldwide concern due to their environmental persistence, ubiquitous presence, bioaccumulation, and potential toxicity. It has been demonstrated that PFASs can accumulate in human body and cause multiple adverse health outcomes. Notably, PFASs have been detected in the semen of human, posing a potential hazard to male fecundity. This article reviews the evidence about the toxic effects of exposure to PFASs on male reproduction, focusing on the sperm quality. Epidemiological studies showed that PFASs, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), were adversely associated with the semen parameters in humans, including sperm count, morphology and motility. Experimental results also confirmed that PFAS exposure led to testicular and epididymal damage, therefore impairing spermatogenesis and sperm quality. The mechanisms of reproductive toxicity of PFASs may be involved in blood-testosterone barrier destruction, testicular apoptosis, testosterone synthesis disorder, and membrane lipid composition alteration, oxidative stress and Ca2+ influx in sperm. In conclusion, this review highlighted the potential threat of exposure to PFASs to human spermatozoa. |
| Author | Fu, Zhendong Yuan, Yangyang Wen, Yiqian Wang, Binhui Zhang, Dalei Sun, Zhangbei Zhang, Fan Deng, Shiyi |
| AuthorAffiliation | 3 Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Nanchang University , Nanchang , China 2 Clinical Medical Experimental Center, Nanchang University , Nanchang , China 1 School of Basic Medical Sciences, Nanchang University , Nanchang , China |
| AuthorAffiliation_xml | – name: 2 Clinical Medical Experimental Center, Nanchang University , Nanchang , China – name: 1 School of Basic Medical Sciences, Nanchang University , Nanchang , China – name: 3 Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Nanchang University , Nanchang , China |
| Author_xml | – sequence: 1 givenname: Zhangbei surname: Sun fullname: Sun, Zhangbei – sequence: 2 givenname: Yiqian surname: Wen fullname: Wen, Yiqian – sequence: 3 givenname: Binhui surname: Wang fullname: Wang, Binhui – sequence: 4 givenname: Shiyi surname: Deng fullname: Deng, Shiyi – sequence: 5 givenname: Fan surname: Zhang fullname: Zhang, Fan – sequence: 6 givenname: Zhendong surname: Fu fullname: Fu, Zhendong – sequence: 7 givenname: Yangyang surname: Yuan fullname: Yuan, Yangyang – sequence: 8 givenname: Dalei surname: Zhang fullname: Zhang, Dalei |
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| ContentType | Journal Article |
| Copyright | Copyright © 2023 Sun, Wen, Wang, Deng, Zhang, Fu, Yuan and Zhang. Copyright © 2023 Sun, Wen, Wang, Deng, Zhang, Fu, Yuan and Zhang 2023 Sun, Wen, Wang, Deng, Zhang, Fu, Yuan and Zhang |
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| Keywords | male fecundity sperm per- and polyfluoroalkyl substances testosterone reproductive toxicity |
| Language | English |
| License | Copyright © 2023 Sun, Wen, Wang, Deng, Zhang, Fu, Yuan and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Xiaoning Zhang, Nantong University, China; Yuling Mi, Zhejiang University, China; Xinbao Ding, Cornell University, United States These authors have contributed equally to this work Edited by: Katja Teerds, Wageningen University and Research, Netherlands This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology |
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