Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main f...

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Published inFrontiers in immunology Vol. 14; p. 1120034
Main Authors Zhu, Peng, Ke, Zhuo-Ran, Chen, Jing-Xian, Li, Shi-Jin, Ma, Tian-Liang, Fan, Xiao-Lei
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 09.02.2023
Subjects
Apoptosis - physiology
Cell Death
Humans
Immunology
infection
Necroptosis
Neurodegenerative Diseases - therapy
PANoptosis
PANoptosome
PCD
Pyroptosis
PCD
infection
cell death
PANoptosis
PANoptosome
Online AccessGet full text
ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2023.1120034

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Abstract PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main features of pyroptosis, apoptosis, and necroptosis. Many variables, such as infection, injury, or self-defect, may be involved in the occurrence of PANoptosis, with the assembly and activation of the PANoptosome being the most critical. PANoptosis has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, it is necessary to clarify the process of occurrence, the regulatory mechanism of PANoptosis, and its relation to diseases. In this paper, we summarized the differences and relations between PANoptosis and the three types of programmed cell death, and emphatically expounded molecular mechanism and regulatory patterns of PANoptosis, with the expectation of facilitating the application of PANoptosis regulation in disease treatment.
AbstractList PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main features of pyroptosis, apoptosis, and necroptosis. Many variables, such as infection, injury, or self-defect, may be involved in the occurrence of PANoptosis, with the assembly and activation of the PANoptosome being the most critical. PANoptosis has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, it is necessary to clarify the process of occurrence, the regulatory mechanism of PANoptosis, and its relation to diseases. In this paper, we summarized the differences and relations between PANoptosis and the three types of programmed cell death, and emphatically expounded molecular mechanism and regulatory patterns of PANoptosis, with the expectation of facilitating the application of PANoptosis regulation in disease treatment.
PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main features of pyroptosis, apoptosis, and necroptosis. Many variables, such as infection, injury, or self-defect, may be involved in the occurrence of PANoptosis, with the assembly and activation of the PANoptosome being the most critical. PANoptosis has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, it is necessary to clarify the process of occurrence, the regulatory mechanism of PANoptosis, and its relation to diseases. In this paper, we summarized the differences and relations between PANoptosis and the three types of programmed cell death, and emphatically expounded molecular mechanism and regulatory patterns of PANoptosis, with the expectation of facilitating the application of PANoptosis regulation in disease treatment.PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main features of pyroptosis, apoptosis, and necroptosis. Many variables, such as infection, injury, or self-defect, may be involved in the occurrence of PANoptosis, with the assembly and activation of the PANoptosome being the most critical. PANoptosis has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, it is necessary to clarify the process of occurrence, the regulatory mechanism of PANoptosis, and its relation to diseases. In this paper, we summarized the differences and relations between PANoptosis and the three types of programmed cell death, and emphatically expounded molecular mechanism and regulatory patterns of PANoptosis, with the expectation of facilitating the application of PANoptosis regulation in disease treatment.
Author Zhu, Peng
Li, Shi-Jin
Fan, Xiao-Lei
Chen, Jing-Xian
Ma, Tian-Liang
Ke, Zhuo-Ran
AuthorAffiliation 2 School of Anesthesiology, Guizhou Medical University , Guiyang, Guizhou , China
3 Department of Orthopedics, Xiangya Hospital, Central South University , Changsha, Hunan , China
4 Department of Orthopedics, Honghui Hospital, Xi’an Jiaotong University , Xi’an , China
1 XiangYa School of Medicine, Central South University , Changsha, Hunan , China
AuthorAffiliation_xml – name: 2 School of Anesthesiology, Guizhou Medical University , Guiyang, Guizhou , China
– name: 3 Department of Orthopedics, Xiangya Hospital, Central South University , Changsha, Hunan , China
– name: 1 XiangYa School of Medicine, Central South University , Changsha, Hunan , China
– name: 4 Department of Orthopedics, Honghui Hospital, Xi’an Jiaotong University , Xi’an , China
Author_xml – sequence: 1
  givenname: Peng
  surname: Zhu
  fullname: Zhu, Peng
– sequence: 2
  givenname: Zhuo-Ran
  surname: Ke
  fullname: Ke, Zhuo-Ran
– sequence: 3
  givenname: Jing-Xian
  surname: Chen
  fullname: Chen, Jing-Xian
– sequence: 4
  givenname: Shi-Jin
  surname: Li
  fullname: Li, Shi-Jin
– sequence: 5
  givenname: Tian-Liang
  surname: Ma
  fullname: Ma, Tian-Liang
– sequence: 6
  givenname: Xiao-Lei
  surname: Fan
  fullname: Fan, Xiao-Lei
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36845112$$D View this record in MEDLINE/PubMed
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Keywords PCD
infection
cell death
PANoptosis
PANoptosome
Language English
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This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
These authors have contributed equally to this work
Edited by: Yong Huang, Northwest A&F University, China
Reviewed by: Youwei Ai, Institute of Genetics and Developmental Biology (CAS), China; Yaqiu Wang, St. Jude Children’s Research Hospital, United States
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Snippet PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell...
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SubjectTerms Apoptosis - physiology
Cell Death
Humans
Immunology
infection
Necroptosis
Neurodegenerative Diseases - therapy
PANoptosis
PANoptosome
PCD
Pyroptosis
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Title Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
URI https://www.ncbi.nlm.nih.gov/pubmed/36845112
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Volume 14
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